iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mga-059563

UUCD1 version

UUC-MeG-00259

Ensembl Protein ID

ENSMGAP00000005180.1

UniProt Accession

G1N136; G1N136_MELGA

Protein Name

Uncharacterized protein

Gene Name

HERC3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMGAG00000005208.2	ENSMGAT00000005911.1	ENSMGAP00000005180.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.00e-94	317.4	726	1049

Active Site

Position(s)	Description	Evidence
1018	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           dlkk l+v f gEe++d+gGvt+ef+ ll+kel np +g+f+y ++++  ++ +         + ++F+++G+++g+a+++  ++dl
   Q: 726  DLKKPLKVIFDGEEAVDAGGVTKEFFLLLLKELLNPIYGMFTYYPESNLLWFSDTCFV-----EHNWFHLIGIICGLAIYNFTVVDL 807
           899**********************************************999777554.....579********************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklv 177
           +++ ++yk+ll++k  ledl+e+ p+  +sl++++++  +diee+ ++l+f++  e++g t++++L+++G++i+V ++N+e++v+++
   Q: 808  HFPLALYKKLLNVKPCLEDLKELSPTEGRSLQQLLDYPGEDIEET-FCLNFTICRESYGVTEHKNLIEDGDKIQVQKDNREKFVEAY 893
           *******************************************98.******99********************************* PP
   S: 178  veyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkaf 264
           v+y+++ +i+e ++af+ Gf +v+  ++l+lF++ el+ +i G++++++e+l++ + ykg+yt+++p++++Fwe++++f  e++k+f
   Q: 894  VNYIFNCSIHEWYTAFSTGFLKVCGGKVLELFQPTELRAMIVGNSNYNWEELEESAVYKGDYTATHPTVRMFWETFHAFPLEKKKKF 980
           *************************************************************************************** PP
   S: 265  LqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           L F+Tgs+r+P+ G+ +l+   +vi+  ++ ++ lP ++TC+n+L+LP+Ysskeil  +L+ Ai++ +gF+l
   Q: 981  LLFLTGSDRIPIYGMSSLR---IVIQStANGEQYLPVAHTCYNLLDLPKYSSKEILSARLMQAIDHYEGFSL 1049
           *******************...8888868888**************************************97 PP

Organism

Meleagris gallopavo

Protein Sequence
(Fasta)

MLCWGYSSFG QPGIGSNLQV IIPEPQVYGF IHDRNVKEVA CGGNHSVFLL EDGEVYTCGL 60
NTKGQLGHES EGSKPELIGA LAGQHIVHVA CGESHSVALS DQGQVFSWGA GSDGQLGLTT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAGGAGAATA CATGACTTGC TGAAAAGAGA GAAAATGCTA TGCTGGGGTT ACTCATCTTT 60
TGGACAACCT GGGATAGGTA GCAACCTCCA GGTCATCATT CCCGAACCAC AGGTGTATGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0005829--C:cytosol
GO:0004842--F:ubiquitin-protein transferase activity

KEGG

mgp:100539754

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001673	Ailuropoda melanoleuca	88.00	0.00e+00	1867.00
IUUC-Apl-003535	Anas platyrhynchos	98.76	0.00e+00	2079.00
IUUC-Aca-005223	Anolis carolinensis	88.86	0.00e+00	1882.00
IUUC-Ame-010816	Astyanax mexicanus	66.00	0.00e+00	1169.00
IUUC-Bta-013373	Bos taurus	88.00	0.00e+00	1872.00
IUUC-Cel-018150	Caenorhabditis elegans	34.26	5.00e-155	541.00
IUUC-Cja-019609	Callithrix jacchus	87.52	0.00e+00	1860.00
IUUC-Cfa-021071	Canis familiaris	87.81	0.00e+00	1861.00
IUUC-Cpo-021548	Cavia porcellus	86.86	0.00e+00	1852.00
IUUC-Csa-023987	Chlorocebus sabaeus	87.90	0.00e+00	1867.00
IUUC-Cho-024325	Choloepus hoffmanni	89.73	0.00e+00	1103.00
IUUC-Cin-025232	Ciona intestinalis	41.94	0.00e+00	772.00
IUUC-Dre-027472	Danio rerio	67.21	0.00e+00	1409.00
IUUC-Dno-029241	Dasypus novemcinctus	87.17	0.00e+00	1849.00
IUUC-Dor-030672	Dipodomys ordii	80.85	0.00e+00	985.00
IUUC-Dme-032103	Drosophila melanogaster	43.88	0.00e+00	838.00
IUUC-Ete-032642	Echinops telfairi	83.33	0.00e+00	1707.00
IUUC-Eca-033646	Equus caballus	88.10	0.00e+00	1867.00
IUUC-Eeu-035098	Erinaceus europaeus	77.10	0.00e+00	1238.00
IUUC-Fal-036952	Ficedula albicollis	98.10	0.00e+00	2068.00
IUUC-Gmo-039297	Gadus morhua	65.62	0.00e+00	1331.00
IUUC-Gga-040591	Gallus gallus	99.24	0.00e+00	2083.00
IUUC-Gac-041741	Gasterosteus aculeatus	65.94	0.00e+00	1386.00
IUUC-Ggo-044769	Gorilla gorilla	87.44	0.00e+00	1859.00
IUUC-Hsa-046066	Homo sapiens	87.71	0.00e+00	1863.00
IUUC-Itr-048311	Ictidomys tridecemlineatus	87.44	0.00e+00	1860.00
IUUC-Lch-050301	Latimeria chalumnae	73.90	0.00e+00	1615.00
IUUC-Loc-052803	Lepisosteus oculatus	67.63	0.00e+00	1451.00
IUUC-Laf-053364	Loxodonta africana	87.71	0.00e+00	1859.00
IUUC-Mcc-054930	Macaca mulatta	87.81	0.00e+00	1865.00
IUUC-Meu-056274	Macropus eugenii	75.23	0.00e+00	820.00
IUUC-Mtr-058277	Medicago truncatula	38.89	7.00e-53	201.00
IUUC-Mmr-060792	Microcebus murinus	86.67	0.00e+00	1823.00
IUUC-Mdo-062195	Monodelphis domestica	89.25	0.00e+00	1894.00
IUUC-Mmu-063855	Mus musculus	86.19	0.00e+00	1839.00
IUUC-Mpu-066308	Mustela putorius furo	88.10	0.00e+00	1867.00
IUUC-Mlu-066927	Myotis lucifugus	87.81	0.00e+00	1860.00
IUUC-Nle-070090	Nomascus leucogenys	87.71	0.00e+00	1865.00
IUUC-Opr-070891	Ochotona princeps	77.05	0.00e+00	1585.00
IUUC-Ont-072201	Oreochromis niloticus	64.34	0.00e+00	1336.00
IUUC-Ocu-074770	Oryctolagus cuniculus	87.81	0.00e+00	1867.00
IUUC-Ola-086550	Oryzias latipes	65.15	0.00e+00	1381.00
IUUC-Olu-087836	Ostreococcus lucimarinus	33.03	6.00e-43	167.00
IUUC-Oga-088831	Otolemur garnettii	87.52	0.00e+00	1863.00
IUUC-Oar-090449	Ovis aries	88.10	0.00e+00	1865.00
IUUC-Pan-092135	Papio anubis	87.82	0.00e+00	1862.00
IUUC-Psi-093832	Pelodiscus sinensis	89.72	0.00e+00	1929.00
IUUC-Pfo-097268	Poecilia formosa	65.81	0.00e+00	1382.00
IUUC-Pab-098249	Pongo abelii	87.43	0.00e+00	1858.00
IUUC-Pca-100855	Procavia capensis	83.61	0.00e+00	1273.00
IUUC-Pva-102506	Pteropus vampyrus	80.30	0.00e+00	1636.00
IUUC-Rno-105242	Rattus norvegicus	86.38	0.00e+00	1876.00
IUUC-Sha-107186	Sarcophilus harrisii	86.11	0.00e+00	1151.00
IUUC-Sar-113612	Sorex araneus	89.77	0.00e+00	699.00
IUUC-Ssc-115473	Sus scrofa	87.43	0.00e+00	1851.00
IUUC-Tgu-116974	Taeniopygia guttata	97.62	0.00e+00	2036.00
IUUC-Tru-118077	Takifugu rubripes	64.49	0.00e+00	1317.00
IUUC-Tsy-119619	Tarsius syrichta	77.14	0.00e+00	1641.00
IUUC-Tni-120807	Tetraodon nigroviridis	65.09	0.00e+00	1342.00
IUUC-Tbe-127640	Tupaia belangeri	83.71	0.00e+00	1733.00
IUUC-Ttr-129172	Tursiops truncatus	87.14	0.00e+00	1847.00
IUUC-Vpa-130442	Vicugna pacos	73.26	0.00e+00	1491.00
IUUC-Xtr-132194	Xenopus tropicalis	70.94	0.00e+00	1410.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence