iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Fca-035971

Ensembl Protein ID

ENSFCAP00000010722.3

UniProt Accession

M3WFA6; M3WFA6_FELCA

Genbank Protein ID

ENSFCAP00000010722

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AANG02056373

Gene Name

SHARPIN

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFCAG00000011548.3	ENSFCAT00000011551.3	ENSFCAP00000010722.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/ZnF/NZF	2.90e-13	49.1	336	364
ULD/UDP/UBQ/UBQ_Other	4.40e-14	52.2	217	281

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/ZnF/NZF

   S: 2    eaqWaCsaCTflNePeavkCemCsrpRgc 30
           +++W+C++CTf+N+P++++CemCs++++c
   Q: 336  QPGWSCPSCTFINAPSRPGCEMCSTQKPC 364
           689*************************9 PP

ULD/UDP/UBQ/UBQ_Other

   S: 2    qvtvksldgs.eltlkvnpsdtVaeLKekiekklgippeqqrLiykGkiLeddktLadyglk.dg 64
           qvtv+++ +s + +l+v+p++t+a+L+e++++++g+pp+ qr+++  ++  + ++La+yg++ dg
   Q: 217  QVTVEDAASSaHVSLHVHPHCTIATLQEQVFSEFGFPPAVQRWVIGRRLCVPERSLASYGVQrDG 281
           89*******************************************55555*********885155 PP

Organism

Felis catus

Protein Sequence
(Fasta)

RRPPDGPAAE EHDPLQPLVV EEVVEGPEAA ILPKGVGVQI RVVTAERGGR FRLELLGSGP 60
GAVSLEWPLE SVSYTVRGPS QHELQPPPGG PGTLSLHFLN PQEAQRWAAL VRGATMEGQN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGGCGCCCAC CTGATGGACC GGCAGCTGAA GAACACGACC CGCTTCAGCC GCTTGTTGTA 60
GAAGAAGTAG TTGAAGGACC AGAGGCTGCC ATCCTCCCCA AAGGGGTCGG AGTCCAAATC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome

Interpro

IPR031912--Sharpin_PH
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom
IPR001876--Znf_RanBP2

PROSITE

PS50053--UBIQUITIN_2
PS01358--ZF_RANBP2_1
PS50199--ZF_RANBP2_2

Pfam

PF16764--Sharpin_PH
PF00641--zf-RanBP

SMART

SM00547--ZnF_RBZ

Gene Ontology

GO:0005829--C:cytosol
GO:0071797--C:LUBAC complex
GO:0043130--F:ubiquitin binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0030262--P:apoptotic nuclear changes
GO:0031424--P:keratinization
GO:0007005--P:mitochondrion organization
GO:0050728--P:negative regulation of inflammatory response
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0097039--P:protein linear polyubiquitination
GO:2000348--P:regulation of CD40 signaling pathway
GO:0010803--P:regulation of tumor necrosis factor-mediated signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001223	Ailuropoda melanoleuca	89.97	1.00e-137	482.00
IUUC-Apl-004151	Anas platyrhynchos	65.96	2.00e-16	76.60
IUUC-Bta-012948	Bos taurus	83.38	5.00e-142	497.00
IUUC-Cja-019031	Callithrix jacchus	78.93	1.00e-118	419.00
IUUC-Cfa-020863	Canis familiaris	82.99	2.00e-127	448.00
IUUC-Cpo-022499	Cavia porcellus	76.26	9.00e-116	409.00
IUUC-Csa-023641	Chlorocebus sabaeus	75.81	3.00e-111	395.00
IUUC-Dno-029459	Dasypus novemcinctus	70.94	1.00e-64	239.00
IUUC-Dor-030914	Dipodomys ordii	59.06	2.00e-71	262.00
IUUC-Ete-032940	Echinops telfairi	69.72	3.00e-86	311.00
IUUC-Eca-033537	Equus caballus	86.06	2.00e-138	485.00
IUUC-Eeu-035176	Erinaceus europaeus	70.77	2.00e-61	229.00
IUUC-Gmo-039219	Gadus morhua	38.01	1.00e-45	177.00
IUUC-Gga-040198	Gallus gallus	42.94	1.00e-28	119.00
IUUC-Ggo-044678	Gorilla gorilla	77.78	6.00e-115	407.00
IUUC-Hsa-046578	Homo sapiens	80.12	8.00e-122	430.00
IUUC-Itr-047913	Ictidomys tridecemlineatus	75.80	3.00e-126	444.00
IUUC-Mcc-055686	Macaca mulatta	71.73	3.00e-112	398.00
IUUC-Meu-055912	Macropus eugenii	56.20	1.00e-63	236.00
IUUC-Mmr-060584	Microcebus murinus	73.41	7.00e-125	440.00
IUUC-Mdo-062191	Monodelphis domestica	53.49	1.00e-84	306.00
IUUC-Mmu-063740	Mus musculus	66.48	1.00e-102	366.00
IUUC-Mpu-066878	Mustela putorius furo	83.89	3.00e-133	467.00
IUUC-Mlu-067878	Myotis lucifugus	83.28	2.00e-128	451.00
IUUC-Nle-069748	Nomascus leucogenys	78.35	9.00e-110	389.00
IUUC-Ont-072270	Oreochromis niloticus	38.79	4.00e-48	185.00
IUUC-Obr-076087	Oryza brachyantha	54.17	6.00e-04	37.40
IUUC-Oga-088300	Otolemur garnettii	73.28	2.00e-125	442.00
IUUC-Oar-089549	Ovis aries	81.99	7.00e-143	499.00
IUUC-Ptr-090961	Pan troglodytes	80.14	3.00e-108	384.00
IUUC-Pan-092687	Papio anubis	78.40	1.00e-114	406.00
IUUC-Pab-097872	Pongo abelii	71.35	5.00e-108	384.00
IUUC-Pca-100363	Procavia capensis	70.20	1.00e-64	239.00
IUUC-Pva-102595	Pteropus vampyrus	83.70	1.00e-115	409.00
IUUC-Rno-105856	Rattus norvegicus	71.04	2.00e-100	358.00
IUUC-Sha-106838	Sarcophilus harrisii	53.72	2.00e-75	276.00
IUUC-Ssl-108588	Sclerotinia sclerotiorum	38.71	3.10e-02	33.10
IUUC-Sar-113611	Sorex araneus	61.26	7.00e-26	110.00
IUUC-Ssc-116263	Sus scrofa	77.00	5.00e-138	484.00
IUUC-Tru-118089	Takifugu rubripes	42.86	1.00e-54	206.00
IUUC-Tni-120004	Tetraodon nigroviridis	52.69	4.00e-40	158.00
IUUC-Tbe-127471	Tupaia belangeri	64.47	1.00e-86	313.00
IUUC-Ttr-128534	Tursiops truncatus	69.05	5.00e-104	370.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence