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Tag Content
UUCD2 ID IUUC-Xtr-132185
UUCD1 version UUC-XeT-00568
Ensembl Protein ID ENSXETP00000008985.2
UniProt Accession F7A4S9; F7A4S9_XENTR
Genbank Protein ID ENSXETP00000008985
Protein Name HECT and RLD domain-containing E3 ubiquitin protein ligase 2
Genbank Nucleotide ID AAMC01064616
Gene Name herc2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSXETG00000004148.3 ENSXETT00000008985.2 ENSXETP00000008985.2
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/HECT 1.90e-81 274.2 4472 4801
Active Site
Position(s) Description Evidence
4770 Glycyl thioester intermediate {ECO:0000256|PROSITE-ProRule:PRU00104}
Domain Profile

   E3 activity/HECT
   S: 7    krlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknp.....ehlklFeflGrllgkalqdgrll 88
           ++++v+fvgE++ d+gG  +e +a++++elqn  ++l+  ++n++ +   n+d +l np      h+++F+flG l  +++ +g   
   Q: 4472 RVWKVKFVGESVDDCGGGYSESIAEMCEELQNGLTPLLIVTPNGRDESGANRDCFLLNPaakttLHMNMFRFLGSLWHISICEGGNF 4558
           4566******************************************************9***99*********************** PP
   S: 89   dlplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvk 175
             +++++++k+l g +l++ dl+evd++++  l++i++n+ ++ e +++ l f+     +++++ +++  +++++++t +N+ eYv+
   Q: 4559 SSNFAEPVWKQLAGMNLTIADLSEVDKDFIPGLMYIRDNEATSEEFEAMILPFT-----VPSASGQDIQLSSKHTHITLDNRAEYVR 4640
           ***************************************988888888999998.....888999999******************* PP
   S: 176  lvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerk 262
           l + yrl+e ++eqv+a+reG+ +v+p  llslFt  ele+++cG+++i ++ lk+ ++ykg ++++ + iqwFw+v+e+fs++er+
   Q: 4641 LAIGYRLHE-FDEQVAAVREGMARVVPVPLLSLFTGYELETMVCGSPDIPLHLLKSVATYKG-IEPTASLIQWFWDVMESFSNTERS 4725
           *********.**************************************************77.************************ PP
   S: 263  afLqFvTgssrlPlgGfaelkprlfvirk....dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
            fL+Fv+g+ rlP + +a+++ r fvi+     +  d+ lP+s TCf++LkLP+Ys k++l+ekL yAi+ +k++++
   Q: 4726 LFLRFVWGRTRLP-RTIADFRGRDFVIQVldkyNPPDHFLPESYTCFFLLKLPRYSCKQVLEEKLKYAIHFCKSIDT 4801
           *************.8*************999988888***********************************99875 PP
   
Organism Xenopus tropicalis
Protein Sequence
(Fasta)
MSSECFNLVA QSRFDSKWLK TDLQLAFTRD GFCSLWNEMV KDGEIVYTGT DATQTGDLPS 60
RKDEINEAQS SSKKEDQNDK EKKEDDEILA PNYKAKTIME SWVWGRQPDV NELKECLYTL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Xtr-132185|E3,HECT|Xenopus tropicalis
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGTCTTCTG AATGTTTCAA CTTAGTTGCA CAATCAAGGT TTGATTCCAA ATGGCTGAAG 60
ACGGACCTGC AGGTAAAGTA TTTTATTGGC ATGTGATGAT TTTTGTATTT TGGAATTTTG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Xtr-132185|E3,HECT|Xenopus tropicalis
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR004939--APC_su10/DOC_dom
IPR006624--Beta-propeller_rpt_TECPR
IPR016186--C-type_lectin-like/link
IPR021097--CPH_domain
IPR001199--Cyt_B5-like_heme/steroid-bd
IPR008979--Galactose-bd-like
IPR000569--HECT_dom
IPR010606--Mib_Herc2
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens
IPR014722--Rib_L2_dom2
IPR000433--Znf_ZZ
PROSITE

PS50255--CYTOCHROME_B5_2
PS51284--DOC
PS50237--HECT
PS51416--MIB_HERC2
PS00626--RCC1_2
PS50012--RCC1_3
PS01357--ZF_ZZ_1
PS50135--ZF_ZZ_2
Pfam

PF03256--ANAPC10
PF11515--Cul7
PF00173--Cyt-b5
PF00632--HECT
PF06701--MIB_HERC2
PF00415--RCC1
PF00569--ZZ
PRINTS

PR00633--RCCNDNSATION
SMART

SM01337--APC10
SM01117--Cyt-b5
SM00119--HECTc
SM00706--TECPR
SM00291--ZnF_ZZ
Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002112 Ailuropoda melanoleuca 86.29 0.00e+00 6433.00
IUUC-Apl-003983 Anas platyrhynchos 88.72 0.00e+00 8089.00
IUUC-Aca-004300 Anolis carolinensis 87.97 0.00e+00 8045.00
IUUC-Ame-010621 Astyanax mexicanus 84.46 0.00e+00 6801.00
IUUC-Bta-013067 Bos taurus 85.29 0.00e+00 7721.00
IUUC-Bdi-014093 Brachypodium distachyon 35.10 5.00e-45 176.00
IUUC-Cja-019687 Callithrix jacchus 84.60 0.00e+00 7587.00
IUUC-Cfa-020672 Canis familiaris 85.68 0.00e+00 7787.00
IUUC-Cpo-021819 Cavia porcellus 83.80 0.00e+00 7616.00
IUUC-Csa-023817 Chlorocebus sabaeus 85.90 0.00e+00 7782.00
IUUC-Cho-024387 Choloepus hoffmanni 80.13 0.00e+00 1638.00
IUUC-Cin-025709 Ciona intestinalis 53.26 0.00e+00 2123.00
IUUC-Csv-026336 Ciona savignyi 43.73 0.00e+00 2477.00
IUUC-Dre-027717 Danio rerio 81.14 0.00e+00 7124.00
IUUC-Dno-029296 Dasypus novemcinctus 86.17 0.00e+00 7778.00
IUUC-Dor-030979 Dipodomys ordii 79.14 0.00e+00 2520.00
IUUC-Dme-032171 Drosophila melanogaster 36.34 0.00e+00 1369.00
IUUC-Ete-032687 Echinops telfairi 75.30 0.00e+00 2510.00
IUUC-Eca-034046 Equus caballus 85.25 0.00e+00 7730.00
IUUC-Eeu-034859 Erinaceus europaeus 83.46 0.00e+00 1785.00
IUUC-Fca-036262 Felis catus 85.72 0.00e+00 7806.00
IUUC-Fal-037562 Ficedula albicollis 88.75 0.00e+00 8046.00
IUUC-Gmo-039054 Gadus morhua 85.89 0.00e+00 1082.00
IUUC-Gga-040359 Gallus gallus 88.77 0.00e+00 8061.00
IUUC-Gac-041879 Gasterosteus aculeatus 88.97 0.00e+00 1022.00
IUUC-Ggo-044692 Gorilla gorilla 90.32 0.00e+00 4001.00
IUUC-Hsa-045995 Homo sapiens 86.09 0.00e+00 7836.00
IUUC-Itr-048553 Ictidomys tridecemlineatus 81.46 0.00e+00 2095.00
IUUC-Lch-049808 Latimeria chalumnae 87.55 0.00e+00 3382.00
IUUC-Loc-052685 Lepisosteus oculatus 83.48 0.00e+00 7442.00
IUUC-Laf-053372 Loxodonta africana 85.12 0.00e+00 7712.00
IUUC-Mcc-054693 Macaca mulatta 85.94 0.00e+00 7813.00
IUUC-Meu-056660 Macropus eugenii 95.43 0.00e+00 1906.00
IUUC-Mga-059371 Meleagris gallopavo 89.11 0.00e+00 6947.00
IUUC-Mmr-060787 Microcebus murinus 86.15 0.00e+00 7888.00
IUUC-Mdo-062518 Monodelphis domestica 85.52 0.00e+00 7699.00
IUUC-Mmu-063690 Mus musculus 85.33 0.00e+00 7751.00
IUUC-Mpu-066478 Mustela putorius furo 85.38 0.00e+00 7737.00
IUUC-Mlu-067596 Myotis lucifugus 82.35 0.00e+00 3970.00
IUUC-Nle-069445 Nomascus leucogenys 82.98 0.00e+00 1902.00
IUUC-Opr-070990 Ochotona princeps 84.18 0.00e+00 2861.00
IUUC-Ont-072285 Oreochromis niloticus 82.38 0.00e+00 7259.00
IUUC-Oan-072721 Ornithorhynchus anatinus 84.95 0.00e+00 3378.00
IUUC-Ocu-074273 Oryctolagus cuniculus 85.17 0.00e+00 7752.00
IUUC-Ola-087346 Oryzias latipes 90.94 0.00e+00 1174.00
IUUC-Oga-088742 Otolemur garnettii 85.48 0.00e+00 7712.00
IUUC-Oar-090093 Ovis aries 85.45 0.00e+00 7746.00
IUUC-Ptr-091034 Pan troglodytes 81.92 0.00e+00 5151.00
IUUC-Pan-092783 Papio anubis 83.92 0.00e+00 7610.00
IUUC-Psi-094027 Pelodiscus sinensis 88.59 0.00e+00 7715.00
IUUC-Pfo-096208 Poecilia formosa 79.32 0.00e+00 5908.00
IUUC-Pab-097681 Pongo abelii 79.93 0.00e+00 2246.00
IUUC-Pca-100705 Procavia capensis 89.35 0.00e+00 1100.00
IUUC-Pva-103147 Pteropus vampyrus 76.68 0.00e+00 2220.00
IUUC-Rno-105458 Rattus norvegicus 85.28 0.00e+00 7737.00
IUUC-Sha-106959 Sarcophilus harrisii 78.74 0.00e+00 6708.00
IUUC-Sar-113532 Sorex araneus 73.69 0.00e+00 1660.00
IUUC-Sbi-114352 Sorghum bicolor 32.07 3.00e-47 183.00
IUUC-Ssc-115337 Sus scrofa 80.35 0.00e+00 2598.00
IUUC-Tgu-116789 Taeniopygia guttata 88.51 0.00e+00 8039.00
IUUC-Tru-118129 Takifugu rubripes 81.91 0.00e+00 7268.00
IUUC-Tsy-119302 Tarsius syrichta 77.34 0.00e+00 1155.00
IUUC-Tni-120374 Tetraodon nigroviridis 80.35 0.00e+00 7145.00
IUUC-Tbe-128137 Tupaia belangeri 77.33 0.00e+00 2058.00
IUUC-Ttr-128273 Tursiops truncatus 81.15 0.00e+00 2509.00
IUUC-Vpa-130471 Vicugna pacos 72.10 0.00e+00 1303.00
IUUC-Xma-133233 Xiphophorus maculatus 81.73 0.00e+00 7232.00
Created Date 25-Jun-2017

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