iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oar-089317

Ensembl Protein ID

ENSOARP00000013501.1

UniProt Accession

W5PSS2; W5PSS2_SHEEP

Genbank Protein ID

ENSOARP00000013501

Protein Name

E3 ubiquitin-protein ligase

Genbank Nucleotide ID

AMGL01113064

Gene Name

WWP1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000012595.1	ENSOART00000013701.1	ENSOARP00000013501.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	8.20e-135	449.7	589	922

Active Site

Position(s)	Description	Evidence
891	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl+v f+gEegld+gG++re+++lls+e+ np+++lf+y  +++++lq+np+s + np+hl++F f+Gr++++al++g+++d+
   Q: 589  PYDLRRRLYVIFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASTI-NPDHLSYFCFIGRFIAMALFHGKFIDT 676
           6799*******************************************************98.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            +s +fyk++l+kkl+++dle++d e+y+sl +i++n   +iee+gl++ fsv+ eilg++++++Lk gG+ni Vt+eNk+eY+ l++e
   Q: 677  GFSLPFYKRMLSKKLTIKDLESIDTEFYNSLIWIRDN---NIEECGLEMYFSVDMEILGKVTSHDLKLGGSNILVTEENKDEYIGLMTE 762
           ***********************************99...9************************************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +g++eq++af +Gfnev+pl++l++F+e+ele+++cG++e+d+ d++++t y++ yt++s++i+wFw++++e ++e r ++LqFv
   Q: 763  WRFSRGVQEQTKAFLDGFNEVVPLQWLQYFDEKELEVMLCGMQEVDLADWQRNTVYRH-YTRNSKQIIWFWQFVKETDNEVRMRLLQFV 850
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk.....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlPlgGfael+     p++f+i+k ++d++lP+s+TCfn+L+LP+Y+s+e+lkekLl+Aieet+gF++
   Q: 851  TGTCRLPLGGFAELMgrsngPQKFCIEKVGKDTWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQ 922
           **********************************************************************96 PP

Organism

Ovis aries

Protein Sequence
(Fasta)

MATASPRSDT SNNHSGRLQL QVTVVSSAKL KRKKNWFGTA IYTEVAADGE SKKTAKSSSS 60
SNPKWDEQLT VNVTPQTTLE FRVWSHHTIK ADALLGRATV DLKQALLIHN RKLEKVKEQL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCCCGCCAAC ACAACCCCCA CCTCCACCTT TGTGACCTGC TGGGTCCCAG TGACCTTGCA 60
GTTTTTACTC GTCCTTATCT TATTGTGACT CGGACCATTC TCCTTTTCGT CTCTTTAGAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001213	Ailuropoda melanoleuca	91.99	0.00e+00	1692.00
IUUC-Apl-003310	Anas platyrhynchos	82.27	0.00e+00	1518.00
IUUC-Aca-005388	Anolis carolinensis	79.68	0.00e+00	1438.00
IUUC-Ame-010601	Astyanax mexicanus	75.95	0.00e+00	951.00
IUUC-Bta-012857	Bos taurus	96.86	0.00e+00	1766.00
IUUC-Cja-019448	Callithrix jacchus	92.53	0.00e+00	1705.00
IUUC-Cfa-020728	Canis familiaris	92.64	0.00e+00	1688.00
IUUC-Cpo-021635	Cavia porcellus	86.95	0.00e+00	1612.00
IUUC-Cin-025212	Ciona intestinalis	73.75	0.00e+00	904.00
IUUC-Dno-029618	Dasypus novemcinctus	92.53	0.00e+00	1697.00
IUUC-Dor-030665	Dipodomys ordii	75.84	0.00e+00	1125.00
IUUC-Ete-032779	Echinops telfairi	94.73	0.00e+00	1112.00
IUUC-Eca-033313	Equus caballus	90.80	0.00e+00	1643.00
IUUC-Eeu-035259	Erinaceus europaeus	83.87	0.00e+00	1516.00
IUUC-Fca-035420	Felis catus	90.80	0.00e+00	1667.00
IUUC-Fal-037335	Ficedula albicollis	82.35	0.00e+00	1497.00
IUUC-Gmo-039172	Gadus morhua	86.64	0.00e+00	1048.00
IUUC-Gga-040246	Gallus gallus	82.51	0.00e+00	1509.00
IUUC-Gac-042211	Gasterosteus aculeatus	91.14	0.00e+00	1157.00
IUUC-Hsa-046544	Homo sapiens	92.42	0.00e+00	1703.00
IUUC-Itr-048860	Ictidomys tridecemlineatus	90.14	0.00e+00	1635.00
IUUC-Laf-053551	Loxodonta africana	90.92	0.00e+00	1656.00
IUUC-Mga-059986	Meleagris gallopavo	82.85	0.00e+00	1518.00
IUUC-Mmr-060945	Microcebus murinus	90.27	0.00e+00	1642.00
IUUC-Mdo-063024	Monodelphis domestica	82.15	0.00e+00	1446.00
IUUC-Mmu-063202	Mus musculus	88.31	0.00e+00	1574.00
IUUC-Mpu-065773	Mustela putorius furo	92.43	0.00e+00	1682.00
IUUC-Mlu-067373	Myotis lucifugus	96.79	0.00e+00	646.00
IUUC-Nle-069188	Nomascus leucogenys	92.86	0.00e+00	1708.00
IUUC-Opr-070965	Ochotona princeps	87.34	0.00e+00	1583.00
IUUC-Ont-072226	Oreochromis niloticus	91.37	0.00e+00	1162.00
IUUC-Oan-073497	Ornithorhynchus anatinus	84.76	0.00e+00	1501.00
IUUC-Ocu-073891	Oryctolagus cuniculus	87.24	0.00e+00	1576.00
IUUC-Oga-087922	Otolemur garnettii	91.35	0.00e+00	1657.00
IUUC-Ptr-090484	Pan troglodytes	92.32	0.00e+00	1703.00
IUUC-Pan-092117	Papio anubis	92.64	0.00e+00	1706.00
IUUC-Psi-093338	Pelodiscus sinensis	83.55	0.00e+00	1538.00
IUUC-Pma-094279	Petromyzon marinus	73.55	0.00e+00	839.00
IUUC-Pfo-096171	Poecilia formosa	91.71	0.00e+00	1164.00
IUUC-Pva-102811	Pteropus vampyrus	79.87	0.00e+00	1405.00
IUUC-Rno-106125	Rattus norvegicus	88.20	0.00e+00	1590.00
IUUC-Sha-107243	Sarcophilus harrisii	84.30	0.00e+00	1511.00
IUUC-Ssc-115368	Sus scrofa	93.63	0.00e+00	1701.00
IUUC-Tgu-117079	Taeniopygia guttata	82.56	0.00e+00	1486.00
IUUC-Tru-118062	Takifugu rubripes	71.79	0.00e+00	1325.00
IUUC-Tsy-119507	Tarsius syrichta	86.36	0.00e+00	1562.00
IUUC-Tni-120151	Tetraodon nigroviridis	92.02	0.00e+00	1160.00
IUUC-Ttr-129260	Tursiops truncatus	83.98	0.00e+00	1474.00
IUUC-Uma-129332	Ustilago maydis	46.11	4.00e-144	505.00
IUUC-Vpa-130390	Vicugna pacos	83.06	0.00e+00	922.00
IUUC-Xtr-132877	Xenopus tropicalis	69.80	0.00e+00	1182.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence