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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045983
UUCD1 version UUC-HoS-00161
Ensembl Protein ID ENSP00000385328.2
UniProt Accession Q68DV7; A8K4R2; B7Z443; B7Z5D5; B7Z5J5; Q65ZA4; Q6AI04; Q9NXD0; RNF43_HUMAN
Genbank Protein ID BAD51435.1; BAA91085.1; BAF83716.1; BAH12429.1; BAH12871.1; BAH12931.1; CAH10510.1; CAH18113.1; AAI09029.1
Protein Name E3 ubiquitin-protein ligase RNF43; RING finger protein 43; RING-type E3 ubiquitin transferase RNF43
Genbank Nucleotide ID AB081837; AK000322; AK291027; AK296769; AK298789; AK299024; CR627423; CR749257; BC109028
Gene Name RNF43
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000108375.12 ENST00000407977.6 ENSP00000385328.2
ENSG00000108375.12 ENST00000583753.5 ENSP00000462502.1
ENSG00000108375.12 ENST00000581868.1 ENSP00000462447.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPA
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
ClinVarGWASdbOMIM
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusBioGRID
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 18313049; 21108931
Classification
Family E-value Score Start End
E3 activity/RING/RING 2.20e-07 32.9 272 312
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdg..plvlpCgHvfhadClqkwpglknssskefrCPlC 45
           CaiCle+f++g  ++v +C H fh++C+  w        ++ +CPlC
   Q: 272  CAICLEEFSEGqeLRVISCLHEFHRNCVDPW------LHQHRTCPLC 312
           ********55444******************......********** PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone.
 E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone.
Protein Sequence
(Fasta)
MSGGHQLQLA ALWPWLLMAT LQAGFGRTGL VLAAAVESER SAEQKAIIRV IPLKMDPTGK 60
LNLTLEGVFA GVAEITPAEG KLMQSHPLYL CNASDDDNLE PGFISIVKLE SPRRAPRPCL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045983|E3,RING|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGTCCCAGGG GAGGGAGTCA GAGCTAGAAC ACCAATTACA AACCACAGGC TTCCTGCTCT 60
AGGGAGTTGA TCCAGAATTG TCTTTCTGAA AGGAAGCACT CGGAATCCTT CCGAACTTTC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045983|E3,RING|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-1015--Disulfide bond
KW-0256--Endoplasmic reticulum
KW-0325--Glycoprotein
KW-0472--Membrane
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0732--Signal
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0879--Wnt signaling pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50089--ZF_RING_2
Pfam

PF13639--zf-RING_2
SMART

SM00184--RING
Gene Ontology

GO:0005789--C:endoplasmic reticulum membrane
GO:0005887--C:integral component of plasma membrane
GO:0005635--C:nuclear envelope
GO:0005886--C:plasma membrane
GO:0005109--F:frizzled binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0030178--P:negative regulation of Wnt signaling pathway
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0072089--P:stem cell proliferation
GO:0038018--P:Wnt receptor catabolic process
GO:0016055--P:Wnt signaling pathway
KEGG hsa:54894
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001826 Ailuropoda melanoleuca 87.74 0.00e+00 1108.00
IUUC-Apl-003222 Anas platyrhynchos 62.12 6.00e-139 488.00
IUUC-Aly-006256 Arabidopsis lyrata 41.10 6.00e-12 63.20
IUUC-Ath-007583 Arabidopsis thaliana 43.84 1.00e-12 65.10
IUUC-Ame-011450 Astyanax mexicanus 47.74 4.00e-51 196.00
IUUC-Bta-012714 Bos taurus 86.21 0.00e+00 1112.00
IUUC-Cel-018318 Caenorhabditis elegans 59.26 5.00e-15 75.90
IUUC-Cja-018949 Callithrix jacchus 92.99 4.00e-109 387.00
IUUC-Cfa-021169 Canis familiaris 83.17 0.00e+00 1076.00
IUUC-Cpo-022010 Cavia porcellus 92.86 4.00e-173 601.00
IUUC-Csa-023712 Chlorocebus sabaeus 95.73 0.00e+00 1005.00
IUUC-Dno-029646 Dasypus novemcinctus 78.56 0.00e+00 932.00
IUUC-Dor-030965 Dipodomys ordii 74.71 0.00e+00 975.00
IUUC-Ete-033153 Echinops telfairi 80.00 0.00e+00 949.00
IUUC-Eca-034222 Equus caballus 89.66 0.00e+00 1133.00
IUUC-Eeu-035320 Erinaceus europaeus 76.96 1.00e-86 314.00
IUUC-Fca-036163 Felis catus 88.98 0.00e+00 1144.00
IUUC-Fal-037463 Ficedula albicollis 59.93 2.00e-113 403.00
IUUC-Gmo-039022 Gadus morhua 49.00 1.00e-39 155.00
IUUC-Gga-040209 Gallus gallus 58.94 3.00e-122 432.00
IUUC-Ggo-045644 Gorilla gorilla 98.98 0.00e+00 1240.00
IUUC-Itr-049074 Ictidomys tridecemlineatus 88.77 0.00e+00 1159.00
IUUC-Loc-052503 Lepisosteus oculatus 40.63 8.00e-66 244.00
IUUC-Laf-054039 Loxodonta africana 86.79 0.00e+00 1134.00
IUUC-Mcc-054760 Macaca mulatta 96.30 0.00e+00 1227.00
IUUC-Meu-055948 Macropus eugenii 65.16 0.00e+00 707.00
IUUC-Mtr-058712 Medicago truncatula 32.06 3.00e-13 67.80
IUUC-Mga-060022 Meleagris gallopavo 59.80 9.00e-81 294.00
IUUC-Mmr-061100 Microcebus murinus 91.32 0.00e+00 1188.00
IUUC-Mdo-062909 Monodelphis domestica 70.83 0.00e+00 904.00
IUUC-Mmu-063835 Mus musculus 80.94 0.00e+00 1122.00
IUUC-Mpu-066916 Mustela putorius furo 88.76 0.00e+00 1110.00
IUUC-Mlu-067234 Myotis lucifugus 87.29 0.00e+00 1085.00
IUUC-Nle-069493 Nomascus leucogenys 98.21 0.00e+00 1257.00
IUUC-Oan-073037 Ornithorhynchus anatinus 83.97 2.00e-102 366.00
IUUC-Ocu-074655 Oryctolagus cuniculus 87.74 0.00e+00 1135.00
IUUC-Ola-087097 Oryzias latipes 45.37 5.00e-59 221.00
IUUC-Oga-088134 Otolemur garnettii 88.63 0.00e+00 1205.00
IUUC-Oar-089606 Ovis aries 79.69 0.00e+00 1060.00
IUUC-Ptr-090726 Pan troglodytes 99.11 0.00e+00 1270.00
IUUC-Pan-091958 Papio anubis 96.68 0.00e+00 1235.00
IUUC-Psi-093208 Pelodiscus sinensis 47.24 9.00e-145 507.00
IUUC-Pfo-096209 Poecilia formosa 53.85 3.00e-44 173.00
IUUC-Pab-097950 Pongo abelii 98.23 0.00e+00 841.00
IUUC-Pop-099435 Populus trichocarpa 33.00 3.00e-13 68.60
IUUC-Pca-100229 Procavia capensis 80.59 0.00e+00 1074.00
IUUC-Pva-102480 Pteropus vampyrus 84.67 0.00e+00 1123.00
IUUC-Rno-104862 Rattus norvegicus 82.68 0.00e+00 1122.00
IUUC-Sha-107577 Sarcophilus harrisii 73.63 0.00e+00 951.00
IUUC-Sly-111915 Solanum lycopersicum 55.81 8.00e-13 67.80
IUUC-Stu-112568 Solanum tuberosum 53.49 5.00e-12 66.60
IUUC-Sar-113693 Sorex araneus 74.94 0.00e+00 913.00
IUUC-Tgu-116568 Taeniopygia guttata 62.76 3.00e-112 399.00
IUUC-Tru-118126 Takifugu rubripes 43.08 5.00e-54 205.00
IUUC-Tni-120241 Tetraodon nigroviridis 45.38 5.00e-48 185.00
IUUC-Tur-126264 Triticum urartu 50.00 8.00e-11 60.80
IUUC-Tbe-128106 Tupaia belangeri 95.26 4.00e-142 498.00
IUUC-Ttr-128832 Tursiops truncatus 87.23 0.00e+00 863.00
IUUC-Vvi-130945 Vitis vinifera 52.08 2.00e-12 66.20
Created Date 25-Jun-2017

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