iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mlu-067924

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAPE02035895

Gene Name

FBXW8

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMLUG00000011935.2	ENSMLUT00000011938.2	ENSMLUP00000010876.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.20e-11	44.5	474	504
UBD/Beta-Prp	1.10e-42	146.2	203	507

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    HtdsvtclafsdtllvsGsdDgtikvWDlrt 32
           H+ +v++++ +d+ +vsG+  g + vWD+r 
   Q: 474  HQLGVSAVQMDDWKVVSGGEEGLVSVWDYRM 504
           7778999999669***************875 PP

UBD/Beta-Prp

   S: 4    tlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheae..........vtavkfspdgkilvtgseDrtikvwdls 82
           +l++ +++v+++v+   ++ ++++g+++g ++vwd++t+++++ + + e e          v+ v+++++  + v + eD+++++wdl+
   Q: 203  ELEHIPDAVLCDVHS--HDGVVIAGYTSGDVRVWDTRTWDYVAPFLDSEYEeedepgmqpyVSFVRINSS--LAVAAYEDGFLNIWDLR 287
           567778999998888..9***********************8877777777777799*************..9**************** PP
   S: 83   tgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdg.nllvsGslDrtvrlWdlktgk 170
           tgk+ ++  +h++++ +l++s+++ +++++s+ +++++   e+g++  + + + +++v ++++ pd+ ++ v+ ++ + + ++ lk ++
   Q: 288  TGKYPIHRFEHDARIQALALSQEDATVATASAFDVVMLHPNEEGYWQIAAEFEVQKLVDYLEIVPDTeRYPVAVATAGDL-VYLLKADD 375
           ******9999*********************************************************************9.5******* PP
   S: 171  llrtltgghtdsvyslsfdsng.....kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfs.pnderlvsgssDgsiriWdlrs 253
             rtl     ++v++l+++ n+     k+l ++ + +++ +++l++++c+ +l +    +++v++  +  +++vsg++D+ +ri+dlr+
   Q: 376  SARTLHHVYGQPVTCLDVSANQaafgvKSLGWVHEGNKILVYSLEAERCLSKLGNALGDFTCVNLRdSPPHLMVSGNMDRRVRIHDLRT 464
           *****9999*******************************************************99788999***************** PP
   S: 254  gdllktlqlhnssvisvavlsfgdnvlvlgsedskvniwklkknep 299
           +++  +l+ h+  v++v++   +d+++v+g+e++ v +w++++n++
   Q: 465  NKIALSLSAHQLGVSAVQM---DDWKVVSGGEEGLVSVWDYRMNQK 507
           ***********99999999...********************9875 PP

Organism

Myotis lucifugus

Protein Sequence
(Fasta)

MDNHGLDEFR RRWQEELAQA QALRKRRRPE AAERRRAGPR WPRRGEQASG YLALAQGLLE 60
GASRPPAARA TRAERQDAAS RSRSPPARDA AEGEEQLVDQ LIRDLNEMDD VPFFDIQLPY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGACAACC ACGGCCTGGA CGAGTTCCGC CGGCGCTGGC AGGAGGAGCT GGCGCAGGCC 60
CAGGCGCTGA GGAAGCGGCG GCGGCCCGAG GCTGCCGAGC GGCGGCGCGC CGGCCCGAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR001810--F-box_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50181--FBOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12937--F-box-like

SMART

SM00256--FBOX
SM00320--WD40

Gene Ontology

GO:1990393--C:3M complex
GO:0031467--C:Cul7-RING ubiquitin ligase complex
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0048471--C:perinuclear region of cytoplasm
GO:0019005--C:SCF ubiquitin ligase complex
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008283--P:cell proliferation
GO:0007030--P:Golgi organization
GO:0060716--P:labyrinthine layer blood vessel development
GO:0050775--P:positive regulation of dendrite morphogenesis
GO:0060712--P:spongiotrophoblast layer development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001274	Ailuropoda melanoleuca	93.26	0.00e+00	1009.00
IUUC-Apl-003239	Anas platyrhynchos	60.62	0.00e+00	711.00
IUUC-Aca-004756	Anolis carolinensis	60.74	1.00e-138	486.00
IUUC-Ame-011198	Astyanax mexicanus	46.89	1.00e-61	229.00
IUUC-Bta-012430	Bos taurus	59.78	6.00e-150	524.00
IUUC-Bra-016832	Brassica rapa	36.92	1.00e-05	43.90
IUUC-Cja-019131	Callithrix jacchus	80.23	0.00e+00	910.00
IUUC-Cfa-021022	Canis familiaris	83.06	0.00e+00	983.00
IUUC-Cpo-021898	Cavia porcellus	81.98	0.00e+00	973.00
IUUC-Csa-023452	Chlorocebus sabaeus	84.25	0.00e+00	974.00
IUUC-Cho-024759	Choloepus hoffmanni	77.96	0.00e+00	856.00
IUUC-Dre-028123	Danio rerio	45.44	2.00e-156	545.00
IUUC-Dno-029045	Dasypus novemcinctus	92.14	0.00e+00	882.00
IUUC-Dor-030433	Dipodomys ordii	82.32	0.00e+00	829.00
IUUC-Ete-032465	Echinops telfairi	85.32	0.00e+00	813.00
IUUC-Eca-034134	Equus caballus	94.51	0.00e+00	970.00
IUUC-Eeu-035047	Erinaceus europaeus	82.11	0.00e+00	834.00
IUUC-Fca-036574	Felis catus	92.70	0.00e+00	951.00
IUUC-Fal-037665	Ficedula albicollis	60.48	0.00e+00	626.00
IUUC-Gmo-039137	Gadus morhua	45.54	6.00e-71	261.00
IUUC-Gga-040711	Gallus gallus	60.00	0.00e+00	688.00
IUUC-Gac-041675	Gasterosteus aculeatus	54.79	3.00e-57	214.00
IUUC-Ggo-045331	Gorilla gorilla	86.15	0.00e+00	880.00
IUUC-Hsa-046240	Homo sapiens	84.76	0.00e+00	969.00
IUUC-Itr-048412	Ictidomys tridecemlineatus	91.87	0.00e+00	925.00
IUUC-Loc-052631	Lepisosteus oculatus	52.29	3.00e-177	615.00
IUUC-Laf-054127	Loxodonta africana	76.76	2.00e-60	224.00
IUUC-Mcc-055083	Macaca mulatta	84.92	0.00e+00	963.00
IUUC-Mga-060113	Meleagris gallopavo	62.96	0.00e+00	669.00
IUUC-Mmr-061780	Microcebus murinus	88.96	0.00e+00	968.00
IUUC-Mdo-063066	Monodelphis domestica	63.36	0.00e+00	754.00
IUUC-Mmu-063524	Mus musculus	81.77	0.00e+00	894.00
IUUC-Mpu-066913	Mustela putorius furo	92.29	0.00e+00	974.00
IUUC-Nle-069558	Nomascus leucogenys	84.35	0.00e+00	916.00
IUUC-Opr-070506	Ochotona princeps	86.60	0.00e+00	952.00
IUUC-Ont-071514	Oreochromis niloticus	47.09	8.00e-152	530.00
IUUC-Ocu-074477	Oryctolagus cuniculus	88.19	0.00e+00	911.00
IUUC-Ola-087416	Oryzias latipes	46.50	1.00e-152	533.00
IUUC-Oga-088643	Otolemur garnettii	90.60	0.00e+00	984.00
IUUC-Oar-090172	Ovis aries	90.63	0.00e+00	937.00
IUUC-Ptr-090870	Pan troglodytes	84.92	0.00e+00	966.00
IUUC-Pan-092017	Papio anubis	83.92	0.00e+00	974.00
IUUC-Psi-093794	Pelodiscus sinensis	64.85	0.00e+00	681.00
IUUC-Pfo-096192	Poecilia formosa	48.85	2.00e-154	539.00
IUUC-Pab-097882	Pongo abelii	83.58	0.00e+00	947.00
IUUC-Pca-100902	Procavia capensis	81.69	6.00e-158	550.00
IUUC-Pva-103139	Pteropus vampyrus	89.48	0.00e+00	1021.00
IUUC-Rno-105798	Rattus norvegicus	82.08	0.00e+00	912.00
IUUC-Sha-106576	Sarcophilus harrisii	67.21	0.00e+00	707.00
IUUC-Ssc-115923	Sus scrofa	80.43	0.00e+00	954.00
IUUC-Tgu-116667	Taeniopygia guttata	56.27	5.00e-120	424.00
IUUC-Tru-118323	Takifugu rubripes	45.92	5.00e-146	511.00
IUUC-Tsy-118818	Tarsius syrichta	75.40	6.00e-107	380.00
IUUC-Tni-120438	Tetraodon nigroviridis	44.03	7.00e-142	497.00
IUUC-Tbe-127784	Tupaia belangeri	91.75	3.00e-111	394.00
IUUC-Ttr-128288	Tursiops truncatus	82.17	0.00e+00	856.00
IUUC-Vpa-130307	Vicugna pacos	84.42	0.00e+00	833.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence