iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Pab-098527

Ensembl Protein ID

ENSPPYP00000003942.2

UniProt Accession

H2NDX9; H2NDX9_PONAB

Genbank Protein ID

ENSPPYP00000003942

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ABGA01228329

Gene Name

TSG101

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPPYG00000003434.2	ENSPPYT00000004091.2	ENSPPYP00000003942.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UEV	2.40e-45	154.0	2	146
UBD/UBC-like/UBD_UEV	3.50e-68	228.0	2	145

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E2/UEV

   S: 1    avseselkvvvpr......nfrlleeleegekglgdgtvsygldDgddilllsltgtIigpertayegrIyqlklfvgkkYPekPPtv. 82
           avses+lk++v++      ++r+++++++ +k+l+++++sy+++Dg++++l++ltgtI++p+r+++ ++I +++l++ ++YP++PP++ 
   Q: 2    AVSESQLKKMVSKykyrdlTVRETVNVMTLYKDLKPVLDSYVFNDGSSRELMNLTGTIPVPYRGNT-YNI-PICLWLLDTYPYNPPICf 88
           799***************************************************************.***.****************** PP
   S: 83   ...rfsskinmaevndsnGvvdpralpvLanWkreysievvlvqlkkellskenrklqqPp 140
              ++s++i++ +++d+nG++   +lp+L++Wk+++s+++ l+q++++++++e++++++P 
   Q: 89   vkpTSSMTIKTGKHVDANGKI---YLPYLHEWKHPQSDLLGLIQVMIVVFGDEPPVFSRPV 146
           *********************...************************************5 PP

UBD/UBC-like/UBD_UEV

   S: 1    AvsesslkkvpskykdkrltvrellnliesykslkpktasfvlnDgesreLlrltGtipvpergitynipiilwlletYPekPPfvsvk 89
           Avses+lkk++skyk+++ltvre++n+++ yk+lkp+++s+v+nDg+sreL++ltGtipvp+rg+tynipi+lwll+tYP++PP+++vk
   Q: 2    AVSESQLKKMVSKYKYRDLTVRETVNVMTLYKDLKPVLDSYVFNDGSSRELMNLTGTIPVPYRGNTYNIPICLWLLDTYPYNPPICFVK 90
           89*************************************************************************************** PP
   S: 90   ekidmntikssnehvdpnGkialpvLhkWknpasnlvelvqelivllskeppklsrp 146
           ++++m tik++ +hvd+nGki+lp+Lh+Wk+p+s+l+ l+q++iv++++epp++srp
   Q: 91   PTSSM-TIKTG-KHVDANGKIYLPYLHEWKHPQSDLLGLIQVMIVVFGDEPPVFSRP 145
           *****.*****.*******************************************98 PP

Organism

Pongo abelii

Protein Sequence
(Fasta)

MAVSESQLKK MVSKYKYRDL TVRETVNVMT LYKDLKPVLD SYVFNDGSSR ELMNLTGTIP 60
VPYRGNTYNI PICLWLLDTY PYNPPICFVK PTSSMTIKTG KHVDANGKIY LPYLHEWKHP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTCCCACTTG ATGAATCAGT CATTAAGGCT CACTGGCAAG CCCTTCGTAC TTCTTCCCTC 60
TCCGGCACTA GCTTCCTTAA GTCGACTCTG TGAAATACCT GCTAATCTTA TCCTGAACCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR017916--SB_dom
IPR016135--UBQ-conjugating_enzyme/RWD
IPR008883--UEV_N

PROSITE

PS51322--UEV

Pfam

PF05743--UEV
PF09454--Vps23_core

Gene Ontology

GO:0005829--C:cytosol
GO:0005769--C:early endosome
GO:0000813--C:ESCRT I complex
GO:0070062--C:extracellular exosome
GO:0005770--C:late endosome
GO:0005730--C:nucleolus
GO:0005886--C:plasma membrane
GO:0003714--F:transcription corepressor activity
GO:0046790--F:virion binding
GO:0007050--P:cell cycle arrest
GO:0006464--P:cellular protein modification process
GO:1990182--P:exosomal secretion
GO:0030216--P:keratinocyte differentiation
GO:0008285--P:negative regulation of cell proliferation
GO:0042059--P:negative regulation of epidermal growth factor receptor signaling pathway
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:1903543--P:positive regulation of exosomal secretion
GO:2000397--P:positive regulation of ubiquitin-dependent endocytosis
GO:1903774--P:positive regulation of viral budding via host ESCRT complex
GO:1902188--P:positive regulation of viral release from host cell
GO:0015031--P:protein transport
GO:0001558--P:regulation of cell growth
GO:1903551--P:regulation of extracellular exosome assembly
GO:0043405--P:regulation of MAP kinase activity
GO:0043162--P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
GO:0046755--P:viral budding

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001072	Aegilops tauschii	38.21	3.00e-21	95.90
IUUC-Aml-002415	Ailuropoda melanoleuca	96.88	0.00e+00	649.00
IUUC-Atr-002875	Amborella trichopoda	27.38	8.00e-28	117.00
IUUC-Apl-003473	Anas platyrhynchos	87.57	3.00e-174	603.00
IUUC-Aca-004573	Anolis carolinensis	89.55	1.00e-170	592.00
IUUC-Aly-006164	Arabidopsis lyrata	43.14	2.00e-21	97.10
IUUC-Ath-006575	Arabidopsis thaliana	43.14	2.00e-21	97.10
IUUC-Ago-007755	Ashbya gossypii	24.24	1.00e-05	44.30
IUUC-Acl-008218	Aspergillus clavatus	39.84	2.00e-25	110.00
IUUC-Afl-008597	Aspergillus flavus	39.10	2.00e-25	110.00
IUUC-Afu-009017	Aspergillus fumigatus	37.98	2.00e-23	103.00
IUUC-Ani-009468	Aspergillus nidulans	38.64	4.00e-21	95.90
IUUC-Ang-009755	Aspergillus niger	36.51	2.00e-22	100.00
IUUC-Aor-010072	Aspergillus oryzae	37.59	2.00e-25	110.00
IUUC-Ate-010400	Aspergillus terreus	37.98	8.00e-25	108.00
IUUC-Ame-011620	Astyanax mexicanus	77.84	2.00e-161	561.00
IUUC-Bgr-012136	Blumeria graminis	35.77	7.00e-24	105.00
IUUC-Bta-012557	Bos taurus	87.87	0.00e+00	642.00
IUUC-Bci-013881	Botrytis cinerea	36.76	5.00e-26	112.00
IUUC-Bdi-014325	Brachypodium distachyon	32.11	2.00e-14	72.80
IUUC-Bol-016308	Brassica oleracea	40.80	4.00e-26	112.00
IUUC-Bra-017605	Brassica rapa	40.32	3.00e-26	112.00
IUUC-Cel-018697	Caenorhabditis elegans	48.84	4.00e-37	149.00
IUUC-Cja-018963	Callithrix jacchus	91.22	0.00e+00	648.00
IUUC-Cfa-020472	Canis familiaris	96.88	0.00e+00	646.00
IUUC-Cpo-022001	Cavia porcellus	98.87	0.00e+00	655.00
IUUC-Cre-022918	Chlamydomonas reinhardtii	30.03	1.00e-27	117.00
IUUC-Csa-023959	Chlorocebus sabaeus	99.43	0.00e+00	632.00
IUUC-Cho-024389	Choloepus hoffmanni	56.36	2.00e-38	153.00
IUUC-Cin-025688	Ciona intestinalis	42.37	1.00e-82	300.00
IUUC-Cne-026904	Cryptococcus neoformans	29.19	2.00e-14	73.90
IUUC-Cme-027280	Cyanidioschyzon merolae	39.09	1.00e-17	84.00
IUUC-Dre-027913	Danio rerio	78.12	5.00e-152	530.00
IUUC-Dno-029672	Dasypus novemcinctus	97.45	0.00e+00	663.00
IUUC-Dor-030175	Dipodomys ordii	96.86	6.00e-88	317.00
IUUC-Dse-031375	Dothistroma septosporum	32.85	4.00e-23	102.00
IUUC-Dme-031736	Drosophila melanogaster	47.87	3.00e-83	301.00
IUUC-Ete-032343	Echinops telfairi	92.35	1.00e-180	625.00
IUUC-Eca-033926	Equus caballus	97.73	0.00e+00	655.00
IUUC-Eeu-034940	Erinaceus europaeus	88.67	0.00e+00	635.00
IUUC-Fca-035491	Felis catus	96.60	0.00e+00	632.00
IUUC-Fal-037508	Ficedula albicollis	90.40	2.00e-171	595.00
IUUC-Fox-037937	Fusarium oxysporum	32.31	3.00e-21	96.30
IUUC-Fso-038091	Fusarium solani	36.03	5.00e-25	108.00
IUUC-Gmo-039427	Gadus morhua	75.85	1.00e-148	518.00
IUUC-Ggr-039724	Gaeumannomyces graminis	37.31	7.00e-25	108.00
IUUC-Gga-040998	Gallus gallus	87.25	3.00e-178	617.00
IUUC-Gac-041356	Gasterosteus aculeatus	78.41	2.00e-161	561.00
IUUC-Gma-043566	Glycine max	39.68	5.00e-25	108.00
IUUC-Ggo-044967	Gorilla gorilla	99.43	0.00e+00	632.00
IUUC-Hsa-046686	Homo sapiens	99.43	0.00e+00	632.00
IUUC-Hvu-047430	Hordeum vulgare	38.21	3.00e-21	96.30
IUUC-Itr-047929	Ictidomys tridecemlineatus	97.85	5.00e-87	313.00
IUUC-Kpa-049287	Komagataella pastoris	30.41	5.00e-16	79.00
IUUC-Lch-050597	Latimeria chalumnae	85.03	1.00e-171	595.00
IUUC-Lpe-051090	Leersia perrieri	38.02	2.00e-20	93.20
IUUC-Loc-052399	Lepisosteus oculatus	76.70	1.00e-154	538.00
IUUC-Lma-053249	Leptosphaeria maculans	29.82	1.00e-13	71.60
IUUC-Laf-053766	Loxodonta africana	98.30	0.00e+00	654.00
IUUC-Mcc-055641	Macaca mulatta	99.43	0.00e+00	632.00
IUUC-Meu-055919	Macropus eugenii	88.89	1.00e-145	508.00
IUUC-Mor-056970	Magnaporthe oryzae	38.46	6.00e-24	105.00
IUUC-Mpo-057345	Magnaporthe poae	36.92	9.00e-23	101.00
IUUC-Mtr-058436	Medicago truncatula	38.10	9.00e-26	110.00
IUUC-Mla-059037	Melampsora laricipopulina	34.93	2.00e-25	110.00
IUUC-Mga-059263	Meleagris gallopavo	86.46	2.00e-170	591.00
IUUC-Mvi-060463	Microbotryum violaceum	30.20	1.00e-17	85.10
IUUC-Mmr-060915	Microcebus murinus	97.73	0.00e+00	647.00
IUUC-Mdo-062449	Monodelphis domestica	93.48	3.00e-176	610.00
IUUC-Mmu-063151	Mus musculus	94.05	8.00e-180	622.00
IUUC-Mac-065581	Musa acuminata	36.43	8.00e-22	97.80
IUUC-Mpu-066621	Mustela putorius furo	96.88	0.00e+00	649.00
IUUC-Mlu-067336	Myotis lucifugus	97.73	0.00e+00	633.00
IUUC-Nfi-068530	Neosartorya fischeri	38.76	2.00e-23	103.00
IUUC-Ncr-068785	Neurospora crassa	36.03	1.00e-24	107.00
IUUC-Nle-069972	Nomascus leucogenys	99.43	0.00e+00	632.00
IUUC-Opr-071150	Ochotona princeps	72.64	8.00e-109	386.00
IUUC-Ont-071366	Oreochromis niloticus	79.04	2.00e-160	558.00
IUUC-Oan-073290	Ornithorhynchus anatinus	92.71	2.00e-82	298.00
IUUC-Ocu-074351	Oryctolagus cuniculus	98.58	0.00e+00	655.00
IUUC-Oba-075338	Oryza barthii	37.14	2.00e-11	62.80
IUUC-Obr-076135	Oryza brachyantha	37.19	3.00e-20	92.40
IUUC-Ogl-077182	Oryza glaberrima	36.28	3.00e-17	82.40
IUUC-Ogu-078281	Oryza glumaepatula	37.19	3.00e-20	92.40
IUUC-Oin-079068	Oryza indica	36.28	8.00e-17	81.60
IUUC-Olo-080460	Oryza longistaminata	33.33	1.10e-02	32.70
IUUC-Ome-081781	Oryza meridionalis	35.25	1.00e-17	84.00
IUUC-Oni-082517	Oryza nivara	34.40	4.00e-16	79.30
IUUC-Opu-084101	Oryza punctata	36.28	3.00e-17	82.80
IUUC-Oru-084556	Oryza rufipogon	36.84	4.00e-17	82.40
IUUC-Osa-086264	Oryza sativa	36.28	4.00e-17	82.40
IUUC-Ola-086920	Oryzias latipes	78.34	3.00e-74	270.00
IUUC-Olu-087610	Ostreococcus lucimarinus	25.33	2.00e-12	67.00
IUUC-Oga-088304	Otolemur garnettii	97.17	0.00e+00	647.00
IUUC-Oar-089734	Ovis aries	87.87	0.00e+00	642.00
IUUC-Ptr-091476	Pan troglodytes	99.43	0.00e+00	632.00
IUUC-Pan-092341	Papio anubis	99.43	0.00e+00	632.00
IUUC-Psi-093470	Pelodiscus sinensis	92.22	1.00e-170	592.00
IUUC-Pma-094143	Petromyzon marinus	61.96	2.00e-114	405.00
IUUC-Pno-095069	Phaeosphaeria nodorum	31.93	5.00e-14	72.40
IUUC-Ppa-095933	Physcomitrella patens	27.67	4.00e-28	119.00
IUUC-Pfo-096321	Poecilia formosa	78.12	1.00e-150	525.00
IUUC-Pop-099323	Populus trichocarpa	26.41	2.00e-31	130.00
IUUC-Pca-101044	Procavia capensis	77.34	5.00e-134	470.00
IUUC-Ppe-101458	Prunus persica	41.67	8.00e-27	114.00
IUUC-Pva-103014	Pteropus vampyrus	90.43	6.00e-157	546.00
IUUC-Pgr-103615	Puccinia graminis	36.09	3.00e-20	93.20
IUUC-Ptt-103826	Puccinia triticina	40.20	2.00e-16	80.50
IUUC-Pte-104171	Pyrenophora teres	35.29	2.00e-21	97.10
IUUC-Pyt-104433	Pyrenophora triticirepentis	37.70	3.00e-08	53.10
IUUC-Rno-105957	Rattus norvegicus	92.92	8.00e-178	615.00
IUUC-Sce-106262	Saccharomyces cerevisiae	27.34	3.00e-10	59.30
IUUC-Sha-107607	Sarcophilus harrisii	94.86	3.00e-151	527.00
IUUC-Ssl-108672	Sclerotinia sclerotiorum	35.29	2.00e-25	110.00
IUUC-Smo-108973	Selaginella moellendorffii	38.60	2.00e-20	93.60
IUUC-Sly-111373	Solanum lycopersicum	35.71	3.00e-23	102.00
IUUC-Stu-112844	Solanum tuberosum	34.92	2.00e-22	99.80
IUUC-Sar-113653	Sorex araneus	84.00	3.00e-155	541.00
IUUC-Sbi-114390	Sorghum bicolor	35.54	3.00e-20	92.40
IUUC-Sre-115200	Sporisorium reilianum	38.36	7.00e-24	105.00
IUUC-Ssc-115888	Sus scrofa	97.88	2.00e-89	321.00
IUUC-Tgu-117506	Taeniopygia guttata	83.33	6.00e-176	609.00
IUUC-Tru-118063	Takifugu rubripes	76.55	2.00e-147	515.00
IUUC-Tsy-118851	Tarsius syrichta	71.61	1.00e-120	426.00
IUUC-Tni-120010	Tetraodon nigroviridis	76.34	3.00e-146	511.00
IUUC-Tca-121182	Theobroma cacao	38.89	5.00e-22	98.60
IUUC-Tre-122040	Trichoderma reesei	36.15	9.00e-22	98.20
IUUC-Tvi-122660	Trichoderma virens	39.71	1.00e-25	111.00
IUUC-Tae-124561	Triticum aestivum	38.21	3.00e-21	95.90
IUUC-Tur-126651	Triticum urartu	38.21	6.00e-21	94.70
IUUC-Tme-127184	Tuber melanosporum	47.32	2.00e-25	110.00
IUUC-Tbe-127894	Tupaia belangeri	81.15	9.00e-84	303.00
IUUC-Ttr-128264	Tursiops truncatus	87.25	1.00e-179	622.00
IUUC-Uma-129407	Ustilago maydis	36.99	1.00e-24	107.00
IUUC-Vda-130002	Verticillium dahliae	30.82	5.00e-16	79.00
IUUC-Vpa-130156	Vicugna pacos	95.50	3.00e-95	341.00
IUUC-Vvi-131479	Vitis vinifera	41.23	2.00e-23	103.00
IUUC-Xtr-132332	Xenopus tropicalis	81.68	1.00e-63	234.00
IUUC-Xma-133186	Xiphophorus maculatus	75.35	7.00e-151	526.00
IUUC-Yli-134500	Yarrowia lipolytica	31.67	1.00e-06	47.40
IUUC-Zma-135391	Zea mays	36.13	7.00e-20	91.70

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence