iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Bta-013268

Ensembl Protein ID

ENSBTAP00000012486.5

UniProt Accession

Q1RMS5; NXF1_BOVIN

Genbank Protein ID

AAI14740.1

Protein Name

Nuclear RNA export factor 1

Genbank Nucleotide ID

BC114739

Gene Name

NXF1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000009488.5	ENSBTAT00000012486.5	ENSBTAP00000012486.5

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/Alpha-Helix/UBA	23.94	1.00e-10	63.20	IUUC-Sce-106429

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Bos taurus

Functional Description
(View)

Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm (TAP/NFX1 pathway). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 components of the TREX complex. ALYREF/THOC4-bound mRNA is thought to be transferred to the NXF1-NXT1 heterodimer for export.

Protein Sequence
(Fasta)

MADEGKSYNE HDDRVSFPQR RKKGRGPFRW KSGEGNRRSG RGGSSVRSSR LEDDDRDVAM 60
SDVQDAPRVR YTPYAARPNR RGDNWNERTR IHVTLPLRRD RSAAERGGAG TSQDGTSKNW 120

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Nucleotide Sequence
(Fasta)

CTTGGTATTC GGACGTTTGG CTAAGTAGCG GCCCGCGACG CAGCCCGCCC CTGCTTCTAG 60
CTGTGCCATG GCGGACGAGG GGAAGTCATA CAACGGTCAG TGCTGGTCCT TGAGCCGGGG 120

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Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0433--Leucine-rich repeat
KW-0488--Methylation
KW-0509--mRNA transport
KW-0944--Nitration
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0694--RNA-binding
KW-0813--Transport

Interpro

IPR032675--L_dom-like
IPR001611--Leu-rich_rpt
IPR002075--NTF2
IPR032710--NTF2-like_dom
IPR018222--Nuclear_transport_factor_2_euk
IPR012677--Nucleotide-bd_a/b_plait
IPR030217--NXF_fam
IPR000504--RRM_dom
IPR005637--TAP_C_dom
IPR015245--Tap_RNA-bd
IPR009060--UBA-like

PROSITE

PS51450--LRR
PS50177--NTF2_DOMAIN
PS51281--TAP_C

Pfam

PF02136--NTF2
PF09162--Tap-RNA_bind
PF03943--TAP_C

SMART

SM00804--TAP_C

Gene Ontology

GO:0005737--C:cytoplasm
GO:0042405--C:nuclear inclusion body
GO:0005643--C:nuclear pore
GO:0016607--C:nuclear speck
GO:0005634--C:nucleus
GO:0000346--C:transcription export complex
GO:0003729--F:mRNA binding
GO:0005487--F:nucleocytoplasmic transporter activity
GO:0000166--F:nucleotide binding
GO:0003727--F:single-stranded RNA binding
GO:0016973--P:poly(A)+ mRNA export from nucleus

KEGG

bta:512136

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001516	Ailuropoda melanoleuca	93.02	0.00e+00	1088.00
IUUC-Apl-003526	Anas platyrhynchos	34.09	8.00e-03	33.90
IUUC-Aca-005187	Anolis carolinensis	63.91	0.00e+00	735.00
IUUC-Ago-007780	Ashbya gossypii	23.19	7.00e-19	89.00
IUUC-Acl-008191	Aspergillus clavatus	24.78	5.00e-23	102.00
IUUC-Afl-008512	Aspergillus flavus	26.34	2.00e-27	117.00
IUUC-Afu-009048	Aspergillus fumigatus	26.18	1.00e-25	111.00
IUUC-Ani-009320	Aspergillus nidulans	23.01	4.00e-18	86.70
IUUC-Ang-009834	Aspergillus niger	24.33	3.00e-21	96.30
IUUC-Aor-010039	Aspergillus oryzae	25.88	1.00e-23	104.00
IUUC-Ate-010321	Aspergillus terreus	25.21	2.00e-21	97.40
IUUC-Ame-011034	Astyanax mexicanus	57.83	0.00e+00	636.00
IUUC-Bgr-012142	Blumeria graminis	26.08	7.00e-17	82.40
IUUC-Bci-013951	Botrytis cinerea	26.74	5.00e-21	96.30
IUUC-Cel-018213	Caenorhabditis elegans	33.33	3.10e-01	28.50
IUUC-Cja-019064	Callithrix jacchus	92.27	0.00e+00	1065.00
IUUC-Cfa-020712	Canis familiaris	93.28	0.00e+00	1052.00
IUUC-Cpo-021814	Cavia porcellus	92.58	0.00e+00	1066.00
IUUC-Csa-023652	Chlorocebus sabaeus	92.59	0.00e+00	1076.00
IUUC-Cho-024546	Choloepus hoffmanni	48.48	9.90e-02	30.40
IUUC-Cin-025669	Ciona intestinalis	34.81	4.00e-91	328.00
IUUC-Csv-025957	Ciona savignyi	35.77	2.00e-82	299.00
IUUC-Cgl-026395	Colletotrichum gloeosporioides	27.21	2.00e-26	114.00
IUUC-Cne-026967	Cryptococcus neoformans	21.54	4.00e-07	49.70
IUUC-Dre-028476	Danio rerio	54.43	1.00e-147	516.00
IUUC-Dno-029301	Dasypus novemcinctus	90.97	0.00e+00	1034.00
IUUC-Dor-030764	Dipodomys ordii	92.27	0.00e+00	1058.00
IUUC-Dse-031489	Dothistroma septosporum	24.55	1.00e-16	81.30
IUUC-Dme-031623	Drosophila melanogaster	31.67	3.00e-75	276.00
IUUC-Ete-032992	Echinops telfairi	77.26	0.00e+00	770.00
IUUC-Eca-033208	Equus caballus	94.30	0.00e+00	1005.00
IUUC-Eeu-034759	Erinaceus europaeus	91.13	0.00e+00	1038.00
IUUC-Fca-035671	Felis catus	95.00	0.00e+00	1101.00
IUUC-Fal-036625	Ficedula albicollis	35.06	1.10e-02	33.50
IUUC-Fox-037892	Fusarium oxysporum	28.50	2.00e-20	94.40
IUUC-Fso-038402	Fusarium solani	27.18	3.00e-20	93.60
IUUC-Gmo-039325	Gadus morhua	55.16	3.00e-147	515.00
IUUC-Ggr-039736	Gaeumannomyces graminis	23.78	3.00e-11	63.50
IUUC-Gga-040508	Gallus gallus	71.70	0.00e+00	764.00
IUUC-Gac-041798	Gasterosteus aculeatus	57.59	0.00e+00	690.00
IUUC-Ggo-044655	Gorilla gorilla	92.62	0.00e+00	1043.00
IUUC-Hsa-047028	Homo sapiens	92.75	0.00e+00	1077.00
IUUC-Itr-048415	Ictidomys tridecemlineatus	88.89	0.00e+00	1023.00
IUUC-Kpa-049280	Komagataella pastoris	23.51	9.00e-22	98.60
IUUC-Lch-049501	Latimeria chalumnae	70.38	0.00e+00	836.00
IUUC-Loc-052299	Lepisosteus oculatus	64.14	7.00e-169	586.00
IUUC-Laf-053523	Loxodonta africana	90.81	0.00e+00	1030.00
IUUC-Mcc-055389	Macaca mulatta	93.58	0.00e+00	1007.00
IUUC-Meu-056620	Macropus eugenii	58.35	3.00e-136	478.00
IUUC-Mor-057232	Magnaporthe oryzae	27.19	8.00e-26	112.00
IUUC-Mpo-057539	Magnaporthe poae	25.07	1.00e-09	58.20
IUUC-Mla-059053	Melampsora laricipopulina	26.30	8.00e-26	112.00
IUUC-Mga-059220	Meleagris gallopavo	34.09	8.00e-03	33.90
IUUC-Mvi-060283	Microbotryum violaceum	25.25	5.00e-21	96.30
IUUC-Mmr-061583	Microcebus murinus	93.39	0.00e+00	1082.00
IUUC-Mdo-062158	Monodelphis domestica	80.88	0.00e+00	927.00
IUUC-Mmu-064202	Mus musculus	88.06	0.00e+00	979.00
IUUC-Mpu-065730	Mustela putorius furo	93.71	0.00e+00	1085.00
IUUC-Mlu-066975	Myotis lucifugus	92.28	0.00e+00	1021.00
IUUC-Nfi-068368	Neosartorya fischeri	26.39	3.00e-25	110.00
IUUC-Ncr-068724	Neurospora crassa	25.75	3.00e-15	77.00
IUUC-Nle-069816	Nomascus leucogenys	92.43	0.00e+00	1068.00
IUUC-Opr-070244	Ochotona princeps	43.35	2.00e-123	436.00
IUUC-Ont-072608	Oreochromis niloticus	58.25	0.00e+00	712.00
IUUC-Oan-073580	Ornithorhynchus anatinus	33.33	3.00e-03	35.40
IUUC-Ocu-074226	Oryctolagus cuniculus	91.63	0.00e+00	1091.00
IUUC-Ola-087008	Oryzias latipes	64.02	0.00e+00	668.00
IUUC-Oga-088317	Otolemur garnettii	89.09	0.00e+00	982.00
IUUC-Oar-089720	Ovis aries	99.52	0.00e+00	1104.00
IUUC-Ptr-091148	Pan troglodytes	92.75	0.00e+00	1077.00
IUUC-Pan-091764	Papio anubis	92.59	0.00e+00	1074.00
IUUC-Psi-094071	Pelodiscus sinensis	65.41	0.00e+00	768.00
IUUC-Pno-095045	Phaeosphaeria nodorum	28.57	1.00e-03	37.40
IUUC-Pfo-096500	Poecilia formosa	59.52	0.00e+00	719.00
IUUC-Pab-098014	Pongo abelii	90.98	0.00e+00	1045.00
IUUC-Pca-100121	Procavia capensis	89.68	0.00e+00	990.00
IUUC-Pva-102865	Pteropus vampyrus	93.55	0.00e+00	1036.00
IUUC-Pgr-103333	Puccinia graminis	24.81	1.00e-17	84.70
IUUC-Ptt-103702	Puccinia triticina	24.78	2.00e-20	94.00
IUUC-Pte-104388	Pyrenophora teres	21.47	6.10e-02	31.60
IUUC-Rno-106100	Rattus norvegicus	89.03	0.00e+00	1018.00
IUUC-Sce-106429	Saccharomyces cerevisiae	22.24	4.00e-15	76.30
IUUC-Sha-106834	Sarcophilus harrisii	80.67	0.00e+00	944.00
IUUC-Sja-107818	Schizosaccharomyces japonicus	26.52	2.00e-20	94.00
IUUC-Spo-108301	Schizosaccharomyces pombe	27.03	4.00e-34	139.00
IUUC-Ssl-108512	Sclerotinia sclerotiorum	25.44	5.00e-21	96.30
IUUC-Sar-112963	Sorex araneus	44.43	4.00e-126	444.00
IUUC-Sre-114950	Sporisorium reilianum	23.77	6.00e-21	95.90
IUUC-Ssc-116010	Sus scrofa	95.00	0.00e+00	1050.00
IUUC-Tgu-116603	Taeniopygia guttata	35.23	5.00e-03	35.00
IUUC-Tru-118148	Takifugu rubripes	58.43	0.00e+00	687.00
IUUC-Tsy-119506	Tarsius syrichta	36.46	6.00e-05	40.80
IUUC-Tni-120552	Tetraodon nigroviridis	32.43	6.00e-04	37.70
IUUC-Tre-121894	Trichoderma reesei	26.87	4.00e-27	116.00
IUUC-Tvi-122501	Trichoderma virens	28.23	4.00e-30	126.00
IUUC-Tme-127084	Tuber melanosporum	25.40	1.00e-25	111.00
IUUC-Tbe-127980	Tupaia belangeri	63.04	1.00e-89	322.00
IUUC-Ttr-128656	Tursiops truncatus	56.72	0.00e+00	653.00
IUUC-Uma-129530	Ustilago maydis	24.71	7.00e-27	115.00
IUUC-Vda-129709	Verticillium dahliae	26.16	2.00e-20	94.00
IUUC-Vpa-130739	Vicugna pacos	44.93	2.00e-97	348.00
IUUC-Xtr-132404	Xenopus tropicalis	60.45	0.00e+00	724.00
IUUC-Xma-133051	Xiphophorus maculatus	58.52	0.00e+00	694.00
IUUC-Yli-134681	Yarrowia lipolytica	25.35	4.00e-30	125.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence