iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ggo-045258

UUCD1 version

UUC-GoG-00144

Ensembl Protein ID

ENSGGOP00000003280.2

UniProt Accession

G3QLD1; G3QLD1_GORGO

Protein Name

Uncharacterized protein

Gene Name

TNFAIP3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGGOG00000003334.2	ENSGGOT00000003354.2	ENSGGOP00000003280.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/OTU	2.50e-40	138.5	94	263
UBD/ZnF/ZnF_A20	2.00e-25	88.8	757	791

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/OTU

   S: 2    lilktkgDGnCLlrAvsqsllgvfddds.lsdalveaLreltseyl....qkesdffsefieek........edekefcqklvepe... 74
           ++lkt+gDGnCL++A+sq+++gv+d+d+ l++ l+++L+e+ ++++    q es + +ef+e++        +de++++ k+++++   
   Q: 94   VALKTNGDGNCLMHATSQYMWGVQDTDLvLRKVLFSTLKETDTRNFkfrwQLESLKSQEFVETGlcydtrnwNDEWDNLIKMASTDtpm 182
           789**********************************************9**********************************99766 PP
   S: 75   ak.g......eeihifaLaqiLsrpiivvdvdsles..........kvggillpllfpeek.lkkpivLlYrsgHYdaLva 137
           a+ g      eeihif+L++iL+rpiiv+++++l+s          kvggi+lpl++p+++ +++pivL+Y+s+H+ +Lv+
   Q: 183  ARsGlqynslEEIHIFVLCNILRRPIIVISDKMLRSlesgsnfaplKVGGIYLPLHWPAQEcYRYPIVLGYDSHHFVPLVT 263
           6644999999*********************************************************************97 PP

UBD/ZnF/ZnF_A20

   S: 1    dpskllCkk.gCgfYGnpetngyCSkCyreelrrr 34
           dp+k++C++ +C+++Gn+++ngyC++C++++++++
   Q: 757  DPPKQRCRApACDHFGNAKCNGYCNECFQFKQMYG 791
           8********************************96 PP

Organism

Gorilla gorilla

Protein Sequence
(Fasta)

TMAEQVLPQA LYLSNMRKAV KIRERTPEDI FKPTNGIIHH FKTMHRYTLE MFRTCQFCPQ 60
FREIIHKALI DRNIQATLES QKKLNWCREV RKLVALKTNG DGNCLMHATS QYMWGVQDTD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGCCTTGACC AGGACTTGGG ACTTTGCGAA AGGATCGCGG GGCCCGGAGA GGTAACCGCC 60
GCGCCTCCCC GTGCCGTCTG CCTCGGGCTC ACCGCAGTCA AGGGCTGCGG GTGCATGTTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR033478--A20
IPR003323--OTU_dom
IPR002653--Znf_A20

PROSITE

PS50802--OTU
PS51036--ZF_A20

Pfam

PF02338--OTU
PF01754--zf-A20

SMART

SM00259--ZnF_A20

Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0001922--P:B-1 B cell homeostasis
GO:0070301--P:cellular response to hydrogen peroxide
GO:0072666--P:establishment of protein localization to vacuole
GO:0050869--P:negative regulation of B cell activation
GO:2000349--P:negative regulation of CD40 signaling pathway
GO:0002677--P:negative regulation of chronic inflammatory response
GO:0045736--P:negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:2000352--P:negative regulation of endothelial cell apoptotic process
GO:1902042--P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045824--P:negative regulation of innate immune response
GO:0032691--P:negative regulation of interleukin-1 beta production
GO:0032703--P:negative regulation of interleukin-2 production
GO:0032715--P:negative regulation of interleukin-6 production
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0070429--P:negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
GO:0070433--P:negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0031397--P:negative regulation of protein ubiquitination
GO:0048662--P:negative regulation of smooth muscle cell proliferation
GO:0034140--P:negative regulation of toll-like receptor 3 signaling pathway
GO:0034148--P:negative regulation of toll-like receptor 5 signaling pathway
GO:0032720--P:negative regulation of tumor necrosis factor production
GO:1903364--P:positive regulation of cellular protein catabolic process
GO:2000347--P:positive regulation of hepatocyte proliferation
GO:0035871--P:protein K11-linked deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0002634--P:regulation of germinal center formation
GO:0032495--P:response to muramyl dipeptide
GO:0072573--P:tolerance induction to lipopolysaccharide

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001825	Ailuropoda melanoleuca	90.51	0.00e+00	1492.00
IUUC-Apl-003501	Anas platyrhynchos	65.95	0.00e+00	1038.00
IUUC-Aca-004245	Anolis carolinensis	64.30	0.00e+00	1057.00
IUUC-Ame-011789	Astyanax mexicanus	45.15	0.00e+00	692.00
IUUC-Bta-012664	Bos taurus	85.44	0.00e+00	1365.00
IUUC-Cja-019895	Callithrix jacchus	96.46	0.00e+00	1567.00
IUUC-Cfa-020754	Canis familiaris	90.00	0.00e+00	1494.00
IUUC-Cpo-021780	Cavia porcellus	89.39	0.00e+00	1464.00
IUUC-Csa-023568	Chlorocebus sabaeus	98.23	0.00e+00	1608.00
IUUC-Cho-024300	Choloepus hoffmanni	90.09	0.00e+00	651.00
IUUC-Dre-028577	Danio rerio	47.71	0.00e+00	677.00
IUUC-Dno-029382	Dasypus novemcinctus	84.18	0.00e+00	1348.00
IUUC-Dor-030874	Dipodomys ordii	86.46	0.00e+00	1407.00
IUUC-Ete-032721	Echinops telfairi	91.39	0.00e+00	802.00
IUUC-Eca-033596	Equus caballus	87.22	0.00e+00	1407.00
IUUC-Eeu-035159	Erinaceus europaeus	87.90	0.00e+00	1133.00
IUUC-Fca-035847	Felis catus	91.01	0.00e+00	1499.00
IUUC-Fal-036681	Ficedula albicollis	64.89	0.00e+00	1045.00
IUUC-Gmo-038521	Gadus morhua	58.33	2.00e-145	509.00
IUUC-Gga-040975	Gallus gallus	64.56	0.00e+00	1054.00
IUUC-Gac-042216	Gasterosteus aculeatus	60.53	3.00e-152	532.00
IUUC-Hsa-046071	Homo sapiens	99.24	0.00e+00	1623.00
IUUC-Itr-048386	Ictidomys tridecemlineatus	92.28	0.00e+00	1503.00
IUUC-Lch-050326	Latimeria chalumnae	57.09	0.00e+00	915.00
IUUC-Loc-051945	Lepisosteus oculatus	45.59	2.00e-175	609.00
IUUC-Laf-053722	Loxodonta africana	89.37	0.00e+00	1443.00
IUUC-Mcc-055503	Macaca mulatta	97.97	0.00e+00	1603.00
IUUC-Meu-056481	Macropus eugenii	76.21	0.00e+00	1200.00
IUUC-Mga-059690	Meleagris gallopavo	62.72	0.00e+00	970.00
IUUC-Mmr-061233	Microcebus murinus	91.29	0.00e+00	1463.00
IUUC-Mdo-062446	Monodelphis domestica	80.93	0.00e+00	1310.00
IUUC-Mmu-063436	Mus musculus	88.10	0.00e+00	1410.00
IUUC-Mpu-066808	Mustela putorius furo	90.38	0.00e+00	1488.00
IUUC-Mlu-067339	Myotis lucifugus	89.75	0.00e+00	1446.00
IUUC-Nle-069888	Nomascus leucogenys	98.86	0.00e+00	1617.00
IUUC-Opr-070303	Ochotona princeps	89.66	0.00e+00	1448.00
IUUC-Ont-072283	Oreochromis niloticus	58.17	2.00e-146	512.00
IUUC-Oan-072925	Ornithorhynchus anatinus	76.47	0.00e+00	1246.00
IUUC-Ocu-073889	Oryctolagus cuniculus	89.89	0.00e+00	1427.00
IUUC-Oni-082742	Oryza nivara	28.57	2.00e-01	32.70
IUUC-Oru-085223	Oryza rufipogon	28.57	2.00e-01	32.30
IUUC-Ola-087417	Oryzias latipes	58.94	4.00e-147	515.00
IUUC-Oga-088708	Otolemur garnettii	88.35	0.00e+00	1399.00
IUUC-Oar-089271	Ovis aries	85.95	0.00e+00	1380.00
IUUC-Ptr-091296	Pan troglodytes	99.24	0.00e+00	1622.00
IUUC-Pan-092474	Papio anubis	98.10	0.00e+00	1607.00
IUUC-Psi-093447	Pelodiscus sinensis	69.35	0.00e+00	1119.00
IUUC-Pfo-096511	Poecilia formosa	58.65	4.00e-148	518.00
IUUC-Pab-098700	Pongo abelii	98.73	0.00e+00	1613.00
IUUC-Pca-100246	Procavia capensis	75.95	0.00e+00	1191.00
IUUC-Pva-102606	Pteropus vampyrus	78.93	1.00e-180	626.00
IUUC-Rno-105818	Rattus norvegicus	88.13	0.00e+00	1444.00
IUUC-Sha-106559	Sarcophilus harrisii	79.42	0.00e+00	1280.00
IUUC-Sit-110516	Setaria italica	42.86	7.70e-02	33.10
IUUC-Sar-113454	Sorex araneus	93.60	0.00e+00	646.00
IUUC-Ssc-116064	Sus scrofa	88.61	0.00e+00	1418.00
IUUC-Tgu-117212	Taeniopygia guttata	64.68	0.00e+00	1035.00
IUUC-Tru-118230	Takifugu rubripes	60.14	9.00e-152	530.00
IUUC-Tsy-119066	Tarsius syrichta	89.49	0.00e+00	1475.00
IUUC-Tni-119825	Tetraodon nigroviridis	46.58	0.00e+00	680.00
IUUC-Tvi-122358	Trichoderma virens	33.87	7.40e-02	31.60
IUUC-Tur-126383	Triticum urartu	50.00	7.00e-03	32.00
IUUC-Tbe-127601	Tupaia belangeri	96.65	0.00e+00	673.00
IUUC-Ttr-128930	Tursiops truncatus	86.84	0.00e+00	1404.00
IUUC-Vpa-130450	Vicugna pacos	94.26	0.00e+00	796.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence