iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Loc-051760

Ensembl Protein ID

ENSLOCP00000016721.1

UniProt Accession

W5N7W2; W5N7W2_LEPOC

Genbank Protein ID

ENSLOCP00000016721

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AHAT01000485

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLOCG00000013554.1	ENSLOCT00000016751.1	ENSLOCP00000016721.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.60e-129	431.6	436	768

Active Site

Position(s)	Description	Evidence
737	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl krl+v+f+gEegld+gGv+re+l+lls+e+ np++glf+ys +d +tlq+npds + npehl++F+f+Gr++g+a+++g+++d 
   Q: 436  PKDLWKRLMVKFRGEEGLDYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAV-NPEHLSYFHFVGRIMGMAVFHGHYIDG 523
           678999*****************************************************98.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk+llgk+++l+d+e+vdp+l++sl +i++n   di+   ld tf+v+++ +ge+ ++eLkp+G++ipVt+e k+eYv+l+v+
   Q: 524  GFTLPFYKQLLGKPITLDDMESVDPDLHNSLVWILDN---DITGV-LDHTFCVEHNAYGEIIQHELKPSGKSIPVTEESKKEYVRLYVN 608
           ***********************************99...9***8.******************************************* PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +gi+ q+ a+++Gfnevip++ll++F+e+elel+icG  +id+ d+k++t+ k+ +t+ds++++wFw+++e+ ++e r+++LqFv
   Q: 609  WRFLRGIEAQFLALQKGFNEVIPQHLLKSFDEKELELIICGLGKIDIADWKSNTRLKH-CTPDSNVVKWFWKAVESYDEERRARLLQFV 696
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tgssr+Pl+Gf++l+    prlf+i++ das+++lP+++TCfn++++P+Y++ e+l+ekLl+Aieet gF +
   Q: 697  TGSSRVPLQGFKALQgaagPRLFTIHQiDASTNNLPKAHTCFNRIDIPPYETSEKLYEKLLTAIEETCGFAV 768
           **********************************************************************76 PP

Organism

Lepisosteus oculatus

Protein Sequence
(Fasta)

SSPKCLKRFF SVSVAVLCAK NLVKKDFFRL PDPFAKVVVD GSGQCHSTDT VRNTLDPKWN 60
QHYDLYIGKS DSITISVWNH KKIHKKQGAG FLGCVRLLSN VINRLKDTGC TYLSFNSLPP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCATCCCCAA AATGTCTCAA GCGTTTCTTC TCTGTTTCTG TTGCAGTTTT GTGTGCAAAA 60
AACCTGGTGA AGAAAGACTT CTTTCGTAAG TAACATTTTA AAAATACATA TTTTGTGCAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001305	Ailuropoda melanoleuca	88.92	0.00e+00	1379.00
IUUC-Apl-003513	Anas platyrhynchos	89.40	0.00e+00	1403.00
IUUC-Aca-005358	Anolis carolinensis	88.13	0.00e+00	1390.00
IUUC-Ame-011320	Astyanax mexicanus	87.14	0.00e+00	1378.00
IUUC-Bta-013399	Bos taurus	88.06	0.00e+00	1376.00
IUUC-Cja-019355	Callithrix jacchus	88.62	0.00e+00	1374.00
IUUC-Cpo-022200	Cavia porcellus	89.27	0.00e+00	1380.00
IUUC-Cho-024804	Choloepus hoffmanni	95.47	6.00e-180	624.00
IUUC-Cin-025126	Ciona intestinalis	61.91	0.00e+00	935.00
IUUC-Csv-026339	Ciona savignyi	61.13	0.00e+00	967.00
IUUC-Dre-027650	Danio rerio	91.03	0.00e+00	1438.00
IUUC-Dno-029534	Dasypus novemcinctus	88.65	0.00e+00	1376.00
IUUC-Ete-032715	Echinops telfairi	84.59	0.00e+00	1288.00
IUUC-Eca-033580	Equus caballus	89.02	0.00e+00	1379.00
IUUC-Eeu-034945	Erinaceus europaeus	86.11	0.00e+00	1277.00
IUUC-Fal-037275	Ficedula albicollis	89.36	0.00e+00	1400.00
IUUC-Gga-041060	Gallus gallus	84.96	0.00e+00	1322.00
IUUC-Gac-041295	Gasterosteus aculeatus	88.89	0.00e+00	1400.00
IUUC-Hsa-046726	Homo sapiens	88.52	0.00e+00	1375.00
IUUC-Lch-050026	Latimeria chalumnae	88.39	0.00e+00	1380.00
IUUC-Laf-053753	Loxodonta africana	89.01	0.00e+00	1377.00
IUUC-Mcc-054815	Macaca mulatta	88.39	0.00e+00	1375.00
IUUC-Meu-056436	Macropus eugenii	69.79	0.00e+00	1032.00
IUUC-Mmr-060806	Microcebus murinus	88.90	0.00e+00	1380.00
IUUC-Mdo-062805	Monodelphis domestica	88.13	0.00e+00	1367.00
IUUC-Mmu-064034	Mus musculus	87.73	0.00e+00	1376.00
IUUC-Mpu-066762	Mustela putorius furo	88.70	0.00e+00	1382.00
IUUC-Mlu-066981	Myotis lucifugus	89.01	0.00e+00	1376.00
IUUC-Nle-069804	Nomascus leucogenys	88.52	0.00e+00	1374.00
IUUC-Opr-070591	Ochotona princeps	83.53	0.00e+00	1282.00
IUUC-Ont-072243	Oreochromis niloticus	90.17	0.00e+00	1431.00
IUUC-Oan-072699	Ornithorhynchus anatinus	89.09	0.00e+00	1390.00
IUUC-Ocu-074913	Oryctolagus cuniculus	88.79	0.00e+00	1377.00
IUUC-Ola-086597	Oryzias latipes	82.33	0.00e+00	1287.00
IUUC-Oga-089116	Otolemur garnettii	85.70	0.00e+00	1316.00
IUUC-Oar-089366	Ovis aries	88.08	0.00e+00	1379.00
IUUC-Ptr-091382	Pan troglodytes	88.52	0.00e+00	1375.00
IUUC-Psi-093298	Pelodiscus sinensis	88.48	0.00e+00	1381.00
IUUC-Pma-094354	Petromyzon marinus	70.27	0.00e+00	1087.00
IUUC-Pfo-096071	Poecilia formosa	89.78	0.00e+00	1414.00
IUUC-Pab-098682	Pongo abelii	88.52	0.00e+00	1376.00
IUUC-Pca-100516	Procavia capensis	86.34	6.00e-177	614.00
IUUC-Pva-102754	Pteropus vampyrus	88.05	0.00e+00	1343.00
IUUC-Rno-105600	Rattus norvegicus	88.58	0.00e+00	1189.00
IUUC-Sha-107144	Sarcophilus harrisii	86.93	0.00e+00	1261.00
IUUC-Sar-113122	Sorex araneus	78.75	0.00e+00	1165.00
IUUC-Tgu-117112	Taeniopygia guttata	88.26	0.00e+00	1390.00
IUUC-Tru-118497	Takifugu rubripes	86.37	0.00e+00	1330.00
IUUC-Tni-120781	Tetraodon nigroviridis	86.40	0.00e+00	1160.00
IUUC-Tme-126897	Tuber melanosporum	37.75	6.00e-147	514.00
IUUC-Tbe-127371	Tupaia belangeri	78.57	0.00e+00	1101.00
IUUC-Ttr-129305	Tursiops truncatus	81.67	0.00e+00	1185.00
IUUC-Vpa-130591	Vicugna pacos	79.42	0.00e+00	1186.00
IUUC-Xtr-132979	Xenopus tropicalis	71.23	0.00e+00	1046.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence