iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mlu-067588

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

E3 ubiquitin-protein ligase RNF8; RING finger protein 8; RING-type E3 ubiquitin transferase RNF8

Genbank Nucleotide ID

AAPE02049514

Gene Name

RNF8

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMLUG00000013604.2	ENSMLUT00000013606.2	ENSMLUP00000012381.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	2.90e-07	30.9	405	443

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iC e f +  ++l+C H f+  C++ w       +++  CP+Cr
   Q: 405  CIICSEYFIE-AVTLNCAHSFCSYCINEW------MKRKVECPICR 443
           ********99.899***************......**********8 PP

Organism

Myotis lucifugus

Protein Sequence
(Fasta)

MGDPGSRARR ERPGGRSWCL RRVGMDAEWL LLEDGSEVTL GRGFGVTYQL VSKLCPLMIS 60
RNHCVLKQNT EGQWTIMDNK SLNGVWLNRV RLEPLEVYSL HTGDRVQLGV PLENKESAEY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGGGACC CCGGCTCCCG GGCTCGGCGG GAGCGCCCCG GGGGCCGCAG CTGGTGCCTG 60
CGGCGCGTGG GCATGGACGC CGAGTGGCTG CTGCTGGAGG ATGGGAGCGA GGTGCGCGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0156--Chromatin regulator
KW-0158--Chromosome
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0479--Metal-binding
KW-0498--Mitosis
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0779--Telomere
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000253--FHA_dom
IPR017335--RNF8
IPR008984--SMAD_FHA_domain
IPR018957--Znf_C3HC4_RING-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50006--FHA_DOMAIN
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00498--FHA
PF00097--zf-C3HC4

SMART

SM00240--FHA
SM00184--RING

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0035861--C:site of double-strand break
GO:0000151--C:ubiquitin ligase complex
GO:0003682--F:chromatin binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006302--P:double-strand break repair
GO:0070535--P:histone H2A K63-linked ubiquitination
GO:0034244--P:negative regulation of transcription elongation from RNA polymerase II promoter
GO:0045739--P:positive regulation of DNA repair
GO:0051865--P:protein autoubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0010212--P:response to ionizing radiation
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002124	Ailuropoda melanoleuca	81.78	0.00e+00	626.00
IUUC-Apl-003664	Anas platyrhynchos	79.55	3.00e-38	150.00
IUUC-Aca-005036	Anolis carolinensis	56.91	2.00e-117	416.00
IUUC-Ame-011537	Astyanax mexicanus	42.92	3.00e-86	312.00
IUUC-Bta-013297	Bos taurus	80.54	4.00e-175	607.00
IUUC-Cja-019201	Callithrix jacchus	77.12	2.00e-173	601.00
IUUC-Cfa-021041	Canis familiaris	82.82	0.00e+00	687.00
IUUC-Csa-024133	Chlorocebus sabaeus	79.30	0.00e+00	653.00
IUUC-Cho-024624	Choloepus hoffmanni	72.64	6.00e-123	433.00
IUUC-Dre-027918	Danio rerio	43.15	2.00e-83	302.00
IUUC-Dno-029774	Dasypus novemcinctus	80.12	0.00e+00	653.00
IUUC-Dor-030190	Dipodomys ordii	67.95	4.00e-141	494.00
IUUC-Ete-032301	Echinops telfairi	63.56	1.00e-129	456.00
IUUC-Eca-033607	Equus caballus	83.00	1.00e-166	579.00
IUUC-Eeu-034888	Erinaceus europaeus	77.89	5.00e-118	417.00
IUUC-Fca-036075	Felis catus	80.95	0.00e+00	681.00
IUUC-Fal-037569	Ficedula albicollis	60.56	2.00e-114	406.00
IUUC-Gmo-038588	Gadus morhua	39.75	2.00e-70	259.00
IUUC-Gga-040777	Gallus gallus	58.32	4.00e-119	421.00
IUUC-Gac-042463	Gasterosteus aculeatus	41.20	3.00e-61	229.00
IUUC-Ggo-045269	Gorilla gorilla	79.92	0.00e+00	665.00
IUUC-Hsa-046249	Homo sapiens	79.50	0.00e+00	644.00
IUUC-Itr-048314	Ictidomys tridecemlineatus	80.08	0.00e+00	665.00
IUUC-Kpa-049392	Komagataella pastoris	35.23	4.00e-09	55.50
IUUC-Lch-049805	Latimeria chalumnae	51.06	8.00e-111	394.00
IUUC-Loc-052377	Lepisosteus oculatus	49.15	4.00e-94	338.00
IUUC-Mcc-055344	Macaca mulatta	78.88	0.00e+00	651.00
IUUC-Meu-055950	Macropus eugenii	62.31	3.00e-126	445.00
IUUC-Mla-059052	Melampsora laricipopulina	36.92	3.00e-10	58.50
IUUC-Mga-060049	Meleagris gallopavo	60.09	5.00e-118	417.00
IUUC-Mmr-061431	Microcebus murinus	79.71	1.00e-177	615.00
IUUC-Mdo-062016	Monodelphis domestica	65.16	1.00e-116	415.00
IUUC-Mmu-063235	Mus musculus	71.49	2.00e-175	608.00
IUUC-Mpu-066449	Mustela putorius furo	84.06	0.00e+00	712.00
IUUC-Nle-069192	Nomascus leucogenys	79.92	0.00e+00	662.00
IUUC-Opr-070300	Ochotona princeps	61.08	3.00e-137	481.00
IUUC-Ont-071998	Oreochromis niloticus	41.77	2.00e-66	246.00
IUUC-Oan-073610	Ornithorhynchus anatinus	67.98	1.00e-66	245.00
IUUC-Ocu-074603	Oryctolagus cuniculus	77.23	6.00e-179	620.00
IUUC-Ola-086681	Oryzias latipes	40.91	4.00e-74	271.00
IUUC-Oga-088183	Otolemur garnettii	80.12	0.00e+00	649.00
IUUC-Oar-090255	Ovis aries	80.71	4.00e-160	557.00
IUUC-Ptr-091029	Pan troglodytes	79.34	1.00e-174	605.00
IUUC-Pan-092241	Papio anubis	79.09	0.00e+00	656.00
IUUC-Psi-093506	Pelodiscus sinensis	61.32	2.00e-131	462.00
IUUC-Pma-094579	Petromyzon marinus	55.79	1.00e-28	120.00
IUUC-Pfo-097014	Poecilia formosa	40.93	3.00e-63	236.00
IUUC-Pab-098530	Pongo abelii	80.17	1.00e-179	622.00
IUUC-Pca-100939	Procavia capensis	60.66	3.00e-134	471.00
IUUC-Pva-103148	Pteropus vampyrus	77.23	0.00e+00	633.00
IUUC-Rno-105338	Rattus norvegicus	72.26	2.00e-180	625.00
IUUC-Sha-107187	Sarcophilus harrisii	64.85	2.00e-99	355.00
IUUC-Sja-107948	Schizosaccharomyces japonicus	23.33	3.00e-10	60.10
IUUC-Sar-113356	Sorex araneus	64.27	2.00e-124	439.00
IUUC-Ssc-116290	Sus scrofa	81.33	0.00e+00	710.00
IUUC-Tru-117910	Takifugu rubripes	40.91	2.00e-63	236.00
IUUC-Tsy-119329	Tarsius syrichta	73.99	5.00e-151	527.00
IUUC-Tni-120521	Tetraodon nigroviridis	41.25	1.00e-63	237.00
IUUC-Ttr-128997	Tursiops truncatus	74.66	7.00e-170	590.00
IUUC-Vpa-130154	Vicugna pacos	79.25	0.00e+00	669.00
IUUC-Xtr-132805	Xenopus tropicalis	51.17	7.00e-104	370.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence