iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tru-117914

UUCD1 version

UUC-TaR-00115

Ensembl Protein ID

ENSTRUP00000005603.1

UniProt Accession

H2RZN2; H2RZN2_TAKRU

Protein Name

Uncharacterized protein

Gene Name

HECW1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTRUG00000002422.1	ENSTRUT00000005638.1	ENSTRUP00000005603.1
ENSTRUG00000002422.1	ENSTRUT00000005639.1	ENSTRUP00000005604.1
ENSTRUG00000002422.1	ENSTRUT00000005640.1	ENSTRUP00000005605.1
ENSTRUG00000002422.1	ENSTRUT00000005641.1	ENSTRUP00000005606.1
ENSTRUG00000002422.1	ENSTRUT00000005642.1	ENSTRUP00000005607.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	8.70e-120	401.4	1278	1610

Active Site

Position(s)	Description	Evidence
1578	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
           + ++++l+++f+gEegld++G++ref++lls+el+np++glf+ys+nd++t+q++p s +  ++hl++F+f Gr+lg+al ++ lld
   Q: 1278 ELQRNKLYITFLGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQISPMSAFV-ENHLEWFRFCGRILGLALIHQYLLD 1363
           567899****************************************************985.6************************ PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvkl 176
           ++++++fyk ll+ + +l+dle +d+e+++sl+++k+n   di+++ ldltf+v+ee++g+++e+eLk+gG++++Vt++Nk++Y+++
   Q: 1364 AFFTRPFYKALLRLPTDLSDLEYLDEEFHQSLQWMKDN---DITDI-LDLTFTVNEEVFGQVTERELKSGGSHVQVTEKNKKDYIER 1446
           ************************************99...9***9.**************************************** PP
   S: 177  vveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerka 263
           ++++r+++g+ +q+ea+ +Gf+ev++ +l+s+F+++elel+i G+ eid+ d++++t+y+ggy++ + +++wFw ++e+f++e+r +
   Q: 1447 MAKWRVERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTVEIDLGDWRSNTEYRGGYHDGHIVMRWFWAAVERFNNEQRLR 1533
           *************************************************************************************** PP
   S: 264  fLqFvTgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           +LqFvTg+s++P +Gfa+l+     r+f+i+k+++ ++lP+++TCfn+L+LP+Y+s++ l+ekLl+A+eet+ F+l+
   Q: 1534 LLQFVTGTSSVPYEGFAALRgsngLRRFCIEKWGRVASLPRAHTCFNRLDLPPYPSYTMLYEKLLIAVEETSTFGLE 1610
           ************************999***********************************************985 PP

Organism

Takifugu rubripes

Protein Sequence
(Fasta)

ASGSLVIMLM PLCSIKNLYQ NRLLGLAAMA SPTRSSHPRQ RCKDVARHSC GPDTYAVNGL 60
NQEAFVLGLS RSTSDTDLLS PDTRSTLAIS SSHYVIGQSE DLVVTWDIKE EVDAGDWIGM 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCTTCTGGTT CACTGGTCAT TATGCTGATG CCACTCTGTA GCATTAAGGT TAGTGCACCC 60
CGCCTCATCA CCACTTCATT TGCTCACTTG CTTCAGCCAC TCATTCACAC CAAGCTTGCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR032348--HECW_N
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF16562--HECW_N
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001636	Ailuropoda melanoleuca	72.08	0.00e+00	1374.00
IUUC-Apl-003299	Anas platyrhynchos	73.07	0.00e+00	1426.00
IUUC-Aca-005024	Anolis carolinensis	65.38	0.00e+00	1921.00
IUUC-Bta-012604	Bos taurus	71.05	0.00e+00	1407.00
IUUC-Cel-018137	Caenorhabditis elegans	30.93	1.00e-104	374.00
IUUC-Cja-019880	Callithrix jacchus	62.45	0.00e+00	1598.00
IUUC-Cfa-021216	Canis familiaris	78.02	0.00e+00	1348.00
IUUC-Cpo-021466	Cavia porcellus	77.88	0.00e+00	1348.00
IUUC-Csa-023080	Chlorocebus sabaeus	65.91	0.00e+00	1910.00
IUUC-Cho-024740	Choloepus hoffmanni	82.94	0.00e+00	1026.00
IUUC-Dre-028750	Danio rerio	76.06	0.00e+00	1395.00
IUUC-Dno-030019	Dasypus novemcinctus	71.44	0.00e+00	1417.00
IUUC-Ete-032352	Echinops telfairi	83.28	0.00e+00	1130.00
IUUC-Eca-033948	Equus caballus	70.48	0.00e+00	1377.00
IUUC-Eeu-034474	Erinaceus europaeus	63.38	0.00e+00	753.00
IUUC-Fca-036148	Felis catus	72.32	0.00e+00	1407.00
IUUC-Fal-036957	Ficedula albicollis	72.48	0.00e+00	1431.00
IUUC-Gmo-038714	Gadus morhua	67.22	0.00e+00	1078.00
IUUC-Gga-041194	Gallus gallus	72.87	0.00e+00	1438.00
IUUC-Gac-041366	Gasterosteus aculeatus	78.99	0.00e+00	1649.00
IUUC-Ggo-045442	Gorilla gorilla	69.31	0.00e+00	1273.00
IUUC-Hsa-045730	Homo sapiens	65.98	0.00e+00	1909.00
IUUC-Itr-048439	Ictidomys tridecemlineatus	72.85	0.00e+00	1432.00
IUUC-Loc-052744	Lepisosteus oculatus	65.89	0.00e+00	1961.00
IUUC-Laf-054368	Loxodonta africana	83.35	0.00e+00	1288.00
IUUC-Mcc-055487	Macaca mulatta	72.15	0.00e+00	1415.00
IUUC-Mga-059545	Meleagris gallopavo	73.24	0.00e+00	1435.00
IUUC-Mmr-061078	Microcebus murinus	70.88	0.00e+00	1366.00
IUUC-Mdo-062176	Monodelphis domestica	70.88	0.00e+00	1366.00
IUUC-Mmu-063513	Mus musculus	71.63	0.00e+00	1400.00
IUUC-Mpu-065786	Mustela putorius furo	72.16	0.00e+00	1405.00
IUUC-Mlu-067780	Myotis lucifugus	66.45	0.00e+00	1241.00
IUUC-Nle-069213	Nomascus leucogenys	71.96	0.00e+00	1415.00
IUUC-Opr-070208	Ochotona princeps	82.74	0.00e+00	1276.00
IUUC-Ont-072132	Oreochromis niloticus	87.16	0.00e+00	1545.00
IUUC-Oan-072807	Ornithorhynchus anatinus	77.48	0.00e+00	1351.00
IUUC-Ocu-074745	Oryctolagus cuniculus	71.49	0.00e+00	1404.00
IUUC-Ola-086981	Oryzias latipes	81.63	0.00e+00	1649.00
IUUC-Oga-087965	Otolemur garnettii	72.10	0.00e+00	1388.00
IUUC-Oar-089749	Ovis aries	77.84	0.00e+00	1345.00
IUUC-Ptr-091243	Pan troglodytes	65.91	0.00e+00	1910.00
IUUC-Pan-092201	Papio anubis	72.33	0.00e+00	1417.00
IUUC-Psi-093511	Pelodiscus sinensis	76.64	0.00e+00	1336.00
IUUC-Pfo-097001	Poecilia formosa	81.02	0.00e+00	1678.00
IUUC-Pab-098728	Pongo abelii	63.34	0.00e+00	1800.00
IUUC-Pca-100129	Procavia capensis	66.22	0.00e+00	1001.00
IUUC-Pva-102250	Pteropus vampyrus	70.58	0.00e+00	1254.00
IUUC-Rno-105031	Rattus norvegicus	64.56	0.00e+00	1852.00
IUUC-Tgu-117515	Taeniopygia guttata	72.16	0.00e+00	1427.00
IUUC-Tsy-119379	Tarsius syrichta	71.75	0.00e+00	723.00
IUUC-Tni-120178	Tetraodon nigroviridis	91.76	0.00e+00	1666.00
IUUC-Tbe-127762	Tupaia belangeri	68.02	0.00e+00	1302.00
IUUC-Ttr-128806	Tursiops truncatus	77.68	0.00e+00	1355.00
IUUC-Xtr-132903	Xenopus tropicalis	77.43	0.00e+00	1359.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence