iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Laf-053850

UUCD1 version

UUC-LoA-00379

Ensembl Protein ID

ENSLAFP00000009301.3

UniProt Accession

G3T6W8; G3T6W8_LOXAF

Protein Name

Uncharacterized protein

Gene Name

NEDD4L

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000011109.3	ENSLAFT00000036850.1	ENSLAFP00000020332.1
ENSLAFG00000011109.3	ENSLAFT00000011114.3	ENSLAFP00000009301.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.90e-135	450.9	606	937

Active Site

Position(s)	Description	Evidence
907	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++ lk+rl++ef+ E+gld+gGv+re+++llske++np++glf+ys++d++tlq+np+sgl+n++hl++F+f+Gr+ g+a+++g+lld 
   Q: 606  PDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDG 694
           57899************************************************************************************ PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
           ++ ++fyk++lgk+++l+d+e+vd+e+y+slk+i+en   d +e  ldl+f+++ee++g+t++++Lkp+G++i+VtneNk+eY++lv++
   Q: 695  FFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILEN---DPTE--LDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQ 778
           ***********************************99...6666..7****************************************** PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +++++q++af eGf+e++p++l+++F+e+elell+cG  ++dv+d++++  yk+gy +++p+iqwFw+++  +++e+r ++LqFv
   Q: 779  WRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFV 867
           ***************************************************************************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           Tg+sr+P++Gfael     p+lf+i++++s+++lP+++TCfn+L+LP+Y++ e l+ekLl+A+e+++gFe
   Q: 868  TGTSRVPMNGFAELYgsngPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFE 937
           *********************************************************************8 PP

Organism

Loxodonta africana

Protein Sequence
(Fasta)

QGESRILRVK VVSGIDLAKK DIFGASDPYV KLSLYVADEN RELALVQTKT IKKTLNPKWN 60
EEFYFRVNPS NHRLLFEVFD ENRLTRDDFL GQVDVPLSHL PTEDPTMERP YTFKDFLLRP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAGGGGGAGT CACGTATTCT CAGAGTAAAA GTTGTTTCTG GAATTGATCT CGCCAAAAAG 60
GACATCTTTG GAGCCAGGTA TGTTTGCTTT GTTTATGGTT GGCTTCTGAA GACTTTTGGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

PRINTS

PR00360--C2DOMAIN

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005886--C:plasma membrane
GO:0019870--F:potassium channel inhibitor activity
GO:0019871--F:sodium channel inhibitor activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:1901017--P:negative regulation of potassium ion transmembrane transporter activity
GO:2000009--P:negative regulation of protein localization to cell surface
GO:2000650--P:negative regulation of sodium ion transmembrane transporter activity
GO:1903861--P:positive regulation of dendrite extension
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070936--P:protein K48-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0003254--P:regulation of membrane depolarization
GO:0060306--P:regulation of membrane repolarization
GO:0010038--P:response to metal ion

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001314	Ailuropoda melanoleuca	98.37	0.00e+00	1714.00
IUUC-Apl-003893	Anas platyrhynchos	92.89	0.00e+00	1676.00
IUUC-Aca-004744	Anolis carolinensis	89.99	0.00e+00	1624.00
IUUC-Acl-008273	Aspergillus clavatus	49.26	1.00e-163	570.00
IUUC-Afl-008713	Aspergillus flavus	49.01	5.00e-161	561.00
IUUC-Afu-009103	Aspergillus fumigatus	49.02	1.00e-163	570.00
IUUC-Ani-009259	Aspergillus nidulans	48.45	6.00e-162	564.00
IUUC-Ang-009738	Aspergillus niger	49.33	6.00e-162	564.00
IUUC-Aor-010053	Aspergillus oryzae	58.05	2.00e-101	362.00
IUUC-Ate-010529	Aspergillus terreus	49.42	3.00e-164	572.00
IUUC-Ame-010810	Astyanax mexicanus	86.58	0.00e+00	1031.00
IUUC-Bgr-012148	Blumeria graminis	47.91	2.00e-154	539.00
IUUC-Bta-012679	Bos taurus	95.67	0.00e+00	1576.00
IUUC-Bci-013785	Botrytis cinerea	47.99	5.00e-156	545.00
IUUC-Cel-018564	Caenorhabditis elegans	52.53	0.00e+00	632.00
IUUC-Cja-018732	Callithrix jacchus	96.57	0.00e+00	1788.00
IUUC-Cfa-021226	Canis familiaris	96.67	0.00e+00	1760.00
IUUC-Cpo-021671	Cavia porcellus	98.62	0.00e+00	1763.00
IUUC-Csa-023344	Chlorocebus sabaeus	94.79	0.00e+00	1773.00
IUUC-Cho-024832	Choloepus hoffmanni	100.00	0.00e+00	742.00
IUUC-Csv-026098	Ciona savignyi	59.04	0.00e+00	654.00
IUUC-Dre-027770	Danio rerio	78.20	0.00e+00	1414.00
IUUC-Dno-029466	Dasypus novemcinctus	96.88	0.00e+00	1788.00
IUUC-Dor-030138	Dipodomys ordii	94.53	0.00e+00	1642.00
IUUC-Dse-031241	Dothistroma septosporum	47.70	7.00e-160	557.00
IUUC-Dme-032166	Drosophila melanogaster	67.09	0.00e+00	711.00
IUUC-Ete-033145	Echinops telfairi	91.90	0.00e+00	1292.00
IUUC-Eca-033445	Equus caballus	96.80	0.00e+00	1580.00
IUUC-Eeu-035247	Erinaceus europaeus	91.38	0.00e+00	1511.00
IUUC-Fca-035489	Felis catus	92.87	0.00e+00	1512.00
IUUC-Fal-037604	Ficedula albicollis	90.79	0.00e+00	1685.00
IUUC-Fox-037774	Fusarium oxysporum	48.76	1.00e-158	553.00
IUUC-Gmo-039674	Gadus morhua	76.47	0.00e+00	1363.00
IUUC-Ggr-040107	Gaeumannomyces graminis	47.75	5.00e-156	544.00
IUUC-Gga-040703	Gallus gallus	92.69	0.00e+00	1712.00
IUUC-Gac-042020	Gasterosteus aculeatus	78.28	0.00e+00	1397.00
IUUC-Ggo-045332	Gorilla gorilla	98.80	0.00e+00	1747.00
IUUC-Hsa-045968	Homo sapiens	96.77	0.00e+00	1785.00
IUUC-Lch-050443	Latimeria chalumnae	85.29	0.00e+00	1437.00
IUUC-Loc-052662	Lepisosteus oculatus	79.98	0.00e+00	1414.00
IUUC-Mcc-055821	Macaca mulatta	96.56	0.00e+00	1779.00
IUUC-Meu-056712	Macropus eugenii	85.82	0.00e+00	798.00
IUUC-Mor-057097	Magnaporthe oryzae	47.75	2.00e-156	546.00
IUUC-Mla-058996	Melampsora laricipopulina	53.94	2.00e-149	523.00
IUUC-Mvi-060395	Microbotryum violaceum	53.91	7.00e-150	524.00
IUUC-Mmr-060798	Microcebus murinus	92.52	0.00e+00	1654.00
IUUC-Mdo-062173	Monodelphis domestica	93.87	0.00e+00	1764.00
IUUC-Mmu-064136	Mus musculus	95.63	0.00e+00	1744.00
IUUC-Mpu-066765	Mustela putorius furo	96.66	0.00e+00	1754.00
IUUC-Mlu-067565	Myotis lucifugus	92.95	0.00e+00	1549.00
IUUC-Nfi-068427	Neosartorya fischeri	49.02	5.00e-164	571.00
IUUC-Ncr-068918	Neurospora crassa	47.40	2.00e-157	549.00
IUUC-Nle-069070	Nomascus leucogenys	92.72	0.00e+00	1687.00
IUUC-Opr-071044	Ochotona princeps	99.68	0.00e+00	1212.00
IUUC-Ont-072044	Oreochromis niloticus	76.24	0.00e+00	1428.00
IUUC-Oan-073032	Ornithorhynchus anatinus	91.09	0.00e+00	1403.00
IUUC-Ocu-074160	Oryctolagus cuniculus	97.24	0.00e+00	1733.00
IUUC-Ola-087467	Oryzias latipes	77.03	0.00e+00	1414.00
IUUC-Oga-088460	Otolemur garnettii	91.56	0.00e+00	1553.00
IUUC-Oar-090198	Ovis aries	95.73	0.00e+00	1738.00
IUUC-Ptr-090939	Pan troglodytes	96.77	0.00e+00	1785.00
IUUC-Pan-092284	Papio anubis	96.56	0.00e+00	1782.00
IUUC-Psi-093645	Pelodiscus sinensis	92.81	0.00e+00	1703.00
IUUC-Pma-094364	Petromyzon marinus	82.63	0.00e+00	862.00
IUUC-Pno-095118	Phaeosphaeria nodorum	50.00	4.00e-163	568.00
IUUC-Pfo-096768	Poecilia formosa	90.98	0.00e+00	961.00
IUUC-Pab-098088	Pongo abelii	96.67	0.00e+00	1783.00
IUUC-Pca-100714	Procavia capensis	77.81	0.00e+00	1336.00
IUUC-Pva-102354	Pteropus vampyrus	98.91	0.00e+00	1710.00
IUUC-Pgr-103620	Puccinia graminis	53.53	7.00e-148	517.00
IUUC-Ptt-103806	Puccinia triticina	53.38	1.00e-122	434.00
IUUC-Pte-104016	Pyrenophora teres	49.00	5.00e-162	565.00
IUUC-Pyt-104550	Pyrenophora triticirepentis	49.00	5.00e-162	565.00
IUUC-Rno-105318	Rattus norvegicus	95.01	0.00e+00	1729.00
IUUC-Sce-106289	Saccharomyces cerevisiae	49.25	8.00e-164	570.00
IUUC-Sha-107482	Sarcophilus harrisii	95.35	0.00e+00	1585.00
IUUC-Sja-107786	Schizosaccharomyces japonicus	48.74	7.00e-152	531.00
IUUC-Ssl-108514	Sclerotinia sclerotiorum	48.49	1.00e-157	550.00
IUUC-Ssc-115950	Sus scrofa	71.64	0.00e+00	1170.00
IUUC-Tgu-117130	Taeniopygia guttata	93.02	0.00e+00	1714.00
IUUC-Tru-118610	Takifugu rubripes	79.28	0.00e+00	1442.00
IUUC-Tsy-119492	Tarsius syrichta	94.69	0.00e+00	1656.00
IUUC-Tni-120113	Tetraodon nigroviridis	74.06	0.00e+00	1337.00
IUUC-Tre-122203	Trichoderma reesei	47.45	6.00e-152	531.00
IUUC-Tvi-122595	Trichoderma virens	47.27	2.00e-154	539.00
IUUC-Tbe-127441	Tupaia belangeri	95.21	0.00e+00	811.00
IUUC-Ttr-128235	Tursiops truncatus	92.04	0.00e+00	1567.00
IUUC-Vda-129753	Verticillium dahliae	47.85	8.00e-157	547.00
IUUC-Vpa-130544	Vicugna pacos	80.03	0.00e+00	918.00
IUUC-Xtr-132859	Xenopus tropicalis	88.69	0.00e+00	1628.00
IUUC-Xma-133797	Xiphophorus maculatus	79.92	0.00e+00	1427.00
IUUC-Yli-134668	Yarrowia lipolytica	46.42	3.00e-162	565.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence