iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tru-117908

UUCD1 version

UUC-TaR-01126

Ensembl Protein ID

ENSTRUP00000043585.1

UniProt Accession

H2V304; H2V304_TAKRU

Protein Name

Uncharacterized protein

Gene Name

usp8

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTRUG00000017019.1	ENSTRUT00000043731.1	ENSTRUP00000043585.1
ENSTRUG00000017019.1	ENSTRUT00000043732.1	ENSTRUP00000043586.1
ENSTRUG00000017019.1	ENSTRUT00000043733.1	ENSTRUP00000043587.1
ENSTRUG00000017019.1	ENSTRUT00000043734.1	ENSTRUP00000043588.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	9.50e-108	361.6	741	1071

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsg 86
           tGl+NlgNtCYmNSvLQcL n p l+e++++  +  ++n++n  ++kg++++++  ++++lw++  k +spr+++ +++k++e+fsg
   Q: 741  TGLRNLGNTCYMNSVLQCLCNAPALTEYFNNnYYMDDINRSNILGHKGDVAEEFGVIMKALWSGLYKCISPRDFKITIGKINEQFSG 827
           7******************************778899************************************************** PP
   S: 87   yeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde.....aeekkkkknkslisdlFqgqlksqikclecdnvssreep 168
           yeqqD+qE+l fl+d+l+e+l+k +n ++ +eee+d  +l+d+     a++k+k  n+s+i+ lFqgq+ks+++cl+c+++s ++e+
   Q: 828  YEQQDSQELLLFLMDGLHEDLNKADNRKRYKEEEND--HLDDQtaadvAWRKHKLLNESIIVALFQGQFKSTVQCLTCHRKSRTFET 912
           *********************995555555555554..3333333555*************************************** PP
   S: 169  fldlslpvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvef 255
           f++lslp+ + +++   slqdcL+ f+kee+l+++nk++c++ck++++++kkl+++k+P++L +hLkRfs++ +   ++k++++v+f
   Q: 913  FMYLSLPLASTSKC---SLQDCLRLFSKEEKLTDNNKVFCRHCKAHRDSTKKLEIWKVPPILLVHLKRFSYEGR--WKQKLQTSVDF 994
           *************9...****************************************************99765..556******** PP
   S: 256  ple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaYvlfYk 336
           pl  Ldl+++++ p+++    k+Y+L+av +H+G+l++GHY+ay+k+  ++ W++fdD++V+ ++ ++v++   s aY+lfY 
   Q: 995  PLDsLDLAQYVIGPKQS---LKRYSLYAVSNHYGGLDGGHYTAYCKSALKQrWYKFDDHEVSDISTSSVKS---SAAYILFYS 1071
           *************9988...69*************************65556*******************...********7 PP

Organism

Takifugu rubripes

Protein Sequence
(Fasta)

MPSVSSGVKE LYLSTSLGDL NKKAEVKPEK TSTRSYVQSA CKIFKAAEEC RLDRDEERSY 60
VLYMKYLTVY DIIKKRPDFK KQMDYYMTLL GPSSFKKAIE EAEKLSGSLK LRYEEVEVRK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCCTTCAG TATCTTCCGG GGTCAAGGAG CTGTATCTGT CCACATCTCT GGGGGACCTC 60
AATAAAAAGG CTGAAGTAAA GCCAGAGAAG ACAAGCACCA GAAGGTAACA GACCAAAACT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR001763--Rhodanese-like_dom
IPR015063--USP8_dimer
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH
PF08969--USP8_dimer

Gene Ontology

GO:0005829--C:cytosol
GO:0031313--C:extrinsic component of endosome membrane
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001661	Ailuropoda melanoleuca	76.33	0.00e+00	757.00
IUUC-Apl-003226	Anas platyrhynchos	74.44	0.00e+00	758.00
IUUC-Aca-004936	Anolis carolinensis	55.12	0.00e+00	1020.00
IUUC-Ago-007959	Ashbya gossypii	35.81	6.00e-54	205.00
IUUC-Acl-008102	Aspergillus clavatus	31.59	5.00e-53	203.00
IUUC-Afl-008604	Aspergillus flavus	30.77	3.00e-51	196.00
IUUC-Afu-009001	Aspergillus fumigatus	31.67	3.00e-52	200.00
IUUC-Ani-009291	Aspergillus nidulans	30.77	3.00e-51	197.00
IUUC-Ang-009844	Aspergillus niger	31.76	1.00e-51	197.00
IUUC-Aor-010098	Aspergillus oryzae	30.77	1.00e-50	194.00
IUUC-Ate-010585	Aspergillus terreus	31.22	2.00e-51	197.00
IUUC-Ame-011029	Astyanax mexicanus	68.99	1.00e-90	326.00
IUUC-Bta-013008	Bos taurus	69.35	0.00e+00	756.00
IUUC-Bol-015281	Brassica oleracea	40.30	6.00e-53	201.00
IUUC-Bra-017228	Brassica rapa	40.60	9.00e-53	201.00
IUUC-Cel-018482	Caenorhabditis elegans	32.31	3.00e-54	206.00
IUUC-Cja-019173	Callithrix jacchus	76.48	0.00e+00	759.00
IUUC-Cfa-021243	Canis familiaris	76.33	0.00e+00	757.00
IUUC-Cpo-021522	Cavia porcellus	58.98	0.00e+00	1143.00
IUUC-Cre-022582	Chlamydomonas reinhardtii	44.93	2.00e-87	315.00
IUUC-Csa-023616	Chlorocebus sabaeus	76.69	0.00e+00	753.00
IUUC-Cho-024381	Choloepus hoffmanni	67.18	6.00e-180	624.00
IUUC-Cin-025287	Ciona intestinalis	49.01	2.00e-96	347.00
IUUC-Csv-026253	Ciona savignyi	47.80	2.00e-85	310.00
IUUC-Cne-026821	Cryptococcus neoformans	39.17	8.00e-73	269.00
IUUC-Dre-028440	Danio rerio	64.17	0.00e+00	806.00
IUUC-Dno-029039	Dasypus novemcinctus	76.69	0.00e+00	763.00
IUUC-Dor-031043	Dipodomys ordii	82.06	3.00e-116	413.00
IUUC-Dse-031463	Dothistroma septosporum	29.81	4.00e-46	180.00
IUUC-Dme-032089	Drosophila melanogaster	44.08	8.00e-88	318.00
IUUC-Ete-033040	Echinops telfairi	74.74	2.00e-173	603.00
IUUC-Eca-033449	Equus caballus	76.12	0.00e+00	780.00
IUUC-Eeu-034693	Erinaceus europaeus	82.96	4.00e-110	392.00
IUUC-Fca-035794	Felis catus	75.73	0.00e+00	723.00
IUUC-Fal-037322	Ficedula albicollis	75.00	0.00e+00	756.00
IUUC-Gmo-038584	Gadus morhua	74.76	0.00e+00	795.00
IUUC-Gga-041188	Gallus gallus	75.20	0.00e+00	756.00
IUUC-Gac-041850	Gasterosteus aculeatus	89.23	0.00e+00	874.00
IUUC-Ggo-045565	Gorilla gorilla	76.89	0.00e+00	760.00
IUUC-Hsa-046438	Homo sapiens	76.89	0.00e+00	760.00
IUUC-Itr-048883	Ictidomys tridecemlineatus	59.86	0.00e+00	1143.00
IUUC-Kpa-049321	Komagataella pastoris	32.69	7.00e-48	185.00
IUUC-Lch-050485	Latimeria chalumnae	77.71	0.00e+00	774.00
IUUC-Loc-052769	Lepisosteus oculatus	78.78	0.00e+00	790.00
IUUC-Lma-053021	Leptosphaeria maculans	33.60	6.00e-56	213.00
IUUC-Laf-053432	Loxodonta africana	75.71	0.00e+00	755.00
IUUC-Mcc-055823	Macaca mulatta	76.69	0.00e+00	758.00
IUUC-Meu-056099	Macropus eugenii	83.64	6.00e-143	501.00
IUUC-Mla-059089	Melampsora laricipopulina	41.96	3.00e-73	270.00
IUUC-Mga-059739	Meleagris gallopavo	74.59	0.00e+00	750.00
IUUC-Mvi-060559	Microbotryum violaceum	40.00	3.00e-78	287.00
IUUC-Mmr-061158	Microcebus murinus	76.64	0.00e+00	756.00
IUUC-Mdo-061801	Monodelphis domestica	76.89	0.00e+00	760.00
IUUC-Mmu-063665	Mus musculus	58.96	0.00e+00	1138.00
IUUC-Mpu-066738	Mustela putorius furo	76.12	0.00e+00	754.00
IUUC-Mlu-067307	Myotis lucifugus	76.73	0.00e+00	771.00
IUUC-Nfi-068410	Neosartorya fischeri	31.50	3.00e-52	201.00
IUUC-Nle-069314	Nomascus leucogenys	76.69	0.00e+00	758.00
IUUC-Opr-070378	Ochotona princeps	70.68	2.00e-103	370.00
IUUC-Ont-071545	Oreochromis niloticus	89.87	0.00e+00	960.00
IUUC-Oan-073537	Ornithorhynchus anatinus	71.70	0.00e+00	755.00
IUUC-Ocu-074193	Oryctolagus cuniculus	71.74	0.00e+00	767.00
IUUC-Ola-086622	Oryzias latipes	91.26	0.00e+00	873.00
IUUC-Oga-088271	Otolemur garnettii	75.87	0.00e+00	759.00
IUUC-Oar-090431	Ovis aries	70.34	0.00e+00	757.00
IUUC-Ptr-091339	Pan troglodytes	57.57	0.00e+00	1160.00
IUUC-Pan-092266	Papio anubis	78.01	7.00e-154	536.00
IUUC-Psi-093187	Pelodiscus sinensis	50.00	8.00e-116	411.00
IUUC-Pma-094626	Petromyzon marinus	55.79	3.00e-141	494.00
IUUC-Pfo-096463	Poecilia formosa	88.38	0.00e+00	910.00
IUUC-Pab-097645	Pongo abelii	76.69	0.00e+00	758.00
IUUC-Pva-103222	Pteropus vampyrus	78.95	1.00e-178	620.00
IUUC-Pgr-103408	Puccinia graminis	38.64	6.00e-56	213.00
IUUC-Ptt-103699	Puccinia triticina	46.85	3.00e-67	251.00
IUUC-Pte-104348	Pyrenophora teres	29.73	2.00e-41	164.00
IUUC-Pyt-104711	Pyrenophora triticirepentis	31.33	3.00e-53	204.00
IUUC-Rno-105510	Rattus norvegicus	57.97	0.00e+00	1163.00
IUUC-Sce-106166	Saccharomyces cerevisiae	35.26	4.00e-53	203.00
IUUC-Sha-106879	Sarcophilus harrisii	74.80	0.00e+00	759.00
IUUC-Sja-107836	Schizosaccharomyces japonicus	35.21	5.00e-50	192.00
IUUC-Smo-108711	Selaginella moellendorffii	34.72	3.00e-52	198.00
IUUC-Sar-113019	Sorex araneus	55.68	0.00e+00	1081.00
IUUC-Sre-115031	Sporisorium reilianum	37.99	5.00e-71	263.00
IUUC-Ssc-116334	Sus scrofa	59.59	0.00e+00	1170.00
IUUC-Tgu-117062	Taeniopygia guttata	75.00	0.00e+00	753.00
IUUC-Tsy-118867	Tarsius syrichta	68.30	0.00e+00	650.00
IUUC-Tni-120206	Tetraodon nigroviridis	94.57	0.00e+00	892.00
IUUC-Tme-127144	Tuber melanosporum	42.19	2.00e-82	300.00
IUUC-Tbe-127877	Tupaia belangeri	81.25	2.00e-67	251.00
IUUC-Ttr-128580	Tursiops truncatus	76.07	0.00e+00	755.00
IUUC-Uma-129340	Ustilago maydis	39.78	8.00e-74	272.00
IUUC-Vpa-130541	Vicugna pacos	66.90	0.00e+00	738.00
IUUC-Xtr-132161	Xenopus tropicalis	71.28	0.00e+00	738.00
IUUC-Xma-134271	Xiphophorus maculatus	88.19	0.00e+00	912.00
IUUC-Yli-134561	Yarrowia lipolytica	36.69	1.00e-58	221.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence