iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Eca-034143

UUCD1 version

UUC-EqC-00030

Ensembl Protein ID

ENSECAP00000015017.1

UniProt Accession

F6PSD5; F6PSD5_HORSE

Protein Name

Katanin p80 WD40 repeat-containing subunit B1; p80 katanin

Gene Name

KATNB1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000016979.1	ENSECAT00000018408.1	ENSECAP00000015017.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.80e-42	141.6	143	178
UBD/Beta-Prp	2.50e-57	194.5	15	256

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgv 34
           gH+  v+cl+f +d + l+s++dD+t+k+WDl+ g+
   Q: 143  GHSQAVRCLRFsPDgKWLASAADDHTVKLWDLTAGK 178
           8***********999*****************9997 PP

UBD/Beta-Prp

   S: 4    tlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkg 92
           ++ +h ++v + v  + +++llatg  d ++ +w++++ +++ sl gh+++v +v+++  ++++v gs+ + i+vwdl++ k+++tl g
   Q: 15   EIVAHASNVSSLVLGKASGRLLATGD-DCRVNLWSIKP-NCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMG 101
           677888888888888999******95.*********99.************************************************** PP
   S: 93   hedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtd 181
           h+++++sl+f+p+g++++sGs+d  i++wd++ + c+    +gh+++v+c++++pdg+ l+s+++D tv+lWdl  gk++ ++ g ht+
   Q: 102  HKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVF-RYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPG-HTG 188
           *************************************9.9********************************************9.*** PP
   S: 182  svyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWd 250
           +v+ ++f++n   l+sgs d+t+++wdl++ ++v   +g   +v+sv f p++  l+sg +D s+r++ 
   Q: 189  PVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQD-SLRVYG 256
           ***********************************************************766.556644 PP

Organism

Equus caballus

Functional Description
(View)

Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.

Protein Sequence
(Fasta)

MATPVVTKTA WKLQEIVAHA SNVSSLVLGK ASGRLLATGD DCRVNLWSIK PNCIMSLTGH 60
TSPVESVRLN TPEELIVAGS QSGSIRVWDL EAAKILRTLM GHKANICSLD FHPYGEFVAS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCCACCC CTGTGGTCAC CAAGACAGCC TGGAAGTTGC GTGAGTGGTT TTCTTTTTTC 60
TTTCTGCCCC CATTCACCCC TGTTAGCTGC TTGTTGCTGA GTGCCCTCAA CTCCCAGCTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0493--Microtubule
KW-0498--Mitosis
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR003143--Cyt_cd1_C
IPR020472--G-protein_beta_WD-40_rep
IPR026962--Katanin_bsu1
IPR028021--Katanin_C-terminal
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF13925--Katanin_con80
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0030424--C:axon
GO:0005813--C:centrosome
GO:0005829--C:cytosol
GO:0008352--C:katanin complex
GO:0005874--C:microtubule
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0000922--C:spindle pole
GO:0008568--F:microtubule-severing ATPase activity
GO:0051301--P:cell division
GO:0051013--P:microtubule severing
GO:0007079--P:mitotic chromosome movement towards spindle pole
GO:0007026--P:negative regulation of microtubule depolymerization
GO:0031117--P:positive regulation of microtubule depolymerization

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000954	Aegilops tauschii	47.95	9.00e-83	302.00
IUUC-Aml-002187	Ailuropoda melanoleuca	88.65	0.00e+00	1088.00
IUUC-Atr-002899	Amborella trichopoda	54.11	2.00e-99	357.00
IUUC-Apl-003305	Anas platyrhynchos	76.24	0.00e+00	985.00
IUUC-Aca-004635	Anolis carolinensis	79.57	0.00e+00	942.00
IUUC-Aly-005711	Arabidopsis lyrata	51.16	2.00e-98	353.00
IUUC-Ath-007606	Arabidopsis thaliana	51.16	3.00e-98	353.00
IUUC-Ame-010870	Astyanax mexicanus	53.87	4.00e-91	328.00
IUUC-Bta-012527	Bos taurus	94.57	0.00e+00	1170.00
IUUC-Bdi-014652	Brachypodium distachyon	53.18	1.00e-100	361.00
IUUC-Bol-015242	Brassica oleracea	50.17	1.00e-96	347.00
IUUC-Bra-017390	Brassica rapa	50.50	5.00e-97	348.00
IUUC-Cja-019706	Callithrix jacchus	94.22	0.00e+00	1078.00
IUUC-Cfa-020139	Canis familiaris	81.29	0.00e+00	779.00
IUUC-Cpo-021710	Cavia porcellus	93.74	0.00e+00	1149.00
IUUC-Cre-022746	Chlamydomonas reinhardtii	41.47	6.00e-66	245.00
IUUC-Csa-023546	Chlorocebus sabaeus	95.42	0.00e+00	1038.00
IUUC-Cin-025156	Ciona intestinalis	40.81	7.00e-148	517.00
IUUC-Csv-025962	Ciona savignyi	49.32	3.00e-86	311.00
IUUC-Dre-028215	Danio rerio	61.21	0.00e+00	823.00
IUUC-Dno-029314	Dasypus novemcinctus	93.28	0.00e+00	1098.00
IUUC-Dor-030482	Dipodomys ordii	94.35	0.00e+00	1187.00
IUUC-Dme-032188	Drosophila melanogaster	39.81	7.00e-57	215.00
IUUC-Fca-035924	Felis catus	95.57	0.00e+00	1151.00
IUUC-Fal-037387	Ficedula albicollis	78.18	0.00e+00	972.00
IUUC-Gmo-038692	Gadus morhua	57.86	0.00e+00	725.00
IUUC-Gga-040597	Gallus gallus	78.27	0.00e+00	1021.00
IUUC-Gac-042004	Gasterosteus aculeatus	60.63	0.00e+00	802.00
IUUC-Gma-044134	Glycine max	31.24	5.00e-99	355.00
IUUC-Ggo-044761	Gorilla gorilla	95.88	0.00e+00	1078.00
IUUC-Hsa-045698	Homo sapiens	95.73	0.00e+00	1108.00
IUUC-Hvu-047649	Hordeum vulgare	53.18	1.00e-100	361.00
IUUC-Itr-048697	Ictidomys tridecemlineatus	94.03	0.00e+00	1132.00
IUUC-Lch-049674	Latimeria chalumnae	66.81	0.00e+00	885.00
IUUC-Lpe-051554	Leersia perrieri	54.18	4.00e-103	369.00
IUUC-Loc-052623	Lepisosteus oculatus	66.18	0.00e+00	877.00
IUUC-Laf-054587	Loxodonta africana	94.53	0.00e+00	1153.00
IUUC-Mcc-055851	Macaca mulatta	95.73	0.00e+00	1078.00
IUUC-Meu-056704	Macropus eugenii	88.91	0.00e+00	1157.00
IUUC-Mtr-058053	Medicago truncatula	52.16	2.00e-101	363.00
IUUC-Mga-059608	Meleagris gallopavo	77.74	0.00e+00	1006.00
IUUC-Mmr-061154	Microcebus murinus	93.14	0.00e+00	1101.00
IUUC-Mdo-062365	Monodelphis domestica	84.77	0.00e+00	1090.00
IUUC-Mmu-063754	Mus musculus	93.31	0.00e+00	1127.00
IUUC-Mac-064667	Musa acuminata	52.04	1.00e-97	349.00
IUUC-Mpu-066245	Mustela putorius furo	95.11	0.00e+00	1108.00
IUUC-Mlu-067692	Myotis lucifugus	94.60	0.00e+00	1122.00
IUUC-Nle-070051	Nomascus leucogenys	93.14	0.00e+00	1058.00
IUUC-Opr-070855	Ochotona princeps	93.89	0.00e+00	1145.00
IUUC-Ont-071883	Oreochromis niloticus	58.42	0.00e+00	801.00
IUUC-Oan-073293	Ornithorhynchus anatinus	88.46	0.00e+00	1005.00
IUUC-Ocu-074644	Oryctolagus cuniculus	94.96	0.00e+00	1160.00
IUUC-Oba-075448	Oryza barthii	53.35	9.00e-104	371.00
IUUC-Obr-076385	Oryza brachyantha	53.51	2.00e-102	367.00
IUUC-Ogl-077427	Oryza glaberrima	54.52	9.00e-104	371.00
IUUC-Ogu-079022	Oryza glumaepatula	48.56	6.00e-95	342.00
IUUC-Oin-079811	Oryza indica	52.09	1.00e-100	360.00
IUUC-Olo-080245	Oryza longistaminata	52.09	1.00e-100	360.00
IUUC-Ome-081239	Oryza meridionalis	53.92	4.00e-100	358.00
IUUC-Oni-082640	Oryza nivara	53.35	9.00e-104	371.00
IUUC-Opu-083748	Oryza punctata	54.18	4.00e-103	369.00
IUUC-Oru-084609	Oryza rufipogon	53.35	9.00e-104	371.00
IUUC-Osa-086267	Oryza sativa	48.56	6.00e-95	342.00
IUUC-Ola-087483	Oryzias latipes	55.90	5.00e-178	617.00
IUUC-Oga-087964	Otolemur garnettii	93.89	0.00e+00	1164.00
IUUC-Oar-089483	Ovis aries	93.21	0.00e+00	1136.00
IUUC-Ptr-091387	Pan troglodytes	95.73	0.00e+00	1107.00
IUUC-Pan-092623	Papio anubis	95.73	0.00e+00	1078.00
IUUC-Psi-093830	Pelodiscus sinensis	80.33	0.00e+00	1020.00
IUUC-Pma-094135	Petromyzon marinus	43.00	1.00e-35	142.00
IUUC-Ppa-095379	Physcomitrella patens	54.45	1.00e-94	340.00
IUUC-Pfo-096755	Poecilia formosa	57.70	0.00e+00	780.00
IUUC-Pab-097564	Pongo abelii	94.51	0.00e+00	948.00
IUUC-Pop-099149	Populus trichocarpa	52.16	5.00e-101	362.00
IUUC-Pca-100357	Procavia capensis	98.57	3.00e-122	432.00
IUUC-Ppe-101237	Prunus persica	52.16	9.00e-101	361.00
IUUC-Pva-102397	Pteropus vampyrus	90.84	0.00e+00	1060.00
IUUC-Rno-105349	Rattus norvegicus	93.59	0.00e+00	1174.00
IUUC-Smo-109409	Selaginella moellendorffii	53.92	2.00e-98	353.00
IUUC-Sit-110360	Setaria italica	54.52	3.00e-103	369.00
IUUC-Sly-111307	Solanum lycopersicum	52.49	3.00e-96	346.00
IUUC-Stu-112462	Solanum tuberosum	52.05	1.00e-92	333.00
IUUC-Sar-112953	Sorex araneus	82.02	3.00e-109	388.00
IUUC-Sbi-114389	Sorghum bicolor	46.64	4.00e-91	329.00
IUUC-Ssc-115949	Sus scrofa	92.71	0.00e+00	876.00
IUUC-Tgu-117461	Taeniopygia guttata	77.36	0.00e+00	1004.00
IUUC-Tru-117865	Takifugu rubripes	58.00	0.00e+00	771.00
IUUC-Tsy-119036	Tarsius syrichta	83.27	2.00e-88	319.00
IUUC-Tni-120903	Tetraodon nigroviridis	60.12	0.00e+00	758.00
IUUC-Tca-121185	Theobroma cacao	51.16	4.00e-98	353.00
IUUC-Tae-125263	Triticum aestivum	53.51	5.00e-101	362.00
IUUC-Tur-126181	Triticum urartu	47.62	3.00e-91	329.00
IUUC-Tbe-127518	Tupaia belangeri	80.76	0.00e+00	634.00
IUUC-Ttr-128172	Tursiops truncatus	94.66	0.00e+00	1118.00
IUUC-Vvi-131489	Vitis vinifera	52.82	2.00e-101	363.00
IUUC-Xtr-132915	Xenopus tropicalis	71.68	0.00e+00	934.00
IUUC-Xma-134133	Xiphophorus maculatus	57.41	0.00e+00	769.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence