iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Probable component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (By similarity). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins (By similarity). Required for the metaphase to anaphase transition in meiosis (PubMed:17237515, PubMed:20944012). Plays a role in the segregation of DNA and centrioles during meiosis in male germ cells (PubMed:20944014).

Protein Sequence
(Fasta)

MPPKKAQTRR IVSLDSLFGH TLLNITGEPV TPTKIAIFQL IRTLFHAHFG VGAVPSLKPF 60
DKDEKTRVFT VLYGLIIMKS EISYDDFRCI VRILNDGLGR SIYYRFVTSM EKLAHGEDQI 120

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Nucleotide Sequence
(Fasta)

AATGCCTCCG AAAAAAGCGC AAACTCGACG AATCGTCAGT CTGGATTCAC TTTTTGGCCA 60
TACTCTACTG AATATCACCG GCGAACCTGT GACACCAACG AAAATCGCCA TTTTTCAACT 120

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Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0217--Developmental protein
KW-0469--Meiosis
KW-0498--Mitosis
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR011990--TPR-like_helical_dom

Gene Ontology

GO:0051301--P:cell division
GO:0051321--P:meiotic cell cycle
GO:0007067--P:mitotic nuclear division
GO:0007275--P:multicellular organism development
GO:0016567--P:protein ubiquitination

KEGG

cel:CELE_Y66D12A.17

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000646	Aegilops tauschii	40.62	1.80e-01	30.40
IUUC-Aml-001228	Ailuropoda melanoleuca	20.44	3.00e-09	56.20
IUUC-Apl-003267	Anas platyrhynchos	20.89	1.00e-05	43.90
IUUC-Bta-013451	Bos taurus	20.84	2.00e-07	50.10
IUUC-Cja-019568	Callithrix jacchus	20.44	4.00e-09	55.50
IUUC-Cfa-020050	Canis familiaris	20.31	1.00e-08	53.50
IUUC-Cpo-021705	Cavia porcellus	20.54	4.00e-08	52.00
IUUC-Csa-023099	Chlorocebus sabaeus	20.44	2.00e-07	50.10
IUUC-Cho-024968	Choloepus hoffmanni	28.89	1.00e-03	37.40
IUUC-Dre-028446	Danio rerio	24.07	4.00e-03	35.80
IUUC-Dno-029248	Dasypus novemcinctus	20.00	1.00e-07	50.80
IUUC-Dor-030713	Dipodomys ordii	28.70	3.00e-04	39.30
IUUC-Ete-032483	Echinops telfairi	20.32	3.00e-08	52.80
IUUC-Eca-033381	Equus caballus	20.70	1.00e-07	50.80
IUUC-Fca-035995	Felis catus	21.38	8.00e-05	40.80
IUUC-Fal-037344	Ficedula albicollis	30.56	2.00e-04	40.40
IUUC-Gga-040306	Gallus gallus	20.89	1.00e-04	40.40
IUUC-Gac-042229	Gasterosteus aculeatus	25.23	9.00e-03	34.70
IUUC-Ggo-045040	Gorilla gorilla	21.04	3.00e-09	55.80
IUUC-Hsa-047014	Homo sapiens	21.04	3.00e-09	55.80
IUUC-Hvu-047209	Hordeum vulgare	40.62	2.00e-01	30.00
IUUC-Itr-047936	Ictidomys tridecemlineatus	31.48	6.00e-06	43.90
IUUC-Lch-049595	Latimeria chalumnae	22.69	4.00e-03	35.80
IUUC-Lpe-051682	Leersia perrieri	40.62	1.60e-01	30.40
IUUC-Loc-052640	Lepisosteus oculatus	20.50	1.60e-01	30.40
IUUC-Laf-054391	Loxodonta africana	20.12	9.00e-08	51.20
IUUC-Mcc-055384	Macaca mulatta	21.04	3.00e-09	55.80
IUUC-Meu-056410	Macropus eugenii	33.33	1.10e+00	27.30
IUUC-Mga-059991	Meleagris gallopavo	19.68	4.00e-04	38.90
IUUC-Mmr-060939	Microcebus murinus	21.85	4.00e-06	45.40
IUUC-Mdo-062775	Monodelphis domestica	21.56	2.00e-05	43.10
IUUC-Mmu-063110	Mus musculus	20.24	6.00e-08	51.60
IUUC-Mpu-066382	Mustela putorius furo	20.52	3.00e-08	52.80
IUUC-Mlu-067724	Myotis lucifugus	28.21	1.00e-03	37.40
IUUC-Nle-069022	Nomascus leucogenys	21.04	3.00e-09	55.80
IUUC-Opr-070727	Ochotona princeps	21.98	1.00e-07	50.40
IUUC-Ont-071409	Oreochromis niloticus	25.17	9.00e-03	34.30
IUUC-Oan-073732	Ornithorhynchus anatinus	21.23	5.70e-02	30.80
IUUC-Oba-075329	Oryza barthii	40.62	1.70e-01	30.40
IUUC-Obr-076176	Oryza brachyantha	40.62	1.70e-01	30.40
IUUC-Ogl-076949	Oryza glaberrima	40.62	1.70e-01	30.40
IUUC-Ogu-078835	Oryza glumaepatula	40.62	1.70e-01	30.40
IUUC-Oin-079783	Oryza indica	40.62	1.60e-01	30.40
IUUC-Olo-080921	Oryza longistaminata	40.62	2.30e-01	30.40
IUUC-Ome-081983	Oryza meridionalis	40.62	2.60e-01	30.40
IUUC-Oni-082649	Oryza nivara	40.62	1.60e-01	30.40
IUUC-Opu-083962	Oryza punctata	40.62	1.60e-01	30.40
IUUC-Oru-085221	Oryza rufipogon	40.62	1.70e-01	30.40
IUUC-Osa-086035	Oryza sativa	40.62	1.70e-01	30.40
IUUC-Ola-087386	Oryzias latipes	25.00	7.00e-03	35.00
IUUC-Oga-089166	Otolemur garnettii	19.68	3.00e-06	46.20
IUUC-Oar-090437	Ovis aries	20.76	6.00e-06	45.10
IUUC-Ptr-090917	Pan troglodytes	21.04	3.00e-09	55.80
IUUC-Pan-091739	Papio anubis	21.98	2.00e-07	49.70
IUUC-Psi-093776	Pelodiscus sinensis	20.79	8.00e-04	37.70
IUUC-Ppa-095707	Physcomitrella patens	37.50	9.00e-01	28.10
IUUC-Pfo-096997	Poecilia formosa	25.00	4.00e-03	35.40
IUUC-Pab-098518	Pongo abelii	21.04	3.00e-09	55.80
IUUC-Pca-100400	Procavia capensis	31.48	7.00e-06	44.70
IUUC-Pva-103252	Pteropus vampyrus	21.43	1.00e-07	50.40
IUUC-Rno-104876	Rattus norvegicus	20.24	1.00e-07	50.40
IUUC-Sha-107267	Sarcophilus harrisii	22.14	2.00e-06	46.60
IUUC-Sit-110705	Setaria italica	43.75	5.90e-02	32.00
IUUC-Sar-113485	Sorex araneus	31.48	3.00e-05	42.70
IUUC-Sbi-114673	Sorghum bicolor	43.75	6.40e-02	32.00
IUUC-Ssc-115301	Sus scrofa	20.90	8.00e-08	51.20
IUUC-Tgu-116928	Taeniopygia guttata	21.13	2.00e-05	43.10
IUUC-Tru-117756	Takifugu rubripes	24.54	7.00e-03	35.00
IUUC-Tsy-119155	Tarsius syrichta	22.60	2.00e-05	43.10
IUUC-Tni-120285	Tetraodon nigroviridis	27.65	1.00e-03	37.40
IUUC-Tvi-122315	Trichoderma virens	28.05	1.00e-01	30.40
IUUC-Tae-125147	Triticum aestivum	40.62	1.80e-01	30.40
IUUC-Tur-126507	Triticum urartu	40.62	1.90e-01	30.40
IUUC-Tbe-127653	Tupaia belangeri	33.33	1.00e+00	27.70
IUUC-Ttr-129200	Tursiops truncatus	20.20	7.00e-06	44.70
IUUC-Vpa-130494	Vicugna pacos	29.75	8.00e-06	44.70
IUUC-Xtr-132765	Xenopus tropicalis	26.51	1.00e-04	40.40
IUUC-Xma-133195	Xiphophorus maculatus	24.48	1.70e-02	33.10

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence