iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aca-004377

UUCD1 version

UUC-AnC-00813

Ensembl Protein ID

ENSACAP00000015099.2

UniProt Accession

G1KR08; G1KR08_ANOCA

Protein Name

Uncharacterized protein

Gene Name

HECTD3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSACAG00000015321.3	ENSACAT00000015403.3	ENSACAP00000015099.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.20e-75	253.5	523	848

Active Site

Position(s)	Description	Evidence
818	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 9    levefvgEegldlgGvtreflallskelqnpd......lglflysendketlqpnpdsglknp..ehlklFeflGrllgkalqdgrlld 89
           +e++f  E  +d+gG +r+ +a +s+el+ ++      l++f++++n+ + +  ++d+++ np  +++  +e++G+++g al+ +++l 
   Q: 523  WECKFIAEGIIDQGGGFRDSIADMSEELCPSSaetpvpLPFFVRTSNQGSGTGEARDMYVPNPscKEFTKYEWIGQIMGAALRGKEFLV 611
           45*****************************9999*999*********************999999999******************** PP
   S: 90   lplsksfyklllgkklsl.edleevdpelykslkeikenaesdieelgldltfs...vseeilgetkeeeLkpgGenipVtneNkeeYv 174
           l l+ +++k+l g+++s+ +d++++d+ l+k l+ ++ +     ++++++++f    + +++l++++ +eL+p+G ++ V +e++ +++
   Q: 612  LALPGFVWKQLTGEEVSWsKDFPAIDSMLVKLLEMMEVM-----DKETFEFKFGnelTYTTVLSDQRMVELIPSGTRTVVHYEDRMDFI 695
           *************************************76.....45556666663344556699************************* PP
   S: 175  klvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerka 263
           +lv ++rl+e  keq++a+++G+ +v+p+ +l+l+t++ele  +cG++e++ve+lkk t++++ +++ +  iq+Fwe+l++f++e+r++
   Q: 696  RLVQKARLNE-SKEQIAAMQAGLLKVVPQAVLDLLTWQELEKKVCGDPEVTVEALKKLTRFED-FEPPDTRIQYFWEALNNFTNEDRSR 782
           **********.9*************************************************76.************************* PP
   S: 264  fLqFvTgssrlPlgGfaelkprlfvirk...dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           fL+FvTg+srlP+        r++++++   ++++d lP+s+TC ++L LP+Y s ++++ekL+yA  ++ +++
   Q: 783  FLRFVTGRSRLPA--------RIYIYPDklgSETTDALPESSTCSSTLFLPNYASAKVCEEKLRYAAYNCVAID 848
           ************5........66777777989999*********************************998776 PP

Organism

Anolis carolinensis

Protein Sequence
(Fasta)

MLAAPGGESP HQLLGRLRFL SEAVECLRRA EPLPAALCFV PREVQYKLCK DASGPGLSAA 60
LSRSLLSVWE SPGGGKNGGK AGGKAGKARG AVELRKGSCL RASGEEHCNG QGLWVKLTRE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTGTTATCA GCTTTAGGCA CTTCTGCGGG TCTGCCGCGC GGATAGAGGG TGCTTTACGG 60
TAGCCTTCGA AGCTTGCGGG CCGGCGCTTC GATGAGGAAG CCCCGCGCCT TCCGCCCTGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR004939--APC_su10/DOC_dom
IPR008979--Galactose-bd-like
IPR000569--HECT_dom

PROSITE

PS51284--DOC
PS50237--HECT

Pfam

PF03256--ANAPC10
PF00632--HECT

SMART

SM01337--APC10
SM00119--HECTc

Gene Ontology

GO:0048471--C:perinuclear region of cytoplasm
GO:0004842--F:ubiquitin-protein transferase activity
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001229	Ailuropoda melanoleuca	78.78	0.00e+00	1391.00
IUUC-Apl-003715	Anas platyrhynchos	91.61	0.00e+00	1404.00
IUUC-Ame-011918	Astyanax mexicanus	67.63	0.00e+00	1177.00
IUUC-Bta-012736	Bos taurus	79.12	0.00e+00	1400.00
IUUC-Cja-019926	Callithrix jacchus	79.12	0.00e+00	1396.00
IUUC-Cfa-020753	Canis familiaris	87.18	0.00e+00	1065.00
IUUC-Cpo-021415	Cavia porcellus	78.78	0.00e+00	1389.00
IUUC-Csa-023096	Chlorocebus sabaeus	78.78	0.00e+00	1392.00
IUUC-Dre-028746	Danio rerio	72.88	0.00e+00	1255.00
IUUC-Dno-029293	Dasypus novemcinctus	86.63	0.00e+00	975.00
IUUC-Dor-031113	Dipodomys ordii	87.34	0.00e+00	1129.00
IUUC-Ete-032601	Echinops telfairi	76.50	0.00e+00	1202.00
IUUC-Eca-034198	Equus caballus	78.03	0.00e+00	1380.00
IUUC-Eeu-034708	Erinaceus europaeus	87.05	0.00e+00	825.00
IUUC-Fca-035478	Felis catus	79.83	0.00e+00	1382.00
IUUC-Fal-037366	Ficedula albicollis	84.53	0.00e+00	1460.00
IUUC-Gmo-039020	Gadus morhua	77.71	0.00e+00	1064.00
IUUC-Gga-040332	Gallus gallus	87.68	0.00e+00	1516.00
IUUC-Gac-042336	Gasterosteus aculeatus	72.65	0.00e+00	1302.00
IUUC-Ggo-045382	Gorilla gorilla	78.89	0.00e+00	1393.00
IUUC-Hsa-046562	Homo sapiens	78.89	0.00e+00	1393.00
IUUC-Itr-048208	Ictidomys tridecemlineatus	79.01	0.00e+00	1395.00
IUUC-Lch-049606	Latimeria chalumnae	70.36	0.00e+00	885.00
IUUC-Loc-052448	Lepisosteus oculatus	65.59	0.00e+00	1130.00
IUUC-Laf-054507	Loxodonta africana	78.47	0.00e+00	1401.00
IUUC-Mcc-055690	Macaca mulatta	78.66	0.00e+00	1390.00
IUUC-Meu-055970	Macropus eugenii	79.19	0.00e+00	1367.00
IUUC-Mga-059654	Meleagris gallopavo	91.91	0.00e+00	1386.00
IUUC-Mmr-061069	Microcebus murinus	78.66	0.00e+00	1392.00
IUUC-Mdo-062547	Monodelphis domestica	88.42	0.00e+00	768.00
IUUC-Mmu-063096	Mus musculus	79.01	0.00e+00	1395.00
IUUC-Mpu-065846	Mustela putorius furo	79.01	0.00e+00	1397.00
IUUC-Mlu-067992	Myotis lucifugus	83.03	0.00e+00	1350.00
IUUC-Nle-069565	Nomascus leucogenys	77.82	0.00e+00	1291.00
IUUC-Opr-070853	Ochotona princeps	73.72	0.00e+00	910.00
IUUC-Ont-071628	Oreochromis niloticus	72.85	0.00e+00	1273.00
IUUC-Ocu-074094	Oryctolagus cuniculus	79.01	0.00e+00	1396.00
IUUC-Ola-087384	Oryzias latipes	72.97	0.00e+00	1312.00
IUUC-Oga-088224	Otolemur garnettii	78.87	0.00e+00	1398.00
IUUC-Oar-090043	Ovis aries	76.63	0.00e+00	1329.00
IUUC-Ptr-090852	Pan troglodytes	78.78	0.00e+00	1385.00
IUUC-Pan-092787	Papio anubis	78.66	0.00e+00	1391.00
IUUC-Psi-092986	Pelodiscus sinensis	75.33	0.00e+00	1014.00
IUUC-Pma-094416	Petromyzon marinus	40.68	0.00e+00	629.00
IUUC-Pfo-096720	Poecilia formosa	72.82	0.00e+00	1311.00
IUUC-Pab-098325	Pongo abelii	75.81	0.00e+00	1044.00
IUUC-Pca-100885	Procavia capensis	71.55	0.00e+00	1052.00
IUUC-Pva-102829	Pteropus vampyrus	66.09	0.00e+00	1108.00
IUUC-Rno-104882	Rattus norvegicus	79.35	0.00e+00	1402.00
IUUC-Sha-106811	Sarcophilus harrisii	83.02	3.00e-108	385.00
IUUC-Sar-113020	Sorex araneus	74.58	0.00e+00	648.00
IUUC-Ssc-115436	Sus scrofa	82.59	4.00e-135	474.00
IUUC-Tgu-117042	Taeniopygia guttata	86.94	0.00e+00	1511.00
IUUC-Tru-118419	Takifugu rubripes	71.14	0.00e+00	1228.00
IUUC-Tsy-118829	Tarsius syrichta	78.96	0.00e+00	828.00
IUUC-Tni-120410	Tetraodon nigroviridis	60.05	0.00e+00	987.00
IUUC-Tbe-128113	Tupaia belangeri	86.42	0.00e+00	703.00
IUUC-Ttr-128167	Tursiops truncatus	74.74	0.00e+00	1296.00
IUUC-Xtr-132910	Xenopus tropicalis	68.98	0.00e+00	1135.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence