iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Oan-072925

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAPN01322127

Gene Name

TNFAIP3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOANG00000014797.2	ENSOANT00000023308.2	ENSOANP00000023304.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/OTU	3.30e-38	131.4	121	290
UBD/ZnF/ZnF_A20	2.40e-21	75.6	792	824

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/OTU

   S: 2    lilktkgDGnCLlrAvsqsllgvfddds.lsdalveaLreltseyl....qkesdffsefieek........edekefcqklvepeak. 76
           ++lkt+gDGnCL++A+sq+++gv+d+d+ l++ l+ aL+e+ ++++    q+es + +ef+e++         +e+e++ k+++ ++  
   Q: 121  VALKTNGDGNCLMHAASQYMWGVQDTDLvLRKTLFGALKETDTRNFkfrwQNESIKSQEFVETGlrydtrnwDEEWENLVKMASADTSv 209
           789******************************************************************99999999999999999554 PP
   S: 77   g.........eeihifaLaqiLsrpiivvdvdsles..........kvggillpllfpeek.lkkpivLlYrsgHYdaLva 137
           +         eeihif+La+iL+rpii++++++l+s          kvggi+lpl++p+ + +++pivL+Y+s H+ +Lv+
   Q: 210  SrsalqynslEEIHIFVLANILRRPIIIISDKMLRSlesgssfsplKVGGIYLPLHWPAHEcYRYPIVLGYDSQHFVPLVT 290
           577999999**********************************************************************97 PP

UBD/ZnF/ZnF_A20

   S: 3    skllCkk.gCgfYGnpetngyCSkCyreelrrr 34
           +k++C++ +C++YGn ++ngyC++Cy+++++++
   Q: 792  PKQRCRAtACDHYGNTKCNGYCNECYQFKQMYG 824
           79*****************************96 PP

Organism

Ornithorhynchus anatinus

Protein Sequence
(Fasta)

MVPSGGKGAF CGADGSRGPR WGGAGSAMAE QPLLPPALYL SNLRKAVKIR ERTPGDLARP 60
ANGIIHHLKT MHRYSLEMFR TCQFGLPFRE VIHGALLDRT LQASLEDQKK LNWCREVRRL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TAGAAATGGA AGGTCCGGGG GCGGGGGGGG GCCAGCCAGA GCGGGCGGCC GGCCGGCGCG 60
CGACGGGGGA GCCCAGCGCC CGATGGTCCC GTCCGGCGGG AAGGGAGCGT TCTGCGGGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR033478--A20
IPR003323--OTU_dom
IPR002653--Znf_A20

PROSITE

PS50802--OTU
PS51036--ZF_A20

Pfam

PF02338--OTU
PF01754--zf-A20

SMART

SM00259--ZnF_A20

Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0070530--F:K63-linked polyubiquitin binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0001922--P:B-1 B cell homeostasis
GO:0070301--P:cellular response to hydrogen peroxide
GO:0072666--P:establishment of protein localization to vacuole
GO:0006955--P:immune response
GO:0050869--P:negative regulation of B cell activation
GO:2000349--P:negative regulation of CD40 signaling pathway
GO:0002677--P:negative regulation of chronic inflammatory response
GO:0045736--P:negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:2000352--P:negative regulation of endothelial cell apoptotic process
GO:1902042--P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045824--P:negative regulation of innate immune response
GO:0032691--P:negative regulation of interleukin-1 beta production
GO:0032703--P:negative regulation of interleukin-2 production
GO:0032715--P:negative regulation of interleukin-6 production
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0070429--P:negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
GO:0070433--P:negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0031397--P:negative regulation of protein ubiquitination
GO:0048662--P:negative regulation of smooth muscle cell proliferation
GO:0034140--P:negative regulation of toll-like receptor 3 signaling pathway
GO:0034148--P:negative regulation of toll-like receptor 5 signaling pathway
GO:0032720--P:negative regulation of tumor necrosis factor production
GO:1903364--P:positive regulation of cellular protein catabolic process
GO:2000347--P:positive regulation of hepatocyte proliferation
GO:0071947--P:protein deubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0035871--P:protein K11-linked deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0002634--P:regulation of germinal center formation
GO:0050727--P:regulation of inflammatory response
GO:0045088--P:regulation of innate immune response
GO:0032495--P:response to muramyl dipeptide
GO:0072573--P:tolerance induction to lipopolysaccharide

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001825	Ailuropoda melanoleuca	77.07	0.00e+00	1227.00
IUUC-Apl-003501	Anas platyrhynchos	67.17	0.00e+00	1064.00
IUUC-Aca-004245	Anolis carolinensis	64.79	0.00e+00	1076.00
IUUC-Ame-011789	Astyanax mexicanus	48.31	0.00e+00	696.00
IUUC-Bta-012664	Bos taurus	74.19	0.00e+00	1160.00
IUUC-Cja-019895	Callithrix jacchus	76.57	0.00e+00	1225.00
IUUC-Cfa-020754	Canis familiaris	77.07	0.00e+00	1231.00
IUUC-Cpo-021780	Cavia porcellus	74.72	0.00e+00	1199.00
IUUC-Csa-023568	Chlorocebus sabaeus	76.69	0.00e+00	1234.00
IUUC-Cho-024300	Choloepus hoffmanni	81.98	2.00e-171	595.00
IUUC-Dre-028577	Danio rerio	49.50	0.00e+00	695.00
IUUC-Dno-029382	Dasypus novemcinctus	72.85	0.00e+00	1149.00
IUUC-Dor-030874	Dipodomys ordii	72.43	0.00e+00	1147.00
IUUC-Ete-032721	Echinops telfairi	82.68	0.00e+00	698.00
IUUC-Eca-033596	Equus caballus	73.43	0.00e+00	1179.00
IUUC-Eeu-035159	Erinaceus europaeus	74.17	0.00e+00	923.00
IUUC-Fca-035847	Felis catus	77.19	0.00e+00	1228.00
IUUC-Fal-036681	Ficedula albicollis	66.38	0.00e+00	1093.00
IUUC-Gmo-038521	Gadus morhua	61.08	5.00e-147	514.00
IUUC-Gga-040975	Gallus gallus	66.17	0.00e+00	1090.00
IUUC-Gac-042216	Gasterosteus aculeatus	63.33	5.00e-154	537.00
IUUC-Ggo-045258	Gorilla gorilla	76.47	0.00e+00	1231.00
IUUC-Hsa-046071	Homo sapiens	76.57	0.00e+00	1233.00
IUUC-Itr-048386	Ictidomys tridecemlineatus	76.69	0.00e+00	1228.00
IUUC-Lch-050326	Latimeria chalumnae	58.45	0.00e+00	918.00
IUUC-Loc-051945	Lepisosteus oculatus	49.14	0.00e+00	631.00
IUUC-Laf-053722	Loxodonta africana	75.69	0.00e+00	1212.00
IUUC-Mcc-055503	Macaca mulatta	76.44	0.00e+00	1230.00
IUUC-Meu-056481	Macropus eugenii	71.83	0.00e+00	1135.00
IUUC-Mga-059690	Meleagris gallopavo	63.22	0.00e+00	984.00
IUUC-Mmr-061233	Microcebus murinus	75.25	0.00e+00	1184.00
IUUC-Mdo-062446	Monodelphis domestica	77.32	0.00e+00	1258.00
IUUC-Mmu-063436	Mus musculus	76.07	0.00e+00	1189.00
IUUC-Mpu-066808	Mustela putorius furo	77.32	0.00e+00	1239.00
IUUC-Mlu-067339	Myotis lucifugus	76.44	0.00e+00	1219.00
IUUC-Nle-069888	Nomascus leucogenys	76.57	0.00e+00	1231.00
IUUC-Opr-070303	Ochotona princeps	75.59	0.00e+00	1219.00
IUUC-Ont-072283	Oreochromis niloticus	61.37	2.00e-148	519.00
IUUC-Ocu-073889	Oryctolagus cuniculus	75.72	0.00e+00	1189.00
IUUC-Ola-087417	Oryzias latipes	61.12	3.00e-148	518.00
IUUC-Oga-088708	Otolemur garnettii	73.06	0.00e+00	1128.00
IUUC-Oar-089271	Ovis aries	75.06	0.00e+00	1184.00
IUUC-Ptr-091296	Pan troglodytes	76.57	0.00e+00	1232.00
IUUC-Pan-092474	Papio anubis	76.50	0.00e+00	1233.00
IUUC-Psi-093447	Pelodiscus sinensis	70.04	0.00e+00	1133.00
IUUC-Pfo-096511	Poecilia formosa	61.37	1.00e-149	522.00
IUUC-Pab-098700	Pongo abelii	76.44	0.00e+00	1229.00
IUUC-Pca-100246	Procavia capensis	63.28	0.00e+00	961.00
IUUC-Pva-102606	Pteropus vampyrus	69.37	1.00e-154	540.00
IUUC-Rno-105818	Rattus norvegicus	75.50	0.00e+00	1205.00
IUUC-Sha-106559	Sarcophilus harrisii	77.07	0.00e+00	1252.00
IUUC-Sar-113454	Sorex araneus	83.59	7.00e-169	587.00
IUUC-Ssc-116064	Sus scrofa	74.69	0.00e+00	1178.00
IUUC-Tgu-117212	Taeniopygia guttata	66.29	0.00e+00	1085.00
IUUC-Tru-118230	Takifugu rubripes	62.84	2.00e-153	535.00
IUUC-Tsy-119066	Tarsius syrichta	74.15	0.00e+00	1186.00
IUUC-Tni-119825	Tetraodon nigroviridis	48.04	0.00e+00	681.00
IUUC-Tbe-127601	Tupaia belangeri	86.32	7.00e-174	603.00
IUUC-Ttr-128930	Tursiops truncatus	74.19	0.00e+00	1181.00
IUUC-Vpa-130450	Vicugna pacos	84.83	0.00e+00	697.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence