iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Fca-036574

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AANG02105615

Gene Name

FBXW8

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFCAG00000002632.3	ENSFCAT00000002632.3	ENSFCAP00000002425.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.10e-12	47.7	370	400
E3 adaptor/Cullin RING/SCF/F-box	6.10e-06	26.4	7	55
UBD/Beta-Prp	2.00e-41	142.1	100	403

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    HtdsvtclafsdtllvsGsdDgtikvWDlrt 32
           H+ +v++++ +d+ +vsG+  g + vWD+r 
   Q: 370  HQLGVSAVQMDDWKIVSGGEEGLVSVWDYRM 400
           7778999999669***************875 PP

E3 adaptor/Cullin RING/SCF/F-box

   S: 98   pdaglldrlpeeilveilklldkeellraarvcrrwqelasqkalwktv 146
                  +lp+e+ ++i+++ld+++l+r+a+v+++w+ +a+++ lw ++
   Q: 7    DVPFFDIQLPYELAINIFQYLDRRDLGRCAQVSKTWKVIAEDEVLWYRL 55
           45567789*****************************999999999765 PP

UBD/Beta-Prp

   S: 4    tlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheae.........vtavkfspdgkilvtgseDrtikvwdlst 83
           +l++ +++v+++v+   ++ ++++g+++g ++vwd++t+++ + + + e e         v+ v+++++  + v + eD+++++wdl+t
   Q: 100  ELEHVPDAVLCDVHS--HDGVVIAGYTSGDVRVWDTRTWDYTAPFLDSEYEedepgmqpyVSFVRINSS--LAVAAYEDGFLNIWDLRT 184
           67888999***8888..************************6666666666666679999*********..9***************** PP
   S: 84   gkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdg.nllvsGslDrtvrlWdlktgkl 171
           gk+ ++  +h++++ +l++s+++ +++++s+ +++++   ++g++  + + + +++v ++++ pd+ ++ v+ ++ + + ++ lk ++ 
   Q: 185  GKYPIHRFEHDARIQALALSQEDATVATASAFDVVMLRPNDEGYWQIAAEFEVQKLVDYLEIVPDTgRYPVAVATAGDL-VYLLKAEDS 272
           *****9999*************************************99******************************9.5******** PP
   S: 172  lrtltgghtdsvyslsfdsng.....kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfs.pnderlvsgssDgsiriWdlrsg 254
            rtl     ++v++l+++ n+     k+l ++ + +++ +++l++++c+ +l +    +++v++  +  +++vsg++D+ +ri+d r++
   Q: 273  ARTLHYVYGQPVTCLDVSANQaafgvKSLGWVYEGNKILVYSLEAERCLSKLGNALGDFTCVNLRdSPPNLMVSGNMDRRVRIHDFRTD 361
           ****999********************************************************9978899******************* PP
   S: 255  dllktlqlhnssvisvavlsfgdnvlvlgsedskvniwklkknep 299
           ++  +l+ h+  v++v++   +d+++v+g+e++ v +w++++n++
   Q: 362  KIALSLSAHQLGVSAVQM---DDWKIVSGGEEGLVSVWDYRMNQK 403
           **********99999999...********************9875 PP

Organism

Felis catus

Protein Sequence
(Fasta)

PQNEMDDVPF FDIQLPYELA INIFQYLDRR DLGRCAQVSK TWKVIAEDEV LWYRLCRQEG 60
HLPESSISDY SCWKLIFQEC RAKEHMLRTN WKNRKGAVSE LEHVPDAVLC DVHSHDGVVI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCTCAGAATG AGATGGATGA CGTGCCCTTC TTTGACATCC AGCTGCCTTA CGAACTGGCA 60
ATCAACATAT TTCAGTATCT GGACAGGAGA GACCTGGGAA GGTGTGCACA GGTAAGCAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR001810--F-box_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50181--FBOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12937--F-box-like

SMART

SM00256--FBOX
SM00320--WD40

Gene Ontology

GO:1990393--C:3M complex
GO:0031467--C:Cul7-RING ubiquitin ligase complex
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0048471--C:perinuclear region of cytoplasm
GO:0019005--C:SCF ubiquitin ligase complex
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008283--P:cell proliferation
GO:0007030--P:Golgi organization
GO:0060716--P:labyrinthine layer blood vessel development
GO:0050775--P:positive regulation of dendrite morphogenesis
GO:0060712--P:spongiotrophoblast layer development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001274	Ailuropoda melanoleuca	94.67	0.00e+00	967.00
IUUC-Apl-003239	Anas platyrhynchos	65.52	0.00e+00	697.00
IUUC-Aca-004756	Anolis carolinensis	63.12	3.00e-142	498.00
IUUC-Ame-011198	Astyanax mexicanus	54.55	1.00e-53	203.00
IUUC-Bta-012430	Bos taurus	55.16	5.00e-141	494.00
IUUC-Cja-019131	Callithrix jacchus	84.02	0.00e+00	839.00
IUUC-Cfa-021022	Canis familiaris	95.29	0.00e+00	971.00
IUUC-Cpo-021898	Cavia porcellus	90.65	0.00e+00	939.00
IUUC-Csa-023452	Chlorocebus sabaeus	87.06	0.00e+00	880.00
IUUC-Cho-024759	Choloepus hoffmanni	78.37	0.00e+00	779.00
IUUC-Dre-028123	Danio rerio	50.40	6.00e-147	514.00
IUUC-Dno-029045	Dasypus novemcinctus	93.63	0.00e+00	886.00
IUUC-Dor-030433	Dipodomys ordii	90.22	0.00e+00	773.00
IUUC-Ete-032465	Echinops telfairi	91.15	0.00e+00	788.00
IUUC-Eca-034134	Equus caballus	94.29	0.00e+00	962.00
IUUC-Eeu-035047	Erinaceus europaeus	81.50	0.00e+00	825.00
IUUC-Fal-037665	Ficedula albicollis	61.66	7.00e-180	623.00
IUUC-Gmo-039137	Gadus morhua	46.33	8.00e-62	230.00
IUUC-Gga-040711	Gallus gallus	64.71	0.00e+00	679.00
IUUC-Gac-041675	Gasterosteus aculeatus	55.03	1.00e-57	215.00
IUUC-Ggo-045331	Gorilla gorilla	86.91	0.00e+00	874.00
IUUC-Hsa-046240	Homo sapiens	87.50	0.00e+00	880.00
IUUC-Itr-048412	Ictidomys tridecemlineatus	92.45	0.00e+00	924.00
IUUC-Loc-052631	Lepisosteus oculatus	56.19	7.00e-170	590.00
IUUC-Laf-054127	Loxodonta africana	78.01	3.00e-59	220.00
IUUC-Mcc-055083	Macaca mulatta	87.50	0.00e+00	884.00
IUUC-Mga-060113	Meleagris gallopavo	64.57	0.00e+00	681.00
IUUC-Mmr-061780	Microcebus murinus	91.45	0.00e+00	935.00
IUUC-Mdo-063066	Monodelphis domestica	68.70	0.00e+00	729.00
IUUC-Mmu-063524	Mus musculus	87.14	0.00e+00	868.00
IUUC-Mpu-066913	Mustela putorius furo	94.67	0.00e+00	961.00
IUUC-Mlu-067924	Myotis lucifugus	92.70	0.00e+00	924.00
IUUC-Nle-069558	Nomascus leucogenys	87.15	0.00e+00	842.00
IUUC-Opr-070506	Ochotona princeps	89.84	0.00e+00	921.00
IUUC-Ont-071514	Oreochromis niloticus	49.70	4.00e-145	508.00
IUUC-Ocu-074477	Oryctolagus cuniculus	89.90	0.00e+00	917.00
IUUC-Ola-087416	Oryzias latipes	49.60	3.00e-144	505.00
IUUC-Oga-088643	Otolemur garnettii	93.47	0.00e+00	953.00
IUUC-Oar-090172	Ovis aries	91.68	0.00e+00	946.00
IUUC-Ptr-090870	Pan troglodytes	87.70	0.00e+00	883.00
IUUC-Pan-092017	Papio anubis	86.89	0.00e+00	874.00
IUUC-Psi-093794	Pelodiscus sinensis	66.40	0.00e+00	693.00
IUUC-Pfo-096192	Poecilia formosa	51.71	4.00e-149	521.00
IUUC-Pab-097882	Pongo abelii	86.89	0.00e+00	869.00
IUUC-Pca-100902	Procavia capensis	89.92	2.00e-130	459.00
IUUC-Pva-103139	Pteropus vampyrus	93.67	0.00e+00	957.00
IUUC-Rno-105798	Rattus norvegicus	85.92	0.00e+00	885.00
IUUC-Sha-106576	Sarcophilus harrisii	68.72	0.00e+00	715.00
IUUC-Ssc-115923	Sus scrofa	84.08	0.00e+00	860.00
IUUC-Tgu-116667	Taeniopygia guttata	57.91	4.00e-122	431.00
IUUC-Tru-118323	Takifugu rubripes	48.29	3.00e-140	491.00
IUUC-Tsy-118818	Tarsius syrichta	77.47	5.00e-108	384.00
IUUC-Tni-120438	Tetraodon nigroviridis	48.09	1.00e-133	470.00
IUUC-Tbe-127784	Tupaia belangeri	95.15	3.00e-113	401.00
IUUC-Ttr-128288	Tursiops truncatus	82.93	0.00e+00	833.00
IUUC-Vpa-130307	Vicugna pacos	88.96	0.00e+00	814.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence