iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000160410.14	ENST00000291842.9	ENSP00000291842.4
ENSG00000160410.14	ENST00000595803.5	ENSP00000470514.1
ENSG00000160410.14	ENST00000600733.5	ENSP00000472711.1
ENSG00000160410.14	ENST00000595945.5	ENSP00000469878.1
ENSG00000160410.14	ENST00000599575.5	ENSP00000472813.1
ENSG00000160410.14	ENST00000600718.5	ENSP00000471406.1
ENSG00000160410.14	ENST00000595631.5	ENSP00000469014.1
ENSG00000160410.14	ENST00000595523.5	ENSP00000468885.1
ENSG00000160410.14	ENST00000602011.5	ENSP00000470517.1
ENSG00000160410.14	ENST00000593764.5	ENSP00000471173.1
ENSG00000160410.14	ENST00000600320.5	ENSP00000469713.1
ENSG00000160410.14	ENST00000594298.5	ENSP00000471296.1
ENSG00000160410.14	ENST00000596163.5	ENSP00000472222.1
ENSG00000160410.14	ENST00000597396.5	ENSP00000471408.1
ENSG00000160410.14	ENST00000595726.1	ENSP00000470505.1
ENSG00000160410.14	ENST00000594862.1	ENSP00000471845.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	miRNAMap	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Variation
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	UniProt	BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	1.20e-08	36.9	22	85
E3 adaptor/Cullin RING/DCX/DWD	1.20e-06	30.3	429	461

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 4    ilvvggeeffahkivLaas.SsvFyalflmele.esksklmveikdvqpevfrallkFlYtgkld 66
            l+vgg++f++ + +L+    s+F++l+++  +  +++++ + i+ ++p+vf  +l+Fl+t++ld
   Q: 22   HLNVGGKRFSTSRQTLTWIpDSFFSSLLSGRIStLKDETGAIFID-RDPTVFAPILNFLRTKELD 85
           69****************99*************9999********.*****************98 PP

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclafsd.tllvsGsdDgtikvWDlrtg 33
           H ++vt + +s+ +l+++++d++ ++ W+++++
   Q: 429  HRSPVTKIMLSEkHLISVCADNNHVRTWSVTRF 461
           99******9988566677888888*****9976 PP

Organism

Homo sapiens

Functional Description
(View)

Inhibits CBL-SH3KBP1 complex mediated down-regulation of EGFR signaling by sequestration of SH3KBP1. Binds to SH3KBP1 and prevents its interaction with CBL and inhibits translocation of SH3KBP1 to EGFR containing vesicles upon EGF stimulation.

Protein Sequence
(Fasta)

MAAAATAAEG VPSRGPPGEV IHLNVGGKRF STSRQTLTWI PDSFFSSLLS GRISTLKDET 60
GAIFIDRDPT VFAPILNFLR TKELDPRGVH GSSLLHEAQF YGLTPLVRRL QLREELDRSS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGTGCACAC CCGGAAGTGG GTGCGGGCCA GCCGGCTCGC CCGGGGGCCA TGGCAGCAGC 60
GGCTACTGCA GCCGAGGGGG TCCCCAGTCG GGGGCCTCCC GGGGAAGTCA TTCATCTGAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0458--Lysosome
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR000210--BTB/POZ_dom
IPR011333--SKP1/BTB/POZ
IPR003131--T1-type_BTB
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS50097--BTB
PS00678--WD_REPEATS_1

Pfam

PF02214--BTB_2

SMART

SM00225--BTB
SM00320--WD40

Gene Ontology

GO:0045742--P:positive regulation of epidermal growth factor receptor signaling pathway
GO:0051260--P:protein homooligomerization

KEGG

hsa:92799

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002379	Ailuropoda melanoleuca	89.41	0.00e+00	1127.00
IUUC-Aca-004906	Anolis carolinensis	73.99	0.00e+00	961.00
IUUC-Ath-006820	Arabidopsis thaliana	38.54	6.00e-09	55.50
IUUC-Afl-008395	Aspergillus flavus	27.55	1.00e-05	44.30
IUUC-Ame-011252	Astyanax mexicanus	68.78	0.00e+00	869.00
IUUC-Bta-012690	Bos taurus	95.79	0.00e+00	1180.00
IUUC-Bci-013656	Botrytis cinerea	37.96	8.00e-10	57.40
IUUC-Bol-016458	Brassica oleracea	40.00	8.00e-09	55.10
IUUC-Cja-018763	Callithrix jacchus	96.61	0.00e+00	1342.00
IUUC-Cfa-020543	Canis familiaris	93.49	0.00e+00	1174.00
IUUC-Cpo-021962	Cavia porcellus	91.65	0.00e+00	1190.00
IUUC-Dre-027729	Danio rerio	74.17	0.00e+00	963.00
IUUC-Dno-028972	Dasypus novemcinctus	91.30	0.00e+00	1110.00
IUUC-Dor-030553	Dipodomys ordii	93.64	0.00e+00	1126.00
IUUC-Dme-031935	Drosophila melanogaster	50.38	0.00e+00	662.00
IUUC-Eca-033315	Equus caballus	98.43	0.00e+00	1129.00
IUUC-Eeu-035311	Erinaceus europaeus	93.55	0.00e+00	1021.00
IUUC-Fca-036552	Felis catus	93.42	0.00e+00	1199.00
IUUC-Fso-038119	Fusarium solani	32.67	2.00e-06	47.40
IUUC-Gmo-039368	Gadus morhua	74.87	0.00e+00	902.00
IUUC-Gac-041846	Gasterosteus aculeatus	70.74	0.00e+00	941.00
IUUC-Ggo-045623	Gorilla gorilla	81.89	0.00e+00	999.00
IUUC-Itr-048663	Ictidomys tridecemlineatus	96.66	0.00e+00	1179.00
IUUC-Loc-051959	Lepisosteus oculatus	68.74	0.00e+00	973.00
IUUC-Laf-054452	Loxodonta africana	86.59	0.00e+00	989.00
IUUC-Mcc-055544	Macaca mulatta	98.87	0.00e+00	1273.00
IUUC-Meu-056159	Macropus eugenii	89.24	0.00e+00	1066.00
IUUC-Mmr-061709	Microcebus murinus	97.17	0.00e+00	1212.00
IUUC-Mdo-062553	Monodelphis domestica	81.74	0.00e+00	1070.00
IUUC-Mmu-063367	Mus musculus	92.79	0.00e+00	1232.00
IUUC-Mpu-066614	Mustela putorius furo	94.47	0.00e+00	1150.00
IUUC-Nle-069872	Nomascus leucogenys	95.33	0.00e+00	1223.00
IUUC-Opr-070600	Ochotona princeps	80.40	0.00e+00	977.00
IUUC-Ont-071375	Oreochromis niloticus	75.92	0.00e+00	946.00
IUUC-Oga-088526	Otolemur garnettii	96.18	0.00e+00	1227.00
IUUC-Oar-089898	Ovis aries	93.93	0.00e+00	1170.00
IUUC-Ptr-091353	Pan troglodytes	96.04	0.00e+00	1294.00
IUUC-Pan-091730	Papio anubis	98.86	0.00e+00	1269.00
IUUC-Pfo-097224	Poecilia formosa	73.49	0.00e+00	947.00
IUUC-Pab-098142	Pongo abelii	96.07	0.00e+00	1246.00
IUUC-Pca-100847	Procavia capensis	86.01	0.00e+00	949.00
IUUC-Pva-102652	Pteropus vampyrus	98.43	0.00e+00	1153.00
IUUC-Rno-104907	Rattus norvegicus	91.94	0.00e+00	1241.00
IUUC-Stu-112405	Solanum tuberosum	39.18	3.00e-10	59.70
IUUC-Sar-113577	Sorex araneus	80.23	0.00e+00	928.00
IUUC-Tru-118507	Takifugu rubripes	69.90	0.00e+00	972.00
IUUC-Tni-120814	Tetraodon nigroviridis	71.64	0.00e+00	943.00
IUUC-Tre-121919	Trichoderma reesei	32.00	3.00e-06	46.60
IUUC-Tvi-122427	Trichoderma virens	32.80	9.00e-07	48.50
IUUC-Vda-129852	Verticillium dahliae	32.84	1.00e-04	40.80
IUUC-Xtr-132155	Xenopus tropicalis	71.47	0.00e+00	967.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence