iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mdo-061984

Ensembl Protein ID

ENSMODP00000005995.3

UniProt Accession

F6T8D2; F6T8D2_MONDO

Protein Name

Histone-lysine N-methyltransferase

Gene Name

NSD1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000004870.3	ENSMODT00000006122.3	ENSMODP00000005995.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	1.10e-11	44.9	1415	1455

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 3    vClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCr 52
           +C vC egg+    l++C+ C  +fH +Cl++      p+ + w+C++C+
   Q: 1415 WCFVCSEGGS----LLCCDSCPAAFHRECLNID----IPEGN-WYCNDCK 1455
           8*********....*******************....99996.******8 PP

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

MPLKKRTPLS DDPESSTSTL GNMIELPGTS SSSTSQELQF CQPKKKPAPL KYGVGQLVWA 60
KFNRRPWWPS RICCDPLINT HSKMKVSSQR PYRQYYVEAL GDPSEKAWVA GKSIVLFEGR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN GAGTGGGGGG CGCTACAGGC TGCTAAGGCA 60
GAACCATGTG TGGCCGCAGC GGGACTTGGA GCGGGAGCAA AGGCGGCAGA GCCCAGTGGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0949--S-adenosyl-L-methionine
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR006560--AWS_dom
IPR003616--Post-SET_dom
IPR000313--PWWP_dom
IPR001214--SET_dom
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51215--AWS
PS50868--POST_SET
PS50812--PWWP
PS50280--SET
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2

Pfam

PF00855--PWWP
PF00856--SET

SMART

SM00570--AWS
SM00249--PHD
SM00508--PostSET
SM00293--PWWP
SM00317--SET

Gene Ontology

GO:0005634--C:nucleus
GO:0046975--F:histone methyltransferase activity (H3-K36 specific)
GO:0000979--F:RNA polymerase II core promoter sequence-specific DNA binding
GO:0003712--F:transcription cofactor activity
GO:0008270--F:zinc ion binding
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0000414--P:regulation of histone H3-K36 methylation
GO:0033135--P:regulation of peptidyl-serine phosphorylation
GO:1903025--P:regulation of RNA polymerase II regulatory region sequence-specific DNA binding

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000310	Aegilops tauschii	30.05	4.00e-12	66.60
IUUC-Aml-001795	Ailuropoda melanoleuca	68.99	0.00e+00	3115.00
IUUC-Apl-003953	Anas platyrhynchos	57.74	0.00e+00	2225.00
IUUC-Aca-005339	Anolis carolinensis	58.42	0.00e+00	1459.00
IUUC-Ath-007184	Arabidopsis thaliana	31.12	9.00e-15	75.10
IUUC-Bta-012966	Bos taurus	69.31	0.00e+00	3191.00
IUUC-Bol-016259	Brassica oleracea	31.63	1.00e-13	72.00
IUUC-Bra-017530	Brassica rapa	31.63	2.00e-13	71.60
IUUC-Cja-018780	Callithrix jacchus	70.25	0.00e+00	2975.00
IUUC-Cfa-020975	Canis familiaris	68.92	0.00e+00	3141.00
IUUC-Cpo-021331	Cavia porcellus	69.53	0.00e+00	2071.00
IUUC-Csa-024226	Chlorocebus sabaeus	68.98	0.00e+00	3072.00
IUUC-Cho-024464	Choloepus hoffmanni	56.14	0.00e+00	942.00
IUUC-Dre-028152	Danio rerio	55.33	0.00e+00	1207.00
IUUC-Dno-029230	Dasypus novemcinctus	67.41	0.00e+00	3027.00
IUUC-Dor-031016	Dipodomys ordii	68.79	0.00e+00	1134.00
IUUC-Eca-033591	Equus caballus	68.43	0.00e+00	3105.00
IUUC-Fca-035791	Felis catus	69.24	0.00e+00	3199.00
IUUC-Fal-037378	Ficedula albicollis	59.21	0.00e+00	2080.00
IUUC-Gmo-038919	Gadus morhua	69.71	0.00e+00	906.00
IUUC-Gga-040881	Gallus gallus	58.27	0.00e+00	2170.00
IUUC-Gac-041378	Gasterosteus aculeatus	76.60	0.00e+00	1031.00
IUUC-Hsa-046436	Homo sapiens	68.96	0.00e+00	3100.00
IUUC-Itr-048194	Ictidomys tridecemlineatus	68.23	0.00e+00	3099.00
IUUC-Lch-049684	Latimeria chalumnae	48.68	0.00e+00	1520.00
IUUC-Lpe-051661	Leersia perrieri	29.53	1.00e-12	68.90
IUUC-Laf-054046	Loxodonta africana	68.97	0.00e+00	3072.00
IUUC-Mcc-055593	Macaca mulatta	68.76	0.00e+00	3082.00
IUUC-Mga-059756	Meleagris gallopavo	57.85	0.00e+00	2239.00
IUUC-Mmr-061182	Microcebus murinus	68.60	0.00e+00	3119.00
IUUC-Mmu-063605	Mus musculus	65.21	0.00e+00	2895.00
IUUC-Mpu-066446	Mustela putorius furo	68.51	0.00e+00	3159.00
IUUC-Mlu-067261	Myotis lucifugus	69.11	0.00e+00	3127.00
IUUC-Nle-069818	Nomascus leucogenys	68.95	0.00e+00	3088.00
IUUC-Opr-070842	Ochotona princeps	67.72	0.00e+00	1842.00
IUUC-Ont-072448	Oreochromis niloticus	72.74	0.00e+00	1104.00
IUUC-Oan-073496	Ornithorhynchus anatinus	79.38	0.00e+00	1581.00
IUUC-Ocu-074918	Oryctolagus cuniculus	69.24	0.00e+00	3201.00
IUUC-Obr-076753	Oryza brachyantha	54.84	9.00e-08	53.50
IUUC-Ola-087518	Oryzias latipes	73.47	0.00e+00	1018.00
IUUC-Oga-088743	Otolemur garnettii	67.77	0.00e+00	2975.00
IUUC-Oar-090265	Ovis aries	69.32	0.00e+00	3188.00
IUUC-Ptr-090521	Pan troglodytes	69.05	0.00e+00	3107.00
IUUC-Psi-093245	Pelodiscus sinensis	59.99	0.00e+00	2009.00
IUUC-Pfo-096066	Poecilia formosa	61.90	0.00e+00	1185.00
IUUC-Pab-098644	Pongo abelii	68.99	0.00e+00	3075.00
IUUC-Pva-103094	Pteropus vampyrus	75.02	0.00e+00	1543.00
IUUC-Rno-105803	Rattus norvegicus	65.22	0.00e+00	2863.00
IUUC-Sha-107278	Sarcophilus harrisii	90.77	0.00e+00	4122.00
IUUC-Sar-113402	Sorex araneus	62.43	0.00e+00	2030.00
IUUC-Ssc-116193	Sus scrofa	68.74	0.00e+00	3065.00
IUUC-Tgu-116532	Taeniopygia guttata	87.07	0.00e+00	1197.00
IUUC-Tru-117988	Takifugu rubripes	75.53	0.00e+00	1150.00
IUUC-Tsy-118830	Tarsius syrichta	70.43	0.00e+00	2816.00
IUUC-Tca-121456	Theobroma cacao	30.81	1.00e-20	95.10
IUUC-Tae-124687	Triticum aestivum	30.05	5.00e-12	66.60

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence