iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ame-011004

Ensembl Protein ID

ENSAMXP00000021115.1

UniProt Accession

W5LMQ3; W5LMQ3_ASTMX

Genbank Protein ID

ENSAMXP00000021115

Protein Name

Phosphoinositide phospholipase C

Genbank Nucleotide ID

APWO01022169

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMXG00000020468.1	ENSAMXT00000021115.1	ENSAMXP00000021115.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.00e-11	44.8	770	828

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 2    skekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGl.fPenFvekle 63
           +k +v+++y+y+aq ddeL++ k  +++ +  ++q++gW+kg  +  gk+ l fP+n+ve+++
   Q: 770  FKCTVKAMYEYKAQRDDELSFSKNSIIQNV--DKQEGGWWKG--DFGGKKQLwFPANYVEEIS 828
           6779*************************9..9*********..777777766*******986 PP

Organism

Astyanax mexicanus

Protein Sequence
(Fasta)

VAMAAAFFSS NGPVPWTPSD TELNSIYRDL ELGTVLTLFY SKKSQRPERR TFQVKLETRQ 60
IIWTRGTDKI EGEIDIREIK EIRQGQKSRD FDRYLEDASA RTDQAHCFVI LYGTEFRLKS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGGCCATGG CTGCCGCCTT CTTCTCCTCC AACGGCCCAG TGCCGTGGAC CCCCAGCGAC 60
ACGGAGCTCA ACAGCATCTA CCGGGACCTG GAGCTGGGAA CTGTGCTGAC TCTTTTCTAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0442--Lipid degradation
KW-0443--Lipid metabolism
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0807--Transducer

Interpro

IPR000008--C2_dom
IPR011992--EF-hand-dom_pair
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR001192--PI-PLC_fam
IPR016279--PLC-gamma
IPR028380--PLC-gamma1
IPR017946--PLC-like_Pdiesterase_TIM-brl
IPR000909--PLipase_C_PInositol-sp_X_dom
IPR001711--PLipase_C_Pinositol-sp_Y
IPR000980--SH2
IPR001452--SH3_domain

PROSITE

PS50004--C2
PS50003--PH_DOMAIN
PS50007--PIPLC_X_DOMAIN
PS50008--PIPLC_Y_DOMAIN
PS50001--SH2
PS50002--SH3

Pfam

PF00168--C2
PF00388--PI-PLC-X
PF00387--PI-PLC-Y
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00390--PHPHLIPASEC
PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00239--C2
SM00233--PH
SM00148--PLCXc
SM00149--PLCYc
SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005622--C:intracellular
GO:0004435--F:phosphatidylinositol phospholipase C activity
GO:0004871--F:signal transducer activity
GO:0001525--P:angiogenesis
GO:0048844--P:artery morphogenesis
GO:0031101--P:fin regeneration
GO:0030851--P:granulocyte differentiation
GO:0060218--P:hematopoietic stem cell differentiation
GO:0035556--P:intracellular signal transduction
GO:0009395--P:phospholipid catabolic process
GO:0035477--P:regulation of angioblast cell migration involved in selective angioblast sprouting
GO:0008016--P:regulation of heart contraction
GO:0001570--P:vasculogenesis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001452	Ailuropoda melanoleuca	68.86	0.00e+00	1825.00
IUUC-Apl-003541	Anas platyrhynchos	61.82	0.00e+00	1556.00
IUUC-Aca-005291	Anolis carolinensis	68.47	0.00e+00	1809.00
IUUC-Bta-012660	Bos taurus	69.15	0.00e+00	1720.00
IUUC-Cja-019206	Callithrix jacchus	68.93	0.00e+00	1813.00
IUUC-Cfa-020257	Canis familiaris	69.63	0.00e+00	1745.00
IUUC-Cpo-022391	Cavia porcellus	65.30	0.00e+00	1676.00
IUUC-Csa-024170	Chlorocebus sabaeus	69.08	0.00e+00	1297.00
IUUC-Cin-025520	Ciona intestinalis	45.53	0.00e+00	1030.00
IUUC-Dre-027944	Danio rerio	78.62	0.00e+00	2004.00
IUUC-Dno-029440	Dasypus novemcinctus	69.12	0.00e+00	1655.00
IUUC-Dor-031001	Dipodomys ordii	68.82	0.00e+00	1819.00
IUUC-Eca-033809	Equus caballus	69.47	0.00e+00	1743.00
IUUC-Fca-036510	Felis catus	69.63	0.00e+00	1749.00
IUUC-Fal-037541	Ficedula albicollis	69.11	0.00e+00	1628.00
IUUC-Gmo-038630	Gadus morhua	67.81	0.00e+00	1432.00
IUUC-Gga-040142	Gallus gallus	69.15	0.00e+00	1770.00
IUUC-Ggo-045063	Gorilla gorilla	69.04	0.00e+00	1828.00
IUUC-Hsa-046428	Homo sapiens	69.04	0.00e+00	1825.00
IUUC-Itr-048245	Ictidomys tridecemlineatus	69.67	0.00e+00	1802.00
IUUC-Lch-049766	Latimeria chalumnae	69.37	0.00e+00	1685.00
IUUC-Loc-052285	Lepisosteus oculatus	77.43	0.00e+00	2041.00
IUUC-Laf-053365	Loxodonta africana	69.07	0.00e+00	1727.00
IUUC-Mcc-054871	Macaca mulatta	68.98	0.00e+00	1810.00
IUUC-Meu-056724	Macropus eugenii	66.19	0.00e+00	1634.00
IUUC-Mga-059329	Meleagris gallopavo	67.76	0.00e+00	1659.00
IUUC-Mmr-061110	Microcebus murinus	68.95	0.00e+00	1817.00
IUUC-Mdo-062448	Monodelphis domestica	69.42	0.00e+00	1826.00
IUUC-Mmu-063565	Mus musculus	69.74	0.00e+00	1814.00
IUUC-Mpu-066683	Mustela putorius furo	69.58	0.00e+00	1836.00
IUUC-Mlu-067779	Myotis lucifugus	69.31	0.00e+00	1731.00
IUUC-Nle-069219	Nomascus leucogenys	71.55	0.00e+00	1540.00
IUUC-Opr-070766	Ochotona princeps	71.23	0.00e+00	1129.00
IUUC-Ont-072524	Oreochromis niloticus	79.02	0.00e+00	2028.00
IUUC-Oan-073214	Ornithorhynchus anatinus	71.11	5.00e-38	149.00
IUUC-Ocu-074361	Oryctolagus cuniculus	68.53	0.00e+00	1783.00
IUUC-Ola-086820	Oryzias latipes	75.96	0.00e+00	1996.00
IUUC-Oga-088172	Otolemur garnettii	69.35	0.00e+00	1827.00
IUUC-Oar-090306	Ovis aries	66.35	0.00e+00	1652.00
IUUC-Ptr-090682	Pan troglodytes	68.97	0.00e+00	1827.00
IUUC-Pan-092835	Papio anubis	70.26	0.00e+00	1344.00
IUUC-Psi-093344	Pelodiscus sinensis	68.61	0.00e+00	1783.00
IUUC-Pfo-096984	Poecilia formosa	75.81	0.00e+00	1941.00
IUUC-Pab-097871	Pongo abelii	69.52	0.00e+00	1805.00
IUUC-Pca-100772	Procavia capensis	64.26	0.00e+00	1653.00
IUUC-Pva-102790	Pteropus vampyrus	69.92	0.00e+00	1794.00
IUUC-Rno-105974	Rattus norvegicus	69.46	0.00e+00	1828.00
IUUC-Sar-112995	Sorex araneus	68.06	0.00e+00	1752.00
IUUC-Ssc-115360	Sus scrofa	69.26	0.00e+00	1815.00
IUUC-Tgu-116585	Taeniopygia guttata	66.29	0.00e+00	1684.00
IUUC-Tru-117742	Takifugu rubripes	78.61	0.00e+00	2081.00
IUUC-Tsy-119259	Tarsius syrichta	78.67	0.00e+00	699.00
IUUC-Tni-120833	Tetraodon nigroviridis	59.58	0.00e+00	1508.00
IUUC-Tbe-127504	Tupaia belangeri	68.88	0.00e+00	968.00
IUUC-Xtr-132862	Xenopus tropicalis	63.99	0.00e+00	1627.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence