iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Itr-048314

Ensembl Protein ID

ENSSTOP00000012444.2

UniProt Accession

I3MLW0; I3MLW0_ICTTR

Genbank Protein ID

ENSSTOP00000012444

Protein Name

E3 ubiquitin-protein ligase RNF8; RING finger protein 8; RING-type E3 ubiquitin transferase RNF8

Genbank Nucleotide ID

AGTP01010941

Gene Name

RNF8

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSTOG00000013893.2	ENSSTOT00000013891.2	ENSSTOP00000012444.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	1.90e-07	31.5	401	439

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iC e f +  ++l+C H f+  C++ w       ++++ CP+Cr
   Q: 401  CIICSEYFVE-AVTLNCAHSFCSYCINEW------MKRKIECPICR 439
           ********99.899***************......**********8 PP

Organism

Ictidomys tridecemlineatus

Protein Sequence
(Fasta)

MGEPASLVTE DHAGGRSWCL RRVGMNAEWL LLEDGREVTI GRGFGVTYQL VSKICPLMIS 60
RNHCVLKQNP EGQWTIMDNK SLNGVWLNRE RLEPLKLYFI HKGDHIQLGV PLENKENAEY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGGGAGC CTGCTTCCTT GGTCACTGAA GACCACGCCG GTGGCCGGAG CTGGTGCTTG 60
AGGCGGGTGG GGATGAACGC CGAGTGGCTG CTGCTGGAGG ACGGACGCGA GGTGAGGGCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0156--Chromatin regulator
KW-0158--Chromosome
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0479--Metal-binding
KW-0498--Mitosis
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0779--Telomere
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000253--FHA_dom
IPR017335--RNF8
IPR008984--SMAD_FHA_domain
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50006--FHA_DOMAIN
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00498--FHA

SMART

SM00240--FHA
SM00184--RING

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0035861--C:site of double-strand break
GO:0000151--C:ubiquitin ligase complex
GO:0003682--F:chromatin binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006302--P:double-strand break repair
GO:0070535--P:histone H2A K63-linked ubiquitination
GO:0034244--P:negative regulation of transcription elongation from RNA polymerase II promoter
GO:0045739--P:positive regulation of DNA repair
GO:0051865--P:protein autoubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0010212--P:response to ionizing radiation
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002124	Ailuropoda melanoleuca	85.48	0.00e+00	671.00
IUUC-Apl-003664	Anas platyrhynchos	78.65	2.00e-39	153.00
IUUC-Aca-005036	Anolis carolinensis	58.02	2.00e-116	412.00
IUUC-Ame-011537	Astyanax mexicanus	42.50	2.00e-87	316.00
IUUC-Bta-013297	Bos taurus	86.24	0.00e+00	665.00
IUUC-Cel-018658	Caenorhabditis elegans	39.29	2.00e-07	50.80
IUUC-Cja-019201	Callithrix jacchus	83.30	0.00e+00	638.00
IUUC-Cfa-021041	Canis familiaris	86.80	0.00e+00	710.00
IUUC-Csa-024133	Chlorocebus sabaeus	83.98	0.00e+00	704.00
IUUC-Cho-024624	Choloepus hoffmanni	78.36	2.00e-135	475.00
IUUC-Dre-027918	Danio rerio	42.74	6.00e-80	291.00
IUUC-Dno-029774	Dasypus novemcinctus	85.68	0.00e+00	706.00
IUUC-Dor-030190	Dipodomys ordii	76.07	9.00e-160	556.00
IUUC-Ete-032301	Echinops telfairi	67.43	3.00e-139	488.00
IUUC-Eca-033607	Equus caballus	86.86	5.00e-179	620.00
IUUC-Eeu-034888	Erinaceus europaeus	81.31	2.00e-121	429.00
IUUC-Fca-036075	Felis catus	84.85	0.00e+00	706.00
IUUC-Fal-037569	Ficedula albicollis	61.21	7.00e-111	393.00
IUUC-Gmo-038588	Gadus morhua	40.59	1.00e-73	270.00
IUUC-Gga-040777	Gallus gallus	59.12	5.00e-122	431.00
IUUC-Gac-042463	Gasterosteus aculeatus	41.72	3.00e-62	232.00
IUUC-Ggo-045269	Gorilla gorilla	84.19	0.00e+00	710.00
IUUC-Hsa-046249	Homo sapiens	83.78	0.00e+00	689.00
IUUC-Lch-049805	Latimeria chalumnae	51.68	3.00e-112	398.00
IUUC-Loc-052377	Lepisosteus oculatus	49.26	1.00e-93	337.00
IUUC-Mcc-055344	Macaca mulatta	83.98	0.00e+00	706.00
IUUC-Meu-055950	Macropus eugenii	62.96	7.00e-127	446.00
IUUC-Mla-059052	Melampsora laricipopulina	38.46	2.00e-10	58.50
IUUC-Mga-060049	Meleagris gallopavo	59.65	2.00e-117	415.00
IUUC-Mmr-061431	Microcebus murinus	85.68	0.00e+00	667.00
IUUC-Mdo-062016	Monodelphis domestica	67.19	4.00e-119	423.00
IUUC-Mmu-063235	Mus musculus	74.90	0.00e+00	655.00
IUUC-Mpu-066449	Mustela putorius furo	87.68	0.00e+00	751.00
IUUC-Mlu-067588	Myotis lucifugus	80.08	0.00e+00	631.00
IUUC-Nle-069192	Nomascus leucogenys	84.19	0.00e+00	707.00
IUUC-Opr-070300	Ochotona princeps	67.42	4.00e-153	534.00
IUUC-Ont-071998	Oreochromis niloticus	43.10	4.00e-66	245.00
IUUC-Oan-073610	Ornithorhynchus anatinus	65.50	5.00e-68	250.00
IUUC-Ocu-074603	Oryctolagus cuniculus	81.03	0.00e+00	661.00
IUUC-Ola-086681	Oryzias latipes	40.97	4.00e-73	268.00
IUUC-Oga-088183	Otolemur garnettii	86.80	0.00e+00	720.00
IUUC-Oar-090255	Ovis aries	86.52	2.00e-172	598.00
IUUC-Ptr-091029	Pan troglodytes	83.01	0.00e+00	640.00
IUUC-Pan-092241	Papio anubis	84.19	0.00e+00	711.00
IUUC-Psi-093506	Pelodiscus sinensis	61.07	3.00e-128	451.00
IUUC-Pma-094579	Petromyzon marinus	55.56	2.00e-26	113.00
IUUC-Pfo-097014	Poecilia formosa	43.75	6.00e-65	241.00
IUUC-Pab-098530	Pongo abelii	83.59	0.00e+00	654.00
IUUC-Pca-100939	Procavia capensis	63.07	3.00e-144	504.00
IUUC-Pva-103148	Pteropus vampyrus	79.38	0.00e+00	649.00
IUUC-Rno-105338	Rattus norvegicus	76.49	0.00e+00	681.00
IUUC-Sce-106282	Saccharomyces cerevisiae	35.96	7.00e-07	48.10
IUUC-Sha-107187	Sarcophilus harrisii	65.78	1.00e-98	352.00
IUUC-Sar-113356	Sorex araneus	67.90	1.00e-126	446.00
IUUC-Ssc-116290	Sus scrofa	85.89	0.00e+00	736.00
IUUC-Tru-117910	Takifugu rubripes	40.09	9.00e-63	233.00
IUUC-Tsy-119329	Tarsius syrichta	78.35	1.00e-164	572.00
IUUC-Tni-120521	Tetraodon nigroviridis	39.92	2.00e-62	232.00
IUUC-Tme-126989	Tuber melanosporum	33.90	3.00e-07	50.40
IUUC-Ttr-128997	Tursiops truncatus	80.58	0.00e+00	644.00
IUUC-Vpa-130154	Vicugna pacos	82.51	0.00e+00	710.00
IUUC-Xtr-132805	Xenopus tropicalis	50.32	1.00e-102	366.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence