iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCJAG00000002942.2	ENSCJAT00000005614.1	ENSCJAP00000005320.1
ENSCJAG00000002942.2	ENSCJAT00000005619.2	ENSCJAP00000005325.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.50e-72	244.9	205	526

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqq 90
           Gl NlgNtC+mN+++Q+L+++p lr+++l+ ++++++    ++p+ +l++++ +lf+el++++ +   p +ll+ ++  a+++ gy+qq
   Q: 205  GLINLGNTCFMNCIVQALTHTPILRDFFLS-DRHRCEM---PSPELCLVCEMSSLFRELYSGNPSPHVPYKLLHLVWIHARHLAGYRQQ 289
           9*****************************.9999987...589********************************************* PP
   S: 91   DaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgk 179
           Da+Efl   ld l++++k                  +  +  +++++ +++i+++F g l+s+++c++c+ vs++ +p +d+sl++pg+
   Q: 290  DAHEFLIAALDVLHRHCKG----------------DDVGKAANNPNHCNCIIDQIFTGGLQSDVTCQACHGVSTTIDPCWDISLDLPGS 362
           *****************22................2344668899999****************************************9 PP
   S: 180  eetkke...................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksreki 249
            ++  +                   +l+dcL+ ft++e+l ++ k++c +c+++q ++k+l+++klP v ++     + +     + +i
   Q: 363  CTSFWPmspgressvngeshipgitTLTDCLRRFTRPEHLGSSAKIKCGSCQSYQASTKQLTMTKLPVVACVISDGLNIQP---TEAQI 448
           98766699****************************************************************999996655...6889* PP
   S: 250  nkkvefpleLdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgkWllfdDskVtevkeeevleetgstaYvlfYkrr 338
           +++++f leLd+    ++       ++kY+L+avv+ +  l+sGHY+++++++k++W+++dD  +t+ + ++vl    s++Y+lfY+++
   Q: 449  TTYISFLLELDMXTNSNK-------ENKYSLFAVVITKN-LESGHYTSFIRHHKDQWFKCDDAVITKASIKDVLD---SEGYLLFYHKQ 526
           ************943333.......789*******9886.***********************************...********985 PP

Organism

Callithrix jacchus

Protein Sequence
(Fasta)

PPRPPDPSPR RSRAPRRGPG GGCLDVDFAV GPPGCSHVNS FKVGENWRQE LRVIYQCFVW 60
CGTPETRKSK AKSCICHVCG THLNRLHSCL SCVFFGCFTE KHIHEHAETK QHNLAVDLYY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCACCGCGGC CCCCTGATCC CTCTCCGCGT CGCAGTCGTG CCCCACGCCG CCGACCCCGG 60
CCCCGGCCCC AGACCCGGCT CCGTACCCCG CCGCAGCCTA GGCCCCGGCC CCCTCCCCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

Gene Ontology

GO:1990380--F:Lys48-specific deubiquitinase activity
GO:0061578--F:Lys63-specific deubiquitinase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0043065--P:positive regulation of apoptotic process
GO:0050821--P:protein stabilization
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002084	Ailuropoda melanoleuca	89.31	0.00e+00	963.00
IUUC-Cfa-020956	Canis familiaris	90.27	0.00e+00	941.00
IUUC-Cpo-022014	Cavia porcellus	89.31	0.00e+00	966.00
IUUC-Cho-024938	Choloepus hoffmanni	67.18	4.00e-49	188.00
IUUC-Dno-029905	Dasypus novemcinctus	88.58	0.00e+00	784.00
IUUC-Dor-030481	Dipodomys ordii	73.94	5.00e-81	295.00
IUUC-Eca-033957	Equus caballus	88.37	0.00e+00	952.00
IUUC-Fca-035768	Felis catus	88.93	0.00e+00	961.00
IUUC-Gmo-039143	Gadus morhua	71.94	4.00e-121	428.00
IUUC-Ggo-044925	Gorilla gorilla	89.68	0.00e+00	966.00
IUUC-Itr-048775	Ictidomys tridecemlineatus	89.27	0.00e+00	788.00
IUUC-Laf-053947	Loxodonta africana	87.43	0.00e+00	953.00
IUUC-Mpu-066433	Mustela putorius furo	89.10	0.00e+00	961.00
IUUC-Mlu-067330	Myotis lucifugus	87.80	0.00e+00	952.00
IUUC-Nle-069084	Nomascus leucogenys	89.73	0.00e+00	791.00
IUUC-Ocu-074951	Oryctolagus cuniculus	86.98	0.00e+00	938.00
IUUC-Oga-088771	Otolemur garnettii	90.65	0.00e+00	989.00
IUUC-Oar-089610	Ovis aries	89.69	0.00e+00	937.00
IUUC-Pan-092253	Papio anubis	91.25	0.00e+00	951.00
IUUC-Pab-098324	Pongo abelii	89.68	0.00e+00	966.00
IUUC-Pca-100329	Procavia capensis	87.80	0.00e+00	946.00
IUUC-Pva-102721	Pteropus vampyrus	83.40	0.00e+00	880.00
IUUC-Sar-113174	Sorex araneus	84.96	0.00e+00	853.00
IUUC-Sre-115195	Sporisorium reilianum	25.68	2.00e-44	174.00
IUUC-Ssc-115315	Sus scrofa	90.82	0.00e+00	969.00
IUUC-Tsy-119413	Tarsius syrichta	66.79	0.00e+00	685.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence