iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000012912.3	ENSMMUT00000018113.3	ENSMMUP00000016958.3
ENSMMUG00000012912.3	ENSMMUT00000018112.3	ENSMMUP00000016957.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.70e-135	452.8	529	861

Active Site

Position(s)	Description	Evidence
830	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl+v f gEegld+gGv+re+++lls+e+ np+++lf+y  +d+++lq+np+s++ np+hlk+F+f+Gr++++al++g+++d+
   Q: 529  PQDLRRRLWVIFPGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYI-NPDHLKYFRFIGRFIAMALFHGKIIDT 616
           689*********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            +s +fyk++l+k++ l+dle++dpe+y+sl ++ken   +iee+gl++ fsv++eilge+k+++Lkp+G ni Vt+eNkeeY++ v+e
   Q: 617  SFSLPFYKRILSKPVGLKDLESIDPEFYNSLIWVKEN---NIEECGLEMYFSVDKEILGEIKSHDLKPNGGNILVTEENKEEYIRMVAE 702
           ***********************************99...9************************************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +rl +g++eq++af eGfne++p++ +++F+++ele+l+cG++eid++d+++++ y++ yt++s++i wFw++++e+++e+r ++LqFv
   Q: 703  WRLSRGVEEQTQAFFEGFNEILPQQYVQYFDAKELEVLLCGMQEIDLNDWQRHAIYRH-YTRTSKQIMWFWQFVKEIDNEKRMRLLQFV 790
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlPlgGfa+l+    p++f+i+k +++++lP+s+TCfn+L+LP+Y+s+e+lkekLl+Aieet+gF++
   Q: 791  TGTCRLPLGGFADLMgsngPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQ 861
           *********************************************************************96 PP

Organism

Macaca mulatta

Protein Sequence
(Fasta)

MSDSGSQLGS MGSLTMKSQL QITVISAKLK ENKKNWFGPS PYVEVTVDGQ SKKTEKCNNT 60
NSPKWKQPLT VIVTPVSKLH FRVWSHQTLK SDVLLGTAAL DIYETLKSNN MKLEEVVVTL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTTTTCCAAC CTATTGGTGG TATGTCTGAC AGTGGATCAC AACTTGGTTC AATGGGTAGC 60
CTCACCATGA AATCACAGCT TCAGATCACT GGTAAGTTTT AGAAACATCG GCAGCTTTAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0436--Ligase
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005938--C:cell cortex
GO:0031410--C:cytoplasmic vesicle
GO:0070062--C:extracellular exosome
GO:0005654--C:nucleoplasm
GO:0005886--C:plasma membrane
GO:0016874--F:ligase activity
GO:0043021--F:ribonucleoprotein complex binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0046642--P:negative regulation of alpha-beta T cell proliferation
GO:0043066--P:negative regulation of apoptotic process
GO:0050687--P:negative regulation of defense response to virus
GO:0046329--P:negative regulation of JNK cascade
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0045732--P:positive regulation of protein catabolic process
GO:0002669--P:positive regulation of T cell anergy
GO:0035519--P:protein K29-linked ubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0090085--P:regulation of protein deubiquitination

KEGG

mcc:707640

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002302	Ailuropoda melanoleuca	96.58	0.00e+00	1617.00
IUUC-Apl-003752	Anas platyrhynchos	83.28	0.00e+00	1447.00
IUUC-Aca-005338	Anolis carolinensis	80.95	0.00e+00	1428.00
IUUC-Ago-007742	Ashbya gossypii	48.71	1.00e-162	566.00
IUUC-Ame-010601	Astyanax mexicanus	86.71	0.00e+00	1110.00
IUUC-Bta-012782	Bos taurus	96.17	0.00e+00	1584.00
IUUC-Cja-018899	Callithrix jacchus	92.91	0.00e+00	1575.00
IUUC-Cfa-020648	Canis familiaris	95.30	0.00e+00	1582.00
IUUC-Cpo-022073	Cavia porcellus	97.10	0.00e+00	1640.00
IUUC-Csa-023252	Chlorocebus sabaeus	99.77	0.00e+00	1684.00
IUUC-Cho-024695	Choloepus hoffmanni	89.59	0.00e+00	1615.00
IUUC-Cne-026849	Cryptococcus neoformans	47.46	1.00e-158	553.00
IUUC-Dre-028451	Danio rerio	75.03	0.00e+00	1295.00
IUUC-Dno-029884	Dasypus novemcinctus	96.29	0.00e+00	1666.00
IUUC-Eca-033793	Equus caballus	96.98	0.00e+00	1642.00
IUUC-Eeu-034716	Erinaceus europaeus	91.92	0.00e+00	881.00
IUUC-Fca-035605	Felis catus	96.46	0.00e+00	1644.00
IUUC-Fal-037126	Ficedula albicollis	83.11	0.00e+00	1442.00
IUUC-Gmo-038596	Gadus morhua	79.86	0.00e+00	1008.00
IUUC-Gga-040832	Gallus gallus	83.77	0.00e+00	1460.00
IUUC-Gac-041520	Gasterosteus aculeatus	86.97	0.00e+00	1109.00
IUUC-Ggo-044535	Gorilla gorilla	94.66	0.00e+00	1617.00
IUUC-Hsa-046564	Homo sapiens	94.02	0.00e+00	1642.00
IUUC-Itr-048918	Ictidomys tridecemlineatus	95.82	0.00e+00	1571.00
IUUC-Kpa-049273	Komagataella pastoris	48.88	3.00e-163	568.00
IUUC-Lch-050454	Latimeria chalumnae	76.84	0.00e+00	1391.00
IUUC-Loc-052647	Lepisosteus oculatus	73.87	0.00e+00	1347.00
IUUC-Laf-054383	Loxodonta africana	97.33	0.00e+00	1650.00
IUUC-Mga-059661	Meleagris gallopavo	83.65	0.00e+00	1449.00
IUUC-Mmr-061135	Microcebus murinus	97.10	0.00e+00	1669.00
IUUC-Mdo-062505	Monodelphis domestica	86.53	0.00e+00	1492.00
IUUC-Mmu-063375	Mus musculus	94.91	0.00e+00	1592.00
IUUC-Mpu-066203	Mustela putorius furo	96.93	0.00e+00	1620.00
IUUC-Mlu-067837	Myotis lucifugus	96.29	0.00e+00	1637.00
IUUC-Nle-069244	Nomascus leucogenys	96.88	0.00e+00	1633.00
IUUC-Opr-070585	Ochotona princeps	90.70	0.00e+00	1581.00
IUUC-Ont-071798	Oreochromis niloticus	86.94	0.00e+00	1135.00
IUUC-Ocu-074298	Oryctolagus cuniculus	96.88	0.00e+00	1627.00
IUUC-Ola-086526	Oryzias latipes	84.74	0.00e+00	1114.00
IUUC-Oga-088167	Otolemur garnettii	89.94	0.00e+00	1513.00
IUUC-Oar-090316	Ovis aries	80.19	0.00e+00	1197.00
IUUC-Ptr-090819	Pan troglodytes	93.24	0.00e+00	1603.00
IUUC-Pan-092454	Papio anubis	100.00	0.00e+00	1684.00
IUUC-Psi-093319	Pelodiscus sinensis	81.40	0.00e+00	1423.00
IUUC-Pfo-097346	Poecilia formosa	83.36	0.00e+00	1097.00
IUUC-Pab-097580	Pongo abelii	87.26	0.00e+00	1484.00
IUUC-Pca-100923	Procavia capensis	78.65	0.00e+00	1362.00
IUUC-Pva-103209	Pteropus vampyrus	95.13	0.00e+00	1580.00
IUUC-Rno-104924	Rattus norvegicus	94.44	0.00e+00	1597.00
IUUC-Sha-107175	Sarcophilus harrisii	87.92	0.00e+00	1498.00
IUUC-Sja-107941	Schizosaccharomyces japonicus	44.96	5.00e-161	561.00
IUUC-Sar-113761	Sorex araneus	86.12	0.00e+00	1485.00
IUUC-Tgu-116632	Taeniopygia guttata	79.86	0.00e+00	1320.00
IUUC-Tru-118442	Takifugu rubripes	87.72	0.00e+00	1109.00
IUUC-Tsy-119198	Tarsius syrichta	90.02	0.00e+00	1525.00
IUUC-Tni-120168	Tetraodon nigroviridis	85.82	0.00e+00	1052.00
IUUC-Tbe-127756	Tupaia belangeri	77.74	0.00e+00	1311.00
IUUC-Ttr-128504	Tursiops truncatus	90.67	0.00e+00	1194.00
IUUC-Vpa-130103	Vicugna pacos	82.19	0.00e+00	1399.00
IUUC-Xtr-132885	Xenopus tropicalis	75.58	0.00e+00	1366.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence