iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000141542.10	ENST00000571995.5	ENSP00000461785.1
ENSG00000141542.10	ENST00000538809.6	ENSP00000438897.2
ENSG00000141542.10	ENST00000576148.1	ENSP00000458638.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	HPM
DNA & RNA Element
UTRdb	AREsite	miRTarBase	microRNA
TRANSFAC	TargetScan	RepTar	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Variation
GWASdb
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	4.30e-13	50.6	183	227

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 4    lwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyedy 52
           lw ++s++ SLq+LC++a+++c++ + +   dkLPLP +L+++L+++++
   Q: 183  LW-RPSKVLSLQDLCCRAVVSCTPVHLV---DKLPLPIALRSHLKSFSM 227
           67.99********************888...***************976 PP

Organism

Homo sapiens

Functional Description
(View)

May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Protein Sequence
(Fasta)

MSALGSPVRA YDFLLKFLLV GDSDVGKGEI LASLQDGAAE SPYGHPAGID YKTTTILLDG 60
RRVKLQLWDT SGQGRFCTIF RSYSRGAQGV ILVYDIANRW SFDGIDRWIK EIDEHAPGVP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGCGCTGGGC GGCGGGGCGG GGCCGGAGGC GAGCAAGGAC TCGGGGCCCG CGCGGCGCCT 60
CTCGGGGCCG GGCCGCCGCC TCTGCGCTCA GCCCCGCAGG CCGGGCATGG GTGGGGGCGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0342--GTP-binding
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0547--Nucleotide-binding
KW-0564--Palmitate
KW-0636--Prenylation
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR027417--P-loop_NTPase
IPR005225--Small_GTP-bd_dom
IPR001806--Small_GTPase
IPR001496--SOCS_box

PROSITE

PS51419--RAB
PS50225--SOCS

Pfam

PF00071--Ras
PF07525--SOCS_box

SMART

SM00253--SOCS
SM00969--SOCS_box

Gene Ontology

GO:0005768--C:endosome
GO:0005635--C:nuclear envelope
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0008021--C:synaptic vesicle
GO:0005525--F:GTP binding
GO:1990967--P:multi-organism toxin transport
GO:0072659--P:protein localization to plasma membrane
GO:0009306--P:protein secretion
GO:0016567--P:protein ubiquitination
GO:0007264--P:small GTPase mediated signal transduction
GO:0006904--P:vesicle docking involved in exocytosis

KEGG

hsa:10966

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003206	Anas platyrhynchos	91.85	2.00e-131	461.00
IUUC-Aca-005004	Anolis carolinensis	89.22	1.00e-138	486.00
IUUC-Ame-011456	Astyanax mexicanus	85.25	3.00e-144	504.00
IUUC-Bta-012683	Bos taurus	89.57	9.00e-149	519.00
IUUC-Cfa-020527	Canis familiaris	94.29	1.00e-117	416.00
IUUC-Cpo-021644	Cavia porcellus	95.15	7.00e-151	526.00
IUUC-Csa-023150	Chlorocebus sabaeus	99.64	4.00e-165	573.00
IUUC-Cho-024716	Choloepus hoffmanni	92.07	3.00e-88	317.00
IUUC-Dre-028614	Danio rerio	83.87	5.00e-141	493.00
IUUC-Eca-033492	Equus caballus	95.26	3.00e-133	467.00
IUUC-Fca-035705	Felis catus	95.24	2.00e-131	461.00
IUUC-Gga-040925	Gallus gallus	90.29	2.00e-152	531.00
IUUC-Loc-052325	Lepisosteus oculatus	88.53	2.00e-150	524.00
IUUC-Laf-053340	Loxodonta africana	92.45	8.00e-154	535.00
IUUC-Mcc-054711	Macaca mulatta	97.15	1.00e-160	558.00
IUUC-Mga-059204	Meleagris gallopavo	90.29	2.00e-152	531.00
IUUC-Mmu-064144	Mus musculus	92.81	1.00e-156	545.00
IUUC-Mpu-066352	Mustela putorius furo	93.10	4.00e-129	453.00
IUUC-Nle-070096	Nomascus leucogenys	98.92	4.00e-163	566.00
IUUC-Opr-070662	Ochotona princeps	90.65	1.00e-148	519.00
IUUC-Ont-072397	Oreochromis niloticus	84.56	5.00e-141	493.00
IUUC-Ocu-074559	Oryctolagus cuniculus	93.53	9.00e-146	509.00
IUUC-Oga-088133	Otolemur garnettii	94.60	7.00e-158	549.00
IUUC-Oar-089702	Ovis aries	89.13	6.00e-122	429.00
IUUC-Ptr-090544	Pan troglodytes	100.00	1.00e-154	538.00
IUUC-Pan-092812	Papio anubis	99.64	4.00e-165	573.00
IUUC-Psi-093120	Pelodiscus sinensis	91.01	9.00e-155	538.00
IUUC-Pma-094679	Petromyzon marinus	77.87	9.00e-112	395.00
IUUC-Pab-098735	Pongo abelii	99.64	4.00e-165	573.00
IUUC-Pva-102361	Pteropus vampyrus	93.20	4.00e-140	490.00
IUUC-Rno-105063	Rattus norvegicus	94.24	1.00e-158	552.00
IUUC-Sar-113518	Sorex araneus	87.11	2.00e-129	454.00
IUUC-Ssc-115719	Sus scrofa	90.67	7.00e-144	503.00
IUUC-Tsy-119011	Tarsius syrichta	96.84	4.00e-109	386.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence