iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ptr-091187

UUCD1 version

UUC-PaT-00154

Ensembl Protein ID

ENSPTRP00000005673.5

UniProt Accession

H2Q2Y1; H2Q2Y1_PANTR

Genbank Protein ID

JAA06853.1; JAA16568.1; JAA26338.1; JAA39505.1

Protein Name

Tripartite motif containing 21

Genbank Nucleotide ID

AACZ03079467; GABF01005577; GABD01006762; GABE01005234

Gene Name

TRIM21

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPTRG00000003212.5	ENSPTRT00000006146.5	ENSPTRP00000005673.5

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	3.80e-09	36.9	16	55
E3 activity/RING/U-box	1.00e-09	38.3	12	74

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iCl++f + p++  CgH f+++C+ ++      + +   CP+Cr
   Q: 16   CPICLDPFVE-PVSIECGHSFCQECISQV-----GKGGGSVCPVCR 55
           **********.***************999.....6788888****8 PP

E3 activity/RING/U-box

   S: 4    eeflCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqplteedlvPnltlrrliq 66
           ee  CpI l+++ +Pv +++G+++ +++I +  + gg+ cPv+rq++  ++l Pn  l ++++
   Q: 12   EEVTCPICLDPFVEPVSIECGHSFCQECISQVGKGGGSVCPVCRQRFLLKNLRPNRQLANMVN 74
           6889***************************9999999******************9988875 PP

Organism

Pan troglodytes

Protein Sequence
(Fasta)

MASAARLTMM WEEVTCPICL DPFVEPVSIE CGHSFCQECI SQVGKGGGSV CPVCRQRFLL 60
KNLRPNRQLA NMVNNLKEIS QEAREGTQGE RCAVHGERLH LFCEKDGKAL CWVCAQSRKH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCCTCTGAGC GGAAACTGAA AGTGAAATAG GGAGCTGGCT ACCAGCGTTG AGTCCCCTGT 60
AAAGGTGAGT GAACCCCACT AGATCAAGGG ACCCCTGCCC TCCTAGGGGA CCTCTCTCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR006574--PRY
IPR003877--SPRY_dom
IPR003613--Ubox_domain
IPR000315--Znf_B-box
IPR020457--Znf_B-box_chordata
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50188--B302_SPRY
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF13765--PRY
PF00622--SPRY
PF00643--zf-B_box

PRINTS

PR01406--BBOXZNFINGER
PR01407--BUTYPHLNCDUF

SMART

SM00336--BBOX
SM00589--PRY
SM00184--RING
SM00449--SPRY
SM00504--Ubox

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005654--C:nucleoplasm
GO:0019005--C:SCF ubiquitin ligase complex
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0090086--P:negative regulation of protein deubiquitination
GO:1902187--P:negative regulation of viral release from host cell
GO:0032897--P:negative regulation of viral transcription
GO:0010508--P:positive regulation of autophagy
GO:0045787--P:positive regulation of cell cycle
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0046598--P:positive regulation of viral entry into host cell
GO:0051865--P:protein autoubiquitination
GO:0031648--P:protein destabilization
GO:0006513--P:protein monoubiquitination
GO:0000209--P:protein polyubiquitination
GO:0070206--P:protein trimerization
GO:0034341--P:response to interferon-gamma

KEGG

ptr:450975

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001896	Ailuropoda melanoleuca	78.85	0.00e+00	772.00
IUUC-Aca-004891	Anolis carolinensis	42.61	2.00e-94	339.00
IUUC-Ang-009772	Aspergillus niger	32.94	3.00e-08	51.60
IUUC-Bta-013083	Bos taurus	72.60	0.00e+00	677.00
IUUC-Bol-016562	Brassica oleracea	47.92	4.00e-09	54.30
IUUC-Bra-016652	Brassica rapa	45.10	4.00e-09	55.50
IUUC-Cel-018124	Caenorhabditis elegans	20.87	2.00e-12	65.90
IUUC-Cja-019002	Callithrix jacchus	92.42	0.00e+00	892.00
IUUC-Cfa-020415	Canis familiaris	75.69	0.00e+00	739.00
IUUC-Cpo-021948	Cavia porcellus	72.22	0.00e+00	687.00
IUUC-Csa-023135	Chlorocebus sabaeus	96.21	0.00e+00	848.00
IUUC-Cho-024493	Choloepus hoffmanni	66.08	8.00e-98	349.00
IUUC-Dre-028064	Danio rerio	30.85	4.00e-61	228.00
IUUC-Dno-030061	Dasypus novemcinctus	72.00	0.00e+00	709.00
IUUC-Ete-033168	Echinops telfairi	70.12	1.00e-169	588.00
IUUC-Eca-033578	Equus caballus	81.37	0.00e+00	773.00
IUUC-Eeu-034749	Erinaceus europaeus	57.63	6.00e-132	464.00
IUUC-Fca-035468	Felis catus	74.69	0.00e+00	719.00
IUUC-Gac-041721	Gasterosteus aculeatus	35.56	1.00e-75	276.00
IUUC-Ggo-045190	Gorilla gorilla	98.95	0.00e+00	910.00
IUUC-Hsa-046583	Homo sapiens	100.00	0.00e+00	919.00
IUUC-Itr-048632	Ictidomys tridecemlineatus	78.20	0.00e+00	730.00
IUUC-Laf-053455	Loxodonta africana	75.56	0.00e+00	679.00
IUUC-Mcc-054609	Macaca mulatta	95.79	0.00e+00	842.00
IUUC-Mmr-061369	Microcebus murinus	77.68	0.00e+00	671.00
IUUC-Mmu-063166	Mus musculus	70.50	0.00e+00	661.00
IUUC-Mpu-066889	Mustela putorius furo	76.50	0.00e+00	754.00
IUUC-Mlu-067647	Myotis lucifugus	79.44	0.00e+00	708.00
IUUC-Nle-069567	Nomascus leucogenys	97.47	0.00e+00	899.00
IUUC-Opr-071178	Ochotona princeps	64.42	2.00e-172	598.00
IUUC-Ont-072250	Oreochromis niloticus	34.23	5.00e-71	261.00
IUUC-Olu-087666	Ostreococcus lucimarinus	32.95	2.00e-11	63.90
IUUC-Oar-090413	Ovis aries	77.63	0.00e+00	702.00
IUUC-Pan-092231	Papio anubis	96.15	0.00e+00	832.00
IUUC-Pma-094734	Petromyzon marinus	26.94	4.00e-25	109.00
IUUC-Pab-098079	Pongo abelii	95.18	0.00e+00	640.00
IUUC-Pca-100639	Procavia capensis	74.65	3.00e-151	528.00
IUUC-Pva-102476	Pteropus vampyrus	78.53	0.00e+00	746.00
IUUC-Rno-105054	Rattus norvegicus	70.82	3.00e-175	607.00
IUUC-Sar-113204	Sorex araneus	74.00	0.00e+00	660.00
IUUC-Ssc-116291	Sus scrofa	77.14	0.00e+00	722.00
IUUC-Tsy-118803	Tarsius syrichta	78.40	5.00e-144	504.00
IUUC-Tbe-127337	Tupaia belangeri	62.94	9.00e-113	399.00
IUUC-Ttr-128914	Tursiops truncatus	77.14	0.00e+00	664.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence