iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mcc-055244

UUCD1 version

UUC-MaM-00400

Ensembl Protein ID

ENSMMUP00000017213.2

UniProt Accession

F6ZUB8; F6ZUB8_MACMU

Genbank Protein ID

AFE64593.1; AFH28863.1; AFI36558.1

Protein Name

E3 ubiquitin-protein ligase TRIM32

Genbank Nucleotide ID

JSUE03014371; JU472059; JV046487

Gene Name

TRIM32

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000013107.3	ENSMMUT00000018383.3	ENSMMUP00000017213.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	1.70e-07	32.7	20	64

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdg...plvlpCgHvfhadClqkwpglknssskefrCPlC 45
           C+iC+e+f ++   p++l CgH+++++Cl+k+     ss +  rCP C
   Q: 20   CPICMESFTEEqlrPKLLHCGHTICRQCLEKL---LASSINGVRCPFC 64
           ********76667799*************888...67799999***** PP

Organism

Macaca mulatta

Protein Sequence
(Fasta)

MAAAAASHLN LDALREVLEC PICMESFTEE QLRPKLLHCG HTICRQCLEK LLASSINGVR 60
CPFCSKITRI TSLTQLTDNL TVLKIIDTAG LSEAVGLLMC RSCGRRLPRQ FCRSCGLVLC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCGCTCAAC GGCGCGTGCG CAGAGGACGG CGGGCGGGTG GGCTGGCGGC GGTGGACTCG 60
TCGGAGCTGC GGGCGGTCAG GTAGGGGGCG GGAAGGAGGG CTGGGGACTA GGGACCGCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0436--Ligase
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR001258--NHL_repeat
IPR013017--NHL_repeat_subgr
IPR033569--TRIM32
IPR027370--Znf-RING_LisH
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS51125--NHL
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF01436--NHL
PF13445--zf-RING_UBOX

SMART

SM00336--BBOX
SM00184--RING

Gene Ontology

GO:0005634--C:nucleus
GO:0005863--C:striated muscle myosin thick filament
GO:0016874--F:ligase activity
GO:0003723--F:RNA binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0007014--P:actin ubiquitination
GO:0061564--P:axon development
GO:0045444--P:fat cell differentiation
GO:0045087--P:innate immune response
GO:0046716--P:muscle cell cellular homeostasis
GO:0048147--P:negative regulation of fibroblast proliferation
GO:1902230--P:negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:1902187--P:negative regulation of viral release from host cell
GO:0032897--P:negative regulation of viral transcription
GO:0045787--P:positive regulation of cell cycle
GO:0030307--P:positive regulation of cell growth
GO:0030335--P:positive regulation of cell migration
GO:1903886--P:positive regulation of chemokine (C-C motif) ligand 20 production
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:1903883--P:positive regulation of interleukin-17-mediated signaling pathway
GO:0045666--P:positive regulation of neuron differentiation
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0045732--P:positive regulation of protein catabolic process
GO:0045862--P:positive regulation of proteolysis
GO:0051155--P:positive regulation of striated muscle cell differentiation
GO:1903265--P:positive regulation of tumor necrosis factor-mediated signaling pathway
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0034612--P:response to tumor necrosis factor
GO:0009411--P:response to UV
GO:0001894--P:tissue homeostasis

KEGG

mcc:702595

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000568	Aegilops tauschii	36.51	3.00e-06	45.40
IUUC-Aml-001554	Ailuropoda melanoleuca	97.22	0.00e+00	1225.00
IUUC-Aca-004290	Anolis carolinensis	83.87	0.00e+00	1097.00
IUUC-Aly-006480	Arabidopsis lyrata	40.00	1.00e-08	56.60
IUUC-Ame-011474	Astyanax mexicanus	62.21	0.00e+00	835.00
IUUC-Bta-013335	Bos taurus	93.72	0.00e+00	1194.00
IUUC-Bol-015127	Brassica oleracea	34.04	2.00e-09	55.80
IUUC-Cja-019836	Callithrix jacchus	98.93	0.00e+00	1257.00
IUUC-Cfa-020126	Canis familiaris	98.30	0.00e+00	1242.00
IUUC-Cpo-021619	Cavia porcellus	98.16	0.00e+00	1248.00
IUUC-Cre-022845	Chlamydomonas reinhardtii	43.40	1.00e-05	41.20
IUUC-Csa-023381	Chlorocebus sabaeus	100.00	0.00e+00	1262.00
IUUC-Cho-024696	Choloepus hoffmanni	96.17	0.00e+00	1211.00
IUUC-Dre-028768	Danio rerio	63.03	0.00e+00	855.00
IUUC-Dno-029162	Dasypus novemcinctus	98.01	0.00e+00	1243.00
IUUC-Dor-030490	Dipodomys ordii	96.91	0.00e+00	1209.00
IUUC-Ete-032250	Echinops telfairi	93.26	0.00e+00	1166.00
IUUC-Eca-033392	Equus caballus	98.16	0.00e+00	1243.00
IUUC-Fca-035512	Felis catus	98.45	0.00e+00	1242.00
IUUC-Fal-036745	Ficedula albicollis	84.92	0.00e+00	1094.00
IUUC-Gmo-038737	Gadus morhua	60.15	0.00e+00	787.00
IUUC-Gga-040258	Gallus gallus	82.92	0.00e+00	1078.00
IUUC-Gac-041657	Gasterosteus aculeatus	60.21	0.00e+00	791.00
IUUC-Ggo-045473	Gorilla gorilla	99.69	0.00e+00	1254.00
IUUC-Hsa-046653	Homo sapiens	99.54	0.00e+00	1254.00
IUUC-Hvu-047109	Hordeum vulgare	34.92	4.00e-06	45.10
IUUC-Itr-048947	Ictidomys tridecemlineatus	98.16	0.00e+00	1251.00
IUUC-Lch-049791	Latimeria chalumnae	69.07	0.00e+00	904.00
IUUC-Loc-052573	Lepisosteus oculatus	65.54	0.00e+00	863.00
IUUC-Laf-054514	Loxodonta africana	97.70	0.00e+00	1240.00
IUUC-Meu-056655	Macropus eugenii	82.00	0.00e+00	1080.00
IUUC-Mtr-058731	Medicago truncatula	34.67	1.00e-10	61.20
IUUC-Mga-059343	Meleagris gallopavo	79.26	0.00e+00	1006.00
IUUC-Mmr-061774	Microcebus murinus	98.32	0.00e+00	1244.00
IUUC-Mmu-063743	Mus musculus	95.52	0.00e+00	1224.00
IUUC-Mpu-066801	Mustela putorius furo	98.45	0.00e+00	1244.00
IUUC-Nle-069880	Nomascus leucogenys	99.69	0.00e+00	1259.00
IUUC-Ont-071805	Oreochromis niloticus	58.11	0.00e+00	776.00
IUUC-Oan-073221	Ornithorhynchus anatinus	82.78	0.00e+00	1041.00
IUUC-Ocu-074609	Oryctolagus cuniculus	98.32	0.00e+00	1207.00
IUUC-Olo-080692	Oryza longistaminata	38.10	6.00e-07	47.80
IUUC-Osa-086244	Oryza sativa	39.39	5.00e-08	52.00
IUUC-Oga-088597	Otolemur garnettii	98.62	0.00e+00	1248.00
IUUC-Oar-089322	Ovis aries	91.50	0.00e+00	744.00
IUUC-Ptr-091638	Pan troglodytes	99.69	0.00e+00	1256.00
IUUC-Pan-092001	Papio anubis	100.00	0.00e+00	1262.00
IUUC-Psi-093112	Pelodiscus sinensis	84.15	0.00e+00	1112.00
IUUC-Ppa-095766	Physcomitrella patens	37.35	1.00e-11	63.20
IUUC-Pfo-097226	Poecilia formosa	59.08	0.00e+00	801.00
IUUC-Pab-098115	Pongo abelii	99.85	0.00e+00	1260.00
IUUC-Rno-104950	Rattus norvegicus	96.91	0.00e+00	1231.00
IUUC-Sha-106842	Sarcophilus harrisii	83.92	0.00e+00	1090.00
IUUC-Smo-109517	Selaginella moellendorffii	38.81	2.00e-10	56.60
IUUC-Ssc-115577	Sus scrofa	97.40	0.00e+00	1230.00
IUUC-Tgu-116636	Taeniopygia guttata	84.46	0.00e+00	1092.00
IUUC-Tsy-119479	Tarsius syrichta	99.39	0.00e+00	1254.00
IUUC-Tni-120872	Tetraodon nigroviridis	57.57	0.00e+00	757.00
IUUC-Tae-125903	Triticum aestivum	36.51	3.00e-06	45.40
IUUC-Tur-126036	Triticum urartu	36.51	3.00e-06	45.40
IUUC-Ttr-129170	Tursiops truncatus	97.24	0.00e+00	1253.00
IUUC-Xtr-132839	Xenopus tropicalis	71.21	0.00e+00	951.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence