iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mlu-066929

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AAPE02006959

Gene Name

USP44

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMLUG00000006043.2	ENSMLUT00000006043.2	ENSMLUP00000005518.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.30e-89	300.8	272	664

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle...........kkkeklneenp.................................... 42
           tGl+NlgNtCYmNSvLQ+Ls++  +r+++l+           ++k       +                                    
   Q: 272  TGLRNLGNTCYMNSVLQVLSHLLIFRQCFLKldlnqwlsvttNDKT------Kssykhppitdtvyqvnecqekdmfsvhsrhpslssr 354
           7******************************988777666443333......1334455899999999999999999999999999999 PP
   S: 43   ...................kepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkekn 112
                              +++  +l+++l++lf+ +w++k+  vsp ++l++++++ + f+gy+qqDaqEfl+ lld+++ el     
   Q: 355  lsvgssksrkmeliqpwksSSQYISLCHELHTLFQVMWSGKWAFVSPFAMLHSVWRLIPAFRGYAQQDAQEFLCELLDKIQHEL----- 438
           999988888888888887767777************************************************************..... PP
   S: 113  kpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke.......slqdcLesf 194
               e+++++  +l   +++k  k+  ++++++F+gql sq++cl+cdn+s++ epf+dlsl++p++ +++ +        ++++L++f
   Q: 439  ----ETTGTRLPALIPTSQRKLIKQVLNVVNNIFHGQLLSQVTCLACDNKSNTIEPFWDLSLEFPERYQCNGKdmasqscLVTEMLSKF 523
           ....7788888999999************************************************9998877788999999******** PP
   S: 195  tkeeelegenkyycekckkkqe...........aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekq 272
           t++e leg+  y c++c++k++           a+k+l++ +lP++L lhLkRf++s + ++reki  +v+f++ L+++p+c++++ k+
   Q: 524  TETEALEGKI-YICDHCNSKRRrfssktvvlteAQKQLMICHLPQILRLHLKRFRWSGR-NNREKIGVHVDFKEILNMEPYCCRESVKS 610
           *******965.*******999999999999999***********************998.7778********************88777 PP
   S: 273  ke..kkkYeLiavvvHsG.slssGHYvayvknekgk.WllfdDskVtevkeeev 322
            +  + +Y+L+avv+H+G +++sGHY+ay++n++g+ W++++Dsk + ++++ev
   Q: 611  LRpeCFIYDLSAVVMHHGkGFGSGHYTAYCYNSEGGfWVHCNDSKLSMCTMDEV 664
           65679***************************9999*************99986 PP

Organism

Myotis lucifugus

Protein Sequence
(Fasta)

MLTMDKCKHI GQLQLAQDHS ILNPQKWHCV NCNTSESIWA CLSCSHVACG RYIEEHAVKH 60
FQESSHPVAI EVNDMYVFCY LCDDYVLNDN AAGDLKLLRS TLSAIKSQNY HCTTRRGRVL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTTAACTA TGGATAAATG CAAACACATT GGACAGTTGC AACTTGCTCA AGACCATTCC 60
ATTCTCAACC CTCAGAAATG GCATTGTGTG AACTGCAATA CAAGTGAGTC GATTTGGGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0005634--C:nucleus
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:1904667--P:negative regulation of ubiquitin protein ligase activity
GO:0016579--P:protein deubiquitination
GO:0090231--P:regulation of spindle checkpoint
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001220	Ailuropoda melanoleuca	89.31	0.00e+00	1223.00
IUUC-Apl-003673	Anas platyrhynchos	73.96	0.00e+00	995.00
IUUC-Aca-004434	Anolis carolinensis	70.81	0.00e+00	972.00
IUUC-Ame-010986	Astyanax mexicanus	61.52	0.00e+00	828.00
IUUC-Bta-012774	Bos taurus	86.75	0.00e+00	1184.00
IUUC-Cja-019619	Callithrix jacchus	86.04	0.00e+00	1159.00
IUUC-Cfa-020957	Canis familiaris	88.55	0.00e+00	1233.00
IUUC-Csa-023177	Chlorocebus sabaeus	85.44	0.00e+00	1151.00
IUUC-Cho-024877	Choloepus hoffmanni	84.87	0.00e+00	818.00
IUUC-Csv-025814	Ciona savignyi	43.48	1.00e-144	506.00
IUUC-Dre-027878	Danio rerio	61.45	0.00e+00	800.00
IUUC-Dno-029832	Dasypus novemcinctus	87.65	0.00e+00	1209.00
IUUC-Ete-032627	Echinops telfairi	82.58	0.00e+00	1132.00
IUUC-Eca-033863	Equus caballus	82.33	0.00e+00	1112.00
IUUC-Eeu-035225	Erinaceus europaeus	81.80	0.00e+00	1098.00
IUUC-Fca-036288	Felis catus	88.70	0.00e+00	1221.00
IUUC-Fal-037207	Ficedula albicollis	73.40	0.00e+00	969.00
IUUC-Gga-040457	Gallus gallus	73.50	0.00e+00	964.00
IUUC-Ggo-044926	Gorilla gorilla	85.74	0.00e+00	1149.00
IUUC-Hsa-046079	Homo sapiens	85.29	0.00e+00	1147.00
IUUC-Itr-048737	Ictidomys tridecemlineatus	86.92	0.00e+00	1191.00
IUUC-Lch-050260	Latimeria chalumnae	65.19	0.00e+00	874.00
IUUC-Loc-051981	Lepisosteus oculatus	74.09	1.00e-177	616.00
IUUC-Laf-054491	Loxodonta africana	84.74	0.00e+00	1137.00
IUUC-Mcc-055694	Macaca mulatta	85.14	0.00e+00	1148.00
IUUC-Mga-059523	Meleagris gallopavo	73.77	0.00e+00	982.00
IUUC-Mmr-060885	Microcebus murinus	88.74	0.00e+00	1201.00
IUUC-Mdo-063018	Monodelphis domestica	76.35	0.00e+00	1041.00
IUUC-Mmu-064012	Mus musculus	76.24	0.00e+00	988.00
IUUC-Mpu-066207	Mustela putorius furo	87.05	0.00e+00	1223.00
IUUC-Nle-069313	Nomascus leucogenys	75.45	0.00e+00	979.00
IUUC-Opr-070375	Ochotona princeps	78.38	0.00e+00	1039.00
IUUC-Ont-071637	Oreochromis niloticus	61.82	0.00e+00	807.00
IUUC-Oan-073030	Ornithorhynchus anatinus	74.53	0.00e+00	826.00
IUUC-Ocu-074836	Oryctolagus cuniculus	84.46	0.00e+00	1130.00
IUUC-Oga-088367	Otolemur garnettii	88.14	0.00e+00	1173.00
IUUC-Oar-089953	Ovis aries	87.97	0.00e+00	1220.00
IUUC-Ptr-090980	Pan troglodytes	85.74	0.00e+00	1153.00
IUUC-Pan-092748	Papio anubis	85.71	0.00e+00	1159.00
IUUC-Psi-094078	Pelodiscus sinensis	73.48	0.00e+00	826.00
IUUC-Pab-098514	Pongo abelii	85.89	0.00e+00	1155.00
IUUC-Pva-102984	Pteropus vampyrus	90.21	0.00e+00	1238.00
IUUC-Rno-106019	Rattus norvegicus	76.91	0.00e+00	1043.00
IUUC-Sha-106965	Sarcophilus harrisii	76.01	0.00e+00	1047.00
IUUC-Ssc-115299	Sus scrofa	89.01	0.00e+00	1238.00
IUUC-Tgu-117160	Taeniopygia guttata	73.20	0.00e+00	972.00
IUUC-Tru-118156	Takifugu rubripes	59.36	0.00e+00	796.00
IUUC-Tni-119733	Tetraodon nigroviridis	60.32	0.00e+00	807.00
IUUC-Tbe-128084	Tupaia belangeri	81.20	0.00e+00	1114.00
IUUC-Ttr-128928	Tursiops truncatus	90.21	0.00e+00	1233.00
IUUC-Vpa-130706	Vicugna pacos	89.76	0.00e+00	1224.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence