iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Gga-041016

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AADN04000009

Gene Name

VHL

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGALG00000028009.3	ENSGALT00000043151.3	ENSGALP00000043081.3

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	28.32	1.00e-03	39.70	IUUC-Dme-031988
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	69.93	3.00e-54	208.00	IUUC-Hsa-046547

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Gallus gallus

Protein Sequence
(Fasta)

MRDSLPVSGR LRARVLPSRG RAAGMAPPGP GPAGPCLRSA NTRELSEVVF NNRSPRAVLP 60
IWVDFEGRPR YYPVLRPRTG RIMHSYRGHL WLFRDAGTHD GLLVNRQELF VAAPDVNKAD 120

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Nucleotide Sequence
(Fasta)

ATGCGTGACT CCCTGCCCGT CTCCGGGCGC CTCCGCGCAC GCGTGTTGCC GTCGCGGGGC 60
CGCGCAGCCG GGATGGCGCC GCCGGGTCCG GGTCCCGCCG GGCCGTGCCT GCGCTCCGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR002714--VHL
IPR024048--VHL_alpha_dom
IPR024053--VHL_beta_dom
IPR022772--VHL_tumour_suppress_b/a_dom

Pfam

PF01847--VHL
PF17211--VHL_C

Gene Ontology

GO:0005929--C:cilium
GO:0031462--C:Cul2-RING ubiquitin ligase complex
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0030891--C:VCB complex
GO:0061630--F:ubiquitin protein ligase activity
GO:0001525--P:angiogenesis
GO:0043534--P:blood vessel endothelial cell migration
GO:0061073--P:ciliary body morphogenesis
GO:0030198--P:extracellular matrix organization
GO:0048069--P:eye pigmentation
GO:0048877--P:homeostasis of number of retina cells
GO:0061072--P:iris morphogenesis
GO:0006582--P:melanin metabolic process
GO:0045602--P:negative regulation of endothelial cell differentiation
GO:0010629--P:negative regulation of gene expression
GO:1902072--P:negative regulation of hypoxia-inducible factor-1alpha signaling pathway
GO:0070244--P:negative regulation of thymocyte apoptotic process
GO:0006607--P:NLS-bearing protein import into nucleus
GO:0003310--P:pancreatic A cell differentiation
GO:0050679--P:positive regulation of epithelial cell proliferation
GO:0010498--P:proteasomal protein catabolic process
GO:0016567--P:protein ubiquitination
GO:2001233--P:regulation of apoptotic signaling pathway
GO:1903827--P:regulation of cellular protein localization
GO:0003309--P:type B pancreatic cell differentiation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002327	Ailuropoda melanoleuca	61.11	9.00e-44	169.00
IUUC-Apl-003580	Anas platyrhynchos	86.59	5.00e-37	144.00
IUUC-Aca-004492	Anolis carolinensis	70.63	1.00e-47	181.00
IUUC-Ame-011818	Astyanax mexicanus	48.57	2.00e-34	138.00
IUUC-Bta-013459	Bos taurus	70.42	3.00e-54	204.00
IUUC-Cel-018173	Caenorhabditis elegans	25.60	1.20e-02	32.30
IUUC-Cja-019826	Callithrix jacchus	69.72	9.00e-55	206.00
IUUC-Cfa-021280	Canis familiaris	67.61	3.00e-52	197.00
IUUC-Cpo-022544	Cavia porcellus	68.31	1.00e-53	202.00
IUUC-Cre-022809	Chlamydomonas reinhardtii	32.84	2.70e-02	32.70
IUUC-Csa-023644	Chlorocebus sabaeus	69.72	2.00e-54	205.00
IUUC-Cho-024479	Choloepus hoffmanni	46.34	7.00e-24	102.00
IUUC-Cin-025505	Ciona intestinalis	26.79	1.00e-05	42.40
IUUC-Cme-027232	Cyanidioschyzon merolae	31.43	2.00e-05	42.00
IUUC-Dre-028350	Danio rerio	44.97	2.00e-23	101.00
IUUC-Dno-029207	Dasypus novemcinctus	72.22	2.00e-33	134.00
IUUC-Dor-030912	Dipodomys ordii	46.62	1.00e-30	125.00
IUUC-Dme-031988	Drosophila melanogaster	28.32	1.00e-04	39.30
IUUC-Eca-034007	Equus caballus	65.00	7.00e-10	54.70
IUUC-Fca-036350	Felis catus	67.36	1.00e-51	196.00
IUUC-Fal-037192	Ficedula albicollis	79.73	8.00e-68	248.00
IUUC-Gmo-038921	Gadus morhua	56.94	4.00e-38	150.00
IUUC-Gac-042560	Gasterosteus aculeatus	49.32	4.00e-35	140.00
IUUC-Ggo-045419	Gorilla gorilla	69.93	5.00e-55	206.00
IUUC-Hsa-046547	Homo sapiens	69.93	6.00e-55	206.00
IUUC-Itr-048225	Ictidomys tridecemlineatus	69.01	3.00e-54	203.00
IUUC-Lch-050463	Latimeria chalumnae	54.29	2.00e-40	157.00
IUUC-Loc-052053	Lepisosteus oculatus	53.57	6.00e-39	152.00
IUUC-Laf-053893	Loxodonta africana	64.47	7.00e-53	199.00
IUUC-Mcc-055347	Macaca mulatta	57.89	6.00e-36	143.00
IUUC-Mdo-062169	Monodelphis domestica	59.78	1.00e-24	103.00
IUUC-Mmu-064366	Mus musculus	69.57	5.00e-53	199.00
IUUC-Mpu-066593	Mustela putorius furo	68.31	2.00e-53	201.00
IUUC-Mlu-066926	Myotis lucifugus	70.42	7.00e-55	206.00
IUUC-Nle-069724	Nomascus leucogenys	69.72	2.00e-54	204.00
IUUC-Opr-070679	Ochotona princeps	69.01	2.00e-52	197.00
IUUC-Ont-071332	Oreochromis niloticus	47.65	3.00e-35	140.00
IUUC-Ola-086869	Oryzias latipes	49.32	2.00e-34	137.00
IUUC-Oga-089124	Otolemur garnettii	68.75	4.00e-53	200.00
IUUC-Oar-089799	Ovis aries	72.53	2.00e-33	133.00
IUUC-Ptr-091186	Pan troglodytes	73.12	2.00e-34	137.00
IUUC-Pan-092150	Papio anubis	69.72	4.00e-54	203.00
IUUC-Psi-094039	Pelodiscus sinensis	61.22	1.00e-43	168.00
IUUC-Pma-094129	Petromyzon marinus	41.22	5.00e-22	97.10
IUUC-Pfo-096892	Poecilia formosa	48.20	1.00e-31	128.00
IUUC-Pab-097822	Pongo abelii	69.72	2.00e-54	204.00
IUUC-Pca-101058	Procavia capensis	66.00	2.00e-50	191.00
IUUC-Pva-102932	Pteropus vampyrus	69.01	6.00e-54	203.00
IUUC-Rno-105050	Rattus norvegicus	67.11	3.00e-55	207.00
IUUC-Sha-106738	Sarcophilus harrisii	69.23	6.00e-32	128.00
IUUC-Ssc-115973	Sus scrofa	66.45	4.00e-53	200.00
IUUC-Tgu-116663	Taeniopygia guttata	79.00	1.00e-42	164.00
IUUC-Tru-118654	Takifugu rubripes	53.28	1.00e-36	145.00
IUUC-Ttr-128418	Tursiops truncatus	69.72	6.00e-54	202.00
IUUC-Vpa-130268	Vicugna pacos	58.70	3.00e-25	107.00
IUUC-Xtr-132506	Xenopus tropicalis	59.57	1.00e-44	171.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence