iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ggo-045337

UUCD1 version

UUC-GoG-01095

Ensembl Protein ID

ENSGGOP00000004509.2

UniProt Accession

G3QPL2; G3QPL2_GORGO

Protein Name

Uncharacterized protein

Gene Name

USP4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGGOG00000004591.2	ENSGGOT00000004624.2	ENSGGOP00000004509.2
ENSGGOG00000004591.2	ENSGGOT00000032601.1	ENSGGOP00000024188.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.20e-84	284.8	302	852
ULD/UDP/UBQ/UBQ_Other	2.10e-18	66.4	143	221

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgye 88
           +Gl NlgNtC+mNS+LQcLsn+ +l++++l+ +++ ++n++np ++kge+++++++l++++w++++ +v+pr+++++++++a++fsgy+
   Q: 302  CGLGNLGNTCFMNSALQCLSNTAPLTDYFLKdEYEAEINRDNPLGMKGEIAEAYAELIKQMWSGRDAHVAPRMFKTQVGRFAPQFSGYQ 390
           7******************************9********************************************************* PP
   S: 89   qqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde.....aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldl 172
           qqD+qE+laflld+l+e+l++ k+kp+ e+++++   ++d      a+e++  +n+s+i+d+F+g +ks+++c+ec++vs++++pf++l
   Q: 391  QQDSQELLAFLLDGLHEDLNRVKKKPYLELKDAN--GRPDAvvakeAWENHRLRNDSVIVDTFHGLFKSTLVCPECAKVSVTFDPFCYL 477
           ******************************8888..5555556777******************************************* PP
   S: 173  slpvpgkeetkke............................................................................ 185
           +lp+p k+++ +e                                                                            
   Q: 478  TLPLPLKKDRVMEvflvpadphcrptqyrvtvplmgavsdlcealsrlsgiaaenmvvadvynhrfhkifqmdeglnhimprddifvye 566
           ********99999**************************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 567  vcstsvdgsecvtlpvyfrerksrpsstssasalygqplllsvpkhkltleslyqavcdrisryvkqplpdefgssplepgacngsrns 655
           ***************************************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 656  cegedeeemehqeegkeqlsetegsgedepgndpsettqkkikgqpcpkrlftfslvnsygtadinslaadgkllklnsrstlamdwds 744
           ***************************************************************************************** PP
   S: 186  ................................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfsee 242
                                            l+dc+e ft+ e+l +++ +yc++ckk+q+a+kk++l++lP++L++hLkRfs++++
   Q: 745  etrslyydeqeseayekhvsmlqpqkkkkatvALRDCIELFTTMETLGEHDPWYCPNCKKHQQATKKFDLWSLPKILVVHLKRFSYNRY 833
           ************************************************************************************99885 PP
   S: 243  qksrekinkkvefple.Ldls 262
              r k+++ vefp++ + l+
   Q: 834  --WRDKLDTVVEFPIRwVMLT 852
           ..567*********9855554 PP

ULD/UDP/UBQ/UBQ_Other

   S: 5    vksldgs.eltlkvnpsdtVaeLKekiekklgip.peqqrLiyk......GkiL.eddktLadyglkdgstihllekksg 75
           ++++d + +l+++++++dt+a++ ++++k+++ip +++ rL++k       + L + d+t++d gl++g+++++++++++
   Q: 143  CENSDPTnVLSCHFSKADTIATIEKEMRKLFNIPaERETRLWNKymsntyEQ-LsKLDNTVQDAGLYQGQVLVIEPQNED 221
           78999999**************************888*****9999977444.46********************99986 PP

Organism

Gorilla gorilla

Protein Sequence
(Fasta)

MAEGGGCRER PDAETQKSEL GALMRTTLQR GAQWYLIDSR WFKQWKKYVG FDSWDMYHVG 60
EHNLFPGPID NSGLFSDPES QTLKEHLIDE LDYVLVPTEA WNKLLNWYGC VEGQQPIVRK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCGCGCGCGG GGCGGATGTC CGGGCCGGCT GGGCCGGGGC CGCGGCCGAG ATGGCGGAAG 60
GTGGAGGCTG CCGTGAGCGA CCGGATGCGG AGACTCAGAA GTCCGAGCTT GGAGCCTTAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR028135--Ub_USP-typ
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS51283--DUSP
PS00972--USP_1
PS50235--USP_3

Pfam

PF06337--DUSP
PF14836--Ubiquitin_3
PF00443--UCH

SMART

SM00695--DUSP

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0031397--P:negative regulation of protein ubiquitination
GO:0016579--P:protein deubiquitination
GO:0034394--P:protein localization to cell surface
GO:0031647--P:regulation of protein stability
GO:0000244--P:spliceosomal tri-snRNP complex assembly
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001597	Ailuropoda melanoleuca	92.51	0.00e+00	1500.00
IUUC-Atr-002991	Amborella trichopoda	34.03	1.00e-119	424.00
IUUC-Apl-004068	Anas platyrhynchos	70.16	0.00e+00	1062.00
IUUC-Aca-004459	Anolis carolinensis	67.78	0.00e+00	1078.00
IUUC-Ath-007560	Arabidopsis thaliana	39.72	4.00e-104	372.00
IUUC-Ago-007911	Ashbya gossypii	37.43	2.00e-63	238.00
IUUC-Afu-008878	Aspergillus fumigatus	45.16	2.00e-54	208.00
IUUC-Ani-009479	Aspergillus nidulans	43.06	7.00e-52	199.00
IUUC-Ang-009562	Aspergillus niger	45.16	1.00e-55	213.00
IUUC-Bta-012929	Bos taurus	92.40	0.00e+00	1525.00
IUUC-Bci-013993	Botrytis cinerea	44.64	6.00e-64	239.00
IUUC-Cja-018798	Callithrix jacchus	93.89	0.00e+00	1529.00
IUUC-Cfa-020599	Canis familiaris	93.32	0.00e+00	1537.00
IUUC-Cpo-022144	Cavia porcellus	91.32	0.00e+00	1447.00
IUUC-Csa-023770	Chlorocebus sabaeus	96.06	0.00e+00	1462.00
IUUC-Cho-024595	Choloepus hoffmanni	89.43	0.00e+00	989.00
IUUC-Cgl-026741	Colletotrichum gloeosporioides	43.75	1.00e-60	229.00
IUUC-Dre-027869	Danio rerio	69.12	0.00e+00	889.00
IUUC-Dno-029316	Dasypus novemcinctus	90.21	0.00e+00	1532.00
IUUC-Dor-031038	Dipodomys ordii	86.09	0.00e+00	850.00
IUUC-Ete-032970	Echinops telfairi	83.49	0.00e+00	925.00
IUUC-Eca-034012	Equus caballus	93.32	0.00e+00	1504.00
IUUC-Eeu-035158	Erinaceus europaeus	77.32	0.00e+00	794.00
IUUC-Fca-035373	Felis catus	88.94	0.00e+00	1501.00
IUUC-Fal-037634	Ficedula albicollis	73.70	0.00e+00	1150.00
IUUC-Fox-037986	Fusarium oxysporum	44.49	4.00e-64	240.00
IUUC-Fso-038291	Fusarium solani	44.49	7.00e-64	239.00
IUUC-Gmo-038866	Gadus morhua	68.23	0.00e+00	851.00
IUUC-Ggr-039740	Gaeumannomyces graminis	44.32	1.00e-62	236.00
IUUC-Gga-040729	Gallus gallus	65.72	0.00e+00	1106.00
IUUC-Gac-042631	Gasterosteus aculeatus	67.73	0.00e+00	1131.00
IUUC-Hsa-045669	Homo sapiens	97.35	0.00e+00	1602.00
IUUC-Itr-048610	Ictidomys tridecemlineatus	92.63	0.00e+00	1522.00
IUUC-Lch-050533	Latimeria chalumnae	68.88	0.00e+00	1179.00
IUUC-Lpe-051424	Leersia perrieri	35.50	3.00e-126	446.00
IUUC-Loc-051800	Lepisosteus oculatus	66.00	0.00e+00	1162.00
IUUC-Laf-053803	Loxodonta africana	92.97	0.00e+00	1516.00
IUUC-Mcc-055556	Macaca mulatta	91.82	0.00e+00	1475.00
IUUC-Meu-056742	Macropus eugenii	75.82	0.00e+00	1219.00
IUUC-Mor-056985	Magnaporthe oryzae	43.22	6.00e-62	233.00
IUUC-Mpo-057486	Magnaporthe poae	45.05	1.00e-62	235.00
IUUC-Mtr-058138	Medicago truncatula	42.91	2.00e-112	400.00
IUUC-Mga-059300	Meleagris gallopavo	69.28	0.00e+00	1079.00
IUUC-Mdo-061848	Monodelphis domestica	85.19	0.00e+00	1384.00
IUUC-Mmu-063960	Mus musculus	90.21	0.00e+00	1488.00
IUUC-Mpu-066920	Mustela putorius furo	93.55	0.00e+00	1541.00
IUUC-Mlu-068088	Myotis lucifugus	91.01	0.00e+00	1498.00
IUUC-Nfi-068330	Neosartorya fischeri	45.20	1.00e-54	209.00
IUUC-Ncr-068879	Neurospora crassa	32.19	5.00e-68	253.00
IUUC-Nle-070010	Nomascus leucogenys	96.66	0.00e+00	1592.00
IUUC-Opr-070740	Ochotona princeps	88.36	0.00e+00	1026.00
IUUC-Ont-072573	Oreochromis niloticus	64.27	0.00e+00	1140.00
IUUC-Oan-073363	Ornithorhynchus anatinus	77.59	0.00e+00	1261.00
IUUC-Ocu-074242	Oryctolagus cuniculus	87.53	0.00e+00	1401.00
IUUC-Ola-086553	Oryzias latipes	67.13	0.00e+00	1131.00
IUUC-Olu-087717	Ostreococcus lucimarinus	39.10	2.00e-103	370.00
IUUC-Oga-088562	Otolemur garnettii	89.29	0.00e+00	1408.00
IUUC-Oar-090439	Ovis aries	91.94	0.00e+00	1516.00
IUUC-Ptr-090801	Pan troglodytes	97.35	0.00e+00	1598.00
IUUC-Pan-092717	Papio anubis	90.68	0.00e+00	1450.00
IUUC-Psi-093942	Pelodiscus sinensis	72.93	0.00e+00	1168.00
IUUC-Pab-098522	Pongo abelii	96.09	0.00e+00	1120.00
IUUC-Pca-100161	Procavia capensis	80.30	0.00e+00	1272.00
IUUC-Rno-106081	Rattus norvegicus	89.29	0.00e+00	1490.00
IUUC-Sha-106937	Sarcophilus harrisii	83.59	0.00e+00	1340.00
IUUC-Spo-108291	Schizosaccharomyces pombe	43.08	2.00e-72	267.00
IUUC-Sar-113542	Sorex araneus	85.02	0.00e+00	1399.00
IUUC-Ssc-115637	Sus scrofa	92.97	0.00e+00	1502.00
IUUC-Tgu-117267	Taeniopygia guttata	70.35	0.00e+00	1154.00
IUUC-Tru-118634	Takifugu rubripes	67.38	0.00e+00	1088.00
IUUC-Tca-121001	Theobroma cacao	34.74	2.00e-128	453.00
IUUC-Tme-127062	Tuber melanosporum	34.73	1.00e-76	281.00
IUUC-Tbe-127669	Tupaia belangeri	82.22	0.00e+00	739.00
IUUC-Ttr-128778	Tursiops truncatus	91.94	0.00e+00	1496.00
IUUC-Uma-129498	Ustilago maydis	40.90	9.00e-70	259.00
IUUC-Vpa-130571	Vicugna pacos	96.30	0.00e+00	1132.00
IUUC-Xtr-132305	Xenopus tropicalis	68.04	0.00e+00	1147.00
IUUC-Yli-134392	Yarrowia lipolytica	43.01	9.00e-62	232.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence