iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Ath-007560

UUCD1 version

UUC-ArT-01703

Ensembl Protein ID

AT4G10590.2

UniProt Accession

Q93Y01; Q9T0B8; Q9ZSB6; UBP9_ARATH

Genbank Protein ID

AAD03434.1; CAB40025.1; CAB78182.1; AEE82901.1; AEE82902.1; ANM66517.1; ANM66518.1; AAK96655.1; AAQ56806.1

Protein Name

Ubiquitin carboxyl-terminal hydrolase 9; Deubiquitinating enzyme 9; Ubiquitin thioesterase 9; Ubiquitin-specific-processing protease 9

Genbank Nucleotide ID

AF118222; AL049523; AL161517; CP002687; CP002687; CP002687; CP002687; AY054463; BT010363

Gene Name

UBP9; At4g10590; F3H7.7; T4F9.50

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
AT4G10590	AT4G10590.2	AT4G10590.2

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
TRANSFAC
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.20e-110	370.8	304	893

Active Site

Position(s)	Description	Evidence
312	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
852	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEflafl 99
           Gl+NlgNtC+mNS+LQcL+++p++ e++l+ ++ ++n++np ++ gel+ ++ +l+++lw+s +++v+pr+++++l+++a++fsgy+q+D+qE+lafl
   Q: 304  GLSNLGNTCFMNSALQCLAHTPPIVEYFLQDYSDDINRDNPLGMCGELAIAFGDLLKKLWSSGRNSVAPRAFKTKLARFAPQFSGYNQHDSQELLAFL 401
           9************************************************************************************************* PP
   S: 100  ldqleeelkkeknkpkeeeeeedkselsde...aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke......... 185
           ld+l+e+l+k k+kp+ e++++d++  ++     ++ +k +n+s+i+d+ qgq+ks+++c++c+++s +++pf++ls+p+p+  +++++         
   Q: 402  LDGLHEDLNKVKRKPYIELKDSDSRPDDEVaeeLWNYHKARNDSVIVDVCQGQYKSTLVCPACGKISITFDPFMYLSVPLPSTLTRSMTvtvfycdgs 499
           *********************996655544666899*********************************************999988889******** PP
   S: 186  .................................................................................................. 185
                                                                                                             
   Q: 500  hlpmpytvivpkngsirdlitalgtacllaedeslllaevydhkifkyfenpldslssikddehivayrlnqmpkgsgkakleilhggqkrpilesvr 597
           ************************************************************************************************** PP
   S: 186  .................................................................................................. 185
                                                                                                             
   Q: 598  grdvklfgtpfvtyvnteplsgadidavlsrflsplhkvhapskihngsenghlpdatvdeaseilsspdteiddasdrelsfrifltderglnfkpl 695
           ************************************************************************************************** PP
   S: 186  ....................................................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLi 231
                                                               sl +cLe+f +ee l  +++++c++ck++++a+kkl+l+klP++L+
   Q: 696  qsessislgiatrvlvewnegeherydssylsdlpevhktsfsakktrqesiSLFSCLEAFLAEEPLGPDDMWFCPSCKEHRQANKKLDLWKLPDILV 793
           ************************************************************************************************** PP
   S: 232  lhLkRfsfseeqksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevkeeevleetg 327
           +hLkRf++s+  + ++ki++ v+fp + Ldls+++ +++++   ++ YeL+av +H+G+l++GHY+ay+k  +++ W++fdDs+V++v+e+e+++   
   Q: 794  FHLKRFTYSR--YLKNKIDTFVNFPVHdLDLSKYVKNKNDQ---SYLYELYAVSNHYGGLGGGHYTAYAKLIDDNeWYHFDDSHVSSVNESEIKN--- 883
           ******9987..6999**********99*******996654...8**************************66666*******************... PP
   S: 328  staYvlfYkr 337
           s aYvlfY+r
   Q: 884  SAAYVLFYRR 893
           ********98 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity).

Protein Sequence
(Fasta)

MTIPNSDFMI ENGVCDFPTT PEEEKRIVSE LITESEDNLK EGNLYFVISK RWYTSWEKYV 60
EQSTKEYISG ESSEASRPGP IDNHDIIESE SDVNDPQLRR LLMERVDYVL VPQEVWKRLV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATCACAGACC ATAAATTGGG ATCTTGCGTG AATCCATCAA AGACCTTTCT CTGACTCTTA 60
TTCTTTCTCC TCCAATCTAG GGTTACTCCG AATTCTTCTT CGTGTCCCTC TCCGATTCTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS51283--DUSP
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF06337--DUSP
PF00443--UCH

SMART

SM00695--DUSP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

ath:AT4G10590

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Atr-002991	Amborella trichopoda	53.17	0.00e+00	895.00
IUUC-Aly-006044	Arabidopsis lyrata	90.29	0.00e+00	1639.00
IUUC-Acl-008284	Aspergillus clavatus	37.17	8.00e-50	192.00
IUUC-Afu-008878	Aspergillus fumigatus	45.80	2.00e-50	194.00
IUUC-Ani-009479	Aspergillus nidulans	38.11	6.00e-51	196.00
IUUC-Ang-009562	Aspergillus niger	35.97	8.00e-51	196.00
IUUC-Bgr-012277	Blumeria graminis	42.31	3.00e-58	220.00
IUUC-Bci-013993	Botrytis cinerea	45.04	4.00e-55	210.00
IUUC-Cin-025292	Ciona intestinalis	35.06	8.00e-138	484.00
IUUC-Csv-026109	Ciona savignyi	36.26	6.00e-92	331.00
IUUC-Cne-026852	Cryptococcus neoformans	45.49	2.00e-68	254.00
IUUC-Dre-027869	Danio rerio	38.83	3.00e-107	382.00
IUUC-Dse-031432	Dothistroma septosporum	43.14	2.00e-52	201.00
IUUC-Dme-032088	Drosophila melanogaster	29.22	5.00e-63	236.00
IUUC-Fox-037986	Fusarium oxysporum	37.37	1.00e-59	224.00
IUUC-Fso-038291	Fusarium solani	43.84	2.00e-62	234.00
IUUC-Ggr-039740	Gaeumannomyces graminis	42.81	3.00e-58	220.00
IUUC-Ggo-045337	Gorilla gorilla	35.14	2.00e-123	436.00
IUUC-Lch-050107	Latimeria chalumnae	36.60	8.00e-156	543.00
IUUC-Mor-056985	Magnaporthe oryzae	41.87	2.00e-56	214.00
IUUC-Mpo-057486	Magnaporthe poae	43.49	1.00e-57	218.00
IUUC-Mmu-063960	Mus musculus	42.46	5.00e-128	451.00
IUUC-Mac-064956	Musa acuminata	56.51	0.00e+00	1002.00
IUUC-Nfi-068330	Neosartorya fischeri	45.80	1.00e-50	194.00
IUUC-Pma-094533	Petromyzon marinus	36.76	1.00e-157	549.00
IUUC-Ppe-101587	Prunus persica	62.49	0.00e+00	1069.00
IUUC-Pyt-104812	Pyrenophora triticirepentis	44.49	9.00e-49	189.00
IUUC-Stu-112671	Solanum tuberosum	61.65	0.00e+00	1109.00
IUUC-Sbi-114874	Sorghum bicolor	55.36	0.00e+00	968.00
IUUC-Sre-115130	Sporisorium reilianum	33.17	2.00e-79	290.00
IUUC-Tre-121888	Trichoderma reesei	42.61	9.00e-60	225.00
IUUC-Tvi-122422	Trichoderma virens	41.20	1.00e-57	218.00
IUUC-Vvi-131010	Vitis vinifera	62.27	0.00e+00	1134.00
IUUC-Xtr-132305	Xenopus tropicalis	36.02	4.00e-149	521.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence