iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Pan-092550

Ensembl Protein ID

ENSPANP00000005791.1

UniProt Accession

A0A096N0K4; A0A096N0K4_PAPAN

Genbank Protein ID

ENSPANP00000005791

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AHZZ01080890

Gene Name

VAV3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPANG00000000901.1	ENSPANT00000012119.1	ENSPANP00000005791.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	5.90e-15	55.0	735	786

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 7    qvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
           ++ yd+ a +  eL+l kGdvv++   +   +gW++g  e +g+ G fP+ +ve+
   Q: 735  IARYDFCARDMRELSLLKGDVVKIY-TKMSANGWWRG--EVNGRVGWFPSTYVEE 786
           688*********************9.999999*****..9*************86 PP

Organism

Papio anubis

Protein Sequence
(Fasta)

MRKSELFEAF DLFDVRDFGK VIETLSRLSR TPIALATGIR PFPTEESIND EDVYKGLPDL 60
IDETLVEDEE DLYDCVYGED EGGEVYEDLM KAEEAHQPKC PENDIRSCCL AEIKQTEEKY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTTCTCTGTT TGAAGAACAT AAGGACATTT CTCACGGCCT GTTGTGAGAC ATTTGGAATG 60
AGGAAAAGTG AACTCTTCGA GGCATTTGAC CTGTTTGATG TTCGTGACTT TGGAAAGGTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0344--Guanine-nucleotide releasing factor
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0862--Zinc

Interpro

IPR001715--CH-domain
IPR000219--DH-domain
IPR001331--GDS_CDC24_CS
IPR002219--PE/DAG-bd
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR000980--SH2
IPR011511--SH3_2
IPR001452--SH3_domain

PROSITE

PS00741--DH_1
PS50010--DH_2
PS50003--PH_DOMAIN
PS50001--SH2
PS50002--SH3
PS00479--ZF_DAG_PE_1
PS50081--ZF_DAG_PE_2

Pfam

PF00130--C1_1
PF00169--PH
PF00621--RhoGEF
PF00017--SH2
PF07653--SH3_2

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN

SMART

SM00109--C1
SM00233--PH
SM00325--RhoGEF
SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0005886--C:plasma membrane
GO:0046872--F:metal ion binding
GO:0030676--F:Rac guanyl-nucleotide exchange factor activity
GO:0050853--P:B cell receptor signaling pathway
GO:0006974--P:cellular response to DNA damage stimulus
GO:0007229--P:integrin-mediated signaling pathway
GO:0030032--P:lamellipodium assembly
GO:0030593--P:neutrophil chemotaxis
GO:0030890--P:positive regulation of B cell proliferation
GO:0045785--P:positive regulation of cell adhesion
GO:0043552--P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0008361--P:regulation of cell size
GO:0035023--P:regulation of Rho protein signal transduction
GO:0042493--P:response to drug
GO:0007264--P:small GTPase mediated signal transduction
GO:0006906--P:vesicle fusion

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001362	Ailuropoda melanoleuca	92.51	0.00e+00	1403.00
IUUC-Apl-003734	Anas platyrhynchos	83.38	0.00e+00	1299.00
IUUC-Aca-004477	Anolis carolinensis	85.03	0.00e+00	1310.00
IUUC-Ame-011279	Astyanax mexicanus	62.53	0.00e+00	943.00
IUUC-Bta-012722	Bos taurus	92.13	0.00e+00	1394.00
IUUC-Cja-018941	Callithrix jacchus	95.05	0.00e+00	1441.00
IUUC-Cfa-020266	Canis familiaris	93.02	0.00e+00	1416.00
IUUC-Cpo-021966	Cavia porcellus	91.51	0.00e+00	1369.00
IUUC-Csa-023892	Chlorocebus sabaeus	96.07	0.00e+00	1460.00
IUUC-Dre-028199	Danio rerio	65.49	0.00e+00	997.00
IUUC-Dno-029474	Dasypus novemcinctus	92.51	0.00e+00	1404.00
IUUC-Eca-033961	Equus caballus	92.89	0.00e+00	1442.00
IUUC-Eeu-034719	Erinaceus europaeus	71.65	0.00e+00	769.00
IUUC-Fca-036572	Felis catus	92.26	0.00e+00	1394.00
IUUC-Fal-036802	Ficedula albicollis	87.44	0.00e+00	1386.00
IUUC-Gmo-039409	Gadus morhua	64.77	0.00e+00	978.00
IUUC-Gga-040884	Gallus gallus	82.11	0.00e+00	1278.00
IUUC-Gac-041395	Gasterosteus aculeatus	67.17	0.00e+00	1069.00
IUUC-Ggo-044460	Gorilla gorilla	93.39	0.00e+00	1410.00
IUUC-Hsa-046099	Homo sapiens	98.86	0.00e+00	1521.00
IUUC-Itr-048144	Ictidomys tridecemlineatus	96.24	0.00e+00	1483.00
IUUC-Lch-049650	Latimeria chalumnae	73.03	8.00e-106	375.00
IUUC-Loc-052487	Lepisosteus oculatus	68.64	0.00e+00	1054.00
IUUC-Laf-054564	Loxodonta africana	91.75	0.00e+00	1399.00
IUUC-Mcc-054622	Macaca mulatta	99.75	0.00e+00	1536.00
IUUC-Meu-056680	Macropus eugenii	80.96	0.00e+00	1223.00
IUUC-Mga-060013	Meleagris gallopavo	78.99	0.00e+00	1219.00
IUUC-Mmr-061251	Microcebus murinus	95.04	0.00e+00	1515.00
IUUC-Mdo-061875	Monodelphis domestica	89.47	0.00e+00	1379.00
IUUC-Mmu-063735	Mus musculus	91.37	0.00e+00	1413.00
IUUC-Mpu-065856	Mustela putorius furo	92.89	0.00e+00	1406.00
IUUC-Mlu-068108	Myotis lucifugus	93.27	0.00e+00	1360.00
IUUC-Nle-069863	Nomascus leucogenys	98.10	0.00e+00	1508.00
IUUC-Opr-070372	Ochotona princeps	82.21	0.00e+00	863.00
IUUC-Ont-072286	Oreochromis niloticus	67.60	0.00e+00	1053.00
IUUC-Ocu-074194	Oryctolagus cuniculus	93.27	0.00e+00	1414.00
IUUC-Ola-086336	Oryzias latipes	66.25	0.00e+00	1050.00
IUUC-Oar-089272	Ovis aries	92.13	0.00e+00	1435.00
IUUC-Ptr-090652	Pan troglodytes	92.64	0.00e+00	1422.00
IUUC-Psi-093784	Pelodiscus sinensis	83.90	0.00e+00	1305.00
IUUC-Pma-094372	Petromyzon marinus	51.93	0.00e+00	682.00
IUUC-Ppa-095161	Physcomitrella patens	43.64	3.00e-09	56.20
IUUC-Pfo-097308	Poecilia formosa	70.16	0.00e+00	1125.00
IUUC-Pab-098698	Pongo abelii	92.51	0.00e+00	1424.00
IUUC-Pva-102262	Pteropus vampyrus	92.00	0.00e+00	1340.00
IUUC-Rno-105421	Rattus norvegicus	90.99	0.00e+00	1420.00
IUUC-Sha-107325	Sarcophilus harrisii	89.34	0.00e+00	1389.00
IUUC-Sar-113456	Sorex araneus	86.55	0.00e+00	1326.00
IUUC-Tgu-116595	Taeniopygia guttata	79.52	0.00e+00	1221.00
IUUC-Tru-118577	Takifugu rubripes	68.18	0.00e+00	1101.00
IUUC-Tsy-119429	Tarsius syrichta	85.28	0.00e+00	1284.00
IUUC-Tni-119951	Tetraodon nigroviridis	66.29	0.00e+00	1006.00
IUUC-Tbe-127995	Tupaia belangeri	82.23	2.00e-136	479.00
IUUC-Ttr-128281	Tursiops truncatus	92.39	0.00e+00	1397.00
IUUC-Xtr-132427	Xenopus tropicalis	69.79	0.00e+00	1118.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence