iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000023773.3	ENSMMUT00000033459.3	ENSMMUP00000031315.2
ENSMMUG00000023773.3	ENSMMUT00000074150.1	ENSMMUP00000046380.1
ENSMMUG00000023773.3	ENSMMUT00000033458.3	ENSMMUP00000031314.3
ENSMMUG00000023773.3	ENSMMUT00000057478.1	ENSMMUP00000044785.1
ENSMMUG00000023773.3	ENSMMUT00000075903.1	ENSMMUP00000051976.1
ENSMMUG00000023773.3	ENSMMUT00000069785.1	ENSMMUP00000059782.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.00e-58	199.3	162	648

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.....kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeef 84
           +GlkN+gNtC++ +v+Q+L+++pe+r+l+l+     +  e+++    ++++  ++++lq lf+ ++ s++k v+p++ l+ lk + ++ 
   Q: 162  VGLKNVGNTCWFSAVIQSLFQLPEFRRLVLSynlpqNVLENCRSH-TEKRNIMFMQELQYLFALMMGSNRKFVDPSAALDLLKGAFRS- 248
           6******************************96665445555443.478888*******************************99987. PP
   S: 85   sgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldls 173
           s+ +qqD++Ef++ lld le++++                     + +++ +k+++++++lF g++ ++ + +        +e+f +++
   Q: 249  SEEQQQDVSEFTHKLLDWLEDAFQL------------------AVNVNSPRNKSENPMVQLFYGTFLTEGVREGKPFC--NNETFGQYP 317
           99*********************22..................23467899****************99998665555..5899***** PP
   S: 174  lpvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdls 262
           l+v+g +     +l++cLe  + e  +e    +  +   ++++  ++ +++klP+vL+++L+Rf+f+++ +++eki++k+efp+ + ++
   Q: 318  LQVNGYR-----NLDECLEGAMVEGDVE----LLPSD--HSVKYGQERWFTKLPPVLTFELSRFEFNQSLGQPEKIHNKLEFPQIIYMD 395
           *******.....99****7665555555....55554..556778899***************************************** PP
   S: 263  pfcts.................................................................................... 267
           +++ +                                                                                    
   Q: 396  RYMYRskelirnkrecirklkeeikilqqkleryvkygsgparfplpdmlkyviefastkpasescppesdthmtlplssvhcpvsdqt 484
           *9999778888888777777777777777777777777777777777777777777777777777776666666666666666666555 PP
   S: 268  .peekqke................................................................................. 274
            +     e                                                                                 
   Q: 485  sK-----Eststesssldvestfsspedslhkskpltssrssmempaqpaprtvtdeeinfvktclqrwrseieqdiqdlknciasttq 568
           50.....0455556666666666666677777777777777888888888888888888888888888888888889999999999999 PP
   S: 275  ............kkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevkeeevleetg.....staYvlfYk 336
                       ++ Y+L+av+vH+G+++ GHY+ay++n+ ++ Wl+++D +Vte+++eev++++       +aY+l+Y 
   Q: 569  tieqmycdpllrQVPYRLHAVLVHEGQANAGHYWAYIYNQPRQsWLKYNDISVTESSWEEVERDSYgglrnVSAYCLMYI 648
           999999****99***************************88888*******************8879************6 PP

Organism

Macaca mulatta

Protein Sequence
(Fasta)

MTAELQQDDA AGAADGHSSS CQMLLNQLRE ITGIQDPSFL HEALKASNGD ITQAVSLLTD 60
ERVKEPSQDT VATEPSEVEG SAANKEVLAK VIDLTHDNKD DLQAAIALSL LESPKIQADG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGAGGCTGG GCCGGCGGTG GCAGCGGCGG GAGACGGGTG ACCCGCGGCT GGGCGCCTCG 60
GCCATGACTG CGGAGCTGCA GCAGGACGAC GCGGCCGGCG CGGCCGACGG CCACAGCTCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR011990--TPR-like_helical_dom
IPR009060--UBA-like
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0016604--C:nuclear body
GO:0043234--C:protein complex
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008283--P:cell proliferation
GO:0034644--P:cellular response to UV
GO:0000077--P:DNA damage checkpoint
GO:0042771--P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0016579--P:protein deubiquitination
GO:0007265--P:Ras protein signal transduction
GO:0031647--P:regulation of protein stability
GO:0010212--P:response to ionizing radiation
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001836	Ailuropoda melanoleuca	92.72	0.00e+00	1394.00
IUUC-Apl-004010	Anas platyrhynchos	65.18	0.00e+00	1400.00
IUUC-Aca-004741	Anolis carolinensis	61.23	0.00e+00	1342.00
IUUC-Acl-008164	Aspergillus clavatus	23.21	5.00e-15	77.40
IUUC-Ani-009503	Aspergillus nidulans	35.85	8.00e-11	63.20
IUUC-Ang-009577	Aspergillus niger	36.36	2.00e-11	65.10
IUUC-Ate-010275	Aspergillus terreus	35.24	4.00e-11	64.30
IUUC-Ame-011910	Astyanax mexicanus	44.05	8.00e-179	622.00
IUUC-Bta-013377	Bos taurus	90.96	0.00e+00	1334.00
IUUC-Cja-019977	Callithrix jacchus	98.18	0.00e+00	1450.00
IUUC-Cfa-020378	Canis familiaris	94.65	0.00e+00	2103.00
IUUC-Cpo-021817	Cavia porcellus	88.23	0.00e+00	1316.00
IUUC-Csa-023446	Chlorocebus sabaeus	99.82	0.00e+00	2231.00
IUUC-Cho-024717	Choloepus hoffmanni	81.45	0.00e+00	670.00
IUUC-Cme-027167	Cyanidioschyzon merolae	33.00	8.00e-16	79.70
IUUC-Dor-030955	Dipodomys ordii	88.07	0.00e+00	1321.00
IUUC-Ete-032828	Echinops telfairi	85.77	0.00e+00	802.00
IUUC-Eca-034300	Equus caballus	92.98	0.00e+00	1330.00
IUUC-Eeu-034458	Erinaceus europaeus	89.08	0.00e+00	1285.00
IUUC-Fca-035753	Felis catus	86.93	0.00e+00	1919.00
IUUC-Fal-037062	Ficedula albicollis	67.52	0.00e+00	1427.00
IUUC-Gac-041867	Gasterosteus aculeatus	53.51	0.00e+00	1127.00
IUUC-Ggo-045384	Gorilla gorilla	98.44	0.00e+00	1449.00
IUUC-Hsa-046277	Homo sapiens	98.70	0.00e+00	1454.00
IUUC-Itr-048276	Ictidomys tridecemlineatus	67.77	6.00e-176	610.00
IUUC-Loc-052636	Lepisosteus oculatus	63.31	0.00e+00	1390.00
IUUC-Laf-053808	Loxodonta africana	76.90	0.00e+00	1313.00
IUUC-Meu-056416	Macropus eugenii	71.96	0.00e+00	1014.00
IUUC-Mga-060011	Meleagris gallopavo	62.62	0.00e+00	1320.00
IUUC-Mmr-060720	Microcebus murinus	90.92	0.00e+00	1310.00
IUUC-Mdo-061955	Monodelphis domestica	86.86	0.00e+00	1892.00
IUUC-Mmu-063870	Mus musculus	88.11	0.00e+00	1345.00
IUUC-Mpu-066454	Mustela putorius furo	93.58	0.00e+00	1997.00
IUUC-Mlu-067487	Myotis lucifugus	85.45	0.00e+00	1249.00
IUUC-Nfi-068458	Neosartorya fischeri	33.96	2.00e-10	62.00
IUUC-Nle-070044	Nomascus leucogenys	99.09	0.00e+00	1463.00
IUUC-Opr-070888	Ochotona princeps	98.19	3.00e-162	566.00
IUUC-Ocu-074523	Oryctolagus cuniculus	88.08	0.00e+00	1314.00
IUUC-Ola-086393	Oryzias latipes	51.97	0.00e+00	1095.00
IUUC-Oga-088618	Otolemur garnettii	93.33	0.00e+00	1365.00
IUUC-Oar-089848	Ovis aries	93.14	0.00e+00	2038.00
IUUC-Ptr-091630	Pan troglodytes	98.45	0.00e+00	954.00
IUUC-Pan-092882	Papio anubis	99.77	0.00e+00	1650.00
IUUC-Psi-093422	Pelodiscus sinensis	73.08	0.00e+00	1620.00
IUUC-Pma-094250	Petromyzon marinus	51.88	3.00e-80	291.00
IUUC-Pab-098337	Pongo abelii	98.57	0.00e+00	1453.00
IUUC-Pca-100901	Procavia capensis	70.60	0.00e+00	991.00
IUUC-Pva-102226	Pteropus vampyrus	84.80	0.00e+00	1115.00
IUUC-Rno-105735	Rattus norvegicus	90.66	0.00e+00	2040.00
IUUC-Sha-107489	Sarcophilus harrisii	85.88	0.00e+00	1281.00
IUUC-Ssl-108532	Sclerotinia sclerotiorum	34.57	6.00e-09	57.00
IUUC-Sar-112977	Sorex araneus	74.87	0.00e+00	808.00
IUUC-Ssc-115463	Sus scrofa	91.30	0.00e+00	1113.00
IUUC-Tgu-116609	Taeniopygia guttata	65.60	0.00e+00	928.00
IUUC-Tsy-118971	Tarsius syrichta	96.87	0.00e+00	639.00
IUUC-Ttr-128887	Tursiops truncatus	84.37	0.00e+00	1223.00
IUUC-Vpa-130614	Vicugna pacos	89.92	0.00e+00	886.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence