iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Fal-037378

Ensembl Protein ID

ENSFALP00000009080.1

UniProt Accession

U3K226; U3K226_FICAL

Genbank Protein ID

ENSFALP00000009080

Protein Name

Histone-lysine N-methyltransferase

Genbank Nucleotide ID

AGTO01020930

Gene Name

NSD1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFALG00000008703.1	ENSFALT00000009119.1	ENSFALP00000009080.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	2.40e-16	59.3	1368	1408

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 3    vClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCr 52
           +C vC egg+    l++Ce C  +fH +Cl+++    +p+ + w+C++C+
   Q: 1368 WCFVCSEGGS----LLCCESCPAAFHRECLNIE----MPEGS-WYCNDCK 1408
           8*********....*******************....99998.******8 PP

Organism

Ficedula albicollis

Protein Sequence
(Fasta)

MKVSNQKPYR EYYVDALGEP SEKAWVAGKA IVLFEGRHQF EELPVLRKRG KQKEKAYKQK 60
VPQRFRAKWE VSVGQAEDIL LGGPEDQKCS QNSSEPASEK DVQLEYYSNG PGAERDTQLN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAAAGGTA CTGTATCTAC TCAGACCACA AAGTGAAGGT GTTGTGTATG GCAGGATGCT 60
GCAGTTTTTA ATTAATTTTA AAAGCATTTC TGGCCTTTGA GAAGTGTGAA GAAATAGACT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0949--S-adenosyl-L-methionine
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR006560--AWS_dom
IPR003616--Post-SET_dom
IPR000313--PWWP_dom
IPR001214--SET_dom
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51215--AWS
PS50868--POST_SET
PS50812--PWWP
PS50280--SET
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2

Pfam

PF00855--PWWP
PF00856--SET

SMART

SM00570--AWS
SM00249--PHD
SM00508--PostSET
SM00293--PWWP
SM00317--SET

Gene Ontology

GO:0005634--C:nucleus
GO:0046975--F:histone methyltransferase activity (H3-K36 specific)
GO:0000979--F:RNA polymerase II core promoter sequence-specific DNA binding
GO:0003712--F:transcription cofactor activity
GO:0008270--F:zinc ion binding
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0000414--P:regulation of histone H3-K36 methylation
GO:0033135--P:regulation of peptidyl-serine phosphorylation
GO:1903025--P:regulation of RNA polymerase II regulatory region sequence-specific DNA binding

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000229	Aegilops tauschii	58.33	9.00e-05	43.10
IUUC-Aml-001795	Ailuropoda melanoleuca	57.22	0.00e+00	2137.00
IUUC-Apl-003953	Anas platyrhynchos	91.51	0.00e+00	3375.00
IUUC-Aca-005339	Anolis carolinensis	55.92	0.00e+00	1925.00
IUUC-Bta-012966	Bos taurus	56.46	0.00e+00	2191.00
IUUC-Bdi-014781	Brachypodium distachyon	28.16	5.00e-13	69.30
IUUC-Bol-016001	Brassica oleracea	29.12	1.00e-16	82.80
IUUC-Bra-017864	Brassica rapa	28.57	2.00e-15	79.00
IUUC-Cja-018780	Callithrix jacchus	56.62	0.00e+00	2149.00
IUUC-Cfa-020975	Canis familiaris	57.37	0.00e+00	2165.00
IUUC-Cpo-021331	Cavia porcellus	69.86	0.00e+00	1632.00
IUUC-Csa-024226	Chlorocebus sabaeus	56.46	0.00e+00	2104.00
IUUC-Cho-024464	Choloepus hoffmanni	49.08	0.00e+00	801.00
IUUC-Dre-027488	Danio rerio	77.68	0.00e+00	1250.00
IUUC-Dno-029230	Dasypus novemcinctus	55.30	0.00e+00	2060.00
IUUC-Dor-031016	Dipodomys ordii	78.01	0.00e+00	1064.00
IUUC-Dme-032193	Drosophila melanogaster	36.22	1.00e-122	434.00
IUUC-Eca-033591	Equus caballus	58.34	0.00e+00	2170.00
IUUC-Fca-035791	Felis catus	58.21	0.00e+00	2212.00
IUUC-Gmo-038919	Gadus morhua	71.57	0.00e+00	952.00
IUUC-Gga-040881	Gallus gallus	86.14	0.00e+00	4231.00
IUUC-Gac-041378	Gasterosteus aculeatus	78.51	0.00e+00	1073.00
IUUC-Hsa-046436	Homo sapiens	57.54	0.00e+00	2137.00
IUUC-Itr-048194	Ictidomys tridecemlineatus	61.39	0.00e+00	2163.00
IUUC-Lch-049684	Latimeria chalumnae	57.12	0.00e+00	1426.00
IUUC-Laf-054046	Loxodonta africana	57.37	0.00e+00	2204.00
IUUC-Mcc-055593	Macaca mulatta	57.03	0.00e+00	2111.00
IUUC-Mga-059756	Meleagris gallopavo	83.01	0.00e+00	3288.00
IUUC-Mmr-061182	Microcebus murinus	58.26	0.00e+00	2162.00
IUUC-Mdo-061984	Monodelphis domestica	58.80	0.00e+00	2096.00
IUUC-Mmu-063605	Mus musculus	60.01	0.00e+00	2105.00
IUUC-Mpu-066446	Mustela putorius furo	57.88	0.00e+00	2191.00
IUUC-Mlu-067261	Myotis lucifugus	57.00	0.00e+00	2161.00
IUUC-Nle-069818	Nomascus leucogenys	57.70	0.00e+00	2137.00
IUUC-Opr-070842	Ochotona princeps	60.66	0.00e+00	1414.00
IUUC-Ont-072448	Oreochromis niloticus	64.71	0.00e+00	1160.00
IUUC-Oan-073496	Ornithorhynchus anatinus	73.33	0.00e+00	1593.00
IUUC-Ocu-074918	Oryctolagus cuniculus	58.05	0.00e+00	2164.00
IUUC-Obr-076753	Oryza brachyantha	54.84	5.00e-08	53.90
IUUC-Ogl-077641	Oryza glaberrima	29.38	1.00e-10	60.80
IUUC-Ogu-078898	Oryza glumaepatula	29.38	9.00e-11	60.80
IUUC-Oin-079557	Oryza indica	29.38	9.00e-11	60.80
IUUC-Osa-085353	Oryza sativa	29.38	9.00e-11	60.80
IUUC-Ola-087518	Oryzias latipes	76.38	0.00e+00	1063.00
IUUC-Oga-088743	Otolemur garnettii	60.66	0.00e+00	2155.00
IUUC-Oar-090265	Ovis aries	57.20	0.00e+00	2180.00
IUUC-Ptr-090521	Pan troglodytes	56.90	0.00e+00	2137.00
IUUC-Psi-093245	Pelodiscus sinensis	69.57	0.00e+00	2370.00
IUUC-Pfo-096066	Poecilia formosa	61.59	0.00e+00	1223.00
IUUC-Pab-098644	Pongo abelii	57.44	0.00e+00	2121.00
IUUC-Pva-103094	Pteropus vampyrus	72.59	0.00e+00	1146.00
IUUC-Rno-105803	Rattus norvegicus	59.37	0.00e+00	2115.00
IUUC-Sha-107278	Sarcophilus harrisii	60.35	0.00e+00	2180.00
IUUC-Sar-113402	Sorex araneus	53.11	0.00e+00	1645.00
IUUC-Sbi-114400	Sorghum bicolor	36.54	2.00e-12	64.30
IUUC-Ssc-116193	Sus scrofa	57.65	0.00e+00	2163.00
IUUC-Tgu-116532	Taeniopygia guttata	100.00	0.00e+00	1372.00
IUUC-Tru-117988	Takifugu rubripes	77.37	0.00e+00	1203.00
IUUC-Tsy-118830	Tarsius syrichta	57.06	0.00e+00	2081.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence