iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Eca-033445

UUCD1 version

UUC-EqC-00395

Ensembl Protein ID

ENSECAP00000002515.1

UniProt Accession

F6WJX8; F6WJX8_HORSE

Protein Name

Uncharacterized protein

Gene Name

NEDD4L

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000000751.1	ENSECAT00000003568.1	ENSECAP00000002515.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.00e-135	451.1	542	873

Active Site

Position(s)	Description	Evidence
843	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++ lk+rl++ef+ E+gld+gGv+re+++llske++np++glf+ys++d++tlq+np+sgl+n++hl++F+f+Gr+ g+a+++g+lld 
   Q: 542  PDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDG 630
           57899************************************************************************************ PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
           ++ ++fyk++lgk+++l+d+e+vd+e+y+slk+i+en   d +e  ldl+f+++ee++g+t++++Lkp+G++i+VtneNk+eY++lv++
   Q: 631  FFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILEN---DPTE--LDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQ 714
           ***********************************99...6666..7****************************************** PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +++++q++af eGf+e++p++l+++F+e+elell+cG  ++dv+d++++  yk+gy +++p+iqwFw+++  +++e+r ++LqFv
   Q: 715  WRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFV 803
           ***************************************************************************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           Tg+sr+P++Gfael     p+lf+i++++s+++lP+++TCfn+L+LP+Y++ e l+ekLl+A+e+++gFe
   Q: 804  TGTSRVPMNGFAELYgsngPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFE 873
           *********************************************************************8 PP

Organism

Equus caballus

Protein Sequence
(Fasta)

TRDDFLGQVD VPLSHLPTED PTMERPYTFK DFLLRPRSHK SRVKGFLRLK MAYMPKNGGQ 60
DEENSEQRDD MEHGWEVVDS NDSASQHQEE LPPPPLPPGW EEKVDNLGRT YYVNHNNRTT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACGCGAGACG ACTTCCTGGG CCAGGTGGAC GTGCCCCTTA GCCATCTCCC GGTAAGGATG 60
GTTACCTGCT TTATTTGCGT GCTGTGAGCA ATGGTTTCTG ATTGTTTGCA GTTAGGTATA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00632--HECT
PF00397--WW

SMART

SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005886--C:plasma membrane
GO:0019870--F:potassium channel inhibitor activity
GO:0019871--F:sodium channel inhibitor activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:1901017--P:negative regulation of potassium ion transmembrane transporter activity
GO:2000009--P:negative regulation of protein localization to cell surface
GO:2000650--P:negative regulation of sodium ion transmembrane transporter activity
GO:1903861--P:positive regulation of dendrite extension
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070936--P:protein K48-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0003254--P:regulation of membrane depolarization
GO:0060306--P:regulation of membrane repolarization
GO:0010038--P:response to metal ion

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001314	Ailuropoda melanoleuca	97.15	0.00e+00	1587.00
IUUC-Apl-003893	Anas platyrhynchos	94.52	0.00e+00	1585.00
IUUC-Aca-004744	Anolis carolinensis	90.65	0.00e+00	1521.00
IUUC-Acl-008273	Aspergillus clavatus	49.26	1.00e-163	570.00
IUUC-Afl-008713	Aspergillus flavus	49.01	4.00e-161	561.00
IUUC-Afu-009103	Aspergillus fumigatus	49.02	1.00e-163	570.00
IUUC-Ani-009259	Aspergillus nidulans	48.53	7.00e-162	564.00
IUUC-Ang-009738	Aspergillus niger	49.33	4.00e-162	565.00
IUUC-Aor-010053	Aspergillus oryzae	58.05	2.00e-101	361.00
IUUC-Ate-010529	Aspergillus terreus	49.42	2.00e-164	572.00
IUUC-Ame-010810	Astyanax mexicanus	70.48	0.00e+00	1139.00
IUUC-Bgr-012148	Blumeria graminis	47.91	3.00e-154	539.00
IUUC-Bta-012679	Bos taurus	98.29	0.00e+00	1610.00
IUUC-Bci-013785	Botrytis cinerea	47.99	5.00e-156	544.00
IUUC-Cel-018564	Caenorhabditis elegans	52.53	0.00e+00	632.00
IUUC-Cja-018732	Callithrix jacchus	98.41	0.00e+00	1646.00
IUUC-Cfa-021226	Canis familiaris	98.63	0.00e+00	1645.00
IUUC-Cpo-021671	Cavia porcellus	96.12	0.00e+00	1582.00
IUUC-Csa-023344	Chlorocebus sabaeus	96.31	0.00e+00	1632.00
IUUC-Cho-024832	Choloepus hoffmanni	100.00	0.00e+00	743.00
IUUC-Csv-026098	Ciona savignyi	59.04	0.00e+00	654.00
IUUC-Cgl-026642	Colletotrichum gloeosporioides	47.66	1.00e-155	543.00
IUUC-Cne-026849	Cryptococcus neoformans	48.58	3.00e-158	552.00
IUUC-Dre-027770	Danio rerio	79.20	0.00e+00	1274.00
IUUC-Dno-029466	Dasypus novemcinctus	98.63	0.00e+00	1650.00
IUUC-Dor-030138	Dipodomys ordii	94.06	0.00e+00	1527.00
IUUC-Dse-031241	Dothistroma septosporum	47.70	5.00e-160	558.00
IUUC-Dme-032166	Drosophila melanogaster	67.09	0.00e+00	711.00
IUUC-Ete-033145	Echinops telfairi	89.04	0.00e+00	1285.00
IUUC-Eeu-035247	Erinaceus europaeus	90.87	0.00e+00	1421.00
IUUC-Fca-035489	Felis catus	95.81	0.00e+00	1548.00
IUUC-Fal-037604	Ficedula albicollis	91.73	0.00e+00	1556.00
IUUC-Fox-037774	Fusarium oxysporum	48.76	1.00e-158	553.00
IUUC-Fso-038393	Fusarium solani	47.41	1.00e-153	536.00
IUUC-Gmo-039674	Gadus morhua	76.78	0.00e+00	1244.00
IUUC-Ggr-040107	Gaeumannomyces graminis	47.75	6.00e-156	544.00
IUUC-Gga-040703	Gallus gallus	93.72	0.00e+00	1581.00
IUUC-Gac-042020	Gasterosteus aculeatus	80.00	0.00e+00	1273.00
IUUC-Ggo-045332	Gorilla gorilla	96.35	0.00e+00	1618.00
IUUC-Hsa-045968	Homo sapiens	98.40	0.00e+00	1645.00
IUUC-Lch-050443	Latimeria chalumnae	86.69	0.00e+00	1439.00
IUUC-Loc-052662	Lepisosteus oculatus	81.36	0.00e+00	1296.00
IUUC-Laf-053850	Loxodonta africana	96.92	0.00e+00	1627.00
IUUC-Mcc-055821	Macaca mulatta	98.29	0.00e+00	1643.00
IUUC-Meu-056712	Macropus eugenii	83.98	0.00e+00	707.00
IUUC-Mor-057097	Magnaporthe oryzae	47.75	9.00e-157	547.00
IUUC-Mla-058996	Melampsora laricipopulina	53.94	9.00e-150	524.00
IUUC-Mga-059264	Meleagris gallopavo	73.86	0.00e+00	1074.00
IUUC-Mvi-060395	Microbotryum violaceum	53.70	6.00e-150	524.00
IUUC-Mmr-060798	Microcebus murinus	93.86	0.00e+00	1516.00
IUUC-Mdo-062173	Monodelphis domestica	95.08	0.00e+00	1635.00
IUUC-Mmu-064136	Mus musculus	97.26	0.00e+00	1607.00
IUUC-Mpu-066765	Mustela putorius furo	99.20	0.00e+00	1627.00
IUUC-Mlu-067565	Myotis lucifugus	96.25	0.00e+00	1584.00
IUUC-Nfi-068427	Neosartorya fischeri	49.02	7.00e-164	570.00
IUUC-Ncr-068918	Neurospora crassa	47.40	2.00e-157	549.00
IUUC-Nle-069070	Nomascus leucogenys	94.07	0.00e+00	1548.00
IUUC-Opr-071044	Ochotona princeps	96.59	0.00e+00	1201.00
IUUC-Ont-072044	Oreochromis niloticus	78.49	0.00e+00	1313.00
IUUC-Oan-073032	Ornithorhynchus anatinus	92.99	0.00e+00	1443.00
IUUC-Ocu-074160	Oryctolagus cuniculus	94.75	0.00e+00	1565.00
IUUC-Ola-087467	Oryzias latipes	79.33	0.00e+00	1286.00
IUUC-Oga-088460	Otolemur garnettii	93.61	0.00e+00	1571.00
IUUC-Oar-090198	Ovis aries	97.95	0.00e+00	1607.00
IUUC-Ptr-090939	Pan troglodytes	98.40	0.00e+00	1645.00
IUUC-Pan-092284	Papio anubis	98.29	0.00e+00	1642.00
IUUC-Psi-093645	Pelodiscus sinensis	94.41	0.00e+00	1580.00
IUUC-Pma-094364	Petromyzon marinus	82.63	0.00e+00	860.00
IUUC-Pno-095118	Phaeosphaeria nodorum	48.17	6.00e-164	571.00
IUUC-Pab-098088	Pongo abelii	98.40	0.00e+00	1645.00
IUUC-Pca-100714	Procavia capensis	79.00	0.00e+00	1274.00
IUUC-Pva-102354	Pteropus vampyrus	96.69	0.00e+00	1582.00
IUUC-Pgr-103620	Puccinia graminis	53.53	6.00e-148	517.00
IUUC-Ptt-103806	Puccinia triticina	53.38	9.00e-123	434.00
IUUC-Pte-104016	Pyrenophora teres	49.00	3.00e-162	565.00
IUUC-Pyt-104550	Pyrenophora triticirepentis	49.00	3.00e-162	565.00
IUUC-Rno-105318	Rattus norvegicus	97.49	0.00e+00	1607.00
IUUC-Sce-106289	Saccharomyces cerevisiae	49.25	5.00e-164	571.00
IUUC-Sha-107482	Sarcophilus harrisii	96.94	0.00e+00	1623.00
IUUC-Ssl-108514	Sclerotinia sclerotiorum	48.49	1.00e-157	550.00
IUUC-Ssc-115950	Sus scrofa	72.17	0.00e+00	1179.00
IUUC-Tgu-117130	Taeniopygia guttata	94.29	0.00e+00	1587.00
IUUC-Tru-118610	Takifugu rubripes	79.95	0.00e+00	1312.00
IUUC-Tsy-119492	Tarsius syrichta	96.23	0.00e+00	1610.00
IUUC-Tni-120113	Tetraodon nigroviridis	74.47	0.00e+00	1249.00
IUUC-Tre-122203	Trichoderma reesei	47.45	4.00e-152	531.00
IUUC-Tvi-122595	Trichoderma virens	47.27	2.00e-154	539.00
IUUC-Tbe-127441	Tupaia belangeri	94.29	0.00e+00	743.00
IUUC-Ttr-128235	Tursiops truncatus	99.10	0.00e+00	1086.00
IUUC-Vda-129753	Verticillium dahliae	47.85	4.00e-157	548.00
IUUC-Xtr-132859	Xenopus tropicalis	89.51	0.00e+00	1510.00
IUUC-Xma-133797	Xiphophorus maculatus	80.82	0.00e+00	1306.00
IUUC-Yli-134668	Yarrowia lipolytica	46.42	5.00e-162	564.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence