iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ame-010768

Ensembl Protein ID

ENSAMXP00000003724.1

UniProt Accession

W5K813; W5K813_ASTMX

Genbank Protein ID

ENSAMXP00000003724

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

APWO01041107

Gene Name

HERC4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMXG00000003650.1	ENSAMXT00000003724.1	ENSAMXP00000003724.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.10e-100	336.1	724	1047

Active Site

Position(s)	Description	Evidence
1016	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           d kk l+v fvgEe++d+gGv +ef+ l++kel +p++g+f+y e+++  ++ +++      e+ +lF+++G+++g+a+++  +++l
   Q: 724  DYKKPLKVIFVGEEAVDAGGVRKEFFLLIMKELLDPKYGMFRYYEESRLIWFADKTF-----EEVDLFHLIGVICGLAIYNLTIVEL 805
           78999***********************************************99977.....689********************** PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklv 177
           +++ ++yk+ll++  +l+dl+e++p++ +sl++++++ e+d+ee+ ++l+f+++ e++g t++ eL+p+G +i+V+n N++++v+++
   Q: 806  NFPVALYKKLLKRTPTLDDLKELMPDVGRSLQQLLDYTEDDVEET-FCLNFTITVENFGATEVLELVPNGMDINVNNHNRQDFVNAY 891
           *************************************99888887.***************************************** PP
   S: 178  veyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkaf 264
           v+y++++++++ ++af++Gf++v+  ++l+lF+++el+ ++ G++++d+++l++ ++ykg+y + +p+i+ Fwev++e+  e++k+f
   Q: 892  VDYIFNTSVAQLFNAFHAGFHKVCGGNVLELFQPNELQAMVIGNTNYDWKELEQSAEYKGEYWAGHPTIKLFWEVFHELPLEKKKQF 978
           *************************************************************************************** PP
   S: 265  LqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           L F+Tgs+r+P+ G+++l     vi+   + ++ lP ++TCfn+L+LP+Y+s +il+ekLl Aie+++gF+l
   Q: 979  LLFLTGSDRIPILGMKSLA---LVIQPtGGGEHYLPVAHTCFNLLDLPKYNSRQILQEKLLKAIEHNQGFNL 1047
           *******************...6666658889**************************************87 PP

Organism

Astyanax mexicanus

Protein Sequence
(Fasta)

MLCWGNASYG QLGLGGIDEE IVVEPRKCSF FNGKLVWDVG CGRRHTVFLL GDGTVYTCGC 60
NDLGQLGHEK TRKKPEQVVA LDAQNIVAVS CGESHTLALN DKGQVFAWGQ ASEGQLGLAN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGCAGTGGGA ATCTGTTGAA GGTGAAAACA GGAATTAAAG TAGAGCCCAG AGGAGGCAGG 60
AGCCATGCTG TGCTGGGGTA ATGCCTCCTA TGGCCAGCTC GGATTGGGTG GAATCGATGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001666	Ailuropoda melanoleuca	72.97	0.00e+00	1510.00
IUUC-Apl-003295	Anas platyrhynchos	73.02	0.00e+00	1555.00
IUUC-Aca-004336	Anolis carolinensis	72.68	0.00e+00	1555.00
IUUC-Bta-013279	Bos taurus	73.06	0.00e+00	1514.00
IUUC-Cel-018150	Caenorhabditis elegans	34.48	4.00e-159	555.00
IUUC-Cja-019023	Callithrix jacchus	73.44	0.00e+00	1518.00
IUUC-Cfa-021074	Canis familiaris	73.16	0.00e+00	1515.00
IUUC-Cpo-021461	Cavia porcellus	71.60	0.00e+00	1478.00
IUUC-Csa-024261	Chlorocebus sabaeus	73.06	0.00e+00	1513.00
IUUC-Cin-025232	Ciona intestinalis	43.26	0.00e+00	830.00
IUUC-Dre-028829	Danio rerio	80.78	0.00e+00	1683.00
IUUC-Dno-029445	Dasypus novemcinctus	69.71	0.00e+00	1191.00
IUUC-Dor-030158	Dipodomys ordii	76.32	0.00e+00	702.00
IUUC-Dse-031239	Dothistroma septosporum	34.09	4.00e-77	283.00
IUUC-Dme-032103	Drosophila melanogaster	44.23	0.00e+00	880.00
IUUC-Ete-033072	Echinops telfairi	66.29	0.00e+00	1341.00
IUUC-Eca-033317	Equus caballus	72.68	0.00e+00	1504.00
IUUC-Eeu-035098	Erinaceus europaeus	46.06	0.00e+00	687.00
IUUC-Fca-035682	Felis catus	73.71	0.00e+00	1519.00
IUUC-Fal-036969	Ficedula albicollis	72.52	0.00e+00	1544.00
IUUC-Gmo-038671	Gadus morhua	76.84	0.00e+00	1648.00
IUUC-Ggr-040110	Gaeumannomyces graminis	37.70	4.00e-79	290.00
IUUC-Gga-041174	Gallus gallus	72.90	0.00e+00	1557.00
IUUC-Gac-042600	Gasterosteus aculeatus	77.52	0.00e+00	1587.00
IUUC-Gma-043616	Glycine max	37.46	3.00e-51	196.00
IUUC-Ggo-044589	Gorilla gorilla	73.06	0.00e+00	1529.00
IUUC-Hsa-046772	Homo sapiens	73.16	0.00e+00	1527.00
IUUC-Kpa-049152	Komagataella pastoris	38.81	2.00e-66	247.00
IUUC-Lch-050147	Latimeria chalumnae	70.70	0.00e+00	1239.00
IUUC-Loc-052684	Lepisosteus oculatus	77.24	0.00e+00	1615.00
IUUC-Laf-053844	Loxodonta africana	72.50	0.00e+00	1504.00
IUUC-Mcc-055531	Macaca mulatta	71.35	0.00e+00	1498.00
IUUC-Mga-060151	Meleagris gallopavo	71.03	0.00e+00	1259.00
IUUC-Mmr-060954	Microcebus murinus	72.97	0.00e+00	1511.00
IUUC-Mdo-062246	Monodelphis domestica	71.69	0.00e+00	1387.00
IUUC-Mmu-063369	Mus musculus	73.43	0.00e+00	1554.00
IUUC-Mpu-065936	Mustela putorius furo	72.33	0.00e+00	1382.00
IUUC-Mlu-067326	Myotis lucifugus	72.68	0.00e+00	1478.00
IUUC-Ncr-068903	Neurospora crassa	35.93	7.00e-77	282.00
IUUC-Nle-069453	Nomascus leucogenys	73.62	0.00e+00	1516.00
IUUC-Ont-071720	Oreochromis niloticus	78.88	0.00e+00	1624.00
IUUC-Oan-073464	Ornithorhynchus anatinus	71.82	0.00e+00	1381.00
IUUC-Ocu-074207	Oryctolagus cuniculus	70.19	0.00e+00	1363.00
IUUC-Olo-080768	Oryza longistaminata	35.44	3.00e-51	195.00
IUUC-Ome-081908	Oryza meridionalis	32.96	4.00e-45	175.00
IUUC-Opu-083608	Oryza punctata	34.08	4.00e-46	178.00
IUUC-Osa-086078	Oryza sativa	33.89	2.00e-45	176.00
IUUC-Ola-086762	Oryzias latipes	76.85	0.00e+00	1560.00
IUUC-Oga-088435	Otolemur garnettii	72.78	0.00e+00	1506.00
IUUC-Oar-089233	Ovis aries	73.16	0.00e+00	1514.00
IUUC-Ptr-091368	Pan troglodytes	73.16	0.00e+00	1527.00
IUUC-Pan-092300	Papio anubis	73.06	0.00e+00	1513.00
IUUC-Psi-093406	Pelodiscus sinensis	72.52	0.00e+00	1554.00
IUUC-Pma-094113	Petromyzon marinus	65.87	0.00e+00	1053.00
IUUC-Ppa-095354	Physcomitrella patens	34.01	1.00e-151	530.00
IUUC-Pfo-097021	Poecilia formosa	77.56	0.00e+00	1657.00
IUUC-Pab-098327	Pongo abelii	73.16	0.00e+00	1528.00
IUUC-Pva-102909	Pteropus vampyrus	64.65	0.00e+00	1258.00
IUUC-Pte-104055	Pyrenophora teres	30.50	2.00e-47	184.00
IUUC-Pyt-104647	Pyrenophora triticirepentis	30.32	4.00e-47	183.00
IUUC-Rno-105457	Rattus norvegicus	73.44	0.00e+00	1557.00
IUUC-Sha-106632	Sarcophilus harrisii	72.48	0.00e+00	1526.00
IUUC-Spo-108271	Schizosaccharomyces pombe	32.78	5.00e-73	269.00
IUUC-Sar-113679	Sorex araneus	62.27	0.00e+00	798.00
IUUC-Tgu-116849	Taeniopygia guttata	69.97	0.00e+00	1465.00
IUUC-Tru-118206	Takifugu rubripes	75.33	0.00e+00	1536.00
IUUC-Tsy-119521	Tarsius syrichta	60.50	0.00e+00	1177.00
IUUC-Tni-120233	Tetraodon nigroviridis	75.50	0.00e+00	1539.00
IUUC-Tme-127004	Tuber melanosporum	35.98	4.00e-81	297.00
IUUC-Vpa-130448	Vicugna pacos	72.87	0.00e+00	1513.00
IUUC-Xtr-132719	Xenopus tropicalis	63.59	0.00e+00	1235.00
IUUC-Xma-133389	Xiphophorus maculatus	76.90	0.00e+00	1649.00
IUUC-Yli-134470	Yarrowia lipolytica	32.30	1.00e-61	231.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence