iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMEG00000015135.1	ENSAMET00000016683.1	ENSAMEP00000016014.1
ENSAMEG00000015135.1	ENSAMET00000016691.1	ENSAMEP00000016022.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.10e-135	451.0	590	921

Active Site

Position(s)	Description	Evidence
891	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++ lk+rl++ef+ E+gld+gGv+re+++llske++np++glf+ys++d++tlq+np+sgl+n++hl++F+f+Gr+ g+a+++g+lld 
   Q: 590  PDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDG 678
           57899************************************************************************************ PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
           ++ ++fyk++lgk+++l+d+e+vd+e+y+slk+i+en   d +e  ldl+f+++ee++g+t++++Lkp+G++i+VtneNk+eY++lv++
   Q: 679  FFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILEN---DPTE--LDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQ 762
           ***********************************99...6666..7****************************************** PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +++++q++af eGf+e++p++l+++F+e+elell+cG  ++dv+d++++  yk+gy +++p+iqwFw+++  +++e+r ++LqFv
   Q: 763  WRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFV 851
           ***************************************************************************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           Tg+sr+P++Gfael     p+lf+i++++s+++lP+++TCfn+L+LP+Y++ e l+ekLl+A+e+++gFe
   Q: 852  TGTSRVPMNGFAELYgsngPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFE 921
           *********************************************************************8 PP

Organism

Ailuropoda melanoleuca

Protein Sequence
(Fasta)

PIKSQLFSYS DPYVKLSLYV ADENRELALV QTKTIKKTLN PKWNEEFYFR VNPSNHRLLF 60
EVFDENRLTR DDFLGQVDIP LSHLPTEDPT MERPYTFKDF LLRPRSHKSR VKGFLRLKMA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCCATTAAAT CTCAACTATT TTCTTACAGT GATCCATATG TGAAACTTTC ACTGTACGTA 60
GCGGATGAGA ATAGAGAACT CGCTTTGGTA CAGACAAAAA CAATTAAAAA GGTAGGTGTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005886--C:plasma membrane
GO:0019870--F:potassium channel inhibitor activity
GO:0019871--F:sodium channel inhibitor activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:1901017--P:negative regulation of potassium ion transmembrane transporter activity
GO:2000009--P:negative regulation of protein localization to cell surface
GO:2000650--P:negative regulation of sodium ion transmembrane transporter activity
GO:1903861--P:positive regulation of dendrite extension
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070936--P:protein K48-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0003254--P:regulation of membrane depolarization
GO:0060306--P:regulation of membrane repolarization
GO:0010038--P:response to metal ion

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003893	Anas platyrhynchos	92.36	0.00e+00	1664.00
IUUC-Aca-004744	Anolis carolinensis	88.87	0.00e+00	1592.00
IUUC-Acl-008273	Aspergillus clavatus	49.26	1.00e-163	570.00
IUUC-Afl-008713	Aspergillus flavus	49.01	3.00e-161	562.00
IUUC-Afu-009103	Aspergillus fumigatus	49.02	2.00e-163	570.00
IUUC-Ani-009259	Aspergillus nidulans	48.45	1.00e-161	563.00
IUUC-Ang-009738	Aspergillus niger	49.33	9.00e-162	563.00
IUUC-Aor-010053	Aspergillus oryzae	58.05	2.00e-101	362.00
IUUC-Ate-010529	Aspergillus terreus	49.42	2.00e-164	572.00
IUUC-Bta-012679	Bos taurus	96.01	0.00e+00	1579.00
IUUC-Cel-018564	Caenorhabditis elegans	52.53	0.00e+00	631.00
IUUC-Cja-018732	Callithrix jacchus	95.44	0.00e+00	1737.00
IUUC-Cfa-021226	Canis familiaris	96.50	0.00e+00	1721.00
IUUC-Cpo-021671	Cavia porcellus	97.94	0.00e+00	1713.00
IUUC-Csa-023344	Chlorocebus sabaeus	93.75	0.00e+00	1722.00
IUUC-Cho-024832	Choloepus hoffmanni	100.00	0.00e+00	742.00
IUUC-Cgl-026642	Colletotrichum gloeosporioides	47.66	2.00e-155	543.00
IUUC-Dre-027770	Danio rerio	77.70	0.00e+00	1368.00
IUUC-Dno-029466	Dasypus novemcinctus	95.54	0.00e+00	1738.00
IUUC-Dor-030138	Dipodomys ordii	94.42	0.00e+00	1639.00
IUUC-Dse-031241	Dothistroma septosporum	47.70	5.00e-160	558.00
IUUC-Ete-033145	Echinops telfairi	91.21	0.00e+00	1284.00
IUUC-Eca-033445	Equus caballus	97.03	0.00e+00	1582.00
IUUC-Eeu-035247	Erinaceus europaeus	91.58	0.00e+00	1512.00
IUUC-Fca-035489	Felis catus	93.67	0.00e+00	1517.00
IUUC-Fal-037604	Ficedula albicollis	89.80	0.00e+00	1638.00
IUUC-Fox-037774	Fusarium oxysporum	48.76	1.00e-158	553.00
IUUC-Fso-038393	Fusarium solani	47.41	1.00e-153	537.00
IUUC-Gmo-039674	Gadus morhua	75.97	0.00e+00	1325.00
IUUC-Ggr-040107	Gaeumannomyces graminis	47.75	7.00e-156	544.00
IUUC-Gga-040703	Gallus gallus	91.51	0.00e+00	1663.00
IUUC-Gac-042020	Gasterosteus aculeatus	78.76	0.00e+00	1359.00
IUUC-Ggo-045332	Gorilla gorilla	98.36	0.00e+00	1736.00
IUUC-Hsa-045968	Homo sapiens	95.75	0.00e+00	1734.00
IUUC-Lch-050443	Latimeria chalumnae	84.84	0.00e+00	1426.00
IUUC-Loc-052662	Lepisosteus oculatus	79.34	0.00e+00	1372.00
IUUC-Laf-053850	Loxodonta africana	98.37	0.00e+00	1757.00
IUUC-Mcc-055821	Macaca mulatta	95.54	0.00e+00	1733.00
IUUC-Meu-056712	Macropus eugenii	84.73	0.00e+00	788.00
IUUC-Mor-057097	Magnaporthe oryzae	47.75	2.00e-156	546.00
IUUC-Mla-058996	Melampsora laricipopulina	53.94	2.00e-149	523.00
IUUC-Mmr-060798	Microcebus murinus	91.53	0.00e+00	1607.00
IUUC-Mdo-062173	Monodelphis domestica	92.72	0.00e+00	1711.00
IUUC-Mmu-064136	Mus musculus	94.70	0.00e+00	1697.00
IUUC-Mpu-066765	Mustela putorius furo	96.71	0.00e+00	1719.00
IUUC-Mlu-067565	Myotis lucifugus	93.40	0.00e+00	1552.00
IUUC-Nfi-068427	Neosartorya fischeri	49.02	8.00e-164	570.00
IUUC-Ncr-068918	Neurospora crassa	47.40	2.00e-157	549.00
IUUC-Nle-069070	Nomascus leucogenys	91.73	0.00e+00	1639.00
IUUC-Opr-071044	Ochotona princeps	99.52	0.00e+00	1210.00
IUUC-Ont-072044	Oreochromis niloticus	76.49	0.00e+00	1389.00
IUUC-Oan-073032	Ornithorhynchus anatinus	90.62	0.00e+00	1397.00
IUUC-Ocu-074160	Oryctolagus cuniculus	96.42	0.00e+00	1686.00
IUUC-Ola-087467	Oryzias latipes	77.78	0.00e+00	1373.00
IUUC-Oga-088460	Otolemur garnettii	91.33	0.00e+00	1549.00
IUUC-Oar-090198	Ovis aries	95.54	0.00e+00	1699.00
IUUC-Ptr-090939	Pan troglodytes	95.75	0.00e+00	1734.00
IUUC-Pan-092284	Papio anubis	95.54	0.00e+00	1731.00
IUUC-Psi-093645	Pelodiscus sinensis	92.14	0.00e+00	1658.00
IUUC-Pma-094364	Petromyzon marinus	82.63	0.00e+00	861.00
IUUC-Pno-095118	Phaeosphaeria nodorum	50.00	5.00e-163	568.00
IUUC-Pfo-096768	Poecilia formosa	90.98	0.00e+00	960.00
IUUC-Pab-098088	Pongo abelii	95.75	0.00e+00	1734.00
IUUC-Pca-100714	Procavia capensis	77.81	0.00e+00	1321.00
IUUC-Pva-102354	Pteropus vampyrus	98.58	0.00e+00	1708.00
IUUC-Pgr-103620	Puccinia graminis	53.53	1.00e-147	516.00
IUUC-Ptt-103806	Puccinia triticina	53.38	1.00e-122	433.00
IUUC-Pte-104016	Pyrenophora teres	49.00	3.00e-162	565.00
IUUC-Pyt-104550	Pyrenophora triticirepentis	49.00	3.00e-162	565.00
IUUC-Rno-105318	Rattus norvegicus	95.02	0.00e+00	1698.00
IUUC-Sce-106289	Saccharomyces cerevisiae	49.25	5.00e-164	571.00
IUUC-Sha-107482	Sarcophilus harrisii	94.67	0.00e+00	1574.00
IUUC-Ssc-115950	Sus scrofa	71.75	0.00e+00	1170.00
IUUC-Tgu-117130	Taeniopygia guttata	92.14	0.00e+00	1666.00
IUUC-Tru-118610	Takifugu rubripes	78.83	0.00e+00	1404.00
IUUC-Tsy-119492	Tarsius syrichta	93.95	0.00e+00	1651.00
IUUC-Tni-120113	Tetraodon nigroviridis	74.06	0.00e+00	1335.00
IUUC-Tvi-122595	Trichoderma virens	47.27	4.00e-154	538.00
IUUC-Tbe-127441	Tupaia belangeri	95.21	0.00e+00	811.00
IUUC-Ttr-128235	Tursiops truncatus	92.68	0.00e+00	1571.00
IUUC-Vda-129753	Verticillium dahliae	47.85	6.00e-157	547.00
IUUC-Vpa-130544	Vicugna pacos	80.32	0.00e+00	922.00
IUUC-Xtr-132859	Xenopus tropicalis	88.12	0.00e+00	1590.00
IUUC-Xma-133797	Xiphophorus maculatus	79.29	0.00e+00	1390.00
IUUC-Yli-134668	Yarrowia lipolytica	46.42	4.00e-162	565.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence