iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Itr-047931

Ensembl Protein ID

ENSSTOP00000022046.1

UniProt Accession

I3NCE9; I3NCE9_ICTTR

Genbank Protein ID

ENSSTOP00000022046

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AGTP01090832

Gene Name

VAV2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSTOG00000028773.1	ENSSTOT00000021665.1	ENSSTOP00000022046.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	2.70e-18	65.7	621	672

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 8    vlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
           + y++ a +  eL+l++Gdvv++ +    d+gW+kg  e++g+ G fP+ +ve+
   Q: 621  ARYNFAARDMRELSLREGDVVKIYSRIGGDQGWWKG--ETNGRIGWFPSTYVEE 672
           67**********************************..9*************86 PP

Organism

Ictidomys tridecemlineatus

Protein Sequence
(Fasta)

KMGMTEDDKR SCCLLEIHET EAKYCRTLED IEKNYMGPLR LVLSPVDMAA VFINLEDLMK 60
VHHSLLRAID VSMMAGGSTL AKVFLEFKER LLIYGDYCSH LERAQTTLSQ LLTSRDDFRQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAAATGGGCA TGACGGAGGA TGACAAGAGG AGCTGTTGCC TGCTGGAGAT CCACGAGACC 60
GAGGCCAAGT ACTGCCGGAC CCTGGAGGAC ATCGAGAAGG TGGGCCCTGC CCTGGCCACT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0344--Guanine-nucleotide releasing factor
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0862--Zinc

Interpro

IPR000219--DH-domain
IPR001331--GDS_CDC24_CS
IPR002219--PE/DAG-bd
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR000980--SH2
IPR011511--SH3_2
IPR001452--SH3_domain

PROSITE

PS00741--DH_1
PS50010--DH_2
PS50003--PH_DOMAIN
PS50001--SH2
PS50002--SH3
PS00479--ZF_DAG_PE_1
PS50081--ZF_DAG_PE_2

Pfam

PF00130--C1_1
PF00169--PH
PF00621--RhoGEF
PF00017--SH2
PF07653--SH3_2

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00109--C1
SM00233--PH
SM00325--RhoGEF
SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005886--C:plasma membrane
GO:0046872--F:metal ion binding
GO:0005089--F:Rho guanyl-nucleotide exchange factor activity
GO:0016477--P:cell migration
GO:0030032--P:lamellipodium assembly
GO:0043552--P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0030193--P:regulation of blood coagulation
GO:0008361--P:regulation of cell size
GO:0010468--P:regulation of gene expression
GO:0035023--P:regulation of Rho protein signal transduction
GO:0007264--P:small GTPase mediated signal transduction

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001437	Ailuropoda melanoleuca	87.81	0.00e+00	1145.00
IUUC-Apl-003262	Anas platyrhynchos	86.40	0.00e+00	1145.00
IUUC-Aca-004628	Anolis carolinensis	61.49	0.00e+00	783.00
IUUC-Ath-007352	Arabidopsis thaliana	38.98	2.00e-04	41.20
IUUC-Ame-011608	Astyanax mexicanus	75.91	0.00e+00	1078.00
IUUC-Bta-013147	Bos taurus	88.91	0.00e+00	1197.00
IUUC-Cel-018578	Caenorhabditis elegans	27.43	3.00e-70	260.00
IUUC-Cja-018877	Callithrix jacchus	86.50	0.00e+00	1123.00
IUUC-Cfa-020315	Canis familiaris	88.63	0.00e+00	1194.00
IUUC-Cpo-021543	Cavia porcellus	89.37	0.00e+00	1192.00
IUUC-Csa-024204	Chlorocebus sabaeus	86.70	0.00e+00	1166.00
IUUC-Dre-028308	Danio rerio	76.69	0.00e+00	1064.00
IUUC-Dno-029584	Dasypus novemcinctus	85.82	0.00e+00	1113.00
IUUC-Dor-031014	Dipodomys ordii	78.12	0.00e+00	987.00
IUUC-Eca-033448	Equus caballus	85.49	0.00e+00	1134.00
IUUC-Eeu-035182	Erinaceus europaeus	81.92	1.00e-127	450.00
IUUC-Fca-035460	Felis catus	89.02	0.00e+00	1182.00
IUUC-Fal-036684	Ficedula albicollis	83.78	0.00e+00	1126.00
IUUC-Gmo-038816	Gadus morhua	74.37	0.00e+00	1016.00
IUUC-Gga-040999	Gallus gallus	85.23	0.00e+00	1150.00
IUUC-Gac-041353	Gasterosteus aculeatus	75.37	0.00e+00	1040.00
IUUC-Ggo-044558	Gorilla gorilla	89.11	0.00e+00	1175.00
IUUC-Hsa-046208	Homo sapiens	89.11	0.00e+00	1176.00
IUUC-Loc-052827	Lepisosteus oculatus	78.70	0.00e+00	1109.00
IUUC-Laf-054009	Loxodonta africana	84.65	0.00e+00	1118.00
IUUC-Mcc-055054	Macaca mulatta	88.97	0.00e+00	1174.00
IUUC-Meu-056269	Macropus eugenii	81.70	0.00e+00	703.00
IUUC-Mla-059044	Melampsora laricipopulina	24.03	4.00e-19	90.50
IUUC-Mga-060106	Meleagris gallopavo	86.70	0.00e+00	1149.00
IUUC-Mmr-061118	Microcebus murinus	89.49	0.00e+00	1184.00
IUUC-Mdo-062380	Monodelphis domestica	85.20	0.00e+00	1158.00
IUUC-Mmu-063135	Mus musculus	91.37	0.00e+00	1222.00
IUUC-Mpu-066135	Mustela putorius furo	87.74	0.00e+00	1184.00
IUUC-Nle-069465	Nomascus leucogenys	84.33	0.00e+00	1076.00
IUUC-Ont-071945	Oreochromis niloticus	75.83	0.00e+00	1035.00
IUUC-Oan-073384	Ornithorhynchus anatinus	84.45	0.00e+00	1120.00
IUUC-Ola-087499	Oryzias latipes	74.89	0.00e+00	1028.00
IUUC-Oga-088444	Otolemur garnettii	88.18	0.00e+00	1164.00
IUUC-Oar-089576	Ovis aries	84.13	0.00e+00	1127.00
IUUC-Ptr-090507	Pan troglodytes	89.77	0.00e+00	1177.00
IUUC-Pan-092325	Papio anubis	87.59	0.00e+00	1156.00
IUUC-Psi-094021	Pelodiscus sinensis	84.76	0.00e+00	1140.00
IUUC-Pma-094372	Petromyzon marinus	54.70	0.00e+00	715.00
IUUC-Pfo-096732	Poecilia formosa	76.56	0.00e+00	1050.00
IUUC-Pab-098426	Pongo abelii	74.23	0.00e+00	936.00
IUUC-Pca-100295	Procavia capensis	87.08	0.00e+00	1183.00
IUUC-Rno-105332	Rattus norvegicus	90.79	0.00e+00	1164.00
IUUC-Sha-106529	Sarcophilus harrisii	88.13	0.00e+00	1192.00
IUUC-Ssc-116176	Sus scrofa	88.81	0.00e+00	1160.00
IUUC-Tgu-116917	Taeniopygia guttata	86.38	0.00e+00	1148.00
IUUC-Tru-118398	Takifugu rubripes	76.91	0.00e+00	957.00
IUUC-Tni-120819	Tetraodon nigroviridis	76.27	0.00e+00	1059.00
IUUC-Xtr-132747	Xenopus tropicalis	75.96	0.00e+00	1014.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence