iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Cel-018162

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Probable ubiquitin-conjugating enzyme E2 7; E2 ubiquitin-conjugating enzyme 7; Ubiquitin carrier protein 7; Ubiquitin-protein ligase 7

Genbank Nucleotide ID

Z22179

Gene Name

ubc-7; F58A4.10

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
WBGene00006704	F58A4.10	F58A4.10

Annotation

mRNA Expression
GEO
DNA & RNA Element
microRNA	RAID2
Protein 3D Structure
PDB	MMDB
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E2/UBC	1.90e-49	167.3	8	155

Active Site

Position(s)	Description	Evidence
88	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00388, ECO:0000255\|PROSITE-ProRule:PRU10133}

Domain Profile

E2/UBC

   S: 2    lkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilk...........eeek 91
           lkk+l+++++ p++g+sa++vd++d+++wevl++Gp+dt Yegg+Fk+ ++fp+dYP kPPk+kf+++i+hPn++++G+vC+sil+           +ee+
   Q: 8    LKKQLADMRRVPVDGFSAGLVDDNDIYKWEVLVIGPPDTLYEGGFFKAILDFPRDYPQKPPKMKFISEIWHPNIDKEGNVCISILHdpgddkwgyerPEER 108
           6899*********************************************************************************8889999999999*** PP
   S: 92   Wspalsvesvllsiqsllaepnpesplneeaaellkknreeykkkvr 138
           W p+++ve++lls++s+l++pn+esp+n++aa++ ++n +e+kkkv 
   Q: 109  WLPVHTVETILLSVISMLTDPNFESPANVDAAKMQRENYAEFKKKVA 155
           *********************************************96 PP

Organism

Caenorhabditis elegans

Functional Description
(View)

Catalyzes the covalent attachment of ubiquitin to other proteins.

Protein Sequence
(Fasta)

MEQSSLLLKK QLADMRRVPV DGFSAGLVDD NDIYKWEVLV IGPPDTLYEG GFFKAILDFP 60
RDYPQKPPKM KFISEIWHPN IDKEGNVCIS ILHDPGDDKW GYERPEERWL PVHTVETILL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATAGATGGAG CAATCCTCCC TACTTCTGAA GAAACAGCTG GCAGGTGAGT TGGGATTAAA 60
CGTGATCTAT GATCAAAACT AACTTTTTTC TGTTTCCAGA CATGCGCAGA GTTCCAGTCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005524--F:ATP binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0000209--P:protein polyubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

cel:CELE_F58A4.10

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000411	Aegilops tauschii	46.33	6.00e-42	162.00
IUUC-Aml-001379	Ailuropoda melanoleuca	72.67	2.00e-70	256.00
IUUC-Atr-002446	Amborella trichopoda	64.60	4.00e-46	175.00
IUUC-Apl-003579	Anas platyrhynchos	72.05	4.00e-70	255.00
IUUC-Aca-005146	Anolis carolinensis	73.68	1.00e-67	246.00
IUUC-Aly-005452	Arabidopsis lyrata	66.00	9.00e-53	197.00
IUUC-Ath-007644	Arabidopsis thaliana	67.59	7.00e-52	194.00
IUUC-Acl-008329	Aspergillus clavatus	57.50	3.00e-46	176.00
IUUC-Afl-008660	Aspergillus flavus	56.88	6.00e-47	178.00
IUUC-Afu-008841	Aspergillus fumigatus	59.59	5.00e-45	172.00
IUUC-Ang-009536	Aspergillus niger	57.50	4.00e-46	175.00
IUUC-Aor-009951	Aspergillus oryzae	57.32	6.00e-47	178.00
IUUC-Ate-010276	Aspergillus terreus	57.50	2.00e-46	176.00
IUUC-Ame-010634	Astyanax mexicanus	71.03	9.00e-63	234.00
IUUC-Bta-013324	Bos taurus	76.71	4.00e-67	245.00
IUUC-Bdi-014838	Brachypodium distachyon	62.73	1.00e-54	204.00
IUUC-Bol-016383	Brassica oleracea	69.66	9.00e-61	224.00
IUUC-Bra-017324	Brassica rapa	67.59	1.00e-52	197.00
IUUC-Cja-018734	Callithrix jacchus	69.94	3.00e-68	249.00
IUUC-Cfa-020846	Canis familiaris	71.60	8.00e-70	254.00
IUUC-Cpo-022207	Cavia porcellus	73.86	4.00e-68	248.00
IUUC-Cre-022895	Chlamydomonas reinhardtii	66.25	5.00e-58	215.00
IUUC-Csa-024193	Chlorocebus sabaeus	76.71	4.00e-67	245.00
IUUC-Cho-024621	Choloepus hoffmanni	79.03	1.00e-26	111.00
IUUC-Cin-025131	Ciona intestinalis	68.32	9.00e-67	244.00
IUUC-Csv-026074	Ciona savignyi	71.71	3.00e-65	239.00
IUUC-Cne-026796	Cryptococcus neoformans	58.79	1.00e-48	184.00
IUUC-Cme-027321	Cyanidioschyzon merolae	57.67	7.00e-47	178.00
IUUC-Dre-028653	Danio rerio	74.07	4.00e-73	265.00
IUUC-Dno-029479	Dasypus novemcinctus	76.71	4.00e-67	245.00
IUUC-Dse-031230	Dothistroma septosporum	53.46	8.00e-45	171.00
IUUC-Dme-031951	Drosophila melanogaster	79.63	3.00e-77	279.00
IUUC-Ete-032885	Echinops telfairi	76.71	4.00e-67	245.00
IUUC-Eca-034057	Equus caballus	73.68	1.00e-67	246.00
IUUC-Eeu-035128	Erinaceus europaeus	57.33	3.00e-45	172.00
IUUC-Fca-035835	Felis catus	73.68	1.00e-67	246.00
IUUC-Fal-036778	Ficedula albicollis	76.71	4.00e-67	245.00
IUUC-Gmo-039504	Gadus morhua	73.01	1.00e-70	257.00
IUUC-Gga-040950	Gallus gallus	76.71	4.00e-67	245.00
IUUC-Gac-042210	Gasterosteus aculeatus	74.23	1.00e-71	260.00
IUUC-Gma-044131	Glycine max	65.33	2.00e-45	172.00
IUUC-Ggo-044826	Gorilla gorilla	76.71	4.00e-67	245.00
IUUC-Hsa-046638	Homo sapiens	76.71	4.00e-67	245.00
IUUC-Hvu-047065	Hordeum vulgare	62.00	5.00e-50	189.00
IUUC-Itr-048581	Ictidomys tridecemlineatus	75.00	4.00e-50	188.00
IUUC-Lch-050446	Latimeria chalumnae	74.07	1.00e-72	264.00
IUUC-Lpe-050981	Leersia perrieri	63.45	2.00e-49	187.00
IUUC-Loc-052277	Lepisosteus oculatus	76.71	4.00e-67	245.00
IUUC-Lma-053320	Leptosphaeria maculans	56.60	1.00e-45	174.00
IUUC-Laf-053491	Loxodonta africana	76.71	4.00e-67	245.00
IUUC-Mcc-055624	Macaca mulatta	74.67	2.00e-67	246.00
IUUC-Meu-056870	Macropus eugenii	74.00	2.00e-62	229.00
IUUC-Mtr-058406	Medicago truncatula	68.67	6.00e-55	204.00
IUUC-Mla-059165	Melampsora laricipopulina	58.28	4.00e-57	212.00
IUUC-Mga-060005	Meleagris gallopavo	74.17	2.00e-67	246.00
IUUC-Mvi-060318	Microbotryum violaceum	61.49	8.00e-49	184.00
IUUC-Mmr-061442	Microcebus murinus	76.71	4.00e-67	245.00
IUUC-Mdo-062364	Monodelphis domestica	72.84	1.00e-71	260.00
IUUC-Mmu-064163	Mus musculus	76.71	4.00e-67	245.00
IUUC-Mac-065294	Musa acuminata	64.00	2.00e-51	193.00
IUUC-Mpu-066561	Mustela putorius furo	71.60	3.00e-69	252.00
IUUC-Mlu-067331	Myotis lucifugus	76.71	4.00e-67	245.00
IUUC-Nfi-068431	Neosartorya fischeri	60.27	3.00e-45	172.00
IUUC-Opr-070958	Ochotona princeps	74.67	2.00e-67	246.00
IUUC-Ont-072627	Oreochromis niloticus	75.31	5.00e-72	261.00
IUUC-Ocu-074321	Oryctolagus cuniculus	70.30	5.00e-68	248.00
IUUC-Oba-075915	Oryza barthii	64.14	1.00e-55	207.00
IUUC-Obr-076863	Oryza brachyantha	64.14	2.00e-50	190.00
IUUC-Ogl-076981	Oryza glaberrima	64.14	1.00e-55	207.00
IUUC-Ogu-078183	Oryza glumaepatula	64.14	1.00e-55	207.00
IUUC-Oin-079755	Oryza indica	64.14	1.00e-55	207.00
IUUC-Olo-080576	Oryza longistaminata	64.14	1.00e-55	207.00
IUUC-Ome-081190	Oryza meridionalis	60.39	2.00e-53	199.00
IUUC-Oni-083010	Oryza nivara	64.14	1.00e-55	207.00
IUUC-Opu-083784	Oryza punctata	63.45	5.00e-49	185.00
IUUC-Oru-084817	Oryza rufipogon	64.14	1.00e-55	207.00
IUUC-Osa-085291	Oryza sativa	64.14	1.00e-55	207.00
IUUC-Ola-087228	Oryzias latipes	74.23	9.00e-72	260.00
IUUC-Olu-087887	Ostreococcus lucimarinus	65.64	3.00e-64	235.00
IUUC-Oga-088473	Otolemur garnettii	72.05	2.00e-70	256.00
IUUC-Oar-090047	Ovis aries	74.17	2.00e-67	246.00
IUUC-Ptr-091331	Pan troglodytes	74.67	2.00e-67	246.00
IUUC-Pan-092230	Papio anubis	76.71	4.00e-67	245.00
IUUC-Psi-093996	Pelodiscus sinensis	74.17	2.00e-67	246.00
IUUC-Ppa-095611	Physcomitrella patens	65.84	4.00e-62	228.00
IUUC-Pfo-096425	Poecilia formosa	74.23	5.00e-72	262.00
IUUC-Pab-098727	Pongo abelii	76.71	4.00e-67	245.00
IUUC-Pop-099940	Populus trichocarpa	66.00	2.00e-53	200.00
IUUC-Pca-100369	Procavia capensis	76.03	2.00e-65	240.00
IUUC-Ppe-101778	Prunus persica	65.33	6.00e-52	194.00
IUUC-Pva-103074	Pteropus vampyrus	76.71	2.00e-67	247.00
IUUC-Pgr-103274	Puccinia graminis	57.60	6.00e-46	174.00
IUUC-Pyt-104551	Pyrenophora triticirepentis	57.23	6.00e-46	175.00
IUUC-Rno-104929	Rattus norvegicus	76.71	4.00e-67	245.00
IUUC-Sha-106753	Sarcophilus harrisii	72.84	1.00e-71	260.00
IUUC-Sja-107917	Schizosaccharomyces japonicus	68.91	7.00e-48	181.00
IUUC-Spo-108104	Schizosaccharomyces pombe	66.88	6.00e-61	224.00
IUUC-Smo-109401	Selaginella moellendorffii	65.03	2.00e-51	193.00
IUUC-Sit-110012	Setaria italica	57.06	6.00e-52	195.00
IUUC-Sly-111843	Solanum lycopersicum	63.98	3.00e-56	209.00
IUUC-Stu-112654	Solanum tuberosum	67.59	9.00e-53	197.00
IUUC-Sbi-113787	Sorghum bicolor	62.73	5.00e-55	205.00
IUUC-Sre-114933	Sporisorium reilianum	62.58	1.00e-53	200.00
IUUC-Ssc-115912	Sus scrofa	71.43	2.00e-68	249.00
IUUC-Tgu-116635	Taeniopygia guttata	74.17	2.00e-67	246.00
IUUC-Tru-118534	Takifugu rubripes	73.62	2.00e-71	259.00
IUUC-Tsy-119168	Tarsius syrichta	76.71	2.00e-67	247.00
IUUC-Tni-119748	Tetraodon nigroviridis	73.01	7.00e-71	258.00
IUUC-Tca-121649	Theobroma cacao	66.21	2.00e-51	192.00
IUUC-Tae-123772	Triticum aestivum	63.98	6.00e-56	208.00
IUUC-Tur-126873	Triticum urartu	63.82	8.00e-53	199.00
IUUC-Tme-126974	Tuber melanosporum	57.41	1.00e-40	157.00
IUUC-Tbe-127917	Tupaia belangeri	74.67	2.00e-67	246.00
IUUC-Ttr-128609	Tursiops truncatus	76.71	6.00e-67	245.00
IUUC-Uma-129506	Ustilago maydis	63.19	3.00e-54	202.00
IUUC-Vpa-130208	Vicugna pacos	74.67	1.00e-67	248.00
IUUC-Vvi-131387	Vitis vinifera	66.00	7.00e-52	194.00
IUUC-Xtr-131942	Xenopus tropicalis	77.40	1.00e-67	246.00
IUUC-Xma-134052	Xiphophorus maculatus	74.23	1.00e-71	261.00
IUUC-Zma-135764	Zea mays	62.00	4.00e-50	189.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence