iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ggo-045126

UUCD1 version

UUC-GoG-00446

Ensembl Protein ID

ENSGGOP00000010840.2

UniProt Accession

G3R697; G3R697_GORGO

Protein Name

Uncharacterized protein

Gene Name

RNF41

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGGOG00000011122.2	ENSGGOT00000011161.2	ENSGGOP00000010840.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	4.10e-06	27.6	18	57
E3 activity/RING/U-box	1.30e-06	28.8	12	69

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlp.CgHvfhadClqkwpglknssskefrCPlCr 46
           C+iC   +++ p+  p C H+f+  C+ +w       s++++CP++r
   Q: 18   CPICSGVLEE-PVQAPhCEHAFCNACITQW------FSQQQTCPVDR 57
           ****999999.777777*************......********987 PP

E3 activity/RING/U-box

   S: 2    vpeeflCpIslelMrdPvvlp.sGitydrssIekwlasggktcPvtrqplteedlvPnl 59
           v e+++CpI   + ++Pv +p + + +  ++I +w++++++ cPv+r+ +t   l P  
   Q: 12   VDEDLICPICSGVLEEPVQAPhCEHAFCNACITQWFSQQQT-CPVDRSVVTVAHLRPVP 69
           56899******************************998887.******99998887764 PP

Organism

Gorilla gorilla

Protein Sequence
(Fasta)

MGYDVTRFQG DVDEDLICPI CSGVLEEPVQ APHCEHAFCN ACITQWFSQQ QTCPVDRSVV 60
TVAHLRPVPR IMRNMLSKLQ IACDNAVFGC SAVVRLDNLM SHLSDCEHNP KRPVTCEQGC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTGAGGCGGC GACGAGTGGT AGGAGTCTTC TTTCCCCTCC TTCCCCTTTC CCTTCCCTTC 60
CCGGGAGAGG CTGGGACCCG GCACCAGGGC AGTACTGTGG CCGCTGCGGC CTCAGCTCCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR008974--TRAF-like
IPR015036--USP8_interacting
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
IPR013010--Znf_SIAH

PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2
PS51081--ZF_SIAH

Pfam

PF08941--USP8_interact

SMART

SM00184--RING

Gene Ontology

GO:0016881--F:acid-amino acid ligase activity
GO:0031386--F:protein tag
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0097191--P:extrinsic apoptotic signaling pathway
GO:0030336--P:negative regulation of cell migration
GO:0008285--P:negative regulation of cell proliferation
GO:1901525--P:negative regulation of macromitophagy
GO:2000379--P:positive regulation of reactive oxygen species metabolic process
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0010498--P:proteasomal protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0000209--P:protein polyubiquitination
GO:2000114--P:regulation of establishment of cell polarity
GO:0045619--P:regulation of lymphocyte differentiation
GO:0043408--P:regulation of MAPK cascade
GO:0045637--P:regulation of myeloid cell differentiation
GO:0051896--P:regulation of protein kinase B signaling

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002398	Ailuropoda melanoleuca	99.37	0.00e+00	655.00
IUUC-Apl-003568	Anas platyrhynchos	95.92	0.00e+00	628.00
IUUC-Aca-005119	Anolis carolinensis	96.54	0.00e+00	640.00
IUUC-Ame-010708	Astyanax mexicanus	90.88	8.00e-178	615.00
IUUC-Bta-013428	Bos taurus	93.40	1.00e-177	614.00
IUUC-Cja-019844	Callithrix jacchus	100.00	0.00e+00	662.00
IUUC-Cfa-021124	Canis familiaris	99.69	0.00e+00	655.00
IUUC-Cpo-022325	Cavia porcellus	99.37	0.00e+00	654.00
IUUC-Csa-023113	Chlorocebus sabaeus	99.69	0.00e+00	655.00
IUUC-Cho-024991	Choloepus hoffmanni	98.97	5.00e-113	399.00
IUUC-Cne-026870	Cryptococcus neoformans	38.52	4.00e-20	93.20
IUUC-Dre-028730	Danio rerio	90.57	2.00e-177	614.00
IUUC-Dno-028908	Dasypus novemcinctus	99.31	1.00e-170	591.00
IUUC-Dor-030411	Dipodomys ordii	99.37	0.00e+00	655.00
IUUC-Dse-031478	Dothistroma septosporum	30.10	3.00e-09	57.00
IUUC-Dme-031868	Drosophila melanogaster	57.28	2.00e-109	388.00
IUUC-Ete-032896	Echinops telfairi	81.20	5.00e-124	436.00
IUUC-Eca-034135	Equus caballus	99.69	0.00e+00	655.00
IUUC-Eeu-034675	Erinaceus europaeus	99.37	0.00e+00	654.00
IUUC-Fca-035612	Felis catus	99.69	0.00e+00	655.00
IUUC-Fal-036922	Ficedula albicollis	97.56	3.00e-41	159.00
IUUC-Gmo-039648	Gadus morhua	87.42	6.00e-171	592.00
IUUC-Gga-040474	Gallus gallus	96.86	0.00e+00	642.00
IUUC-Gac-041951	Gasterosteus aculeatus	88.68	6.00e-174	602.00
IUUC-Hsa-046402	Homo sapiens	99.69	0.00e+00	655.00
IUUC-Itr-047895	Ictidomys tridecemlineatus	99.69	0.00e+00	655.00
IUUC-Lch-050266	Latimeria chalumnae	93.40	0.00e+00	626.00
IUUC-Loc-052547	Lepisosteus oculatus	91.82	1.00e-178	618.00
IUUC-Laf-054332	Loxodonta africana	99.69	0.00e+00	661.00
IUUC-Mcc-055869	Macaca mulatta	99.69	0.00e+00	655.00
IUUC-Meu-056735	Macropus eugenii	99.65	6.00e-171	592.00
IUUC-Mla-059147	Melampsora laricipopulina	37.11	4.00e-13	68.90
IUUC-Mga-060100	Meleagris gallopavo	96.86	0.00e+00	642.00
IUUC-Mvi-060553	Microbotryum violaceum	34.31	3.00e-13	69.70
IUUC-Mmr-061382	Microcebus murinus	99.69	0.00e+00	655.00
IUUC-Mmu-064225	Mus musculus	99.37	0.00e+00	655.00
IUUC-Mpu-066709	Mustela putorius furo	99.69	0.00e+00	655.00
IUUC-Mlu-067168	Myotis lucifugus	98.74	0.00e+00	653.00
IUUC-Nle-070176	Nomascus leucogenys	99.69	0.00e+00	655.00
IUUC-Opr-070259	Ochotona princeps	99.37	0.00e+00	655.00
IUUC-Ont-071235	Oreochromis niloticus	89.94	3.00e-176	610.00
IUUC-Oan-072850	Ornithorhynchus anatinus	96.05	8.00e-84	303.00
IUUC-Ocu-074165	Oryctolagus cuniculus	99.37	0.00e+00	655.00
IUUC-Ola-086658	Oryzias latipes	88.36	3.00e-172	597.00
IUUC-Oga-088933	Otolemur garnettii	99.69	0.00e+00	655.00
IUUC-Oar-090089	Ovis aries	99.37	0.00e+00	655.00
IUUC-Ptr-091263	Pan troglodytes	99.69	0.00e+00	655.00
IUUC-Pan-092926	Papio anubis	99.69	0.00e+00	655.00
IUUC-Psi-093934	Pelodiscus sinensis	89.34	4.00e-167	580.00
IUUC-Pma-094578	Petromyzon marinus	68.75	1.00e-125	442.00
IUUC-Pno-094854	Phaeosphaeria nodorum	36.59	2.00e-13	70.90
IUUC-Pfo-097431	Poecilia formosa	89.94	7.00e-176	609.00
IUUC-Pab-097852	Pongo abelii	99.69	0.00e+00	655.00
IUUC-Pca-100496	Procavia capensis	91.22	7.00e-168	582.00
IUUC-Ppe-101708	Prunus persica	28.70	2.00e-06	48.90
IUUC-Pva-103157	Pteropus vampyrus	98.51	2.00e-115	407.00
IUUC-Pgr-103416	Puccinia graminis	32.04	2.00e-13	70.50
IUUC-Pte-104279	Pyrenophora teres	31.14	2.00e-12	68.20
IUUC-Pyt-104429	Pyrenophora triticirepentis	37.61	1.00e-12	67.80
IUUC-Rno-105928	Rattus norvegicus	99.37	0.00e+00	654.00
IUUC-Sha-107556	Sarcophilus harrisii	99.69	0.00e+00	660.00
IUUC-Sar-113208	Sorex araneus	99.69	0.00e+00	655.00
IUUC-Ssc-116011	Sus scrofa	99.37	0.00e+00	655.00
IUUC-Tgu-116882	Taeniopygia guttata	75.00	1.00e-74	271.00
IUUC-Tru-117987	Takifugu rubripes	89.62	2.00e-175	607.00
IUUC-Tsy-118785	Tarsius syrichta	99.37	0.00e+00	650.00
IUUC-Tni-120165	Tetraodon nigroviridis	89.31	5.00e-175	606.00
IUUC-Tbe-127920	Tupaia belangeri	99.00	2.00e-117	414.00
IUUC-Ttr-129160	Tursiops truncatus	99.06	0.00e+00	654.00
IUUC-Vpa-130629	Vicugna pacos	99.69	0.00e+00	655.00
IUUC-Xtr-131895	Xenopus tropicalis	94.97	0.00e+00	631.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence