iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Laf-054142

UUCD1 version

UUC-LoA-00673

Ensembl Protein ID

ENSLAFP00000028452.1

UniProt Accession

G3UKU3; G3UKU3_LOXAF

Protein Name

Uncharacterized protein

Gene Name

UBR2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000014978.3	ENSLAFT00000035846.1	ENSLAFP00000028452.1
ENSLAFG00000014978.3	ENSLAFT00000014990.3	ENSLAFP00000012550.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/N-recognin/N-domain	3.90e-39	133.0	227	302
E3 activity/RING/RING	2.10e-09	38.1	1110	1215
E3 activity/N-recognin/UBR-box	1.30e-31	109.2	97	167

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/N-recognin/N-domain

   S: 1    YylvLfNDEkHsyeqviyslqkAleleqkeakkfatiidkeGRravkaGdyavceeakkeilknseklaqipLkVev 77
           Yy++LfNDE+H+yeqviy+lqkA++++qkea++fat++d++GRr+v++Gd+++ce+ak++i++ ++++++ pLkV+v
   Q: 227  YYCMLFNDEVHTYEQVIYTLQKAVNCTQKEAIGFATTVDRDGRRSVRYGDFQYCEQAKSVIVRSTSRQTK-PLKVQV 302
           9*********************************************************************.****98 PP

E3 activity/RING/RING

   S: 1    CaiC......................................ledf......kdgplvlpCgHvfhadClqkw.............. 29
           C++C                                      ++++      ++g+++++CgH++ha+C+q++              
   Q: 1110 CILCqeeqevkvesramvlaafiqrstvlsknrskfiqdpekYDPLfthpdlSCGTHTGSCGHIMHAHCWQRYfdsvqakeqrrqqr 1196
           888844444444444444444444444444443333333333222244444455899****************************** PP
   S: 30   ...pglknssskefrCPlC 45
              + +++++++ef+CPlC
   Q: 1197 lrlHTSYDVENGEFLCPLC 1215
           ******************* PP

E3 activity/N-recognin/UBR-box

   S: 1    slCgrvfkvgetiyeCrtCsvdetlvlCteCfakvvHkdHeyklkksggggfCdCGdteAwedgskCkkll 71
           +lCgrvfkvge +y+Cr+C+vd+t+vlC+eCf  +vH+dH+y++++sggggfCdCGdteAw++g++C+k++
   Q: 97   HLCGRVFKVGEPTYSCRDCAVDPTCVLCMECFLGSVHRDHRYRMTTSGGGGFCDCGDTEAWKEGPYCQKHE 167
           68******************************************************************996 PP

Organism

Loxodonta africana

Protein Sequence
(Fasta)

MASELEPEVQ AIDRSLLECS AEETAGKWLQ ATDLTREVYQ HLAHYVPKIY CRGPNPFPQK 60
EDMLAQHILL GPMEWYLCGE DPGFGFSKLE QANKPSHLCG RVFKVGEPTY SCRDCAVDPT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCGTCGG AGCTGGAGCC CGAGGTGCAG GCCATCGACC GGAGTTTGCT GGAATGTTCG 60
GCCGAGGAAA CCGCGGGGGT GAGTGCCGGA CCCGGGCGGG GACGTCCAGC CCTCGCTGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR003769--ClpS_core
IPR014719--Ribosomal_L7/12_C/ClpS-like
IPR011991--WHTH_DNA-bd_dom
IPR013083--Znf_RING/FYVE/PHD
IPR003126--Znf_UBR

PROSITE

PS51157--ZF_UBR

Pfam

PF02617--ClpS
PF02207--zf-UBR

SMART

SM00396--ZnF_UBR1

Gene Ontology

GO:0000785--C:chromatin
GO:0000151--C:ubiquitin ligase complex
GO:0070728--F:leucine binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0071233--P:cellular response to leucine
GO:0006342--P:chromatin silencing
GO:0033522--P:histone H2A ubiquitination
GO:0007141--P:male meiosis I
GO:0032007--P:negative regulation of TOR signaling
GO:0007283--P:spermatogenesis
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000949	Aegilops tauschii	27.35	3.00e-20	95.10
IUUC-Aml-001876	Ailuropoda melanoleuca	83.14	0.00e+00	2678.00
IUUC-Atr-002501	Amborella trichopoda	29.17	9.00e-26	113.00
IUUC-Apl-003828	Anas platyrhynchos	86.89	0.00e+00	3037.00
IUUC-Aca-005189	Anolis carolinensis	84.36	0.00e+00	2984.00
IUUC-Aly-005901	Arabidopsis lyrata	32.24	2.00e-24	108.00
IUUC-Ath-007148	Arabidopsis thaliana	32.56	6.00e-24	107.00
IUUC-Ago-007946	Ashbya gossypii	22.42	1.00e-25	113.00
IUUC-Afl-008479	Aspergillus flavus	22.87	4.00e-44	174.00
IUUC-Afu-008929	Aspergillus fumigatus	24.15	2.00e-50	195.00
IUUC-Ang-009550	Aspergillus niger	24.42	4.00e-45	177.00
IUUC-Aor-010124	Aspergillus oryzae	22.69	4.00e-44	174.00
IUUC-Ame-011917	Astyanax mexicanus	72.99	0.00e+00	2453.00
IUUC-Bta-012768	Bos taurus	91.87	0.00e+00	3216.00
IUUC-Bdi-014635	Brachypodium distachyon	26.36	2.00e-28	122.00
IUUC-Bol-015669	Brassica oleracea	32.16	1.00e-30	130.00
IUUC-Bra-017776	Brassica rapa	32.51	1.00e-31	133.00
IUUC-Cel-018476	Caenorhabditis elegans	31.81	4.00e-82	300.00
IUUC-Cja-019797	Callithrix jacchus	92.37	0.00e+00	2526.00
IUUC-Cfa-020950	Canis familiaris	93.57	0.00e+00	3269.00
IUUC-Cpo-022385	Cavia porcellus	91.41	0.00e+00	3224.00
IUUC-Csa-024082	Chlorocebus sabaeus	93.40	0.00e+00	3261.00
IUUC-Cho-025029	Choloepus hoffmanni	84.94	0.00e+00	2130.00
IUUC-Cin-025148	Ciona intestinalis	35.94	1.00e-136	480.00
IUUC-Csv-026296	Ciona savignyi	31.11	8.00e-21	94.70
IUUC-Cne-026823	Cryptococcus neoformans	21.26	9.00e-36	146.00
IUUC-Dre-028343	Danio rerio	72.79	0.00e+00	2476.00
IUUC-Dno-030002	Dasypus novemcinctus	91.38	0.00e+00	1949.00
IUUC-Dor-030207	Dipodomys ordii	77.92	0.00e+00	1550.00
IUUC-Dse-031531	Dothistroma septosporum	24.42	2.00e-51	199.00
IUUC-Dme-031910	Drosophila melanogaster	33.13	0.00e+00	807.00
IUUC-Ete-033162	Echinops telfairi	83.93	0.00e+00	1363.00
IUUC-Eca-033454	Equus caballus	92.15	0.00e+00	3212.00
IUUC-Eeu-034783	Erinaceus europaeus	75.28	0.00e+00	1466.00
IUUC-Fca-036588	Felis catus	93.01	0.00e+00	3233.00
IUUC-Fal-036919	Ficedula albicollis	86.18	0.00e+00	2946.00
IUUC-Fso-038463	Fusarium solani	24.00	2.00e-40	162.00
IUUC-Gmo-039698	Gadus morhua	69.55	0.00e+00	1607.00
IUUC-Ggr-040070	Gaeumannomyces graminis	23.07	3.00e-41	165.00
IUUC-Gga-041123	Gallus gallus	88.17	0.00e+00	3090.00
IUUC-Gac-042622	Gasterosteus aculeatus	65.62	0.00e+00	2179.00
IUUC-Gma-043622	Glycine max	31.23	2.00e-25	112.00
IUUC-Ggo-045583	Gorilla gorilla	92.02	0.00e+00	3231.00
IUUC-Hsa-046343	Homo sapiens	94.19	0.00e+00	3286.00
IUUC-Hvu-047626	Hordeum vulgare	29.82	9.00e-27	116.00
IUUC-Kpa-049088	Komagataella pastoris	22.90	3.00e-43	171.00
IUUC-Lch-049649	Latimeria chalumnae	74.90	0.00e+00	2583.00
IUUC-Lpe-051516	Leersia perrieri	26.32	7.00e-29	124.00
IUUC-Loc-052818	Lepisosteus oculatus	74.89	0.00e+00	2613.00
IUUC-Lma-053059	Leptosphaeria maculans	22.88	4.00e-44	174.00
IUUC-Mcc-055677	Macaca mulatta	93.28	0.00e+00	3244.00
IUUC-Meu-056204	Macropus eugenii	65.93	0.00e+00	702.00
IUUC-Mor-057051	Magnaporthe oryzae	22.65	5.00e-45	177.00
IUUC-Mpo-057372	Magnaporthe poae	24.65	3.00e-43	171.00
IUUC-Mtr-058538	Medicago truncatula	31.23	7.00e-28	120.00
IUUC-Mla-058963	Melampsora laricipopulina	24.52	6.00e-54	207.00
IUUC-Mga-059698	Meleagris gallopavo	88.39	0.00e+00	3063.00
IUUC-Mvi-060535	Microbotryum violaceum	24.26	3.00e-47	184.00
IUUC-Mmr-060901	Microcebus murinus	90.32	0.00e+00	3142.00
IUUC-Mdo-062014	Monodelphis domestica	89.70	0.00e+00	3161.00
IUUC-Mmu-063699	Mus musculus	89.13	0.00e+00	3122.00
IUUC-Mac-064773	Musa acuminata	31.23	4.00e-26	114.00
IUUC-Mpu-066153	Mustela putorius furo	93.28	0.00e+00	3260.00
IUUC-Mlu-068151	Myotis lucifugus	91.70	0.00e+00	3183.00
IUUC-Nfi-068403	Neosartorya fischeri	23.86	3.00e-50	194.00
IUUC-Ncr-068864	Neurospora crassa	23.27	3.00e-39	158.00
IUUC-Nle-069529	Nomascus leucogenys	93.40	0.00e+00	3264.00
IUUC-Opr-071107	Ochotona princeps	85.96	0.00e+00	1317.00
IUUC-Ont-072189	Oreochromis niloticus	65.97	0.00e+00	2132.00
IUUC-Oan-072893	Ornithorhynchus anatinus	89.13	0.00e+00	3125.00
IUUC-Ocu-074082	Oryctolagus cuniculus	91.41	0.00e+00	3197.00
IUUC-Obr-076117	Oryza brachyantha	26.23	5.00e-25	111.00
IUUC-Ogl-077571	Oryza glaberrima	28.30	1.00e-21	99.80
IUUC-Olo-081056	Oryza longistaminata	27.87	9.00e-16	80.50
IUUC-Opu-083202	Oryza punctata	26.82	1.00e-29	126.00
IUUC-Osa-085336	Oryza sativa	27.39	3.00e-22	100.00
IUUC-Ola-087460	Oryzias latipes	63.75	0.00e+00	2106.00
IUUC-Olu-087832	Ostreococcus lucimarinus	27.87	1.20e-02	35.40
IUUC-Oga-088432	Otolemur garnettii	92.55	0.00e+00	3257.00
IUUC-Oar-090206	Ovis aries	90.20	0.00e+00	3184.00
IUUC-Ptr-091180	Pan troglodytes	92.26	0.00e+00	3226.00
IUUC-Pan-092375	Papio anubis	93.28	0.00e+00	3257.00
IUUC-Psi-093049	Pelodiscus sinensis	87.83	0.00e+00	3046.00
IUUC-Pma-094152	Petromyzon marinus	48.36	0.00e+00	655.00
IUUC-Ppa-095715	Physcomitrella patens	28.90	5.00e-22	101.00
IUUC-Pfo-096524	Poecilia formosa	64.00	0.00e+00	2041.00
IUUC-Pab-097989	Pongo abelii	91.63	0.00e+00	3176.00
IUUC-Pca-100207	Procavia capensis	82.59	0.00e+00	1304.00
IUUC-Ppe-101802	Prunus persica	30.94	1.00e-25	112.00
IUUC-Pva-102538	Pteropus vampyrus	91.27	0.00e+00	1191.00
IUUC-Pgr-103372	Puccinia graminis	24.44	4.00e-50	194.00
IUUC-Ptt-103878	Puccinia triticina	23.97	2.00e-46	182.00
IUUC-Rno-105567	Rattus norvegicus	87.71	0.00e+00	3018.00
IUUC-Sce-106272	Saccharomyces cerevisiae	21.58	6.00e-29	124.00
IUUC-Sha-106980	Sarcophilus harrisii	89.09	0.00e+00	3013.00
IUUC-Sja-107980	Schizosaccharomyces japonicus	23.75	6.00e-45	177.00
IUUC-Spo-108183	Schizosaccharomyces pombe	24.75	1.00e-48	189.00
IUUC-Smo-108719	Selaginella moellendorffii	32.03	1.00e-27	119.00
IUUC-Sit-110716	Setaria italica	28.69	2.00e-29	125.00
IUUC-Sly-111286	Solanum lycopersicum	31.80	6.00e-25	110.00
IUUC-Sar-113332	Sorex araneus	84.61	0.00e+00	2123.00
IUUC-Sbi-114577	Sorghum bicolor	28.57	1.00e-29	126.00
IUUC-Sre-115045	Sporisorium reilianum	26.33	3.00e-43	171.00
IUUC-Ssc-115525	Sus scrofa	92.11	0.00e+00	2496.00
IUUC-Tgu-116943	Taeniopygia guttata	88.00	0.00e+00	3082.00
IUUC-Tru-117673	Takifugu rubripes	64.74	0.00e+00	2146.00
IUUC-Tsy-119032	Tarsius syrichta	89.11	0.00e+00	1764.00
IUUC-Tni-119987	Tetraodon nigroviridis	65.13	0.00e+00	2124.00
IUUC-Tca-121077	Theobroma cacao	35.21	1.00e-25	113.00
IUUC-Tre-122137	Trichoderma reesei	24.83	1.00e-57	219.00
IUUC-Tvi-122272	Trichoderma virens	23.48	4.00e-52	201.00
IUUC-Tae-125501	Triticum aestivum	29.05	1.00e-27	119.00
IUUC-Tur-126562	Triticum urartu	30.82	7.00e-27	116.00
IUUC-Tme-127156	Tuber melanosporum	23.88	1.00e-48	189.00
IUUC-Tbe-128103	Tupaia belangeri	84.49	0.00e+00	1206.00
IUUC-Ttr-128253	Tursiops truncatus	86.45	0.00e+00	2976.00
IUUC-Vda-129778	Verticillium dahliae	23.92	2.00e-42	168.00
IUUC-Vpa-130540	Vicugna pacos	88.01	0.00e+00	2882.00
IUUC-Vvi-131290	Vitis vinifera	33.18	4.00e-26	114.00
IUUC-Xtr-132690	Xenopus tropicalis	80.73	0.00e+00	2841.00
IUUC-Xma-133748	Xiphophorus maculatus	64.23	0.00e+00	1987.00
IUUC-Zma-135553	Zea mays	30.69	1.00e-15	80.10

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence