iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Nle-069213

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ADFV01046791

Gene Name

HECW1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSNLEG00000003209.1	ENSNLET00000004189.1	ENSNLEP00000003992.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.00e-122	408.8	1275	1607

Active Site

Position(s)	Description	Evidence
1575	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
           + ++++l+v+fvgEegld++G++ref++lls+el+np++glf+ys+nd++t+q++p s +  ++hl++F+f Gr+lg+al ++ lld
   Q: 1275 ELQRNKLYVTFVGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQISPMSAFV-ENHLEWFRFSGRILGLALIHQYLLD 1360
           567899****************************************************985.6************************ PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvkl 176
           ++++++fyk ll+ +++l+dle +d+e+++sl+++k+n   +i+++ ldltf+v+ee++g+++e+eLk+gG+n++Vt++Nk+eY+++
   Q: 1361 AFFTRPFYKALLRLPCDLSDLEYLDEEFHQSLQWMKDN---NITDI-LDLTFTVNEEVFGQVTERELKSGGANTQVTEKNKKEYIER 1443
           ************************************99...9***9.**************************************** PP
   S: 177  vveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerka 263
           +v++r+++g+ +q+ea+ +Gf+ev++ +l+s+F+++elel+i G++eid++d++++t+y+ggy++ + +i+wFw ++e+f++e+r +
   Q: 1444 MVKWRVERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTAEIDLNDWRNNTEYRGGYHDGHLVIRWFWAAVERFNNEQRLR 1530
           *************************************************************************************** PP
   S: 264  fLqFvTgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           +LqFvTg+s++P +Gfa+l+     r+f+i+k+++ ++lP+++TCfn+L+LP+Y+s++ l+ekLl+A+eet+ F+l+
   Q: 1531 LLQFVTGTSSVPYEGFAALRgsngLRRFCIEKWGKITSLPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETSTFGLE 1607
           ************************999***********************************************985 PP

Organism

Nomascus leucogenys

Protein Sequence
(Fasta)

MLLHLCSVKN LYQNRFLGLA AMASPSRNSQ SRRRCKEPLR YSYNPDQFHN MDLRGGPHDG 60
VTIPRSTSDT DLVTSDSRST LTVSSSYYSI GHSQDLVIHW DIKEEVDAGD WIGMYLIDEV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGGATGCAA GCGGGAGGAT AAAGCGATGA AGTGTGCTGC GTTACCGCGC ATCAGGCGCT 60
GTTGTTGGAG CCGGAACACC GTGCGACTCT GACCGAACCG GCCCCCTCCT CGCGCACACA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR032348--HECW_N
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF16562--HECW_N
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005829--C:cytosol
GO:0004842--F:ubiquitin-protein transferase activity

KEGG

nle:100607707

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001636	Ailuropoda melanoleuca	86.27	0.00e+00	2184.00
IUUC-Apl-003299	Anas platyrhynchos	80.21	0.00e+00	2431.00
IUUC-Aca-005024	Anolis carolinensis	79.52	0.00e+00	2408.00
IUUC-Bta-012604	Bos taurus	88.25	0.00e+00	2637.00
IUUC-Cja-019880	Callithrix jacchus	91.37	0.00e+00	2405.00
IUUC-Cfa-021216	Canis familiaris	91.42	0.00e+00	1814.00
IUUC-Cpo-021466	Cavia porcellus	96.99	0.00e+00	1724.00
IUUC-Csa-023080	Chlorocebus sabaeus	98.57	0.00e+00	2922.00
IUUC-Cho-024740	Choloepus hoffmanni	83.21	0.00e+00	1174.00
IUUC-Dre-028750	Danio rerio	81.50	0.00e+00	1506.00
IUUC-Dno-030019	Dasypus novemcinctus	90.23	0.00e+00	2659.00
IUUC-Dor-031030	Dipodomys ordii	73.45	0.00e+00	1137.00
IUUC-Ete-032352	Echinops telfairi	94.29	0.00e+00	1263.00
IUUC-Eca-033948	Equus caballus	88.88	0.00e+00	2563.00
IUUC-Eeu-034474	Erinaceus europaeus	70.39	0.00e+00	835.00
IUUC-Fca-036148	Felis catus	91.35	0.00e+00	2639.00
IUUC-Fal-036957	Ficedula albicollis	80.51	0.00e+00	2437.00
IUUC-Gmo-038714	Gadus morhua	69.00	0.00e+00	1020.00
IUUC-Gga-041194	Gallus gallus	80.37	0.00e+00	2417.00
IUUC-Gac-041366	Gasterosteus aculeatus	77.78	0.00e+00	1377.00
IUUC-Ggo-045442	Gorilla gorilla	84.83	0.00e+00	1713.00
IUUC-Hsa-045730	Homo sapiens	99.07	0.00e+00	2932.00
IUUC-Itr-048439	Ictidomys tridecemlineatus	92.30	0.00e+00	2755.00
IUUC-Lch-050185	Latimeria chalumnae	72.55	0.00e+00	1390.00
IUUC-Loc-052744	Lepisosteus oculatus	74.21	0.00e+00	2228.00
IUUC-Laf-054368	Loxodonta africana	98.58	0.00e+00	1507.00
IUUC-Mcc-055487	Macaca mulatta	98.63	0.00e+00	2936.00
IUUC-Meu-056751	Macropus eugenii	91.60	0.00e+00	731.00
IUUC-Mga-059545	Meleagris gallopavo	80.74	0.00e+00	2420.00
IUUC-Mmr-061078	Microcebus murinus	91.06	0.00e+00	2583.00
IUUC-Mdo-062176	Monodelphis domestica	84.54	0.00e+00	1708.00
IUUC-Mmu-063513	Mus musculus	87.12	0.00e+00	2561.00
IUUC-Mpu-065786	Mustela putorius furo	90.37	0.00e+00	2647.00
IUUC-Mlu-067780	Myotis lucifugus	82.81	0.00e+00	2345.00
IUUC-Opr-070208	Ochotona princeps	97.31	0.00e+00	1497.00
IUUC-Ont-072132	Oreochromis niloticus	81.49	0.00e+00	1369.00
IUUC-Oan-072807	Ornithorhynchus anatinus	87.93	0.00e+00	1793.00
IUUC-Ocu-074745	Oryctolagus cuniculus	89.16	0.00e+00	2573.00
IUUC-Ola-086981	Oryzias latipes	73.96	0.00e+00	1490.00
IUUC-Oga-087965	Otolemur garnettii	89.34	0.00e+00	2527.00
IUUC-Oar-089749	Ovis aries	90.88	0.00e+00	1872.00
IUUC-Ptr-091243	Pan troglodytes	98.94	0.00e+00	2929.00
IUUC-Pan-092201	Papio anubis	97.32	0.00e+00	2894.00
IUUC-Psi-093511	Pelodiscus sinensis	78.28	0.00e+00	2362.00
IUUC-Pfo-097001	Poecilia formosa	65.62	0.00e+00	1587.00
IUUC-Pab-098728	Pongo abelii	96.71	0.00e+00	2816.00
IUUC-Pca-100129	Procavia capensis	82.80	0.00e+00	1261.00
IUUC-Pva-102250	Pteropus vampyrus	79.46	0.00e+00	2167.00
IUUC-Rno-105031	Rattus norvegicus	87.51	0.00e+00	2575.00
IUUC-Tgu-117515	Taeniopygia guttata	81.32	0.00e+00	2410.00
IUUC-Tru-117914	Takifugu rubripes	75.86	0.00e+00	1383.00
IUUC-Tsy-119379	Tarsius syrichta	90.37	0.00e+00	804.00
IUUC-Tni-120178	Tetraodon nigroviridis	76.07	0.00e+00	1400.00
IUUC-Tbe-127762	Tupaia belangeri	84.72	0.00e+00	2002.00
IUUC-Ttr-128806	Tursiops truncatus	93.14	0.00e+00	1742.00
IUUC-Xtr-132903	Xenopus tropicalis	75.13	0.00e+00	1878.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence