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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Sce-106131
UUCD1 version UUC-SaC-00006
Ensembl Protein ID YJL041W
UniProt Accession P14907; D6VWE3; NSP1_YEAST
Genbank Protein ID AAA34821.1; CAA89332.1; CAA89331.1; DAA08759.1
Protein Name Nucleoporin NSP1; Nuclear pore protein NSP1; Nucleoskeletal-like protein; p110
Genbank Nucleotide ID M37160; Z49316; Z49314; BK006943
Gene Name NSP1; YJL041W; J1207
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
YJL041W YJL041W YJL041W
Annotation
mRNA Expression
GEOFFGED
Protein-protein Interaction
IIDiRefIndexHINTMentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
CPLMdbPAFdbPTMUniProt
BioGRID
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/Other E3 activity/Other 19420080
Organism Saccharomyces cerevisiae
Functional Description
(View)

Functional Description


     Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope (GSP1 and GSP2 GTPases associated predominantly with GTP in the nucleus, with GDP in the cytoplasm). NSP1 plays an important role in several nuclear transport pathways including poly(A)+ RNA, tRNA, pre-ribosome, signal recognition particle (SRP), and protein transport.
 Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope (GSP1 and GSP2 GTPases associated predominantly with GTP in the nucleus, with GDP in the cytoplasm). NSP1 plays an important role in several nuclear transport pathways including poly(A)+ RNA, tRNA, pre-ribosome, signal recognition particle (SRP), and protein transport.
Protein Sequence
(Fasta)
MNFNTPQQNK TPFSFGTANN NSNTTNQNSS TGAGAFGTGQ STFGFNNSAP NNTNNANSSI 60
TPAFGSNNTG NTAFGNSNPT SNVFGSNNST TNTFGSNSAG TSLFGSSSAQ QTKSNGTAGG 120
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Protein Fasta Sequence


>IUUC-Sce-106131|E3,E3 activity/Other|Saccharomyces cerevisiae
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Nucleotide Sequence
(Fasta)
AGTATGTTTC TTTCCATTGG ACGGTTGTCT TCCGATCAAA ATTTTATCTC CTATACAATT 60
TCTTCCTATT TACTAACGAA AACCTGCGAA CCTGTAAACT ACATGATTTT TAATATTAGT 120
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Nucleotide Fasta Sequence


>IUUC-Sce-106131|E3,E3 activity/Other|Saccharomyces cerevisiae
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Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0131--Cell cycle
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0472--Membrane
KW-0509--mRNA transport
KW-0906--Nuclear pore complex
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0811--Translocation
KW-0813--Transport
Interpro

IPR026010--NSP1/NUP62
IPR007758--Nucleoporin_NSP1_C
Pfam

PF05064--Nsp1_C
Gene Ontology

GO:0031965--C:nuclear membrane
GO:0005643--C:nuclear pore
GO:0044613--C:nuclear pore central transport channel
GO:0044615--C:nuclear pore nuclear basket
GO:0005487--F:nucleocytoplasmic transporter activity
GO:0005543--F:phospholipid binding
GO:0017056--F:structural constituent of nuclear pore
GO:0007049--P:cell cycle
GO:0097064--P:ncRNA export from nucleus
GO:0006607--P:NLS-bearing protein import into nucleus
GO:0016973--P:poly(A)+ mRNA export from nucleus
GO:0006606--P:protein import into nucleus
GO:0000055--P:ribosomal large subunit export from nucleus
GO:0000056--P:ribosomal small subunit export from nucleus
GO:0006409--P:tRNA export from nucleus
KEGG sce:YJL041W
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000103 Aegilops tauschii 21.88 9.00e-07 46.20
IUUC-Aml-002215 Ailuropoda melanoleuca 27.81 8.00e-17 79.70
IUUC-Atr-002951 Amborella trichopoda 20.31 9.00e-08 50.10
IUUC-Apl-003795 Anas platyrhynchos 28.88 7.00e-22 96.30
IUUC-Aca-004808 Anolis carolinensis 29.41 1.00e-20 92.80
IUUC-Aly-005471 Arabidopsis lyrata 21.08 3.00e-09 55.10
IUUC-Ath-007120 Arabidopsis thaliana 19.29 1.00e-07 49.70
IUUC-Ago-007770 Ashbya gossypii 46.17 2.00e-84 305.00
IUUC-Acl-008342 Aspergillus clavatus 32.64 1.00e-30 126.00
IUUC-Afl-008407 Aspergillus flavus 33.68 2.00e-31 129.00
IUUC-Ani-009240 Aspergillus nidulans 35.75 4.00e-35 140.00
IUUC-Ang-009754 Aspergillus niger 34.20 3.00e-33 134.00
IUUC-Aor-010138 Aspergillus oryzae 33.68 6.00e-32 130.00
IUUC-Ate-010408 Aspergillus terreus 33.68 7.00e-33 133.00
IUUC-Ame-011356 Astyanax mexicanus 29.09 2.00e-25 108.00
IUUC-Bgr-012171 Blumeria graminis 32.09 6.00e-30 123.00
IUUC-Bta-013564 Bos taurus 31.76 3.00e-06 46.20
IUUC-Bci-013631 Botrytis cinerea 32.64 1.00e-28 119.00
IUUC-Bdi-014451 Brachypodium distachyon 18.78 8.00e-09 51.60
IUUC-Bol-015251 Brassica oleracea 20.10 7.00e-07 47.40
IUUC-Bra-017238 Brassica rapa 20.10 2.00e-07 48.90
IUUC-Cel-018406 Caenorhabditis elegans 19.88 1.00e-05 43.10
IUUC-Cja-019404 Callithrix jacchus 27.81 1.00e-18 85.90
IUUC-Cfa-020656 Canis familiaris 27.81 8.00e-17 79.70
IUUC-Cpo-021577 Cavia porcellus 27.66 2.00e-15 75.10
IUUC-Cre-022786 Chlamydomonas reinhardtii 27.92 4.00e-08 52.40
IUUC-Csa-023298 Chlorocebus sabaeus 27.27 2.00e-16 78.60
IUUC-Cho-024303 Choloepus hoffmanni 36.04 6.00e-07 48.50
IUUC-Cin-025543 Ciona intestinalis 31.44 2.00e-13 68.90
IUUC-Csv-026171 Ciona savignyi 29.90 3.00e-11 60.80
IUUC-Cgl-026616 Colletotrichum gloeosporioides 34.22 3.00e-26 109.00
IUUC-Cne-026912 Cryptococcus neoformans 30.59 6.00e-25 107.00
IUUC-Dre-027936 Danio rerio 29.41 9.00e-20 89.40
IUUC-Dno-029425 Dasypus novemcinctus 26.06 9.00e-16 76.30
IUUC-Dor-030759 Dipodomys ordii 24.24 2.00e-11 62.00
IUUC-Dse-031327 Dothistroma septosporum 25.26 3.00e-19 88.60
IUUC-Dme-031695 Drosophila melanogaster 27.76 2.00e-16 80.50
IUUC-Ete-032242 Echinops telfairi 31.02 1.00e-08 54.30
IUUC-Eca-034163 Equus caballus 28.88 2.00e-17 80.50
IUUC-Fca-035933 Felis catus 27.81 9.00e-18 82.80
IUUC-Fal-036641 Ficedula albicollis 28.21 5.00e-22 97.10
IUUC-Fox-038065 Fusarium oxysporum 34.46 1.00e-29 122.00
IUUC-Fso-038180 Fusarium solani 32.81 1.00e-31 129.00
IUUC-Gmo-038896 Gadus morhua 28.88 2.00e-16 78.60
IUUC-Ggr-040080 Gaeumannomyces graminis 33.85 1.00e-31 129.00
IUUC-Gga-041135 Gallus gallus 28.88 1.00e-22 99.00
IUUC-Gac-041923 Gasterosteus aculeatus 29.74 8.00e-25 106.00
IUUC-Gma-043083 Glycine max 18.69 1.00e-07 50.10
IUUC-Ggo-044765 Gorilla gorilla 27.81 8.00e-18 82.80
IUUC-Hsa-046692 Homo sapiens 27.81 7.00e-18 83.20
IUUC-Itr-048010 Ictidomys tridecemlineatus 27.81 1.00e-17 82.40
IUUC-Kpa-049305 Komagataella pastoris 42.46 1.00e-90 325.00
IUUC-Lch-050204 Latimeria chalumnae 29.78 1.00e-19 89.00
IUUC-Lpe-050941 Leersia perrieri 23.00 8.00e-07 44.70
IUUC-Loc-051832 Lepisosteus oculatus 28.88 1.00e-20 92.80
IUUC-Laf-054586 Loxodonta africana 28.02 2.00e-20 92.00
IUUC-Mcc-054910 Macaca mulatta 27.27 2.00e-16 78.60
IUUC-Meu-056117 Macropus eugenii 31.62 6.00e-15 71.20
IUUC-Mor-057022 Magnaporthe oryzae 34.64 1.00e-30 125.00
IUUC-Mpo-057380 Magnaporthe poae 35.20 2.00e-30 125.00
IUUC-Mtr-057916 Medicago truncatula 18.27 1.00e-08 51.20
IUUC-Mga-059208 Meleagris gallopavo 28.88 9.00e-22 95.90
IUUC-Mvi-060361 Microbotryum violaceum 31.50 1.00e-16 79.70
IUUC-Mmr-061579 Microcebus murinus 27.81 5.00e-18 83.60
IUUC-Mdo-062211 Monodelphis domestica 27.27 1.00e-17 83.20
IUUC-Mmu-063320 Mus musculus 26.92 9.00e-16 76.30
IUUC-Mac-065316 Musa acuminata 19.39 1.00e-05 43.10
IUUC-Mpu-066778 Mustela putorius furo 27.81 9.00e-17 79.70
IUUC-Mlu-067961 Myotis lucifugus 27.81 9.00e-18 82.80
IUUC-Nfi-068470 Neosartorya fischeri 33.68 1.00e-31 129.00
IUUC-Ncr-068853 Neurospora crassa 33.16 1.00e-28 119.00
IUUC-Nle-069776 Nomascus leucogenys 31.71 2.00e-09 53.50
IUUC-Ont-071804 Oreochromis niloticus 29.74 5.00e-24 103.00
IUUC-Oan-073171 Ornithorhynchus anatinus 29.41 8.00e-22 96.30
IUUC-Ocu-074502 Oryctolagus cuniculus 23.28 4.00e-09 53.10
IUUC-Oba-075227 Oryza barthii 20.83 1.00e-07 47.40
IUUC-Obr-076100 Oryza brachyantha 17.26 4.00e-07 48.10
IUUC-Ogl-077722 Oryza glaberrima 17.26 7.00e-08 48.50
IUUC-Ogu-078656 Oryza glumaepatula 20.83 3.00e-07 46.60
IUUC-Oin-079356 Oryza indica 17.05 7.00e-05 38.90
IUUC-Olo-080776 Oryza longistaminata 20.83 3.00e-06 43.50
IUUC-Ome-081497 Oryza meridionalis 17.26 1.00e-07 48.10
IUUC-Oni-082204 Oryza nivara 17.26 2.00e-07 47.40
IUUC-Opu-083759 Oryza punctata 20.83 4.00e-08 48.50
IUUC-Ola-086898 Oryzias latipes 30.85 3.00e-23 100.00
IUUC-Olu-087583 Ostreococcus lucimarinus 60.00 4.00e-03 36.20
IUUC-Oga-088255 Otolemur garnettii 27.81 2.00e-16 79.00
IUUC-Oar-089798 Ovis aries 25.67 8.00e-14 69.30
IUUC-Ptr-091608 Pan troglodytes 27.81 8.00e-18 83.20
IUUC-Pan-092757 Papio anubis 27.27 1.00e-16 79.00
IUUC-Psi-093357 Pelodiscus sinensis 28.88 8.00e-22 96.30
IUUC-Pma-094710 Petromyzon marinus 28.72 3.00e-20 91.30
IUUC-Pno-094791 Phaeosphaeria nodorum 29.69 5.00e-26 110.00
IUUC-Ppa-095481 Physcomitrella patens 25.00 1.00e-07 49.70
IUUC-Pfo-097470 Poecilia formosa 29.95 1.00e-21 95.50
IUUC-Pab-098408 Pongo abelii 27.81 8.00e-18 82.80
IUUC-Pop-100081 Populus trichocarpa 19.80 6.00e-09 52.00
IUUC-Pca-100349 Procavia capensis 28.72 1.00e-21 95.90
IUUC-Ppe-101825 Prunus persica 19.29 6.00e-08 50.40
IUUC-Pva-102608 Pteropus vampyrus 28.27 2.00e-15 74.30
IUUC-Pgr-103532 Puccinia graminis 33.17 1.00e-30 126.00
IUUC-Pte-104213 Pyrenophora teres 30.48 9.00e-27 113.00
IUUC-Pyt-104505 Pyrenophora triticirepentis 30.48 2.00e-25 108.00
IUUC-Rno-104985 Rattus norvegicus 26.92 9.00e-17 79.30
IUUC-Sha-107579 Sarcophilus harrisii 26.09 3.00e-16 77.00
IUUC-Sja-107816 Schizosaccharomyces japonicus 30.38 5.00e-30 123.00
IUUC-Spo-108243 Schizosaccharomyces pombe 28.50 1.00e-22 99.40
IUUC-Sit-110530 Setaria italica 18.27 4.00e-10 57.80
IUUC-Sly-111305 Solanum lycopersicum 20.10 1.00e-09 56.20
IUUC-Sar-113578 Sorex araneus 30.53 9.00e-04 38.10
IUUC-Sbi-114353 Sorghum bicolor 22.22 5.00e-06 43.90
IUUC-Sre-115119 Sporisorium reilianum 29.15 1.00e-23 102.00
IUUC-Ssc-116032 Sus scrofa 27.81 5.00e-17 80.50
IUUC-Tgu-117392 Taeniopygia guttata 26.06 1.00e-15 75.50
IUUC-Tru-118364 Takifugu rubripes 30.48 2.00e-22 98.20
IUUC-Tsy-119443 Tarsius syrichta 26.18 5.00e-14 70.50
IUUC-Tni-120115 Tetraodon nigroviridis 30.00 1.00e-22 99.40
IUUC-Tca-120955 Theobroma cacao 19.70 4.00e-08 51.60
IUUC-Tre-122173 Trichoderma reesei 32.77 8.00e-26 109.00
IUUC-Tvi-122527 Trichoderma virens 32.09 7.00e-24 101.00
IUUC-Tae-123047 Triticum aestivum 18.78 9.00e-09 53.50
IUUC-Tur-125980 Triticum urartu 24.70 6.00e-07 47.00
IUUC-Tme-127155 Tuber melanosporum 34.38 4.00e-30 124.00
IUUC-Tbe-127667 Tupaia belangeri 24.06 1.00e-13 68.20
IUUC-Ttr-128589 Tursiops truncatus 27.81 3.00e-18 84.30
IUUC-Vda-129888 Verticillium dahliae 33.90 2.00e-27 115.00
IUUC-Vpa-130367 Vicugna pacos 25.67 2.00e-16 77.40
IUUC-Vvi-131500 Vitis vinifera 18.18 1.00e-07 50.10
IUUC-Xtr-132497 Xenopus tropicalis 28.34 2.00e-22 98.20
IUUC-Xma-133341 Xiphophorus maculatus 29.74 3.00e-23 101.00
IUUC-Yli-134543 Yarrowia lipolytica 34.24 8.00e-41 159.00
IUUC-Zma-135505 Zea mays 18.69 3.00e-10 58.50
Created Date 25-Jun-2017

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