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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046551
UUCD1 version UUC-HoS-01095
Ensembl Protein ID ENSP00000218348.3
UniProt Accession P51784; B2RTX1; Q8IUG6; Q9BWE1; UBP11_HUMAN
Genbank Protein ID CAD20056.1; AAI40850.1; AAH00350.4; BAC20463.1; AAC50450.1
Protein Name Ubiquitin carboxyl-terminal hydrolase 11; Deubiquitinating enzyme 11; Ubiquitin thioesterase 11; Ubiquitin-specific-processing protease 11
Genbank Nucleotide ID AL096791; BC140849; BC000350; AB073597; U44839
Gene Name USP11; UHX1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000102226.9 ENST00000218348.7 ENSP00000218348.3
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
RepTarmiRNAMapSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
DUB/USP USP 12084015
Classification
Family E-value Score Start End
DUB/USP 6.60e-113 379.0 309 930
Active Site
Position(s) Description Evidence
318 Nucleophile
888 Proton acceptor ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
Domain Profile

   DUB/USP
   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqD 91
           +Gl+NlgNtC+mNS+LQcLsn+p+l+e++l+  + e+ln +np ++kge+++++++l+++ w+++++++ p+ ++++++++a++f gy+q+D
   Q: 309  CGLTNLGNTCFMNSALQCLSNVPQLTEYFLNnCYLEELNFRNPLGMKGEIAEAYADLVKQAWSGHHRSIVPHVFKNKVGHFASQFLGYQQHD 400
           7******************************99*********************************************************** PP
   S: 92   aqEflaflldqleeelkkeknkpkeeeeeedkselsde...aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgke 180
           +qE+l+flld+l+e+l++ k+k++ e+++++ +  ++    a++++k++n+s+i+d+F+g +ks+++c++c+nvs++++pf++ls+p+p ++
   Q: 401  SQELLSFLLDGLHEDLNRVKKKEYVELCDAAGRPDQEVaqeAWQNHKRRNDSVIVDTFHGLFKSTLVCPDCGNVSVTFDPFCYLSVPLPISH 492
           **************************998874333322555*************************************************** PP
   S: 181  etkke....................................................................................... 185
           ++ +e                                                                                       
   Q: 493  KRVLEvffipmdprrkpeqhrlvvpkkgkisdlcvalskhtgispermmvadvfshrfyklyqleeplssildrddifvyevsgrieaiegs 584
           99888*************************************************************************************** PP
   S: 186  ............................................................................................ 185
                                                                                                       
   Q: 585  redivvpvylrertpardynnsyyglmlfghpllvsvprdrftweglynvlmyrlsryvtkpnsddeddgdekeddeedkddvpgpstggsl 676
           ******************************************************************************************** PP
   S: 186  ............................................................................................ 185
                                                                                                       
   Q: 677  rdpepeqagpssgvtnrcpflldnclgtsqwpprrrrkqlftlqtvnsngtsdrttspeevhaqpyiaidwepemkkryydeveaegyvkhd 768
           ******************************************************************************************** PP
   S: 186  ...........slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefple.Ldlspfc 265
                       lq+c+e ft+ e+le+en +yc++ck++q a+kkl+l+ lPe+Li+hLkRfs+++   srek+++ vefp++ Ld s+f+
   Q: 769  cvgyvmkkapvRLQECIELFTTVETLEKENPWYCPSCKQHQLATKKLDLWMLPEILIIHLKRFSYTK--FSREKLDTLVEFPIRdLDFSEFV 858
           ***************************************************************8866..89********************9 PP
   S: 266  tspeekqke.kkkYeLiavvvHsGslssGHYvayvkn.ekgkWllfdDskVtevkeeevleetgstaYvlfYkrr 338
           ++p+++++   +kY+Liav +H+G+++ GHY++++ n ++g+W +fdD++V++v+e+++++   + aYvlfY+r+
   Q: 859  IQPQNESNPeLYKYDLIAVSNHYGGMRDGHYTTFACNkDSGQWHYFDDNSVSPVNENQIES---KAAYVLFYQRQ 930
           999887764489*********************988834566*******************...*********96 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains (PubMed:12084015, PubMed:15314155, PubMed:17897950, PubMed:19874889, PubMed:20233726, PubMed:24724799). Inhibits the degradation of target proteins by the proteasome (PubMed:12084015). Cleaves preferentially 'Lys-6' and 'Lys-63'-linked ubiquitin chains. Has lower activity with 'Lys-11' and 'Lys-33'-linked ubiquitin chains, and extremely low activity with 'Lys-27', 'Lys-29' and 'Lys-48'-linked ubiquitin chains (in vitro) (PubMed:24724799). Plays a role in the regulation of pathways leading to NF-kappa-B activation (PubMed:17897950, PubMed:19874889). Plays a role in the regulation of DNA repair after double-stranded DNA breaks (PubMed:15314155, PubMed:20233726). Acts as a chromatin regulator via its association with the Polycomb group (PcG) multiprotein PRC1-like complex; may act by deubiquitinating components of the PRC1-like complex (PubMed:20601937).
 Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains (PubMed:12084015, PubMed:15314155, PubMed:17897950, PubMed:19874889, PubMed:20233726, PubMed:24724799). Inhibits the degradation of target proteins by the proteasome (PubMed:12084015). Cleaves preferentially 'Lys-6' and 'Lys-63'-linked ubiquitin chains. Has lower activity with 'Lys-11' and 'Lys-33'-linked ubiquitin chains, and extremely low activity with 'Lys-27', 'Lys-29' and 'Lys-48'-linked ubiquitin chains (in vitro) (PubMed:24724799). Plays a role in the regulation of pathways leading to NF-kappa-B activation (PubMed:17897950, PubMed:19874889). Plays a role in the regulation of DNA repair after double-stranded DNA breaks (PubMed:15314155, PubMed:20233726). Acts as a chromatin regulator via its association with the Polycomb group (PcG) multiprotein PRC1-like complex; may act by deubiquitinating components of the PRC1-like complex (PubMed:20601937).
Protein Sequence
(Fasta)
MAVAPRLFGG LCFRFRDQNP EVAVEGRLPI SHSCVGCRRE RTAMATVAAN PAAAAAAVAA 60
AAAVTEDREP QHEELPGLDS QWRQIENGES GRERPLRAGE SWFLVEKHWY KQWEAYVQGG 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046551|DUB,USP|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GATGGTACAA TGAAGGGCAT TCTGATCAGG CTAACAAAAA CACTGCTCCC AGGGTAGGAG 60
TCCTAGCCCA CCTCGGGAAC CTCAGCCTCC ACTTTCCATG CCACCTGTGC CCTAAGTCTA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046551|DUB,USP|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
Interpro

IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR028135--Ub_USP-typ
IPR029346--USP_C
IPR018200--USP_CS
IPR028889--USP_dom
PROSITE

PS51283--DUSP
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
Pfam

PF06337--DUSP
PF14836--Ubiquitin_3
PF00443--UCH
PF14533--USP7_C2
SMART

SM00695--DUSP
Gene Ontology

GO:0005694--C:chromosome
GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG hsa:8237
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001760 Ailuropoda melanoleuca 83.63 0.00e+00 1495.00
IUUC-Aca-004532 Anolis carolinensis 65.68 0.00e+00 1146.00
IUUC-Ago-007911 Ashbya gossypii 33.06 8.00e-64 239.00
IUUC-Afu-008878 Aspergillus fumigatus 37.14 4.00e-55 211.00
IUUC-Ani-009479 Aspergillus nidulans 42.35 1.00e-52 202.00
IUUC-Aor-009949 Aspergillus oryzae 36.41 4.00e-53 203.00
IUUC-Ate-010323 Aspergillus terreus 37.14 3.00e-56 214.00
IUUC-Bta-013284 Bos taurus 82.70 0.00e+00 1485.00
IUUC-Bol-016335 Brassica oleracea 33.19 2.00e-125 443.00
IUUC-Cja-019746 Callithrix jacchus 96.77 0.00e+00 1704.00
IUUC-Cfa-020134 Canis familiaris 83.78 0.00e+00 1600.00
IUUC-Cpo-022535 Cavia porcellus 82.62 0.00e+00 1533.00
IUUC-Csa-023828 Chlorocebus sabaeus 99.27 0.00e+00 1854.00
IUUC-Dre-027398 Danio rerio 60.14 0.00e+00 733.00
IUUC-Dno-028853 Dasypus novemcinctus 84.10 0.00e+00 1287.00
IUUC-Dor-030384 Dipodomys ordii 84.23 0.00e+00 1568.00
IUUC-Eca-033271 Equus caballus 84.30 0.00e+00 1516.00
IUUC-Fca-036012 Felis catus 84.08 0.00e+00 1530.00
IUUC-Gac-042574 Gasterosteus aculeatus 54.72 0.00e+00 890.00
IUUC-Itr-048915 Ictidomys tridecemlineatus 84.91 0.00e+00 1600.00
IUUC-Kpa-049332 Komagataella pastoris 34.14 5.00e-73 270.00
IUUC-Laf-054561 Loxodonta africana 80.06 0.00e+00 1547.00
IUUC-Mcc-054881 Macaca mulatta 98.86 0.00e+00 1848.00
IUUC-Meu-056749 Macropus eugenii 77.65 0.00e+00 883.00
IUUC-Mla-058848 Melampsora laricipopulina 42.27 2.00e-71 265.00
IUUC-Mvi-060324 Microbotryum violaceum 31.03 7.00e-80 293.00
IUUC-Mmr-061400 Microcebus murinus 91.90 0.00e+00 1672.00
IUUC-Mmu-063241 Mus musculus 82.07 0.00e+00 1509.00
IUUC-Mpu-066507 Mustela putorius furo 84.09 0.00e+00 1538.00
IUUC-Mlu-066961 Myotis lucifugus 77.00 0.00e+00 1382.00
IUUC-Nle-069284 Nomascus leucogenys 99.89 0.00e+00 1782.00
IUUC-Ont-071847 Oreochromis niloticus 57.72 0.00e+00 973.00
IUUC-Oan-073387 Ornithorhynchus anatinus 69.68 0.00e+00 1206.00
IUUC-Ocu-074066 Oryctolagus cuniculus 87.18 0.00e+00 1643.00
IUUC-Oga-088424 Otolemur garnettii 91.65 0.00e+00 1659.00
IUUC-Oar-089732 Ovis aries 78.70 0.00e+00 1494.00
IUUC-Pan-092292 Papio anubis 98.13 0.00e+00 1847.00
IUUC-Pab-098779 Pongo abelii 91.21 0.00e+00 1556.00
IUUC-Pca-100851 Procavia capensis 78.25 0.00e+00 917.00
IUUC-Pva-103244 Pteropus vampyrus 80.89 0.00e+00 1496.00
IUUC-Ptt-103847 Puccinia triticina 33.13 2.00e-64 241.00
IUUC-Rno-105100 Rattus norvegicus 82.41 0.00e+00 1512.00
IUUC-Sha-107502 Sarcophilus harrisii 76.66 0.00e+00 881.00
IUUC-Sja-107752 Schizosaccharomyces japonicus 36.40 9.00e-82 298.00
IUUC-Spo-108291 Schizosaccharomyces pombe 33.56 2.00e-75 277.00
IUUC-Ssc-116345 Sus scrofa 83.94 0.00e+00 1536.00
IUUC-Tru-117788 Takifugu rubripes 56.37 0.00e+00 924.00
IUUC-Tsy-119414 Tarsius syrichta 83.05 0.00e+00 1236.00
IUUC-Tni-120107 Tetraodon nigroviridis 48.98 8.00e-157 548.00
IUUC-Tre-121888 Trichoderma reesei 43.75 3.00e-63 238.00
IUUC-Tvi-122422 Trichoderma virens 41.54 6.00e-58 220.00
IUUC-Tae-125515 Triticum aestivum 33.16 4.00e-123 436.00
IUUC-Tur-126392 Triticum urartu 31.73 8.00e-112 398.00
IUUC-Tbe-128081 Tupaia belangeri 91.08 0.00e+00 1013.00
IUUC-Ttr-128502 Tursiops truncatus 79.98 0.00e+00 1483.00
Created Date 25-Jun-2017

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