iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Loc-052371

Ensembl Protein ID

ENSLOCP00000018317.1

UniProt Accession

W5NCF8; W5NCF8_LEPOC

Genbank Protein ID

ENSLOCP00000018317

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AHAT01004900

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLOCG00000014869.1	ENSLOCT00000018349.1	ENSLOCP00000018317.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	8.40e-100	334.4	161	512
UBD/ZnF/ZnF_UBP	5.80e-26	90.7	27	106

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle...........kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalk 78
           tGl+NlgNtC+mN++LQ+Lsni+++ ++++e             ++  + +++ +++ +l+++++k + +lw+++++a+sp++l+ +++
   Q: 161  TGLRNLGNTCFMNAILQSLSNIQQFCCYFKElpavelrsgktAGRRMYHTRSQGDTSVSLVEEFRKTLCSLWQGSQTAFSPESLFYVIW 249
           7******************************888877666664444444445588899******************************* PP
   S: 79   keaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssree 167
           k+ ++f+gy+qqDa+Ef+++lld+l+ el+   n    ++ ++d   + +   +   + ++++++ +F+g l++++ cl c+++s +++
   Q: 250  KIMPNFRGYQQQDAHEFMRYLLDHLHLELQGDCNGVSCSTISQD-GVMLSAGGKCCINGTSTVVTAIFGGVLQNEVNCLICGTESRKFD 337
           *****************************553333333333333.444445789999******************************** PP
   S: 168  pfldlslpvpgkeetkke.........slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksre 247
           pfldlsl++p++  +k +         +l+dcL+sft  eel++ + y c kckk+q+++kk++++klP+vL+lhLkRf+++   + r+
   Q: 338  PFLDLSLDIPSQFRNKRSknqengpicTLRDCLRSFTDLEELDETELYMCHKCKKRQKSTKKFWIQKLPKVLCLHLKRFHWTA--YLRN 424
           **********66655444667899999****************************************************7755..799* PP
   S: 248  kinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsG.slssGHYvayvknekgkWllfdDskVtevkeeevleetgstaYvlf 334
           ki+++vefpl+ Ld++ ++ +pe++  +++ Y+L avvvH+G +++sGHY+ay+ + +g+W++f+Ds+Vt ++ee+v++   ++aY+lf
   Q: 425  KIDTYVEFPLRgLDMKCYLLEPENSGPDSCLYDLAAVVVHHGsGVGSGHYTAYATH-EGRWFHFNDSTVTLTDEETVVK---AKAYILF 509
           ********************************************************.9*********************...******* PP
   S: 335  Ykr 337
           Y +
   Q: 510  YVE 512
           *76 PP

UBD/ZnF/ZnF_UBP

   S: 1    kkcsvcdktenlWlcLtcgsvgCGRyvegHalkHyeetqhpl..................vlslstlsvycYacddyvhr 62
           ++csvc++++++W+cLtc+sv+CGRyv+gHa+kH+e+tq p                   ++++s++s+ycY+cdd+v++
   Q: 27   WCCSVCRSNKSPWVCLTCSSVHCGRYVNGHAKKHFEDTQSPAsnhkksekhdkekplhavCMDCSSYSTYCYRCDDFVVN 106
           9*****************************************************************************85 PP

Organism

Lepisosteus oculatus

Protein Sequence
(Fasta)

MECPHLNSSV CIAPDSSRFP NGSPSSWCCS VCRSNKSPWV CLTCSSVHCG RYVNGHAKKH 60
FEDTQSPASN HKKSEKHDKE KPLHAVCMDC SSYSTYCYRC DDFVVNDNKL GMVQKVREHL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGCGGCCGCG GTGGATTCGG CGCACACGGA CGGGATCCTC TTCCGCCGCG CAGTCTGAAA 60
ACGCGGCCTG GGCCCCCCCC CTCGCCGCTC CAGTTCCGGA GCTGGCTCGG CTGCCGTGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001537	Ailuropoda melanoleuca	89.23	0.00e+00	900.00
IUUC-Apl-003358	Anas platyrhynchos	89.59	0.00e+00	831.00
IUUC-Aca-004454	Anolis carolinensis	86.77	0.00e+00	778.00
IUUC-Aor-010035	Aspergillus oryzae	36.92	2.00e-35	142.00
IUUC-Ame-011544	Astyanax mexicanus	78.95	0.00e+00	767.00
IUUC-Bta-012738	Bos taurus	88.87	0.00e+00	855.00
IUUC-Cel-018186	Caenorhabditis elegans	36.97	2.00e-59	223.00
IUUC-Cja-018893	Callithrix jacchus	89.04	0.00e+00	865.00
IUUC-Cfa-020607	Canis familiaris	89.81	0.00e+00	865.00
IUUC-Cpo-021828	Cavia porcellus	88.08	0.00e+00	849.00
IUUC-Csa-023884	Chlorocebus sabaeus	90.54	0.00e+00	717.00
IUUC-Cho-024863	Choloepus hoffmanni	80.77	0.00e+00	745.00
IUUC-Dre-028452	Danio rerio	77.82	0.00e+00	788.00
IUUC-Dno-029531	Dasypus novemcinctus	88.78	0.00e+00	795.00
IUUC-Dor-030913	Dipodomys ordii	78.57	1.00e-156	546.00
IUUC-Ete-032611	Echinops telfairi	83.65	0.00e+00	805.00
IUUC-Eca-033622	Equus caballus	89.39	0.00e+00	803.00
IUUC-Eeu-035268	Erinaceus europaeus	84.25	0.00e+00	729.00
IUUC-Fca-035801	Felis catus	89.39	0.00e+00	830.00
IUUC-Fal-036749	Ficedula albicollis	88.59	0.00e+00	793.00
IUUC-Gmo-039598	Gadus morhua	78.75	0.00e+00	796.00
IUUC-Gga-040883	Gallus gallus	89.80	0.00e+00	803.00
IUUC-Gac-042235	Gasterosteus aculeatus	79.46	0.00e+00	785.00
IUUC-Ggo-044767	Gorilla gorilla	84.73	0.00e+00	766.00
IUUC-Hsa-046581	Homo sapiens	89.23	0.00e+00	888.00
IUUC-Itr-047898	Ictidomys tridecemlineatus	89.23	0.00e+00	860.00
IUUC-Lch-049732	Latimeria chalumnae	89.29	0.00e+00	928.00
IUUC-Laf-054565	Loxodonta africana	89.42	0.00e+00	860.00
IUUC-Mcc-055522	Macaca mulatta	89.42	0.00e+00	892.00
IUUC-Meu-056754	Macropus eugenii	80.38	9.00e-161	560.00
IUUC-Mga-060095	Meleagris gallopavo	86.43	3.00e-167	580.00
IUUC-Mmr-060839	Microcebus murinus	89.42	0.00e+00	861.00
IUUC-Mdo-062339	Monodelphis domestica	91.22	0.00e+00	711.00
IUUC-Mmu-063638	Mus musculus	88.27	0.00e+00	832.00
IUUC-Mpu-066647	Mustela putorius furo	90.76	0.00e+00	708.00
IUUC-Mlu-067921	Myotis lucifugus	88.16	0.00e+00	823.00
IUUC-Nle-069752	Nomascus leucogenys	89.62	0.00e+00	892.00
IUUC-Opr-070636	Ochotona princeps	77.50	0.00e+00	684.00
IUUC-Ont-071638	Oreochromis niloticus	79.79	0.00e+00	740.00
IUUC-Oan-073417	Ornithorhynchus anatinus	84.62	0.00e+00	826.00
IUUC-Ocu-074620	Oryctolagus cuniculus	88.65	0.00e+00	854.00
IUUC-Ola-087281	Oryzias latipes	80.79	0.00e+00	653.00
IUUC-Olu-087697	Ostreococcus lucimarinus	39.55	3.00e-52	198.00
IUUC-Oga-088448	Otolemur garnettii	89.04	0.00e+00	885.00
IUUC-Oar-090132	Ovis aries	89.04	0.00e+00	859.00
IUUC-Ptr-090696	Pan troglodytes	89.21	0.00e+00	831.00
IUUC-Pan-092124	Papio anubis	89.23	0.00e+00	889.00
IUUC-Psi-093801	Pelodiscus sinensis	91.22	0.00e+00	709.00
IUUC-Pma-094472	Petromyzon marinus	73.91	5.00e-96	343.00
IUUC-Pfo-096330	Poecilia formosa	80.08	0.00e+00	825.00
IUUC-Pab-098191	Pongo abelii	89.62	0.00e+00	893.00
IUUC-Pca-100341	Procavia capensis	86.24	0.00e+00	656.00
IUUC-Pva-103177	Pteropus vampyrus	87.69	0.00e+00	850.00
IUUC-Rno-105048	Rattus norvegicus	87.12	0.00e+00	820.00
IUUC-Sha-107429	Sarcophilus harrisii	88.93	0.00e+00	803.00
IUUC-Sar-113024	Sorex araneus	88.49	0.00e+00	754.00
IUUC-Ssc-115749	Sus scrofa	85.77	4.00e-137	480.00
IUUC-Tgu-117277	Taeniopygia guttata	88.78	0.00e+00	822.00
IUUC-Tru-117844	Takifugu rubripes	81.57	0.00e+00	824.00
IUUC-Tsy-119456	Tarsius syrichta	87.53	0.00e+00	799.00
IUUC-Tni-120251	Tetraodon nigroviridis	77.59	0.00e+00	838.00
IUUC-Tbe-127423	Tupaia belangeri	84.23	0.00e+00	789.00
IUUC-Ttr-128401	Tursiops truncatus	82.82	0.00e+00	722.00
IUUC-Vpa-130549	Vicugna pacos	78.27	1.00e-145	508.00
IUUC-Xtr-131892	Xenopus tropicalis	79.43	0.00e+00	769.00
IUUC-Xma-133369	Xiphophorus maculatus	80.27	0.00e+00	816.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence