iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-012440

UUCD1 version

UUC-BoT-01076

Ensembl Protein ID

ENSBTAP00000013418.2

UniProt Accession

Q5EAE5; A5D797; JOS1_BOVIN

Genbank Protein ID

AAX08641.1; AAI40478.1

Protein Name

Josephin-1; Josephin domain-containing protein 1

Genbank Nucleotide ID

BT020624; BC140477

Gene Name

JOSD1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000010171.2	ENSBTAT00000013418.2	ENSBTAP00000013418.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/Josephin	4.00e-100	333.1	1	201

Active Site

Position(s)	Description	Evidence
36	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU00331}
139	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU00331}

Domain Profile

DUB/Josephin

   S: 1    msqvpg............aqaapesiyhekqrrelCalhalnnvlqd.elfsreeldeiakrldeeerlqPs.kslldtGnydvnvisa 75
           ms+vp+            +qaap++iyhekqrrelCalhalnnv+qd ++f+re+l+ei++rl+++++++P+ ks+l++Gnydvnvi+a
   Q: 1    MSCVPWkgdkvkseslelPQAAPPQIYHEKQRRELCALHALNNVFQDsNAFTRETLQEIFQRLSPNTMVTPHkKSMLGNGNYDVNVIMA 89
           8**********************************************9************************99*************** PP
   S: 76   alkvlGleavwfdkrrelqklaldnvlgfilnlpsslslgllklplkkqhWvtvrkvgkayynldsklkaPeligdetelrkflakllq 164
           al+++G+eavw+dkrr+++ +al+nv+gfi+nlpssl++g+lklplk+qhW++vr+vg+ayynldsklk+Pe+ig+++elrkfl+++l+
   Q: 90   ALQTKGYEAVWWDKRRDVGAIALTNVMGFIMNLPSSLCWGPLKLPLKRQHWICVREVGGAYYNLDSKLKMPEWIGGKSELRKFLKHHLR 178
           ***************************************************************************************** PP
   S: 165  qkyselllvvkeevedkesdqrld 188
           +k++elllvv+eeve+++s+ r d
   Q: 179  GKNCELLLVVPEEVEAHQSW-RAD 201
           ********************.665 PP

Organism

Bos taurus

Functional Description
(View)

Deubiquitinates monoubiquitinated probes (in vitro). When ubiquitinated, cleaves 'Lys-63'-linked and 'Lys-48'-linked poly-ubiquitin chains (in vitro), hence may act as a deubiquitinating enzyme. May increase macropinocytosis and suppress clathrin- and caveolae-mediated endocytosis. May enhance membrane dynamics and cell motility independently of its catalytic activity (By similarity).

Protein Sequence
(Fasta)

MSCVPWKGDK VKSESLELPQ AAPPQIYHEK QRRELCALHA LNNVFQDSNA FTRETLQEIF 60
QRLSPNTMVT PHKKSMLGNG NYDVNVIMAA LQTKGYEAVW WDKRRDVGAI ALTNVMGFIM 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGAGTTCGC GCTTTCCGAA GGAGCTGCGT CCGTCTCGGC CTCTCGAGGT CCCGCCGCAC 60
CCAAGAGGAT GGAGAGCCTC CCCCGAGGCC GCAGCAGGGC CCGCGAACCC ACGCCGGCCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway

Interpro

IPR006155--Josephin

PROSITE

PS50957--JOSEPHIN

Pfam

PF02099--Josephin

SMART

SM01246--Josephin

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005886--C:plasma membrane
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0016579--P:protein deubiquitination

KEGG

bta:510781

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002429	Ailuropoda melanoleuca	98.02	1.00e-110	391.00
IUUC-Apl-003240	Anas platyrhynchos	88.67	2.00e-95	341.00
IUUC-Aca-004262	Anolis carolinensis	90.10	1.00e-102	365.00
IUUC-Afl-008651	Aspergillus flavus	32.35	8.40e-02	29.30
IUUC-Ame-011040	Astyanax mexicanus	70.05	5.00e-81	293.00
IUUC-Cja-019461	Callithrix jacchus	96.53	3.00e-109	387.00
IUUC-Cfa-021002	Canis familiaris	98.02	1.00e-110	391.00
IUUC-Cpo-021309	Cavia porcellus	98.02	5.00e-111	392.00
IUUC-Csa-023194	Chlorocebus sabaeus	97.03	2.00e-110	390.00
IUUC-Cho-025019	Choloepus hoffmanni	96.04	1.00e-109	388.00
IUUC-Cin-025666	Ciona intestinalis	59.76	3.00e-54	204.00
IUUC-Dre-028692	Danio rerio	69.44	2.00e-80	291.00
IUUC-Dno-029803	Dasypus novemcinctus	96.04	2.00e-109	387.00
IUUC-Dor-030619	Dipodomys ordii	98.57	7.00e-73	266.00
IUUC-Ete-032777	Echinops telfairi	94.65	1.00e-105	374.00
IUUC-Eca-034395	Equus caballus	96.53	6.00e-110	389.00
IUUC-Eeu-035075	Erinaceus europaeus	74.75	6.00e-77	279.00
IUUC-Fca-035819	Felis catus	98.02	3.00e-111	393.00
IUUC-Fal-037330	Ficedula albicollis	92.57	3.00e-100	357.00
IUUC-Gmo-038979	Gadus morhua	80.35	2.00e-76	278.00
IUUC-Gga-040456	Gallus gallus	93.60	6.00e-99	352.00
IUUC-Gac-041797	Gasterosteus aculeatus	73.63	7.00e-81	292.00
IUUC-Ggo-045586	Gorilla gorilla	97.52	8.00e-111	392.00
IUUC-Hsa-047008	Homo sapiens	97.52	9.00e-111	392.00
IUUC-Itr-048432	Ictidomys tridecemlineatus	97.52	1.00e-110	391.00
IUUC-Lch-049682	Latimeria chalumnae	79.21	1.00e-84	305.00
IUUC-Loc-051775	Lepisosteus oculatus	80.79	2.00e-77	281.00
IUUC-Laf-054283	Loxodonta africana	96.57	1.00e-108	385.00
IUUC-Mcc-055073	Macaca mulatta	97.40	8.00e-112	395.00
IUUC-Meu-056650	Macropus eugenii	93.07	5.00e-105	373.00
IUUC-Mga-059703	Meleagris gallopavo	93.56	3.00e-100	357.00
IUUC-Mdo-062114	Monodelphis domestica	94.06	7.00e-107	379.00
IUUC-Mmu-064230	Mus musculus	96.53	1.00e-109	388.00
IUUC-Mpu-065845	Mustela putorius furo	97.52	3.00e-110	390.00
IUUC-Mlu-067564	Myotis lucifugus	94.06	3.00e-99	353.00
IUUC-Nfi-068472	Neosartorya fischeri	30.00	2.00e-01	29.30
IUUC-Nle-069516	Nomascus leucogenys	97.03	4.00e-110	389.00
IUUC-Opr-070945	Ochotona princeps	79.21	2.00e-84	304.00
IUUC-Ont-071439	Oreochromis niloticus	70.05	2.00e-78	285.00
IUUC-Oan-073122	Ornithorhynchus anatinus	90.21	2.00e-68	250.00
IUUC-Ocu-074128	Oryctolagus cuniculus	84.30	8.00e-55	204.00
IUUC-Ola-086972	Oryzias latipes	67.46	1.00e-70	258.00
IUUC-Oga-088786	Otolemur garnettii	96.53	1.00e-116	411.00
IUUC-Oar-089212	Ovis aries	99.51	1.00e-111	395.00
IUUC-Ptr-090936	Pan troglodytes	97.52	9.00e-111	392.00
IUUC-Pan-092234	Papio anubis	97.52	9.00e-111	392.00
IUUC-Psi-093448	Pelodiscus sinensis	92.57	6.00e-104	369.00
IUUC-Pfo-096711	Poecilia formosa	81.25	8.00e-79	286.00
IUUC-Pab-097628	Pongo abelii	97.03	7.00e-109	385.00
IUUC-Pop-099793	Populus trichocarpa	35.64	2.00e-22	99.00
IUUC-Pca-100555	Procavia capensis	95.54	1.00e-85	308.00
IUUC-Pva-102259	Pteropus vampyrus	98.02	5.00e-111	392.00
IUUC-Rno-105045	Rattus norvegicus	96.53	1.00e-109	388.00
IUUC-Sha-107606	Sarcophilus harrisii	94.55	2.00e-107	381.00
IUUC-Ssc-115663	Sus scrofa	99.01	4.00e-112	396.00
IUUC-Tgu-117374	Taeniopygia guttata	92.08	1.00e-102	365.00
IUUC-Tru-118030	Takifugu rubripes	80.11	3.00e-77	281.00
IUUC-Tsy-119298	Tarsius syrichta	96.53	4.00e-109	386.00
IUUC-Tni-119797	Tetraodon nigroviridis	79.55	6.00e-77	279.00
IUUC-Tbe-127896	Tupaia belangeri	98.02	3.00e-111	393.00
IUUC-Ttr-128523	Tursiops truncatus	97.52	5.00e-110	389.00
IUUC-Vpa-130184	Vicugna pacos	94.55	2.00e-112	397.00
IUUC-Xtr-131903	Xenopus tropicalis	84.16	2.00e-93	334.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence