iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Spo-108291

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Probable ubiquitin carboxyl-terminal hydrolase 12; Deubiquitinating enzyme 12; Ubiquitin thioesterase 12; Ubiquitin-specific-processing protease 12

Genbank Nucleotide ID

CU329672

Gene Name

ubp12; SPCC1494.05c

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
SPCC1494.05c	SPCC1494.05c.1	SPCC1494.05c.1:pep

Annotation

mRNA Expression
GEO
Post-translational Modifications (PTMs)
dbPAF	dbPTM	UniProt
Protein Expression/Proteomics

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/USP	USP	16045761

Classification

Family	E-value	Score	Start	End
DUB/USP	2.20e-106	353.9	311	977

Active Site

Position(s)	Description	Evidence
320	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
935	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqq 90
           +Gl+NlgNtCYmNS+LQcL++++elr+++ + + k+++ne+np ++ g++++ +++l+++l++ ++++++pr+++++++k++++f gy qq
   Q: 311  CGLSNLGNTCYMNSALQCLTHTRELRDFFTSdEWKNQVNESNPLGMGGQVASIFASLIKSLYSPEHSSFAPRQFKATIGKFNHSFLGYGQQ 401
           7******************************99********************************************************** PP
   S: 91   DaqEflaflldqleeelkkeknkpkeeeeeedkselsde......aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslp 175
           D+qEflaflld+l+e+l++  +kp++++ +  + + +++       ++ +k +n+sli+dlFqg ++s+++c+ c++vs +++pf+dl+lp
   Q: 402  DSQEFLAFLLDGLHEDLNRIYQKPYTSKPDLYEVDEEKIkntaeeCWRLHKLRNDSLIVDLFQGMYRSTLVCPVCNTVSITFDPFMDLTLP 492
           *******************77777776655443333333444555********************************************** PP
   S: 176  vpgkeetkke................................................................................. 185
           +p k+  +++                                                                                 
   Q: 493  LPVKQVWSHTvtfipadtnltplaievvleskaatiedlvkyvaeksgcsdyrkilvtetykgrfyrfltqlsksllmeiseedeiylyel 583
           *****99999********************************************************************************* PP
   S: 186  ........................................................................................... 185
                                                                                                      
   Q: 584  erpyedgsddilvpvyhisddstnsansymssrdfghpfvlqlsdnevtdasfiseklklkyqqfttlknlknidsleslelghedeqvqk 674
           ******************************************************************************************* PP
   S: 186  ........................................................................................... 185
                                                                                                      
   Q: 675  gpldvdmdhsqtplfemrvfhdrfekiptgwnmsvsnlpllterdkkdlestvdpldahsieeeddsefkdvapgsypepsksnentklta 765
           ******************************************************************************************* PP
   S: 186  ............................................................slqdcLesftkeeelegenkyycekckkkqe 216
                                                                       +l+dcL++f k+e+l +e+ +yc++ck+ ++
   Q: 766  kendrlliqgdllvcewpeksyqfvfsvapsspqmgrslwlesktilsdkkddsedsrtiTLNDCLDEFEKTEQLGEEDPWYCPTCKEFRQ 856
           ******************************************************************************************* PP
   S: 217  aekklklkklPevLilhLkRfsfseeqksrekinkkvefple.Ldls....pfctspeekqkekkkYeLiavvvHsGslssGHYvayvkn. 301
           a+k+++++++Pe+Li+hLkRf  s+e+ +r ki++ vefp+  Ld+s    ++  s++e+   k +YeL+av +H+G+l++GHY+a++kn 
   Q: 857  ASKQMEIWRCPEILIFHLKRF--SSERRFRDKIDDLVEFPIDnLDMSmrtgSYKLSEKENP--KLIYELYAVDNHYGGLGGGHYTAFAKNp 943
           *********************..778899***********999****66555555544444..99*************************5 PP
   S: 302  ekgkWllfdDskVtevkeeevleetgstaYvlfYkrr 338
           ++g++++fdDs+Vt+v  ee ++   s aY+lfY+r+
   Q: 944  DNGQFYCFDDSRVTPVCPEETVT---SAAYLLFYRRK 977
           5566************9999999...9*******985 PP

Organism

Schizosaccharomyces pombe

Protein Sequence
(Fasta)

MDSLSESSTS SYHGKRPRSL SEESQSSSNM DDISQKSISL GDASEISKNL PSIAEQKQLI 60
GELVNNQPEL ELGQVDNYIL SYSWYERLCS YLAEDGPFPG PVDQEDIADL ETGTLKPDLQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AATTAATTTA CCGTTTTTAA AAATTCTCTT ATCCTCCCAT TTGAACAACG CAATTTTCCA 60
TATTGAGCTG GACTTGTTGA CATCGACAAA AGAGACTTCA TTTTATATGG ATTCTCTGTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS51283--DUSP
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF06337--DUSP
PF00443--UCH

SMART

SM00695--DUSP

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

spo:SPCC1494.05c

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000058	Aegilops tauschii	45.27	2.00e-58	219.00
IUUC-Aml-001597	Ailuropoda melanoleuca	41.72	1.00e-68	252.00
IUUC-Atr-002955	Amborella trichopoda	40.37	2.00e-62	231.00
IUUC-Apl-003249	Anas platyrhynchos	42.86	2.00e-73	268.00
IUUC-Aca-004532	Anolis carolinensis	33.33	9.00e-81	293.00
IUUC-Aly-005456	Arabidopsis lyrata	42.44	2.00e-62	231.00
IUUC-Ago-007911	Ashbya gossypii	35.08	4.00e-81	294.00
IUUC-Acl-008284	Aspergillus clavatus	31.95	2.00e-123	435.00
IUUC-Afl-008507	Aspergillus flavus	37.02	1.00e-110	393.00
IUUC-Afu-008878	Aspergillus fumigatus	32.24	7.00e-125	440.00
IUUC-Ani-009479	Aspergillus nidulans	37.58	4.00e-116	411.00
IUUC-Ang-009562	Aspergillus niger	36.14	5.00e-115	407.00
IUUC-Aor-009949	Aspergillus oryzae	36.87	1.00e-109	389.00
IUUC-Ate-010323	Aspergillus terreus	39.65	1.00e-63	237.00
IUUC-Ame-010757	Astyanax mexicanus	43.12	2.00e-74	271.00
IUUC-Bgr-012277	Blumeria graminis	39.56	4.00e-71	261.00
IUUC-Bta-013128	Bos taurus	33.28	3.00e-79	288.00
IUUC-Bci-013993	Botrytis cinerea	46.28	7.00e-71	261.00
IUUC-Bdi-014013	Brachypodium distachyon	31.73	6.00e-72	263.00
IUUC-Bol-015158	Brassica oleracea	33.57	1.00e-65	243.00
IUUC-Cel-018257	Caenorhabditis elegans	29.04	5.00e-63	234.00
IUUC-Cja-019746	Callithrix jacchus	33.28	3.00e-79	287.00
IUUC-Cfa-020134	Canis familiaris	33.10	3.00e-79	288.00
IUUC-Cpo-022535	Cavia porcellus	33.98	1.00e-78	285.00
IUUC-Csa-023828	Chlorocebus sabaeus	33.56	7.00e-79	286.00
IUUC-Cho-024595	Choloepus hoffmanni	42.22	4.00e-65	241.00
IUUC-Csv-026109	Ciona savignyi	30.40	1.00e-72	266.00
IUUC-Cgl-026741	Colletotrichum gloeosporioides	40.25	2.00e-73	269.00
IUUC-Cne-026852	Cryptococcus neoformans	39.58	5.00e-72	264.00
IUUC-Cme-027338	Cyanidioschyzon merolae	51.56	4.00e-57	214.00
IUUC-Dre-027398	Danio rerio	34.58	3.00e-79	288.00
IUUC-Dno-029025	Dasypus novemcinctus	33.90	2.00e-80	291.00
IUUC-Dor-030384	Dipodomys ordii	33.04	8.00e-76	276.00
IUUC-Dse-031432	Dothistroma septosporum	35.12	9.00e-61	227.00
IUUC-Dme-032094	Drosophila melanogaster	29.49	1.00e-42	167.00
IUUC-Ete-032970	Echinops telfairi	38.85	4.00e-58	218.00
IUUC-Eca-033271	Equus caballus	30.65	2.00e-73	268.00
IUUC-Eeu-034488	Erinaceus europaeus	42.03	1.00e-72	266.00
IUUC-Fca-035373	Felis catus	34.11	3.00e-76	278.00
IUUC-Fal-037634	Ficedula albicollis	44.62	1.00e-69	256.00
IUUC-Fox-037986	Fusarium oxysporum	38.64	2.00e-71	263.00
IUUC-Fso-038291	Fusarium solani	31.60	1.00e-80	293.00
IUUC-Gmo-038866	Gadus morhua	42.63	1.00e-70	259.00
IUUC-Ggr-039740	Gaeumannomyces graminis	47.70	5.00e-70	258.00
IUUC-Gga-040729	Gallus gallus	44.92	7.00e-75	273.00
IUUC-Gac-041679	Gasterosteus aculeatus	33.28	1.00e-78	286.00
IUUC-Gma-042830	Glycine max	35.85	1.00e-94	338.00
IUUC-Ggo-045337	Gorilla gorilla	41.72	1.00e-66	246.00
IUUC-Hsa-046551	Homo sapiens	33.56	7.00e-79	286.00
IUUC-Hvu-047108	Hordeum vulgare	42.50	3.00e-62	231.00
IUUC-Itr-048306	Ictidomys tridecemlineatus	33.62	2.00e-79	288.00
IUUC-Kpa-049332	Komagataella pastoris	37.36	6.00e-93	333.00
IUUC-Lch-050107	Latimeria chalumnae	32.83	3.00e-78	284.00
IUUC-Lpe-051047	Leersia perrieri	34.89	1.00e-97	349.00
IUUC-Loc-051800	Lepisosteus oculatus	42.06	1.00e-73	269.00
IUUC-Lma-052981	Leptosphaeria maculans	30.81	1.00e-82	300.00
IUUC-Laf-053803	Loxodonta africana	42.68	9.00e-68	249.00
IUUC-Mcc-054881	Macaca mulatta	33.39	5.00e-79	287.00
IUUC-Meu-056749	Macropus eugenii	34.14	3.00e-82	297.00
IUUC-Mpo-057486	Magnaporthe poae	45.96	3.00e-68	252.00
IUUC-Mtr-058138	Medicago truncatula	32.18	3.00e-72	265.00
IUUC-Mla-058848	Melampsora laricipopulina	47.52	2.00e-69	255.00
IUUC-Mga-059300	Meleagris gallopavo	44.92	3.00e-75	274.00
IUUC-Mvi-060324	Microbotryum violaceum	33.73	4.00e-89	321.00
IUUC-Mmr-061400	Microcebus murinus	33.78	6.00e-80	290.00
IUUC-Mdo-062470	Monodelphis domestica	34.56	9.00e-76	276.00
IUUC-Mmu-063960	Mus musculus	42.36	9.00e-68	249.00
IUUC-Mpu-066507	Mustela putorius furo	32.61	2.00e-78	285.00
IUUC-Mlu-066961	Myotis lucifugus	32.80	5.00e-76	277.00
IUUC-Nfi-068330	Neosartorya fischeri	32.15	4.00e-126	444.00
IUUC-Ncr-068879	Neurospora crassa	38.96	3.00e-71	262.00
IUUC-Nle-069284	Nomascus leucogenys	33.56	6.00e-79	287.00
IUUC-Opr-071212	Ochotona princeps	42.94	1.00e-72	266.00
IUUC-Ont-071847	Oreochromis niloticus	34.92	1.00e-76	279.00
IUUC-Oan-073387	Ornithorhynchus anatinus	33.99	9.00e-79	286.00
IUUC-Ocu-074066	Oryctolagus cuniculus	33.95	3.00e-80	291.00
IUUC-Oba-075553	Oryza barthii	34.56	3.00e-97	347.00
IUUC-Obr-076902	Oryza brachyantha	41.16	9.00e-65	239.00
IUUC-Ogl-077583	Oryza glaberrima	34.56	3.00e-97	347.00
IUUC-Ogu-077990	Oryza glumaepatula	34.17	2.00e-93	335.00
IUUC-Oin-079300	Oryza indica	34.71	3.00e-98	350.00
IUUC-Olo-080387	Oryza longistaminata	33.99	2.00e-91	328.00
IUUC-Ome-081819	Oryza meridionalis	34.78	3.00e-92	330.00
IUUC-Oni-082303	Oryza nivara	34.12	2.00e-92	331.00
IUUC-Opu-083770	Oryza punctata	34.26	9.00e-98	349.00
IUUC-Oru-085141	Oryza rufipogon	34.32	1.00e-94	339.00
IUUC-Osa-085641	Oryza sativa	34.71	3.00e-98	350.00
IUUC-Ola-086553	Oryzias latipes	42.77	5.00e-73	267.00
IUUC-Olu-087717	Ostreococcus lucimarinus	43.01	5.00e-62	230.00
IUUC-Oga-088424	Otolemur garnettii	34.86	3.00e-83	301.00
IUUC-Oar-090439	Ovis aries	42.36	2.00e-68	252.00
IUUC-Ptr-091319	Pan troglodytes	33.62	2.00e-79	288.00
IUUC-Pan-092292	Papio anubis	33.39	4.00e-79	287.00
IUUC-Psi-093942	Pelodiscus sinensis	42.65	2.00e-73	268.00
IUUC-Pma-094533	Petromyzon marinus	32.25	2.00e-75	275.00
IUUC-Pno-094890	Phaeosphaeria nodorum	39.90	1.00e-74	273.00
IUUC-Pfo-096414	Poecilia formosa	33.88	4.00e-83	300.00
IUUC-Pab-098522	Pongo abelii	41.72	2.00e-66	244.00
IUUC-Pop-099333	Populus trichocarpa	36.10	1.00e-99	355.00
IUUC-Pca-100161	Procavia capensis	41.72	1.00e-66	246.00
IUUC-Ppe-102062	Prunus persica	36.54	2.00e-95	341.00
IUUC-Pva-103244	Pteropus vampyrus	32.66	8.00e-77	280.00
IUUC-Pgr-103546	Puccinia graminis	30.86	7.00e-91	327.00
IUUC-Ptt-103847	Puccinia triticina	36.30	2.00e-65	243.00
IUUC-Pte-104102	Pyrenophora teres	37.04	1.00e-70	260.00
IUUC-Pyt-104812	Pyrenophora triticirepentis	42.86	8.00e-64	238.00
IUUC-Rno-105383	Rattus norvegicus	33.79	1.00e-79	289.00
IUUC-Sce-106170	Saccharomyces cerevisiae	31.48	3.00e-76	278.00
IUUC-Sha-107502	Sarcophilus harrisii	33.51	1.00e-77	282.00
IUUC-Sja-107752	Schizosaccharomyces japonicus	50.75	0.00e+00	940.00
IUUC-Sit-110601	Setaria italica	30.20	4.00e-64	237.00
IUUC-Sly-111891	Solanum lycopersicum	45.02	6.00e-62	230.00
IUUC-Stu-112671	Solanum tuberosum	32.26	8.00e-73	266.00
IUUC-Sar-113498	Sorex araneus	43.25	4.00e-73	267.00
IUUC-Sbi-114874	Sorghum bicolor	31.71	8.00e-70	256.00
IUUC-Sre-115130	Sporisorium reilianum	32.05	1.00e-88	320.00
IUUC-Ssc-116345	Sus scrofa	32.27	1.00e-77	282.00
IUUC-Tgu-117267	Taeniopygia guttata	44.31	9.00e-71	259.00
IUUC-Tru-117788	Takifugu rubripes	32.07	2.00e-77	282.00
IUUC-Tsy-119414	Tarsius syrichta	40.85	1.00e-71	262.00
IUUC-Tni-120107	Tetraodon nigroviridis	32.10	8.00e-75	273.00
IUUC-Tca-121598	Theobroma cacao	32.95	1.00e-95	342.00
IUUC-Tre-121888	Trichoderma reesei	43.45	1.00e-69	257.00
IUUC-Tvi-122422	Trichoderma virens	30.79	1.00e-75	276.00
IUUC-Tae-125295	Triticum aestivum	31.55	1.00e-74	272.00
IUUC-Tme-127062	Tuber melanosporum	33.97	2.00e-92	332.00
IUUC-Tbe-127672	Tupaia belangeri	43.25	5.00e-73	267.00
IUUC-Ttr-128441	Tursiops truncatus	43.25	7.00e-73	266.00
IUUC-Uma-129498	Ustilago maydis	45.28	7.00e-68	251.00
IUUC-Vda-129781	Verticillium dahliae	39.16	3.00e-74	272.00
IUUC-Vpa-130571	Vicugna pacos	42.14	5.00e-68	250.00
IUUC-Vvi-131066	Vitis vinifera	36.31	7.00e-100	356.00
IUUC-Xtr-132305	Xenopus tropicalis	46.57	2.00e-70	258.00
IUUC-Xma-133550	Xiphophorus maculatus	33.28	1.00e-78	286.00
IUUC-Yli-134392	Yarrowia lipolytica	33.86	4.00e-77	281.00
IUUC-Zma-135699	Zea mays	46.07	6.00e-67	247.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence