iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aml-001459

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ACTA01073277

Gene Name

SMURF1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMEG00000006728.1	ENSAMET00000007454.1	ENSAMEP00000007152.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.10e-127	426.1	420	752

Active Site

Position(s)	Description	Evidence
721	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dlkkrl+v+f+gEegld+gGv+re+l+ll++e+ np++glf+ys ++ ++lq+npds + np+hl++F+f+Gr++g+a+++g++++ 
   Q: 420  PKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSI-NPDHLSYFHFVGRIMGLAVFHGHYING 507
           689*********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk+llgk+++l+dle+vdpel+ksl +i+en   di+   ld tf+v+++ +g + ++eLkp+G+n+pVt+eNk+eYv+l+v+
   Q: 508  GFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILEN---DITPV-LDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVN 592
           ***********************************99...9***8.******************************************* PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +gi+ q+ a+++Gfne+ip++ll+ F+++elel+i G ++idv+d+k++t+ k+ + +ds+ ++wFw+++e f++e r+++LqFv
   Q: 593  WRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDVSDWKSNTRLKH-CVADSNIVRWFWQAVETFDEERRARLLQFV 680
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tgs r+Pl+Gf++l+    prlf+i+  da++d+lP+++TCfn++++P+Y+s+e+l+ekLl+A+eet gF +
   Q: 681  TGSTRVPLQGFKALQgaagPRLFTIHLiDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAV 752
           ***************************99999**************************************76 PP

Organism

Ailuropoda melanoleuca

Protein Sequence
(Fasta)

LAEIISRFFF PLQIQFSVLC AKNLAKKDFF RLPDPFAKIV VDGSGQCHST DTVKNTLDPK 60
WNQHYDLYVG KTDSITISVW NHKKIHKKQG AGFLGCARLL SNAISRLKDT GYQRLDLCKL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTGGCAGAGA TAATTTCTAG GTTTTTTTTC CCATTGCAAA TACAGACTTG TGTCTCAGTC 60
GTTTGTGCTG CTATAACAAA ATACCACAGA ATGCGTGGCT TAAATACATC TATTTCTCAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005739--C:mitochondrion
GO:0005886--C:plasma membrane
GO:0061630--F:ubiquitin protein ligase activity
GO:0030509--P:BMP signaling pathway
GO:0061736--P:engulfment of target by autophagosome
GO:0030279--P:negative regulation of ossification
GO:0030512--P:negative regulation of transforming growth factor beta receptor signaling pathway
GO:0061734--P:parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization
GO:1903861--P:positive regulation of dendrite extension
GO:2000060--P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0006611--P:protein export from nucleus
GO:0034394--P:protein localization to cell surface
GO:0000209--P:protein polyubiquitination
GO:0071211--P:protein targeting to vacuole involved in autophagy
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0032801--P:receptor catabolic process
GO:0061753--P:substrate localization to autophagosome
GO:0030579--P:ubiquitin-dependent SMAD protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-004155	Anas platyrhynchos	89.00	0.00e+00	1395.00
IUUC-Aca-005238	Anolis carolinensis	90.41	0.00e+00	1402.00
IUUC-Ame-010901	Astyanax mexicanus	85.51	0.00e+00	1321.00
IUUC-Bta-013221	Bos taurus	92.33	0.00e+00	1350.00
IUUC-Cja-018985	Callithrix jacchus	89.96	0.00e+00	1425.00
IUUC-Cfa-020568	Canis familiaris	90.28	0.00e+00	1415.00
IUUC-Cpo-022531	Cavia porcellus	89.45	0.00e+00	1415.00
IUUC-Csa-024145	Chlorocebus sabaeus	93.18	0.00e+00	1442.00
IUUC-Cho-024963	Choloepus hoffmanni	72.73	0.00e+00	891.00
IUUC-Dre-028341	Danio rerio	85.66	0.00e+00	1328.00
IUUC-Dno-029705	Dasypus novemcinctus	89.88	0.00e+00	1387.00
IUUC-Eca-034125	Equus caballus	90.27	0.00e+00	1416.00
IUUC-Fca-035905	Felis catus	93.27	0.00e+00	1428.00
IUUC-Fal-037336	Ficedula albicollis	91.50	0.00e+00	1398.00
IUUC-Gmo-039486	Gadus morhua	79.17	0.00e+00	850.00
IUUC-Gga-040218	Gallus gallus	90.30	0.00e+00	1405.00
IUUC-Gac-041707	Gasterosteus aculeatus	79.31	0.00e+00	1218.00
IUUC-Ggo-045408	Gorilla gorilla	84.73	0.00e+00	1311.00
IUUC-Hsa-045878	Homo sapiens	89.83	0.00e+00	1424.00
IUUC-Itr-048317	Ictidomys tridecemlineatus	90.26	0.00e+00	1415.00
IUUC-Loc-052628	Lepisosteus oculatus	84.66	0.00e+00	1332.00
IUUC-Laf-053644	Loxodonta africana	93.40	0.00e+00	1398.00
IUUC-Mcc-055479	Macaca mulatta	84.95	0.00e+00	1278.00
IUUC-Mga-059723	Meleagris gallopavo	91.83	0.00e+00	1397.00
IUUC-Mdo-063005	Monodelphis domestica	92.01	0.00e+00	1423.00
IUUC-Mmu-063634	Mus musculus	92.28	0.00e+00	1404.00
IUUC-Mpu-065898	Mustela putorius furo	92.97	0.00e+00	1426.00
IUUC-Mlu-067584	Myotis lucifugus	90.17	0.00e+00	1417.00
IUUC-Nle-069033	Nomascus leucogenys	90.40	0.00e+00	1419.00
IUUC-Ont-072265	Oreochromis niloticus	78.23	0.00e+00	1232.00
IUUC-Oan-073621	Ornithorhynchus anatinus	92.31	0.00e+00	1443.00
IUUC-Ocu-073960	Oryctolagus cuniculus	89.13	0.00e+00	1386.00
IUUC-Oga-088579	Otolemur garnettii	89.83	0.00e+00	1421.00
IUUC-Oar-090396	Ovis aries	88.26	0.00e+00	1318.00
IUUC-Ptr-091624	Pan troglodytes	89.83	0.00e+00	1424.00
IUUC-Pan-092479	Papio anubis	90.17	0.00e+00	1419.00
IUUC-Ppa-095250	Physcomitrella patens	44.57	6.00e-83	301.00
IUUC-Pfo-097203	Poecilia formosa	80.05	0.00e+00	1248.00
IUUC-Pab-097540	Pongo abelii	89.25	0.00e+00	1352.00
IUUC-Pca-100379	Procavia capensis	72.73	0.00e+00	639.00
IUUC-Rno-105396	Rattus norvegicus	92.28	0.00e+00	1404.00
IUUC-Sha-107216	Sarcophilus harrisii	88.52	0.00e+00	1409.00
IUUC-Ssc-116413	Sus scrofa	91.99	0.00e+00	1386.00
IUUC-Tgu-116723	Taeniopygia guttata	88.37	0.00e+00	1370.00
IUUC-Tru-117843	Takifugu rubripes	81.38	0.00e+00	1256.00
IUUC-Tsy-119455	Tarsius syrichta	88.52	0.00e+00	1323.00
IUUC-Tni-120829	Tetraodon nigroviridis	79.95	0.00e+00	1199.00
IUUC-Tbe-127879	Tupaia belangeri	77.19	0.00e+00	1154.00
IUUC-Ttr-128423	Tursiops truncatus	88.96	0.00e+00	1335.00
IUUC-Xtr-132237	Xenopus tropicalis	82.99	0.00e+00	1322.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence