iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Fal-037457

Ensembl Protein ID

ENSFALP00000012038.1

UniProt Accession

U3KAI4; U3KAI4_FICAL

Genbank Protein ID

ENSFALP00000012038

Protein Name

Presenilin

Genbank Nucleotide ID

AGTO01020503

Gene Name

PSEN2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFALG00000011534.1	ENSFALT00000012087.1	ENSFALP00000012038.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/CUE	5.00e-06	26.2	284	319

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/CUE

   S: 2    letaleqLkeiFPnldysviqvvLeantgsleaavn 37
           +eta+e++++iFP+l+ys+ + + + +++ ++aa +
   Q: 284  VETAQERNEPIFPALIYSSAMMWTVGMAKPDTAARG 319
           89**********************999987777765 PP

Organism

Ficedula albicollis

Functional Description
(View)

Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.

Protein Sequence
(Fasta)

MITFMNNSDS EEEPCNERTS LMSAESPPVP SYQDGLQASA AGEAQAHRKR RAGSNRGPNN 60
IAGGEMSGSG IPVRESALEN EEEELTLKYG AKHVIMLFVP VTLCMIVVVA TIKSVRFYTE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGAAGAGATA AGTTGGTAAG CACTTAAGCT TTCCAATACT TGAAAGGAGT TTACAAAAAA 60
AGACATGGAT TTTTTACAAG AGCATTTAGT GGCAAGACAA GGGGGAATGT AAGACTGTAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0378--Hydrolase
KW-0472--Membrane
KW-0914--Notch signaling pathway
KW-0645--Protease
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR001493--Pept_A22A_PS2
IPR001108--Peptidase_A22A
IPR006639--Preselin/SPP

Pfam

PF01080--Presenilin

PRINTS

PR01072--PRESENILIN
PR01074--PRESENILIN2

SMART

SM00730--PSN

Gene Ontology

GO:0005813--C:centrosome
GO:0005789--C:endoplasmic reticulum membrane
GO:0000139--C:Golgi membrane
GO:0005887--C:integral component of plasma membrane
GO:0000776--C:kinetochore
GO:0005637--C:nuclear inner membrane
GO:0004190--F:aspartic-type endopeptidase activity
GO:0035556--P:intracellular signal transduction
GO:0006509--P:membrane protein ectodomain proteolysis
GO:0007219--P:Notch signaling pathway
GO:0043085--P:positive regulation of catalytic activity
GO:0016485--P:protein processing

KEGG

fab:101821118

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002356	Ailuropoda melanoleuca	70.87	9.00e-133	466.00
IUUC-Apl-003959	Anas platyrhynchos	90.75	0.00e+00	711.00
IUUC-Aca-005160	Anolis carolinensis	82.79	2.00e-179	621.00
IUUC-Ath-006730	Arabidopsis thaliana	60.49	2.00e-17	83.60
IUUC-Ame-010686	Astyanax mexicanus	79.57	4.00e-139	487.00
IUUC-Bta-013097	Bos taurus	76.09	6.00e-161	560.00
IUUC-Bra-017580	Brassica rapa	61.73	1.00e-17	84.00
IUUC-Cja-018824	Callithrix jacchus	75.22	2.00e-157	548.00
IUUC-Cfa-020253	Canis familiaris	76.30	1.00e-160	559.00
IUUC-Cpo-021401	Cavia porcellus	74.73	2.00e-159	555.00
IUUC-Csa-023369	Chlorocebus sabaeus	76.09	1.00e-161	562.00
IUUC-Dre-028526	Danio rerio	70.99	1.00e-145	509.00
IUUC-Dor-031127	Dipodomys ordii	73.81	2.00e-157	548.00
IUUC-Ete-033081	Echinops telfairi	69.79	2.00e-74	273.00
IUUC-Eca-034387	Equus caballus	75.43	1.00e-154	539.00
IUUC-Eeu-034846	Erinaceus europaeus	60.47	5.00e-106	377.00
IUUC-Fca-035396	Felis catus	76.25	3.00e-165	574.00
IUUC-Gmo-038550	Gadus morhua	70.95	2.00e-124	438.00
IUUC-Gga-040706	Gallus gallus	89.74	0.00e+00	687.00
IUUC-Gac-042511	Gasterosteus aculeatus	67.67	3.00e-133	468.00
IUUC-Gma-043822	Glycine max	37.31	5.00e-24	105.00
IUUC-Ggo-045338	Gorilla gorilla	76.09	2.00e-161	561.00
IUUC-Hsa-046455	Homo sapiens	76.09	2.00e-161	561.00
IUUC-Itr-048731	Ictidomys tridecemlineatus	75.87	5.00e-161	560.00
IUUC-Lch-049638	Latimeria chalumnae	67.37	2.00e-149	521.00
IUUC-Loc-052427	Lepisosteus oculatus	74.24	6.00e-162	563.00
IUUC-Laf-053758	Loxodonta africana	75.33	4.00e-169	587.00
IUUC-Mcc-054755	Macaca mulatta	76.09	4.00e-161	560.00
IUUC-Mmr-060890	Microcebus murinus	75.43	3.00e-160	557.00
IUUC-Mdo-062197	Monodelphis domestica	77.51	4.00e-172	597.00
IUUC-Mmu-063823	Mus musculus	75.16	6.00e-161	560.00
IUUC-Mpu-066181	Mustela putorius furo	76.09	2.00e-160	558.00
IUUC-Nle-069596	Nomascus leucogenys	72.97	2.00e-146	511.00
IUUC-Opr-070344	Ochotona princeps	75.87	1.00e-163	569.00
IUUC-Ont-071867	Oreochromis niloticus	69.30	5.00e-135	474.00
IUUC-Oan-073378	Ornithorhynchus anatinus	75.31	4.00e-154	536.00
IUUC-Ocu-074652	Oryctolagus cuniculus	75.60	4.00e-159	554.00
IUUC-Ola-086707	Oryzias latipes	68.71	3.00e-103	367.00
IUUC-Oga-088560	Otolemur garnettii	74.95	2.00e-156	545.00
IUUC-Oar-089200	Ovis aries	75.87	3.00e-159	554.00
IUUC-Ptr-090569	Pan troglodytes	75.87	6.00e-161	560.00
IUUC-Pan-091742	Papio anubis	76.09	2.00e-161	561.00
IUUC-Psi-093297	Pelodiscus sinensis	84.96	4.00e-160	556.00
IUUC-Pma-094612	Petromyzon marinus	75.52	4.00e-128	451.00
IUUC-Ppa-095431	Physcomitrella patens	32.93	1.00e-24	107.00
IUUC-Pab-098531	Pongo abelii	76.09	1.00e-161	562.00
IUUC-Pca-101120	Procavia capensis	73.70	3.00e-152	531.00
IUUC-Pva-102934	Pteropus vampyrus	69.78	2.00e-153	535.00
IUUC-Rno-106052	Rattus norvegicus	75.43	5.00e-165	573.00
IUUC-Sha-106876	Sarcophilus harrisii	77.59	7.00e-172	596.00
IUUC-Ssc-115380	Sus scrofa	76.30	3.00e-162	564.00
IUUC-Tgu-117280	Taeniopygia guttata	98.47	0.00e+00	768.00
IUUC-Tbe-127632	Tupaia belangeri	73.55	2.00e-131	462.00
IUUC-Ttr-129008	Tursiops truncatus	75.22	1.00e-156	545.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence